The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?

Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels

(2017) Vigdis Andersen Eidsvaag et al.   GLIA

Identification of the Upward Movement of Human CSF In Vivo and its Relation to the Brain Venous System

(2017) Steffi Dreha-Kulaczewski et al.   JOURNAL OF NEUROSCIENCE

Probing nano-organization of astroglia with multi-color super-resolution microscopy

(2017) Janosch P. Heller et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Interstitial solute transport in 3D reconstructed neuropil occurs by diffusion rather than bulk flow

(2017) Karl Erik Holter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Test of the 'glymphatic' hypothesis demonstrates diffusive and aquaporin-4-independent solute transport in rodent brain parenchyma

(2017) Alex J Smith et al.   eLife

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

(2017) Douglas M. Zeppenfeld et al.   JAMA Neurology

Lymphatic Clearance of the Brain: Perivascular, Paravascular and Significance for Neurodegenerative Diseases

(2016) Erik N. T. P. Bakker et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Spatial model of convective solute transport in brain extracellular space does not support a “glymphatic” mechanism

(2016) Byung-Ju Jin et al.   JOURNAL OF GENERAL PHYSIOLOGY

No diurnal variation of classical and candidate biomarkers of Alzheimer’s disease in CSF

(2016) Claudia Cicognola et al.   Molecular Neurodegeneration

Single-nanotube tracking reveals the nanoscale organization of the extracellular space in the live brain

(2016) Antoine G. Godin et al.   Nature Nanotechnology

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Glymphatic solute transport does not require bulk flow

(2016) Mahdi Asgari et al.   Scientific Reports

Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections

(2015) Alex J. Smith et al.   BIOPHYSICAL JOURNAL

A balanced view of the cerebrospinal fluid composition and functions: Focus on adult humans

(2015) Reynold Spector et al.   EXPERIMENTAL NEUROLOGY

The Effect of Body Posture on Brain Glymphatic Transport

(2015) H. Lee et al.   JOURNAL OF NEUROSCIENCE

Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways

(2015) C. Bohm et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

Muddying the water in brain edema?

(2015) Alex J. Smith et al.   TRENDS IN NEUROSCIENCES

How astrocyte networks may contribute to cerebral metabolite clearance

(2015) Mahdi Asgari et al.   Scientific Reports

Clearing Your Mind: A Glymphatic System?

(2015) Ferdinand K. Hui   World Neurosurgery

Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation

(2015) Natalya Korogod et al.   eLife

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Vascular Supply of the Cerebral Cortex is Specialized for Cell Layers but Not Columns

(2014) Daniel L. Adams et al.   CEREBRAL CORTEX

Prion-like Properties of Tau Protein: The Importance of Extracellular Tau as a Therapeutic Target

(2014) Brandon B. Holmes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregation state determines the localization and function of M1– and M23–aquaporin-4 in astrocytes

(2014) Alex J. Smith et al.   JOURNAL OF CELL BIOLOGY

Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain

(2014) A. A. Sosunov et al.   JOURNAL OF NEUROSCIENCE

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes

(2014) Soyon Hong et al.   NEURON

‘Hit & Run’ Model of Closed-Skull Traumatic Brain Injury (TBI) Reveals Complex Patterns of Post-Traumatic AQP4 Dysregulation

(2013) Zeguang Ren et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebral Arterial Pulsation Drives Paravascular CSF-Interstitial Fluid Exchange in the Murine Brain

(2013) J. J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Diffusion of Macromolecules in the Brain: Implications for Drug Delivery

(2013) Daniel J. Wolak et al.   MOLECULAR PHARMACEUTICS

Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy

(2013) R. O. Carare et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Sleep Facilitates Clearance of Metabolites from the Brain: Glymphatic Function in Aging and Neurodegenerative Diseases

(2013) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Garbage Truck of the Brain

(2013) M. Nedergaard   SCIENCE

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Loss of astrocyte polarization upon transient focal brain ischemia as a possible mechanism to counteract early edema formation

(2012) Esther Steiner et al.   GLIA

Topology and Hemodynamics of the Cortical Cerebrovascular System

(2012) Sven Hirsch et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Extracellular sheets and tunnels modulate glutamate diffusion in hippocampal neuropil

(2012) Justin P. Kinney et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of  -Amyloid in Mice with Alzheimer's Disease Pathology

(2012) J. H. Roh et al.   Science Translational Medicine

Trafficking of Glucose, Lactate, and Amyloid-β from the Inferior Colliculus through Perivascular Routes

(2009) Kelly K Ball et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Electrostatic and electrokinetic effects on hindered convection in pores

(2009) Panadda Dechadilok et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

(2009) D.M. Wilcock et al.   NEUROSCIENCE

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE

Lymphatic drainage of the brain and the pathophysiology of neurological disease

(2008) Roy O. Weller et al.   ACTA NEUROPATHOLOGICA

Aquaporin-4-Deficient Mice Have Increased Extracellular Space without Tortuosity Change

(2008) X. Yao et al.   JOURNAL OF NEUROSCIENCE

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS

Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain

(2007) Zsolt Zador et al.   FASEB JOURNAL