☆ 4.7 Article

STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage

CELL DEATH & DISEASE (2016)

获取全文
添加到收藏夹

期刊

CELL DEATH & DISEASE
卷 7, 期 -, 页码 -

出版社

NATURE PUBLISHING GROUP
DOI: 10.1038/cddis.2016.171

关键词

-

类别

Cell Biology

资金

  1. Fund for Scientific Research Flanders
  2. Universitaire Stichting van Belgie
  3. Interuniversity Attraction Pole network [VII-P07]
  4. Stichting Diabetes Onderzoek Nederland
  5. Vrije Universiteit Brussel Research Council
  6. JDRF Advanced Postdoctoral Grant

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

Partial pancreatic duct ligation (PDL) of mouse pancreas induces a doubling of the beta-cell mass mainly through proliferation of preexisting and newly formed beta-cells. The molecular mechanism governing this process is still largely unknown. Given the inflammatory nature of PDL and inflammation-induced signaling via the signal transducer and activator of transcription 3 (STAT3), the activation and the role of STAT3 in PDL-induced beta-cell proliferation were investigated. Duct ligation stimulates the expression of several cytokines that can act as ligands inducing STAT3 signaling and phosphorylation in beta-cells. beta-Cell cycling increased by conditional beta-cell-specific Stat3 knockout and decreased by STAT3 activation through administration of interleukin-6. In addition, the level of DNA damage in beta-cells of PDL pancreas increased after deletion of Stat3. These data indicate a role for STAT3 in maintaining a steady state in the beta-cell, by modulating its cell cycle and protection from DNA damage.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Letter Medicine, General & Internal

Lessons from the Belgian experience with regulatory control during the COVID-19 pandemic for the implementation of the European IVD regulation 2017/746

Pieter Vermeersch, Frederic Cotton, Dieter De Smet, Geert Martens, Matthijs Oyaert, Etienne Cavalier

ACTA CLINICA BELGICA (2022)

添加到收藏夹
Article Gastroenterology & Hepatology

Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease

Sandrina Martens, Katarina Coolens, Mathias Van Bulck, Tatjana Arsenijevic, Joan Casamitjana, Angel Fernandez Ruiz, Abdessamad El Kaoutari, Jaime Martinez de Villareal, Hediel Madhloum, Farzad Esni, Yves Heremans, Gunter Leuckx, Harry Heimberg, Luc Bouwens, Patrick Jacquemin, Diedert Luc De Paep, Peter in't Veld, Nicky D'Haene, Christelle Bouchart, Nelson Dusetti, Jean-Luc Van Laethem, Wim Waelput, Pierre Lefesvre, Francisco X. Real, Meritxell Rovira, Ilse Rooman

Summary: In larger human pancreatic ducts, basal cells exist. Delta Np63 suppresses duct cell identity. These cells may play an important role in pancreatic disease, including PDAC ontogeny, but are not present in mouse models.

GUT (2022)

添加到收藏夹
Article Pathology

Cycle Threshold Probability Score for Immediate and Sensitive Detection of B.1.351 SARS-CoV-2 Lineage

Dieter De Smet, Merijn Vanhee, Brigitte Maes, Koen Swaerts, Peter De Jaeger, Karel Maelegheer, Frederik Van Hoecke, Geert Antoine Martens

Summary: The delayed N gene amplification in the Allplex SARS-CoV-2 Assay can be used for fast and highly sensitive screening of the B.1.351 variant, providing a potential tool for safeguarding vaccination efficacy.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2022)

添加到收藏夹
Article Infectious Diseases

Pitfalls of SARS-CoV-2 antigen testing at emergency department

Eleonora Cottone, Frederik Van Hoecke, Geert Antoine Martens, Emmanuel De Laere, Roos De Smedt, Steven Vervaeke, Merijn Vanhee, Dieter De Smet

Summary: Our study showed inferior performance of the Roche SARS-CoV-2 Rapid Antigen test (SD Biosensor) for detection of SARS-CoV-2, limiting its use as a diagnostic gatekeeper in ER departments, but it is able to differentiate contagious individuals.

