Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis
出版年份 2018 全文链接
标题
Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis
作者
关键词
Non-alcoholic fatty liver disease (NAFLD), Non-alcoholic steatohepatitis (NASH), Organotypic liver system, Lipitoxic system, Diet induced animal model of non-alcoholic fatty liver disease (DIAMOND), Farnesoid X receptor (FXR)
出版物
Hepatology International
Volume 12, Issue 1, Pages 6-16
出版商
Springer Nature
发表日期
2018-01-04
DOI
10.1007/s12072-017-9838-6
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
- (2017) Naga Chalasani et al. HEPATOLOGY
- Therapies in non-alcoholic steatohepatitis (NASH)
- (2017) Abdul M. Oseini et al. LIVER INTERNATIONAL
- Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system
- (2017) A. Dash et al. TOXICOLOGY IN VITRO
- Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease
- (2017) Tomasz Kostrzewski et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum
- (2016) Timothy Hardy et al. Annual Review of Pathology-Mechanisms of Disease
- Liver and Kidney on Chips: Microphysiological Models to Understand Transporter Function
- (2016) SY Chang et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
- (2016) et al. DIABETOLOGIA
- Histological Assessment of NAFLD
- (2016) Pierre Bedossa DIGESTIVE DISEASES AND SCIENCES
- Elafibranor, an Agonist of the Peroxisome Proliferator−Activated Receptor−α and −δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening
- (2016) Vlad Ratziu et al. GASTROENTEROLOGY
- Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
- (2016) Zobair M. Younossi et al. HEPATOLOGY
- A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
- (2016) Amon Asgharpour et al. JOURNAL OF HEPATOLOGY
- Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid
- (2016) Noortje Ijssennagger et al. JOURNAL OF HEPATOLOGY
- Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease
- (2016) Manoela Mota et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes
- (2016) Kimberly A. Chapman et al. MOLECULAR GENETICS AND METABOLISM
- Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device
- (2016) Manuele Gori et al. PLoS One
- Bioprinted 3D Primary Liver Tissues Allow Assessment of Organ-Level Response to Clinical Drug Induced Toxicity In Vitro
- (2016) Deborah G. Nguyen et al. PLoS One
- Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
- (2016) Catherine C. Bell et al. Scientific Reports
- The impact of PPARα activation on whole genome gene expression in human precision cut liver slices
- (2015) Aafke W.F. Janssen et al. BMC GENOMICS
- A human liver microphysiology platform for investigating physiology, drug safety, and disease models
- (2015) Lawrence A Vernetti et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop
- (2015) Arun J. Sanyal et al. HEPATOLOGY
- NAFLD: A multisystem disease
- (2015) Christopher D. Byrne et al. JOURNAL OF HEPATOLOGY
- Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
- (2015) Brent A Neuschwander-Tetri et al. LANCET
- Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens
- (2015) Sandra March et al. Nature Protocols
- Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis
- (2015) Pegah Golabi et al. Expert Review of Gastroenterology & Hepatology
- In vitro platforms for evaluating liver toxicity
- (2014) Shyam Sundhar Bale et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Ballooned hepatocytes, undead cells, sonic hedgehog, and Vitamin E: Therapeutic implications for nonalcoholic steatohepatitis
- (2014) Petra Hirsova et al. HEPATOLOGY
- Microfluidic organs-on-chips
- (2014) Sangeeta N Bhatia et al. NATURE BIOTECHNOLOGY
- Microfabrication of human organs-on-chips
- (2013) Dongeun Huh et al. Nature Protocols
- The global NAFLD epidemic
- (2013) Rohit Loomba et al. Nature Reviews Gastroenterology & Hepatology
- A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity
- (2013) Radina Kostadinova et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Multi-cell type human liver microtissues for hepatotoxicity testing
- (2012) S. Messner et al. ARCHIVES OF TOXICOLOGY
- Organotypic liver culture models: Meeting current challenges in toxicity testing
- (2012) Edward L. LeCluyse et al. CRITICAL REVIEWS IN TOXICOLOGY
- Organotypic systems in drug metabolism and toxicity: challenges and opportunities
- (2012) Ajit Dash et al. Expert Opinion on Drug Metabolism & Toxicology
- Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans
- (2012) Salman R. Khetani et al. TOXICOLOGICAL SCIENCES
- Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
- (2011) Michael Charlton et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Changes in the Prevalence of the Most Common Causes of Chronic Liver Diseases in the United States From 1988 to 2008
- (2011) Zobair M. Younossi et al. Clinical Gastroenterology and Hepatology
- Frequency and Outcomes of Liver Transplantation for Nonalcoholic Steatohepatitis in the United States
- (2011) Michael R. Charlton et al. GASTROENTEROLOGY
- A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues
- (2010) S. N. Hart et al. DRUG METABOLISM AND DISPOSITION
- A microfluidic hepatic coculture platform for cell-based drug metabolism studies
- (2009) Eric Novik et al. BIOCHEMICAL PHARMACOLOGY
- Epidemiology and Natural History of Non-Alcoholic Steatohepatitis
- (2009) Curtis K. Argo et al. Clinics in Liver Disease
- Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells
- (2009) Petra Krause et al. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
- Perfused multiwell plate for 3D liver tissue engineering
- (2009) Karel Domansky et al. LAB ON A CHIP
- Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal
- (2009) Naim Alkhouri et al. Expert Review of Gastroenterology & Hepatology
- Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
- (2008) Laura H. Tetri et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
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