Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

Novel CLK1 inhibitors based on N -aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands

(2017) Miroslav Murár et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins

(2017) Ahmed K. ElHady et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hypoxia is a Key Driver of Alternative Splicing in Human Breast Cancer Cells

(2017) Jian Han et al.   Scientific Reports

Global profiling of the gene expression and alternative splicing events during hypoxia-regulated chondrogenic differentiation in human cartilage endplate-derived stem cells

(2016) Yuan Yao et al.   GENOMICS

Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response

(2016) Danish Memon et al.   npj Genomic Medicine

Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates

(2015) M. M. Keshwani et al.   BIOCHEMICAL JOURNAL

Deciphering targeting rules of splicing modulator compounds: case of TG003

(2015) Maki Sakuma et al.   BMC MOLECULAR BIOLOGY

Adenovirus-mediated FIR demonstrated TP53-independent cell-killing effect and enhanced antitumor activity of carbon-ion beams

(2015) M Kano et al.   GENE THERAPY

Increased Serine-Arginine (SR) Protein Phosphorylation Changes Pre-mRNA Splicing in Hypoxia

(2015) Egle Jakubauskiene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Discovery of Host CLK1 Inhibitors for Influenza Treatment

(2015) Mian Zu et al.   MOLECULES

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1

(2015) Kazuyuki Matsushita et al.   Oncotarget

Apaf1 inhibition promotes cell recovery from apoptosis

(2015) Anna Gortat et al.   Protein & Cell

Hypoxia reduces MAX expression in endothelial cells by unproductive splicing

(2014) Katrin Kemmerer et al.   FEBS LETTERS

Hypoxia Regulates Alternative Splicing of HIF and non-HIF Target Genes

(2014) J. A. Sena et al.   MOLECULAR CANCER RESEARCH

Regulation of splicing by SR proteins and SR protein-specific kinases

(2013) Zhihong Zhou et al.   CHROMOSOMA

The SmgGDS Splice Variant SmgGDS-558 Is a Key Promoter of Tumor Growth and RhoA Signaling in Breast Cancer

(2013) Andrew D. Hauser et al.   MOLECULAR CANCER RESEARCH

Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells

(2013) ANDREAS EISENREICH et al.   ONCOLOGY REPORTS

Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT)

(2012) Giuseppe Biamonti et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia is a modifier of SMN2 splicing and disease severity in a severe SMA mouse model

(2012) Thomas W. Bebee et al.   HUMAN MOLECULAR GENETICS

Multiple Novel Nesprin-1 and Nesprin-2 Variants Act as Versatile Tissue-Specific Intracellular Scaffolds

(2012) Dipen Rajgor et al.   PLoS One

Hypoxia-Induced Alternative Splicing in Endothelial Cells

(2012) Julia E. Weigand et al.   PLoS One

The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer

(2012) Maud H.W. Starmans et al.   RADIOTHERAPY AND ONCOLOGY

HIF-1 versus HIF-2 — Is one more important than the other?

(2012) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy

(2011) Raymond Wong et al.   Retrovirology

Transcription and splicing regulation in human umbilical vein endothelial cells under hypoxic stress conditions by exon array

(2009) Xingyi Hang et al.   BMC GENOMICS

Multiple Alternative Splicing Markers for Ovarian Cancer

(2008) R. Klinck et al.   CANCER RESEARCH

Multiple and Specific mRNA Processing Targets for the Major Human hnRNP Proteins

(2008) J. P. Venables et al.   MOLECULAR AND CELLULAR BIOLOGY

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS