Article
Cell Biology
Edmund Battey, Regula Furrer, Jacob Ross, Christoph Handschin, Julien Ochala, Matthew J. Stroud
Summary: PGC-1α plays a critical role in myonuclear accretion during adaptation to endurance training, especially in larger muscle fibers. Myonuclear accretion in PGC-1α mKO mice is slightly affected with increasing fiber size, but is significantly altered in trained larger fibers compared to sedentary mice, highlighting the importance of PGC-1α in myonuclear accretion in these fibers.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Physiology
Elisabeth Skoglund, Per Stal, Tommy R. Lundberg, Thomas Gustafsson, Per A. Tesch, Lars -Eric Thornell
Summary: This study compared muscle morphology in three advanced aging cohorts, including a unique cohort of lifelong endurance athletes. The findings suggest that lifelong endurance training is associated with higher muscle oxidative capacity, even in individuals over the age of 80.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Julia Villarroel, Ida Donkin, Camille Champion, Remy Burcelin, Romain Barres
Summary: Accumulating evidence suggests the existence of a tissue microbiota, which plays a role in regulating the physiological function of tissues. A study conducted on healthy male individuals found that endurance training specifically remodels the bacterial DNA profile of skeletal muscle, but not blood.
Review
Physiology
Ian A. J. Darragh, Lorraine O'Driscoll, Brendan Egan
Summary: Exercise factors are a key area of research, potentially influencing acute exercise metabolism and adaptation to exercise training. Exercise training may alter the resting profile of circulating exercise factors, some of which may be transported as small EVs in circulation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Wei Wei, Nicholas M. Riley, Xuchao Lyu, Xiaotao Shen, Jing Guo, Steffen H. Raun, Meng Zhao, Maria Dolores Moya-Garzon, Himanish Basu, Alan Sheng-Hwa Tung, Veronica L. Li, Wentao Huang, Amanda L. Wiggenhorn, Katrin J. Svensson, Michael P. Snyder, Carolyn R. Bertozzi, Jonathan Z. Long
Summary: There is a need to identify blood-borne factors that mediate tissue crosstalk during physical activity. This study used a cell-type-specific proteomic approach to map exercise training-regulated secretomes in mice, identifying over 200 previously unreported cell-type-secreted protein pairs. The study also found exercise-induced secretion of proteoforms of intracellular carboxylesterases from the liver, which had anti-obesity, anti-diabetic, and exercise performance-enhancing activities.
Article
Multidisciplinary Sciences
Eduardo Iglesias-Gutierrez, Manuel Fernandez-Sanjurjo, Alvaro F. Fernandez, Francisco Jose Rodriguez Diaz, Isabel Lopez-Taboada, Cristina Tomas-Zapico, Benjamin Fernandez-Garcia
Summary: Resistance training using ladders and weights is a versatile method in animal research, allowing for assessment of physical strength and adjustment of training load. Training programs need to be flexible to adapt to the adaptive and behavioral response of animals or the presence of injuries.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Physiology
Nicki Winfield Almquist, Hanne Berg Eriksen, Malene Wilhelmsen, Havard Hamarsland, Steven Ing, Stian Ellefsen, Oyvind Sandbakk, Bent R. Ronnestad, Knut Skovereng
Summary: This study compared the effects of load-matched block periodization and traditional periodization on trained cyclists. The results showed no difference in performance and muscular adaptations between the two training methods, but differences were found in hematological and muscle capillary adaptations.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Patrick M. Schaefer, Komal Rathi, Arrienne Butic, Wendy Tan, Katherine Mitchell, Douglas C. Wallace
Summary: Primary mitochondrial diseases are metabolic disorders caused by mutations in mitochondrial and nuclear DNA genes. This study found that endurance exercise may be beneficial for some mitochondrial disorders but not for others. Gene expression analysis identified key pathways involved in the exercise response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Physiology
