HIF prolyl hydroxylase inhibitors for anemia

HIF and the Lung

(2011) Larissa A. Shimoda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

The Therapeutic Potential of Erythropoiesis-Stimulating Agents for Tissue Protection: A Tale of Two Receptors

(2010) Michael Brines   BLOOD PURIFICATION

PHD2 in tumour angiogenesis

(2010) D A Chan et al.   BRITISH JOURNAL OF CANCER

A therapeutic role for targeting c-Myc/Hif-1- dependent signaling pathways

(2010) Klaus Podar et al.   CELL CYCLE

The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism

(2010) Na Zhang et al.   Cell Metabolism

Myocardial Transfection of Hypoxia Inducible Factor-1α via an Adenoviral Vector During Coronary Artery Bypass Grafting

(2010) Eckehard Gerd Kilian et al.   CIRCULATION JOURNAL

Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury

(2010) Jaana Hyvärinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat

(2010) Weike Bao et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets

(2010) Kim Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction

(2010) Amaya Ortiz-Barahona et al.   NUCLEIC ACIDS RESEARCH

Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection

(2009) Sarah K. Harten et al.   ANTIOXIDANTS & REDOX SIGNALING

HIF Prolyl Hydroxylase Inhibitors Prevent Neuronal Death Induced by Mitochondrial Toxins: Therapeutic Implications for Huntington's Disease and Alzheimer's Disease

(2009) Zoya Niatsetskaya et al.   ANTIOXIDANTS & REDOX SIGNALING

Iron Homeostasis and Its Interaction with Prolyl Hydroxylases

(2009) David R. Mole   ANTIOXIDANTS & REDOX SIGNALING

Erythropoiesis Stimulatory Agent- Resistant Anemia in Dialysis Patients: Review of Causes and Management

(2009) Mehmet Kanbay et al.   BLOOD PURIFICATION

Breast Cancer Src Activity: Bad to the Bone

(2009) Dennis C. Sgroi   CANCER CELL

Intestinal Hypoxia-Inducible Transcription Factors Are Essential for Iron Absorption following Iron Deficiency

(2009) Yatrik M. Shah et al.   Cell Metabolism

Erythrocytosis associated with a novel missense mutation in the HIF2A gene

(2009) R. van Wijk et al.   HAEMATOLOGICA

Erythrocytosis-associated HIF-2α Mutations Demonstrate a Critical Role for Residues C-terminal to the Hydroxylacceptor Proline

(2009) Paul W. Furlow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Inducible Factor-1 Upregulates Adiponectin in Diabetic Mouse Hearts And Attenuates Post-Ischemic Injury

(2009) Ramesh Natarajan et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factor-2α-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization

(2009) Alexander Paliege et al.   KIDNEY INTERNATIONAL

A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease

(2009) Marc A. Pfeffer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autosomal dominant erythrocytosis and pulmonary arterial hypertension associated with an activating HIF2  mutation

(2008) D. P. Gale et al.   BLOOD

The role of hypoxia-inducible factors in tumorigenesis

(2008) E B Rankin et al.   CELL DEATH AND DIFFERENTIATION

Evaluation of aspirin metabolites as inhibitors of hypoxia-inducible factor hydroxylases

(2008) Benoit M. Lienard et al.   CHEMICAL COMMUNICATIONS

The human oxygen sensing machinery and its manipulation

(2008) Rasheduzzaman Chowdhury et al.   CHEMICAL SOCIETY REVIEWS

A novel heterozygous HIF2AM535I mutation reinforces the role of oxygen sensing pathway disturbances in the pathogenesis of familial erythrocytosis

(2008) M. Martini et al.   HAEMATOLOGICA

The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1

(2008) Marie-Pierre Simon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HIF Activation Protects From Acute Kidney Injury

(2008) A. Weidemann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Secondary analysis of the CHOIR trial epoetin-α dose and achieved hemoglobin outcomes

(2008) Lynda A. Szczech et al.   KIDNEY INTERNATIONAL

Proteomics-based Identification of Novel Factor Inhibiting Hypoxia-inducible Factor (FIH) Substrates Indicates Widespread Asparaginyl Hydroxylation of Ankyrin Repeat Domain-containing Proteins

(2008) Matthew E. Cockman et al.   MOLECULAR & CELLULAR PROTEOMICS

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice

(2008) T. Bishop et al.   MOLECULAR AND CELLULAR BIOLOGY

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

Endothelial Activation Markers in Anemic Non-Dialysis Chronic Kidney Disease Patients

(2008) Tejas V. Patel et al.   NEPHRON CLINICAL PRACTICE

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

(2008) X. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

(2007) K. Takeda et al.   BLOOD

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD

Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin

(2007) Erika V. Valore et al.   BLOOD CELLS MOLECULES AND DISEASES

Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion

(2007) Elisabeth L. Pagé et al.   MOLECULAR BIOLOGY OF THE CELL