期刊
CANCER TREATMENT REVIEWS
卷 49, 期 -, 页码 25-36出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ctrv.2016.07.001
关键词
Cancer; Conventional therapy; CSC; Metastasis; Oxidative stress; Stem cell therapy
类别
资金
- Miguel Servet grant [CP03/00101]
- Instituto de Salud Carlos III [PI12/01104, PI15/01262]
- European Regional Development Fund (ERDF)
- Spanish Ministry of Economy and Competitivity
- Plan Nacional de I+D+I
- Plan Estatal de I+D+I [PIE13/0004]
- ISCIII [FIS PI12/00137, PI15/00045, RTICC RD12/0036/0028]
- FEDER from Regional Development European Funds (European Union)
- Consejeria de Ciencia e Innovacion [CTS-6844, CTS-1848]
- Consejeria de Salud of the Junta de Andalucia [PI-0135-2010, PI-0306-2012, PI-0096-2014]
- FEDER funds
- VHIR
- Miguel Servet grant [CP03/00101]
- Instituto de Salud Carlos III [PI12/01104, PI15/01262]
- European Regional Development Fund (ERDF)
- Spanish Ministry of Economy and Competitivity
- Plan Nacional de I+D+I
- Plan Estatal de I+D+I [PIE13/0004]
- ISCIII [FIS PI12/00137, PI15/00045, RTICC RD12/0036/0028]
- FEDER from Regional Development European Funds (European Union)
- Consejeria de Ciencia e Innovacion [CTS-6844, CTS-1848]
- Consejeria de Salud of the Junta de Andalucia [PI-0135-2010, PI-0306-2012, PI-0096-2014]
- FEDER funds
- VHIR
The study of cancer stem cells (CSCs) has shown that tumors are driven by a subpopulation of self renewing CSCs that retain the capacity to engender the various differentiated cell populations that form tumors. The characterization of CSCs has indicated that CSCs are remarkably resistant to conventional radio- and chemo-therapy. Clinically, the remaining populations of CSC are responsible for metastasis and recurrence in patients with cancer, which can lead to the disease becoming chronic and incurable. Therefore, the elimination of CSCs is an important goal of cancer treatments. Furthermore, CSCs are subject to strong regulation by the surrounding microenvironment, which also impacts tumor responses. In this review, we discuss the mechanisms by which pathways that are defective in CSCs influence ultimately therapeutic and clinical outcomes. (C) 2016 Elsevier Ltd. All rights reserved.
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