Baubak Shamim, Donny M. Camera, Jamie Whitfield
Summary: In this study, it was found that resistance, endurance, and concurrent training can similarly induce myofibre hypertrophy without expansion of satellite cell and myonuclear pool. Additionally, the results suggest that myonuclear accretion via satellite cell fusion is positively correlated with hypertrophy after 12 weeks of concurrent training.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Physiology
Aurel B. B. Leuchtmann, Volkan Adak, Sedat Dilbaz, Christoph Handschin
Summary: Exercise induces molecular and cellular adaptations in various organs beyond skeletal muscles. The release of signaling molecules from skeletal muscle plays a central role in systemic plasticity, with the long-term training adaptation secretome still not well understood. Targeting these factors could have implications for athletic performance and disease prevention.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel P. Singh, Luke Pearce, Rocky H. Choi, Aldo Meizoso-Huesca, Stefan G. Wette, John W. Scott, Cedric R. Lamboley, Robyn M. Murphy, Bradley S. Launikonis
Summary: Resting skeletal muscle generates heat for endothermy in mammals but not amphibians, through the regulation of Ca2+ and the sympathetic nervous system. By studying muscle fibers in amphibians and mammals, it was found that mammals have a resistance to Ca2+-activated regenerative Ca2+ release and heat generation is regulated by cAMP-activated RyR Ca2+ leak. This indicates that the loss of a Ca2+-sensitive RyR isoform was an important evolutionary event for heat generation in mammals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Sport Sciences
Felipe C. Vechin, Miguel S. Conceicao, Guilherme D. Telles, Cleiton A. Libardi, Carlos Ugrinowitsch
Summary: Previous research has shown that concurrent training (CT) may reduce muscle strength and mass gains induced by resistance training (RT), but very intense high-intensity interval training (HIIT) protocols can minimize the interference effect. When performing CT, implementing very intense HIIT protocols is recommended to avoid the interference effect on muscle strength and mass.
Article
Multidisciplinary Sciences
Wooi F. Lim, Mitra Forouhan, Thomas C. Roberts, Jesse Dabney, Ruth Ellerington, Alfina A. Speciale, Raquel Manzano, Maria Lieto, Gavinda Sangha, Subhashis Banerjee, Mariana Conceicao, Lara Cravo, Annabelle Biscans, Loic Roux, Naemeh Pourshafie, Christopher Grunseich, Stephanie Duguez, Anastasia Khvorova, Maria Pennuto, Constanza J. Cortes, Albert R. La Spada, Kenneth H. Fischbeck, Matthew J. A. Wood, Carlo Rinaldi
Summary: SBMA is a neuromuscular disease caused by a polyQ expansion in AR protein, with recent studies highlighting the importance of mutant AR-altered transcriptional activity. Targeting AR isoform 2 can ameliorate the disease phenotype in SBMA mice by restoring dysregulated transcriptional activity of polyQ AR protein.
Article
Biochemistry & Molecular Biology
Daniel A. Bizjak, Martina Zuegel, Gunnar Treff, Kay Winkert, Achim Jerg, Jens Hudemann, Frank C. Mooren, Karsten Krueger, Andreas Niess, Juergen M. Steinacker
Summary: The study aimed to investigate skeletal muscle gene expression differences between highly trained endurance and strength athletes compared to untrained individuals in response to acute exercise. It found that differences in gene expression between trained and untrained individuals were smaller compared to differences in exercise mode, with NR4A genes showing significant expression in response to endurance or strength exercise. The study highlights the importance of understanding the adaptive processes of skeletal muscle in developing optimized training strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Victoria L. Wyckelsma, Ada Trepci, Lilly Schwieler, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Henrikas Paulauskas, Helena Gapeyeva, Mati Paasuke, Stefano Gastaldello, Sophie Imbeault, Hakan Westerblad, Sophie Erhardt, Daniel C. Andersson
Summary: In elderly men, three weeks of sprint interval training shifted KP metabolism towards neuroprotection, but this shift was blocked by antioxidant treatment.
