Post-translational modification of OCT4 in breast cancer tumorigenesis

The cancer stem-cell signaling network and resistance to therapy

(2016) A. Carnero et al.   CANCER TREATMENT REVIEWS

Breast cancer stem cell: the roles and therapeutic implications

(2016) Fang Yang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Classification, Treatment Strategy, and Associated Drug Resistance in Breast Cancer

(2016) Yuan Tang et al.   Clinical Breast Cancer

CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3

(2016) Jinho Seo et al.   NATURE CELL BIOLOGY

DPF2 regulates OCT4 protein level and nuclear distribution

(2015) Chao Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A CHIPotle in physiology and disease

(2015) Indranil Paul et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The ubiquitin ligase CHIP inactivates NF-κB signaling and impairs the ability of migration and invasion in gastric cancer cells

(2015) FEI LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy

(2015) Hyun-Woo Lee et al.   BMB Reports

Phosphorylation accelerates geldanamycin-induced Akt degradation

(2013) Chih-Hao Su et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Toll-Like Receptor-2 Ligand Peptidoglycan Upregulates Expression and Ubiquitin Ligase Activity of CHIP through JNK Pathway

(2013) Yan Meng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells

(2012) Shin-Ae Kang et al.   BIOCHEMICAL JOURNAL

Chemotherapy-Resistant Metastatic Breast Cancer

(2012) Carrie Marquette et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Galectin-3 increases the motility of mouse melanoma cells by regulating matrix metalloproteinase-1 expression

(2012) Yuan-Guo Wang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Breast cancer stem cell enrichment and isolation by mammosphere culture and its potential diagnostic applications

(2012) Katayoon Saadin et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Serine 111 Phosphorylation Regulates OCT4A Protein Subcellular Distribution and Degradation

(2012) Renza Spelat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation

(2012) Syed Feroj Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression

(2012) Junwei Guo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction

(2012) Bing Liao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression

(2012) Ramona Schulz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resolving the stem-cell debate

(2012) Richard J. Gilbertson et al.   NATURE

The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity

(2012) I Paul et al.   ONCOGENE

Phosphorylation regulates human OCT4

(2012) J. Brumbaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin ligase CHIP induces TRAF2 proteasomal degradation and NF-κB inactivation to regulate breast cancer cell invasion

(2011) Kang Won Jang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders

(2011) Pravir Kumar et al.   JOURNAL OF NEUROCHEMISTRY

C-Terminus of Heat Shock Cognate 70 Interacting Protein Increases Following Stroke and Impairs Survival Against Acute Oxidative Stress

(2010) Jeannette N. Stankowski et al.   ANTIOXIDANTS & REDOX SIGNALING

Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor

(2010) Chang-Hoon Woo et al.   FASEB JOURNAL

Overall Survival and Post-Progression Survival in Advanced Breast Cancer: A Review of Recent Randomized Clinical Trials

(2010) Everardo D. Saad et al.   JOURNAL OF CLINICAL ONCOLOGY

The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

(2010) Carla Figueira Bento et al.   PLoS One

STAT3 deletion sensitizes cells to oxidative stress

(2009) Seán P. Barry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner

(2009) Bing Liao et al.   CELL RESEARCH

Galectin-3 Increases Gastric Cancer Cell Motility by Up-regulating Fascin-1 Expression

(2009) Seok–Jun Kim et al.   GASTROENTEROLOGY

The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways

(2009) Masashi Kajiro et al.   NATURE CELL BIOLOGY