Article
Biochemistry & Molecular Biology
Lorenzo Chiaverini, Damiano Cirri, Iogann Tolbatov, Francesca Corsi, Ilaria Piano, Alessandro Marrone, Alessandro Pratesi, Tiziano Marzo, Diego La Mendola
Summary: Ammonium trichloro (dioxoethylene-O,O ') tellurate (AS101) is a potential therapeutic prodrug with immunomodulatory properties. This study investigates the activation process of AS101 and its analogues in the presence of water. The results demonstrate that water triggers the conversion of AS101 to the pharmacologically active species, and the effect is influenced by the halogens present. The study provides valuable insights into the chemical and mechanistic implications of AS101 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ge Mu, Ryan B. Gaynor, Baylee N. Mcintyre, Bruno Donnadieu, Sidney E. Creutz
Summary: Metalloenzymes extensively use manganese centers for oxidative catalysis, such as water oxidation. The development of bioinspired manganese complexes as improved synthetic catalysts for these processes has been a long-standing motivation. In this study, we report a series of bpy-(imidazole)(n) (n = 1 or 2) (bpy = 2,2 '-bipyridyl) ligands and their Mn2+ complexes. The structures of four Mn2+ complexes are characterized using single-crystal X-ray diffraction, revealing different coordination modes of tridentate and tetradentate ligands. Cyclic voltammetry results indicate ligand-centered reductions and metal-centered oxidations, while UV-vis spectroscopy and TD-DFT calculations show primarily ligand-centered transitions in the complexes. ESI-MS studies in solution provide evidence of ligand reorganization, suggesting complex speciation behavior. However, the low stability of the complexes in aqueous solution prevents their ultimate application as aqueous electrocatalysts. Possible reasons for the low stability and suggestions for improvement are discussed.
Article
Chemistry, Physical
Awal Noor, Sadaf Qayyum, Zafar Ali, Niaz Muhammad
Summary: Reacting sterically hindered 1,3-bis(2,6-diethylphenyl)thiourea ligand (L) with various metal salts in acetonitrile yielded bulky thiourea ligand stabilized monomeric complexes. Structural characterization revealed tetrahedral or square planar geometries for different metal complexes. Intermolecular hydrogen bonding and significant intermolecular interactions in the crystal network were observed. Molecular docking analysis showed higher SARS-CoV-2 enzyme interacting abilities of the synthesized complexes compared to the free ligand. The compounds were characterized by elemental analyses, NMR spectroscopy, and single-crystal X-ray diffraction. (c) 2022 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Multidisciplinary
Axel Abelein
Summary: Metal ions play a key role in modulating the aggregation of amyloid-beta peptide (Aβ) in Alzheimer's disease (AD). Recent studies have provided detailed insights into the molecular structures and dynamics of metal-bound Aβ complexes and the effect of metal ions on the Aβ aggregation process. The interaction between metal ions and Aβ reduces the fibril-end elongation, leading to an increased formation of Aβ oligomers, which contributes to the understanding of metal-Aβ-associated neurotoxic effects.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Natasha P. Vargo, Jill B. Harland, Bradley W. Musselman, Nicolai Lehnert, Mehmed Z. Ertem, Jerome R. Robinson
Summary: This study reported the reversible interconversion of Cu2O2 cores in copper proteins, as well as the role of CaII in this process. Metal ion binding can stabilize novel reactive fragments and control O-2 activation in biomimetic systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Adrian Joe Urban, Hiroshi M. Yamamoto
Summary: The selective synthesis of nickel and copper complexes of 19-benzoyl-5,10,15-triphenyl-bilatrien-1-one (H2TPBT) with strong metal-ligand interaction and partial radical character in copper coordination is reported. The ECD absorption in the 800 nm range is highly tunable by metal coordination and variation of the aryl groups in TPBT periphery. The radical character of the ligand enables rapid interconversion between (M)- and (P)-enantiomers.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Engineering, Biomedical
Qiao Sun, Xiao Xie, Yujie Song, Litao Sun
Summary: The investigation of the interaction between metal ions and DNA has always been a topic of great interest in the fields of bioinorganic chemistry, supramolecular coordination chemistry, and DNA nanotechnology. The interaction can be divided into non-specific electrostatic adsorption and specific covalent binding. This article focuses on the mechanism of action between Ag+ and DNA mismatch pair C-C, and summarizes the characterization methods and applications. It aims to provide a reference for the field of biological devices. The development of cryo-electron microscopy and liquid-cell TEM is expected to further characterize the structure of C-Ag+-C and enhance its application.