INFECTIOUS DISEASES (2022)

添加到收藏夹
Article Immunology

Three doses of BNT162b2 vaccine confer neutralising antibody capacity against the SARS-CoV-2 Omicron variant

Kevin K. Arien, Leo Heyndrickx, Johan Michiels, Katleen Vereecken, Kurt Van Lent, Sandra Coppens, Betty Willems, Pieter Pannus, Geert A. Martens, Marjan Van Esbroeck, Maria E. Goossens, Arnaud Marchant, Koen Bartholomeeusen, Isabelle Desombere

Summary: This study reports the levels of neutralizing antibodies against Wuhan, Delta, and Omicron variants in different groups of individuals. The findings support the use of booster vaccines to prevent infection and disease caused by the Omicron variant.

NPJ VACCINES (2022)

添加到收藏夹
Article Immunology

CTLA4, SH2B3, and CLEC16A diversely affect the progression of early islet autoimmunity in relatives of Type 1 diabetes patients

Julie Vandewalle, Aster K. Desouter, Bart J. van der Auwera, Sylvie Tenoutasse, Pieter Gillard, Christophe De Block, Bart Keymeulen, Frans K. Gorus, Mark van de Casteele, Belgian Diabetes Registry

Summary: The HLA region is the major genetic risk determinant of Type 1 diabetes. Non-HLA loci, such as INS, SH2B3, PTPN2, PTPN22, CTLA4, CLEC16A, and IL2RA, may also contribute to the genetic risk by impacting the progression of asymptomatic autoimmunity. In this study, the researchers investigated the relationship between SNPs in these susceptibility loci and the progression from single to multiple autoantibody positivity, as well as the development of clinical diabetes. They found that certain genotypes in CTLA4 and CLEC16A were associated with accelerated progression from single to multiple autoantibody positivity, but their effects were limited to specific conditions. The interaction between CTLA4 and HLA-DQ2/DQ8 was found to override the effect of HLA-DQ2/DQ8 alone. The study also showed that SH2B3 genotype was protective for HLA-DQ8 positive subjects, while CTLA4 genotype was a minor independent risk factor for progression towards clinical diabetes. The findings suggest that non-HLA polymorphisms impact the progression of islet autoimmunity in specific ways and may have implications for risk assessment and prevention trials in at-risk groups.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2023)

添加到收藏夹
Editorial Material Biochemistry & Molecular Biology

Short-term nitisinone discontinuation of hereditary tyrosinemia type 1 mice causes metabolic alterations in glutathione metabolism/biosynthesis and multiple amino acid degradation pathways

Colemonts-Vroninks Haaike, Norman P. Brendan, Van Laere Sven, Davison S. Andrew, Marcelis Lionel, Casimir Georges, Goyens Philippe, Claes Paul, De Bundel Dimitri, Martens Geert, Ranganath Lakshminarayan Rao, Vanhaecke Tamara, A. Gallagher James, De Kock Joery

GENES & DISEASES (2023)

添加到收藏夹
Article Biochemical Research Methods

DeltaMSI: artificial intelligence-based modeling of microsatellite instability scoring on next-generation sequencing data

Koen Swaerts, Franceska Dedeurwaerdere, Dieter De Smet, Peter De Jaeger, Geert A. A. Martens

Summary: This study aimed to use machine learning to process the complexity of indel distributions and integrate it into a robust script for dMMR screening on small gene panel-based NGS data of clinical tumor samples. The results showed that the novel script (DeltaMSI) achieved higher robustness and diagnostic power compared to the widely used script mSINGS, indicating its clinical potential for high-throughput MSI screening in all tumor types.

