期刊
JOURNAL OF MOLECULAR STRUCTURE
卷 1049, 期 -, 页码 1-6出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2013.06.034
关键词
Ibuprofen; Silver; Solid-state NMR; Mass spectrometry; Theoretical calculations; Antibacterial agent
资金
- FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) [2012/08230-2]
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/08230-2] Funding Source: FAPESP
The present work describes the synthesis of a silver(I) complex with the non-steroidal anti-inflammatory ibuprofen, Ag-ibu. Elemental and thermal analyses indicate a 1:1 metal/ligand composition. Thermogravimetric analysis shows that Ag-ibu decomposition starts at 180 degrees C, and ends at 400 degrees C (mass loss 64.6%; calcd. 65.5%). UV/Vis kinetic measurements suggest the decomposition of Ag-ibu in dimethyl sulfoxide, with the appearance of a broad band in the spectrum of the complex in the range 300-500 nm. Infrared and solid state C-13 NMR spectra show the coordination of ibuprofen to silver through the carboxylate group. The DFT calculations led us to. propose a dimeric silver bridging structure for the complex. Biological studies show the antibacterial activity of the Ag-ibu complex against Gram-positive and Gram-negative bacterial strains, with MIC values ranging from 6.25 to 12.5 mu g mL(-1). (c) 2013 Elsevier B.V. All rights reserved.
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