Article
Sport Sciences
Marcus Moberg, Malene E. Lindholm, Stefan M. Reitzner, Bjorn Ekblom, Carl-Johan Sundberg, Niklas Psilander
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2020)
Article
Medicine, General & Internal
Helge Brandberg, Thomas Kahan, Jonas Spaak, Kay Sundberg, Sabine Koch, Athena Adeli, Carl Johan Sundberg, David Zakim
Review
Biochemistry & Molecular Biology
James A. Sanford, Christopher D. Nogiec, Malene E. Lindholm, Joshua N. Adkins, David Amar, Surendra Dasari, Jonelle K. Drugan, Facundo M. Fernandez, Shlomit Radom-Aizik, Simon Schenk, Michael P. Snyder, Russell P. Tracy, Patrick Vanderboom, Scott Trappe, Martin J. Walsh
Article
Cell Biology
Mark A. Chapman, Muhammad Arif, Eric B. Emanuelsson, Stefan M. Reitzner, Malene E. Lindholm, Adil Mardinoglu, Carl Johan Sundberg
Article
Health Care Sciences & Services
Helge Brandberg, Carl Johan Sundberg, Jonas Spaak, Sabine Koch, David Zakim, Thomas Kahan
Summary: This study aimed to evaluate the effectiveness of self-reported medical histories collected via a computerized history taking (CHT) program on a tablet among patients with acute chest pain in the emergency department. Results showed that a majority of patients were able to effectively interact with CHT to provide sufficient data for cardiovascular risk stratification. However, utility was somewhat lower in certain patient subgroups, indicating the need for further studies to assess the potential benefits of CHT in improving management and prognosis for this large patient population.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Multidisciplinary Sciences
David Amar, Malene E. Lindholm, Jessica Norrbom, Matthew T. Wheeler, Manuel A. Rivas, Euan A. Ashley
Summary: This study explores the molecular mechanisms driving exercise adaptation by conducting a meta-analysis on human skeletal muscle, revealing time-specific patterns of acute and long-term exercise responses, as well as identifying sex- and age-specific changes.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Shihui Niu, Jiang Li, Wenhao Bo, Weifei Yang, Andrea Zuccolo, Stefania Giacomello, Xi Chen, Fangxu Han, Junhe Yang, Yitong Song, Yumeng Nie, Biao Zhou, Peiyi Wang, Quan Zuo, Hui Zhang, Jingjing Ma, Jun Wang, Lvji Wang, Qianya Zhu, Huanhuan Zhao, Zhanmin Liu, Xuemei Zhang, Tao Liu, Surui Pei, Zhimin Li, Yao Hu, Yehui Yang, Wenzhao Li, Yanjun Zan, Linghua Zhou, Jinxing Lin, Tongqi Yuan, Wei Li, Yue Li, Hairong Wei, Harry X. Wu
Summary: This study provides important resources and insights into conifer evolution and further research on conifer adaptation and development. The researchers found that the large genome size of conifers is mainly due to intergenic regions and transposable element content. Large genes with long introns exhibit higher expression levels. Additionally, the expansion of gene families in conifers is mainly related to stress responses.
Article
Cardiac & Cardiovascular Systems
Malene E. Lindholm, David Jimenez-Morales, Han Zhu, Kinya Seo, David Amar, Chunli Zhao, Archana Raja, Roshni Madhvani, Sarah Abramowitz, Cedric Espenel, Shirley Sutton, Colleen Caleshu, Gerald J. Berry, Kara S. Motonaga, Kyla Dunn, Julia Platt, Euan A. Ashley, Matthew T. Wheeler
Summary: The study revealed characteristics of hypertrophy, structural disarray, impaired contractility, and aberrant Ca2+ signaling in patient-derived iPSC-cardiomyocytes with ACTN2 protein-truncating variants. The loss of ACTN2's C-terminus disrupts interactions with other actinins and sarcolemma-associated proteins, potentially leading to arrhythmic and relaxation defects. This data advances understanding of ACTN2's role in the human heart and establishes recessive inheritance of ACTN2 truncation as causative of disease.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2021)
Article
Health Care Sciences & Services
Kay Sundberg, Athena Adeli, Helge Brandberg, Jonas Spaak, Sabine Koch, Carl J. Sundberg, David Zakim, Thomas Kahan, Kaisa Fritzell
Summary: Most patients had a positive experience with the CLEOS program in the ED setting, although some found it to be extensive. Adjustments to the extent of the interview for better adaptation to the clinical setting should be the future development of the program.