BMC BIOINFORMATICS (2023)

添加到收藏夹
Correction Cell & Tissue Engineering

Ductal Ngn3-expressing progenitors contribute to adult β cell neogenesis in the pancreas (vol 28, pg 2000, 2021)

Christopher Gribben, Christopher Lambert, Hendrik A. Messal, Ella -Louise Hubber, Chloe Rackham, Ian Evans, Harry Heimberg, Peter Jones, Rocio Sancho, Axel Behrens

CELL STEM CELL (2023)

添加到收藏夹
Editorial Material Endocrinology & Metabolism

Editorial: Emerging talents in pediatric endocrinology: 2022

Willem Staels, Michael A. Levine

FRONTIERS IN ENDOCRINOLOGY (2023)

添加到收藏夹
Review Medicine, General & Internal

Peripheral precocious puberty in Li-Fraumeni syndrome: a case report and literature review of pure androgen-secreting adrenocortical tumors

Sofie Ryckx, Jean De Schepper, Philippe Giron, Ken Maes, Freya Vaeyens, Kaat Wilgenhof, Pierre Lefesvre, Caroline Ernst, Kim Vanderlinden, Daniel Klink, Frederik Hes, Jesse Vanbesien, Inge Gies, Willem Staels

Summary: We present a case of a 2.5-year-old boy with a pure androgen-secreting adrenocortical tumor, characterized by penile enlargement, pubic hair, frequent erections, and rapid linear growth. The diagnosis was confirmed through laboratory tests, medical imaging, and histology. Additionally, genetic testing revealed a pathogenic germline variant in the TP53 gene, confirming an underlying Li-Fraumeni syndrome.

JOURNAL OF MEDICAL CASE REPORTS (2023)

添加到收藏夹
Article Gastroenterology & Hepatology

Gut Microbiota Remodeling and Intestinal Adaptation to Lipid Malabsorption After Enteroendocrine Cell Loss in Adult Mice

Florence Blot, Justine Marchix, Miriam Ejarque, Sara Jimenez, Aline Meunier, Celine Keime, Camille Trottier, Mikael Croyal, Celine Lapp, Maxime M. Mahe, Adele De Arcangelis, Gerard Gradwohl

Summary: EECs play a crucial role in regulating energy homeostasis by sensing luminal nutrients and microbial metabolites. The absence of EECs in healthy adult mice leads to weight loss, impaired lipid absorption and metabolism, and altered gut microbiota composition.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2023)

添加到收藏夹
Meeting Abstract Biochemistry & Molecular Biology

Benefits of whole exome sequencing to advance the genetic diagnosis in patients with differences (disorders) of sex development

Hannes Syryn, Hannah Verdin, Julie Van De Velde, Marianne Becker, Cecile Brachet, Marieke den Brinker, Sylvia Depoorter, Julie Fudvoye, Daniel Klink, Philippe Lysy, Guy Massa, Nele Reynaert, Anne Rochtus, Willem Staels, Marlies Van Loocke, Martine Cools, Elfride De Baere

EUROPEAN JOURNAL OF HUMAN GENETICS (2023)

添加到收藏夹
Meeting Abstract Endocrinology & Metabolism

Validation of referral criteria for growth monitoring in Flanders based on height at the start of GH therapy in children with growth hormone deficiency and Turner syndrome

Daniel Klink, Karl Logghe, Muriel Thomas, Mathieu Roelants, Katelijne Van Hoeck, Philippe Lysy, Marianne Becker, Willem Staels, Jean de Schepper

HORMONE RESEARCH IN PAEDIATRICS (2022)

添加到收藏夹
Article Infectious Diseases

From Delta to Omicron SARS-CoV-2 variant: Switch to saliva sampling for higher detection rate

Margot Cornette, Bieke Decaesteker, Geert Antoine Martens, Patricia Vandecandelaere, Stijn Jonckheere

Summary: This study evaluated the performance of oropharyngeal swab, nasopharyngeal swab, and saliva in detecting SARS-CoV-2 Delta and Omicron variants using RT-PCR. The results showed that saliva was superior to nasopharyngeal swab in detecting the Omicron variant. For the Delta variant, nasopharyngeal swab and saliva were considered equivalent specimens. Oropharyngeal swab was the least sensitive sample type and provided little additional value when collected in addition to a single nasopharyngeal swab.

JOURNAL OF CLINICAL VIROLOGY PLUS (2022)

添加到收藏夹
暂无数据
研讨会 海报 问题 讨论圈 基金 期刊 论文 科研社交 资讯集成 审稿人 关于我们 常见问题 移动App 隐私条款 使用条款
© Peeref 2019-2024. All rights reserved.