Ruthenium(ii) arene NSAID complexes: inhibition of cyclooxygenase and antiproliferative activity against cancer cell lines

Novel Antitumor Platinum(II) Conjugates Containing the Nonsteroidal Anti-inflammatory Agent Diclofenac: Synthesis and Dual Mechanisms of Antiproliferative Effects

(2017) Francesco Paolo Intini et al.   INORGANIC CHEMISTRY

Breast Cancer Stem Cell Potent Copper(II)-Non-Steroidal Anti-Inflammatory Drug Complexes

(2016) Janine N. Boodram et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of 5-lipoxygenase suppresses vascular endothelial growth factor-induced angiogenesis in endothelial cells

(2016) Tae Young Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Potent Inhibitory Effect of a Naproxen-Appended Cobalt(III)-Cyclam Complex on Cancer Stem Cells

(2016) Paul B. Cressey et al.   CHEMBIOCHEM

Nanostructured materials functionalized with metal complexes: In search of alternatives for administering anticancer metallodrugs

(2016) Waseem A. Wani et al.   COORDINATION CHEMISTRY REVIEWS

Fine tuning through valence bond tautomerization of ancillary ligands in ruthenium(ii) arene complexes for better anticancer activity and enzyme inhibition properties

(2016) Poulami Mandal et al.   DALTON TRANSACTIONS

Platinum(iv) anticancer prodrugs – hypotheses and facts

(2016) Dan Gibson   DALTON TRANSACTIONS

Metal-based drugs that break the rules

(2016) Claire S. Allardyce et al.   DALTON TRANSACTIONS

Platinum complexes as light promoted anticancer agents: a redefined strategy for controlled activation

(2016) Koushambi Mitra   DALTON TRANSACTIONS

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in Metal Complexes and Their Effect at the Cellular Level

(2016) Christina N. Banti et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds

(2016) Tânia S Morais et al.   Future Medicinal Chemistry

Nonsteroidal Anti-inflammatory—Organometallic Anticancer Compounds

(2016) Emilia Păunescu et al.   INORGANIC CHEMISTRY

Substrate-selective Inhibition of Cyclooxygeanse-2 by Fenamic Acid Derivatives Is Dependent on Peroxide Tone

(2016) Benjamin J. Orlando et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axially-modified paddlewheel diruthenium(II,III)-ibuprofenato metallodrugs and the influence of the structural modification on U87MG and A172 human glioma cell proliferation, apoptosis, mitosis and migration

(2016) Hanif-Ur-Rehman et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Systematical investigation of binding interaction between novel ruthenium(II) arene complex with curcumin analogs and ctDNA

(2016) Shan Huang et al.   LUMINESCENCE

Targeted Drug Delivery System for Platinum-based Anticancer Drugs

(2016) Chuanzhu Gao et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Nickel(II) complexes of the non-steroidal anti-inflammatory drug tolfenamic acid: Synthesis, structure, antioxidant activity and interaction with albumins and calf-thymus DNA

(2016) Xanthippi Totta et al.   POLYHEDRON

Linking the future of anticancer metal-complexes to the therapy of tumour metastases

(2015) Alberta Bergamo et al.   CHEMICAL SOCIETY REVIEWS

Novel mixed metal Ag(I)-Sb(III)-metallotherapeutics of the NSAIDs, aspirin and salicylic acid: Enhancement of their solubility and bioactivity by using the surfactant CTAB

(2015) E.I. Gkaniatsou et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Novel binuclear μ-oxo diruthenium complexes combined with ibuprofen and ketoprofen: Interaction with relevant target biomolecules and anti-allergic potential

(2015) Gabriela Campos Seuanes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease

(2015) Grzegorz A. Czapski et al.   NEUROCHEMICAL RESEARCH

Synthesis, crystal structure and spectroscopy of bioactive Cd(II) polymeric complex of the non-steroidal anti-inflammatory drug diclofenac sodium: Antiproliferative and biological activity

(2015) Leila Tabrizi et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis and Evaluation of Novel Erlotinib–NSAID Conjugates as More Comprehensive Anticancer Agents