BIOMATERIALS RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Changhui Chen, Boran Xu, Ruoqing Yao, Yang Chen, Chunxi Zhang
Summary: In this study, the synthetic mechanism of an artificial Mn4CaO4 cluster, which closely mimics the OEC, was successfully revealed through the isolation and structural characterization of key intermediates for the first time. The findings demonstrate that the Mn4CaO4 cluster can be formed through a specific reaction process and stabilized by binding an organic base. These discoveries have important implications for understanding the synthetic mechanism of the OEC and designing new catalysts for water splitting.
Article
Chemistry, Multidisciplinary
Boran Xu, Yang Chen, Ruoqing Yao, Changhui Chen, Chunxi Zhang
Summary: This study reports two synthetic Mn3XO4 oxygen clusters that mimic the structure and catalytic mechanism of the oxygen-evolving center (OEC) in photosynthesis. By analyzing the crystal structures, significant redox-induced structural changes were identified to occur on the mu(2)-oxide bridge. This research provides chemical insights into the reactivity of three different types of oxide bridges in the Mn4CaO5-cluster in PSII.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Chemistry, Inorganic & Nuclear
Marta Martinez-Alonso, Gilles Gasser
Summary: In recent decades, the research on ruthenium polypyridyl complexes has significantly increased due to their tunable luminescent properties. While these complexes lack intrinsic selectivity towards cancer cells, they have been conjugated to biomolecules for applications in anticancer drugs, sensors, and biocatalysts. Multiple methods of attaching biomolecules to the ruthenium core, such as peptides, antibodies, carbohydrates, lipids, and vitamins, have been summarized in this review.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Alison Butler, Aneta M. Jelowicki, Haley A. Ogasawara, Zachary L. Reitz, Parker R. Stow, Emil Thomsen
Summary: The majority of bacteria require iron for growth, and siderophores play a significant role in iron acquisition. Genome mining tools can be used to predict and discover new peptidic siderophores. The chiral iron(III) complexes formed by these siderophores reveal the stereospecific coordination chemistry encoded in microbial genomes.
Article
Biochemistry & Molecular Biology
Carolina Galuppo, Arnaldo Gomes de Oliveira Junior, Laiane dos Santos Oliveira, Pedro Henrique de Souza Guarda, Regina Buffon, Camilla Abbehausen
Summary: A systematic study was conducted to investigate the effect of phosphine and bis-phosphine ligands on the interaction between NiII, PdII, and PtII complexes and two types of zinc fingers. Phosphine ligands generally favored metal binding to the peptide, while bis-phosphine ligands displayed more specific binding. Nickel complexes exhibited hydrolysis when interacting with the SKH sequence, contrasting with the zinc ejection observed with chelating phosphines. Pd(phosphines) formed Pd2 fingers with triphenylphosphine acting as intermediate species, while bis-phosphine ligands resulted in clean spectra and stable Pd(bis-phosphine)finger signals. Phosphines also induced reactive platinum complexes that promoted zinc ejection and peptide hydrolysis. These findings are important for understanding the mechanism of these interactions and modulating metallocompounds for zinc finger interference.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Jian-Hua Ding, Yu-Feng Liu, Zhao-Teng Tian, Pei-Jie Lin, Feng Yang, Ke Li, Guo-Ping Yang, Yong-Ge Wei
Summary: A novel uranyl-containing polytungstate, U-3, was synthesized using a Keggin-type precursor and UO2(OAc)2, and characterized by X-ray diffraction and various techniques. U-3 exhibited a quadrahedron-like structure with a central {K-4(UO2)(3)(H2O)(3)} cluster surrounded by {α-SiW9} and {γ-SiW10} building units. Furthermore, U-3 showed good catalytic activity in the dehydration condensation of aldehydes, acetoacetates, and urea to synthesize dihydropyrimidin-2(1H)-ones with solvent-free conditions, water as the sole by-product, available starting materials, good compatibility, and operational simplicity.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Shourya Gupta, Sumangla Arora, Aditesh Mondal, S. Chantal E. Stieber, Puneet Gupta, Subrata Kundu