HEALTH EXPECTATIONS
(2022)
Article
Multidisciplinary Sciences
Christer Sylven, Eva Wärdell, Agneta Mänsson-Broberg, Eugenio Cingolani, Konstantinos Ampatzis, Ludvig Larsson, Asa Björklund, Stefania Giacomello
Summary: Human prenatal cardiomyocytes were characterized using single-cell RNA sequencing, spatial transcriptomics, and ligand-receptor interaction information. Eight types of developing cardiomyocytes were identified, more than double the ones in the Human Developmental Cell Atlas. These cells exhibit high variability in cell cycle activity, mitochondrial content, and connexin gene expression, and are differentially distributed in the ventricles and atria. The ligand-receptor crosstalk of cardiomyocytes is mainly with non-cardiomyocyte cell types and involves cardiogenesis-related pathways. Understanding the developmental dynamics of early prenatal human cardiomyocytes may lead to new therapies.
Article
Cell Biology
Sarah Voisin, Kirsten Seale, Macsue Jacques, Shanie Landen, Nicholas R. Harvey, Larisa M. Haupt, Lyn R. Griffiths, Kevin J. Ashton, Vernon G. Coffey, Jamie-Lee M. Thompson, Thomas M. Doering, Malene E. Lindholm, Colum Walsh, Gareth Davison, Rachelle Irwin, Catherine McBride, Ola Hansson, Olof Asplund, Aino E. Heikkinen, Paivi Piirila, Kirsi H. Pietilainen, Miina Ollikainen, Sara Blocquiaux, Martine Thomis, Coletta K. Dawn, Adam P. Sharples, Nir Eynon
Summary: Exercise training can prevent age-related decline in muscle function by targeting epigenetic aging. A meta-analysis of human skeletal muscle samples revealed that individuals with higher aerobic fitness have younger epigenetic and transcriptomic profiles. Exercise training can shift these profiles towards a younger state, while muscle disuse leads to aging of the transcriptome. This comprehensive analysis provides valuable insights for future studies on optimizing longevity through the combination of therapeutics and exercise regimes.
Article
Multidisciplinary Sciences
Hailey Sounart, Denis Voronin, Yuvarani Masarapu, Matthew Chung, Sami Saarenpaa, Elodie Ghedin, Stefania Giacomello
Summary: The study investigates the interaction between the parasitic nematode Brugia malayi and its symbiotic bacteria Wolbachia. Using spatial transcriptomics, the researchers were able to uncover the spatial gene expression patterns and localization of key genes in the reproductive system of the worms. This approach has the potential to advance our understanding of infectious diseases caused by micro-scale parasitic worms.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Physiology
M. E. Lindholm
Article
Management
Danielle Lewensohn, Ebba Sjogren, Carl Johan Sundberg
Summary: This study conducted interviews with 20 Swedish academic inventors and identified two modes of behavior: passive and active. The results showed that individuals' inventive productivity was not necessarily aligned with their behavioral modes, and individual inventors exhibited different modes of behavior across different patent processes.
Meeting Abstract
Cardiac & Cardiovascular Systems
Malene E. Lindholm, Han Zhu, Kinya Seo, David Jimenez-Morales, Chunli Zhao, Euan A. Ashley, Matthew T. Wheeler