(2015) Yanmei Zhang et al.   ACS Medicinal Chemistry Letters

Synthesis, Characterization and Antiproliferative Activity of Transition Metal Complexes with 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanoic Acid (Oxaprozin)

(2015) Bojan Božić et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Conjugation of Cisplatin Analogues and Cyclooxygenase Inhibitors to Overcome Cisplatin Resistance

(2014) Wilma Neumann et al.   ChemMedChem

Manganese-mefenamic acid complexes exhibit high lipoxygenase inhibitory activity

(2014) Jie Feng et al.   DALTON TRANSACTIONS

Synthesis and Structure–Activity Relationship Studies of 4-((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase

(2014) Diane K. Luci et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Ruthenium(η6-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives

(2014) Farhana Aman et al.   ORGANOMETALLICS

100 years of metal coordination chemistry: from Alfred Werner to anticancer metallodrugs

(2014) Nicolas P. E. Barry et al.   PURE AND APPLIED CHEMISTRY

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity ofN-Heterocyclic-[Ru(η6-arene)Cl2] Drug Candidates

(2013) Malay Patra et al.   CHEMISTRY-A EUROPEAN JOURNAL

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(ii), nickel(ii), cobalt(ii) and zinc(ii): structural features, biological evaluation and perspectives

(2013) George Psomas et al.   DALTON TRANSACTIONS

New ruthenium(ii) arene complexes of anthracenyl-appended diazacycloalkanes: effect of ligand intercalation and hydrophobicity on DNA and protein binding and cleavage and cytotoxicity

(2013) Mani Ganeshpandian et al.   DALTON TRANSACTIONS

Synthesis, Pharmacological Characterization, and Docking Analysis of a Novel Family of Diarylisoxazoles as Highly Selective Cyclooxygenase-1 (COX-1) Inhibitors

(2013) Paola Vitale et al.   JOURNAL OF MEDICINAL CHEMISTRY

A silver complex with ibuprofen: Synthesis, solid state characterization, DFT calculations and antibacterial assays

(2013) Irlene Maria Pereira e Silva et al.   JOURNAL OF MOLECULAR STRUCTURE

Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder

(2012) Andrea Kurzwernhart et al.   CHEMICAL COMMUNICATIONS

Synthesis and characterization of a diruthenium(II,III)–ketoprofen compound and study of the in vitro effects on CRC cells in comparison to the naproxen and ibuprofen derivatives

(2012) Rodrigo L.S.R. Santos et al.   POLYHEDRON

Metal-based antitumour drugs in the post-genomic era: what comes next?

(2011) Gianni Sava et al.   DALTON TRANSACTIONS

Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs

(2011) Alberta Bergamo et al.   DALTON TRANSACTIONS

Binding of Ibuprofen, Ketorolac, and Diclofenac to COX-1 and COX-2 Studied by Saturation Transfer Difference NMR

(2011) Aldino Viegas et al.   JOURNAL OF MEDICINAL CHEMISTRY

(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2

(2011) Kelsey C Duggan et al.   Nature Chemical Biology

[Cyclopentadienyl]metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents

(2010) Gerhard Rubner et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiproliferative properties of ibuprofen–oligo(3-hydroxybutyrate) conjugates

(2010) Barbara Zawidlak-Węgrzyńska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Is the Reactivity of M(II)−Arene Complexes of 3-Hydroxy-2(1H)-pyridones to Biomolecules the Anticancer Activity Determining Parameter?

(2010) Muhammad Hanif et al.   INORGANIC CHEMISTRY

Rational Design of an Organometallic Glutathione Transferase Inhibitor

(2009) Wee Han Ang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The interactions of metal ions with nonsteroidal anti-inflammatory drugs (oxicams)

(2009) Nadia E. A. El-Gamel   JOURNAL OF COORDINATION CHEMISTRY

Emerging Protein Targets for Anticancer Metallodrugs: Inhibition of Thioredoxin Reductase and Cathepsin B by Antitumor Ruthenium(II)−Arene Compounds

(2008) Angela Casini et al.   JOURNAL OF MEDICINAL CHEMISTRY