Summary: Nitrous acid (HONO) plays important roles in biogeochemistry, atmospheric chemistry, and mammalian physiology. This study successfully isolated a copper(II) complex with nitrite and investigated its reactivity in anaerobic nitration reactions. The reactivity of this complex is different from closely related copper(II)-nitrite complexes.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Isha Mishra, Bhaskaran Shankar, Malaichamy Sathiyendiran
Summary: Three trinuclear rhenium-(I)-organic complexes with a triangular structure were synthesized via a one-pot approach. The complexes possess unique supramolecular tubular architecture.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Inorganic & Nuclear
Russell J. Needham, Abraha Habtemariam, Nicolas P. E. Barry, Guy Clarkson, Peter J. Sadler
Article
Multidisciplinary Sciences
Jingwen Zhang, Anais Pitto-Barry, Lijun Shang, Nicolas P. E. Barry
ROYAL SOCIETY OPEN SCIENCE
(2017)
Article
Nanoscience & Nanotechnology
Anais Pitto-Barry, Alexandru Lupan, Christopher Ellingford, Amr A. A. Attia, Nicolas P. E. Barry
ACS APPLIED MATERIALS & INTERFACES
(2018)
Review
Biochemistry & Molecular Biology
Maria Azmanova, Anais Pitto-Barry, Nicolas P. E. Barry
Article
Chemistry, Medicinal
James P. C. Coverdale, Hannah E. Bridgewater, Ji-Inn Song, Nichola A. Smith, Nicolas P. E. Barry, Ian Bagley, Peter J. Sadler, Isolda Romero-Canelon
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Multidisciplinary
Anais Pitto-Barry, Nicolas P. E. Barry
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Chemistry, Medicinal
Maria Azmanova, Joan Soldevila-Barreda, Hira Bani Hani, Rianne M. Lord, Anais Pitto-Barry, Steven M. Picksley, Nicolas P. E. Barry
Article
Chemistry, Multidisciplinary
Neil Garrido, Anais Pitto-Barry, Joan J. Soldevila-Barreda, Alexandru Lupan, Louise Comerford Boyes, William H. C. Martin, Nicolas P. E. Barry
JOURNAL OF CHEMICAL EDUCATION
(2020)
Article
Chemistry, Medicinal
Joan J. Soldevila-Barreda, Maria Azmanova, Anais Pitto-Barry, Patricia A. Cooper, Steven D. Shnyder, Nicolas P. E. Barry
Article
Chemistry, Medicinal
Khaled Habas, Joan J. Soldevila-Barreda, Maria Azmanova, Laia Rafols, Anais Pitto-Barry, Diana Anderson, Nicolas P. E. Barry
Summary: The study found that the two 16-electron organoruthenium complexes have no significant effect on the cell viability of human lymphocytes from healthy individuals, but induce an increase in DNA damage, presumably through oxidative stress production.
Article
Chemistry, Multidisciplinary
Joan J. Soldevila-Barreda, Andrea Pettenuzzo, Maria Azmanova, Laia Rafols, Amr A. A. Attia, Alexandru Lupan, Luca Ronconi, Nicolas P. E. Barry, Anais Pitto-Barry
Summary: This article presents the synthesis of five half-sandwich ruthenium and osmium dithiocarbamato isonipecotamide glycoconjugate complexes through transmetallation, as well as their in-depth characterization by IR spectroscopy. The evaluation of these complexes' in vitro cytotoxicity towards ovarian cancer and normal prostate cells, as well as the cytotoxicity of the zinc precursors, is reported. While the compounds exhibit limited cytotoxicity, some selectivity is observed.
HELVETICA CHIMICA ACTA
(2023)
Correction
Chemistry, Inorganic & Nuclear
Anais Pitto-Barry, Alexandru Lupan, Amie Saidykhan, Markus Zegke, Thomas Swift, Amr A. A. Attia, Rianne M. Lord, Nicolas P. E. Barry
DALTON TRANSACTIONS
(2020)
Article
Chemistry, Multidisciplinary
Anais Pitto-Barry, Nicolas P. E. Barry
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Inorganic & Nuclear
Anais Pitto-Barry, Alexandru Lupan, Markus Zegke, Thomas Swift, Amr A. A. Attia, Rianne M. Lord, Nicolas P. E. Barry
DALTON TRANSACTIONS
(2017)
Article
Chemistry, Multidisciplinary
Anais Pitto-Barry, Nicolas P. E. Barry