Exercise training protects human and rodent β cells against endoplasmic reticulum stress and apoptosis

Effects and underlying mechanisms of irisin on the proliferation and apoptosis of pancreatic β cells

(2017) Shiwei Liu et al.   PLoS One

ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death

(2017) Nicola J. Darling et al.   PLoS One

Attenuated PGC-1α Isoforms following Endurance Exercise with Blood Flow Restriction

(2016) MIGUEL SOARES CONCEIÇÃO et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

(2016) S De Groef et al.   Cell Death & Disease

The Impact of Endurance Training on Human Skeletal Muscle Memory, Global Isoform Expression and Novel Transcripts

(2016) Maléne E Lindholm et al.   PLoS Genetics

IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells

(2016) James E. Krolopp et al.   Frontiers in Physiology

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

Exercise increases pancreatic β-cell viability in a model of type 1 diabetes through IL-6 signaling

(2015) Flavia M. M. Paula et al.   FASEB JOURNAL

Exercise and type 2 diabetes: focus on metabolism and inflammation

(2015) Kristian Karstoft et al.   IMMUNOLOGY AND CELL BIOLOGY

Modulating exercise-induced hormesis: Does less equal more?

(2015) Jonathan M. Peake et al.   JOURNAL OF APPLIED PHYSIOLOGY

Skeletal Muscle to Pancreatic β-Cell Cross-talk: The Effect of Humoral Mediators Liberated by Muscle Contraction and Acute Exercise on β-Cell Apoptosis

(2015) Camilla S. Christensen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pancreatic α Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes

(2015) Laura Marroqui et al.   EBioMedicine

Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle

(2014) Kristin I. Stanford et al.   ADVANCES IN PHYSIOLOGY EDUCATION

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic  -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

(2014) L. Marroqui et al.   DIABETES

The time has come to test the beta cell preserving effects of exercise in patients with new onset type 1 diabetes

(2014) Parth Narendran et al.   DIABETOLOGIA

The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer

(2014) SHU-WEI WANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of human exercise-induced myokines using secretome analysis

(2014) Milène Catoire et al.   PHYSIOLOGICAL GENOMICS

STAT3 Target Genes Relevant to Human Cancers

(2014) Richard Carpenter et al.   Cancers

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

(2013) Miriam Cnop et al.   DIABETES

The secretome of the working human skeletal muscle-A promising opportunity to combat the metabolic disaster?

(2013) Cora Weigert et al.   Proteomics Clinical Applications

Endoplasmic reticulum stress sensitizes pancreatic beta cells to interleukin-1β-induced apoptosis via Bim/A1 imbalance

(2013) M Miani et al.   Cell Death & Disease

GLIS3, a Susceptibility Gene for Type 1 and Type 2 Diabetes, Modulates Pancreatic Beta Cell Apoptosis via Regulation of a Splice Variant of the BH3-Only Protein Bim

(2013) Tatiane C. Nogueira et al.   PLoS Genetics

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

(2013) Mariana Igoillo-Esteve et al.   PLoS Genetics

Mitochondrial dysfunction in pancreatic β cells

(2012) Sachin Supale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines

(2012) Décio L. Eizirik et al.   PLoS Genetics

Exercise Increases Insulin Content and Basal Secretion in Pancreatic Islets in Type 1 Diabetic Mice

(2011) Han-Hung Huang et al.   Experimental Diabetes Research

Endurance training stimulates growth and survival pathways and the redox balance in rat pancreatic islets

(2011) Vivian C. Calegari et al.   JOURNAL OF APPLIED PHYSIOLOGY

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Resistance to type 2 diabetes mellitus: a matter of hormesis?

(2011) Hubert Kolb et al.   Nature Reviews Endocrinology

IL-6 Induced STAT3 Signalling Is Associated with the Proliferation of Human Muscle Satellite Cells Following Acute Muscle Damage

(2011) Kyle G. Toth et al.   PLoS One

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

Preconditioning with Endoplasmic Reticulum Stress Mitigates Retinal Endothelial Inflammation via Activation of X-box Binding Protein 1

(2010) Jingming Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress

(2010) Esteban N. Gurzov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Strenuous physical exercise adversely affects monocyte chemotaxis

(2010) F. S. Czepluch et al.   THROMBOSIS AND HAEMOSTASIS

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon- -Induced Pancreatic  -Cell Apoptosis

(2009) F. Moore et al.   DIABETES

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology