Towards the Application of Human Defensins as Antivirals

α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome

(2017) Mayim E. Wiens et al.   mBio

Lessons learned from human HIV vaccine trials

(2017) Justin Pollara et al.   Current Opinion in HIV and AIDS

A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein

(2017) Jarrod J. Mousa et al.   Nature Microbiology

Antimicrobial peptides alter early immune response to influenza A virus infection in C57BL/6 mice

(2016) Kim S. LeMessurier et al.   ANTIVIRAL RESEARCH

Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus

(2016) Vincent Vanheule et al.   BIOCHEMICAL PHARMACOLOGY

Tetravalent Dengue Vaccine: A Review in the Prevention of Dengue Disease

(2016) Lesley J. Scott   DRUGS

Antimicrobial peptides and wound healing: biological and therapeutic considerations

(2016) Maria Luisa Mangoni et al.   EXPERIMENTAL DERMATOLOGY

Expression of Antimicrobial Peptides in Human Monocytic Cells and Neutrophils in Response to Dengue Virus Type 2

(2016) Jorge I. Castañeda-Sánchez et al.   INTERVIROLOGY

Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions

(2016) Sarah S. Wilson et al.   JOURNAL OF VIROLOGY

Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment

(2016) Neil M. Ferguson et al.   SCIENCE

Challenges and opportunities in RSV vaccine development: Meeting report from FDA/NIH workshop

(2016) Jeffrey N. Roberts et al.   VACCINE

Human beta-defensins 2 and -3 cointernalize with human immunodeficiency virus via heparan sulfate proteoglycans and reduce infectivity of intracellular virions in tonsil epithelial cells

(2016) Rossana Herrera et al.   VIROLOGY

Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection

(2016) Anshu P. Gounder et al.   PLoS Pathogens

Original Antigenic Sin Response to RNA Viruses and Antiviral Immunity

(2016) Mee Sook Park et al.   Immune Network

Intratympanic Gene Delivery of Antimicrobial Molecules in Otitis Media

(2015) Sung K. Moon et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Defensins: “Simple” antimicrobial peptides or broad-spectrum molecules?

(2015) Meggy Suarez-Carmona et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Next generation dengue vaccines: A review of the preclinical development pipeline

(2015) Kirsten S. Vannice et al.   VACCINE

Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing

(2015) Kimberly A. Dowd et al.   mBio

Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid

(2015) Fiona Semple et al.   PLoS Genetics

Distinct Upstream Role of Type I IFN Signaling in Hematopoietic Stem Cell-Derived and Epithelial Resident Cells for Concerted Recruitment of Ly-6Chi Monocytes and NK Cells via CCL2-CCL3 Cascade

(2015) Erdenebileg Uyangaa et al.   PLoS Pathogens

An Evolutionary History of Defensins: A Role for Copy Number Variation in Maximizing Host Innate and Adaptive Immune Responses

(2015) Lee R. Machado et al.   Frontiers in Immunology

Inhibition of Pseudomonas aeruginosa with a recombinant RNA-based viral vector expressing human β-defensin 4

(2014) Sehee Park et al.   BMC MICROBIOLOGY

Therapeutic potential of adenovirus-mediated delivery of β-defensin 2 for experimental otitis media

(2014) Jeong-Im Woo et al.   Innate Immunity

Unique Properties of Human β-Defensin 6 (hBD6) and Glycosaminoglycan Complex

(2014) Viviane S. De Paula et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-Defensin HD5 Inhibits Furin Cleavage of Human Papillomavirus 16 L2 To Block Infection

(2014) Mayim E. Wiens et al.   JOURNAL OF VIROLOGY

Combined Effects of the Structural Heterogeneity and Dynamics of Flaviviruses on Antibody Recognition

(2014) K. A. Dowd et al.   JOURNAL OF VIROLOGY

An enteric virus can replace the beneficial function of commensal bacteria

(2014) Elisabeth Kernbauer et al.   NATURE

Pandemic potential of avian influenza A (H7N9) viruses

(2014) Tokiko Watanabe et al.   TRENDS IN MICROBIOLOGY

Construction of Eukaryotic Expression Vector with mBD1-mBD3 Fusion Genes and Exploring Its Activity against Influenza A Virus

(2014) Wanyi Li et al.   Viruses-Basel

Options and Obstacles for Designing a Universal Influenza Vaccine

(2014) Yo Jang et al.   Viruses-Basel

Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection

(2014) Michelle Tate et al.   Viruses-Basel

Defensins and Viral Infection: Dispelling Common Misconceptions

(2014) Mayim E. Wiens et al.   PLoS Pathogens

Delineation of Interfaces on Human Alpha-Defensins Critical for Human Adenovirus and Human Papillomavirus Inhibition

(2014) Victoria R. Tenge et al.   PLoS Pathogens

An optimized Fmoc synthesis of human defensin 5

(2013) Ermelinda Vernieri et al.   AMINO ACIDS

Toward a Universal Influenza Virus Vaccine: Prospects and Challenges

(2013) Natalie Pica et al.   Annual Review of Medicine

Defensins: Natural component of human innate immunity

(2013) Justyna Jarczak et al.   HUMAN IMMUNOLOGY

Nasal delivery of PLG microparticle encapsulated defensin peptides adjuvanted gp41 antigen confers strong and long-lasting immunoprotective response against HIV-1

(2013) Teena Mohan et al.   IMMUNOLOGIC RESEARCH

 -Defensin 2 and 3 Promote the Uptake of Self or CpG DNA, Enhance IFN-  Production by Human Plasmacytoid Dendritic Cells, and Promote Inflammation

(2013) P. Tewary et al.   JOURNAL OF IMMUNOLOGY

HIV Downregulates Interferon-Stimulated Genes in Primary Macrophages

(2013) Seong-Heon Wie et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Antiviral Mechanisms of Human Defensins

(2013) Sarah S. Wilson et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic Requirement for Hemagglutinin Glycosylation and Its Implications for Influenza A H1N1 Virus Evolution

(2013) J. I. Kim et al.   JOURNAL OF VIROLOGY

Antimicrobial peptides stage a comeback

(2013) Jeffrey L Fox   NATURE BIOTECHNOLOGY

An Intrinsically Disordered Region of the Adenovirus Capsid Is Implicated in Neutralization by Human Alpha Defensin 5

(2013) Justin W. Flatt et al.   PLoS One

Beta-defensin 2 enhances immunogenicity and protection of an adenovirus-based H5N1 influenza vaccine at an early time

(2013) Sai V. Vemula et al.   VIRUS RESEARCH

Adenoviral vector expressing murine β-defensin 2 enhances immunogenicity of an adenoviral vector based H5N1 influenza vaccine in aged mice

(2013) Sai V. Vemula et al.   VIRUS RESEARCH

Influenza virus hemagglutinin stalk-based antibodies and vaccines

(2013) Florian Krammer et al.   Current Opinion in Virology

Sub-Inhibitory Concentrations of Human α-defensin Potentiate Neutralizing Antibodies against HIV-1 gp41 Pre-Hairpin Intermediates in the Presence of Serum

(2013) Lusine Demirkhanyan et al.   PLoS Pathogens

Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection

(2012) Marijke M.F. Alen et al.   ANTIVIRAL RESEARCH

Neutrophil Extracellular Traps Mediate a Host Defense Response to Human Immunodeficiency Virus-1

(2012) Tatsuya Saitoh et al.   Cell Host & Microbe

Human antimicrobial peptides LL-37 and human β-defensin-2 reduce viral replication in keratinocytes infected with varicella zoster virus

(2012) L. R. Crack et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Evolutionary origin of β-defensins

(2012) Shunyi Zhu et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

MxA expression induced by α-defensin in healthy human periodontal tissue

(2012) Rangsini Mahanonda et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B cell TLRs and induction of immunoglobulin class-switch DNA recombination

(2012) Egest et al.   Frontiers in Bioscience-Landmark

Critical Determinants of Human α-Defensin 5 Activity against Non-enveloped Viruses

(2012) Anshu P. Gounder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifaceted Mechanisms of HIV-1 Entry Inhibition by Human α-Defensin

(2012) Lusine H. Demirkhanyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Molecular Dynamics Study of Human Defensins HBD-1 and HNP-3 in Water

(2012) Ambure Sharadadevi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Enhancement of Antiviral Activity of Human Alpha-Defensin 5 against Herpes Simplex Virus 2 by Arginine Mutagenesis at Adaptive Evolution Sites

(2012) A. Wang et al.   JOURNAL OF VIROLOGY

Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP-1 dependent pathways in human B cells

(2012) Sung Mi Ju et al.   MOLECULES AND CELLS

Synthesis of a Dicarba Analogue of Human β-Defensin-1 Using a Combined Ring Closing Metathesis–Native Chemical Ligation Strategy

(2012) Amanda M. Heapy et al.   ORGANIC LETTERS

Inhibition of HIV-1 Infection by Human α-Defensin-5, a Natural Antimicrobial Peptide Expressed in the Genital and Intestinal Mucosae

(2012) Lucinda Furci et al.   PLoS One

Multifunctional cationic host defence peptides and their clinical applications

(2011) Amy T. Y. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

α-Defensins in human innate immunity

(2011) Robert I. Lehrer et al.   IMMUNOLOGICAL REVIEWS

Dengue virus replication in infected human keratinocytes leads to activation of antiviral innate immune responses

(2011) Pornapat Surasombatpattana et al.   INFECTION GENETICS AND EVOLUTION

The first influenza pandemic of the new millennium

(2011) Gabriele Neumann et al.   Influenza and Other Respiratory Viruses

Adjunctive therapy with interferon-gamma for the treatment of pulmonary tuberculosis: a systematic review

(2011) X.-F. Gao et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Low-Dose Interferon Type I Treatment Is Effective Against H5N1 and Swine-Origin H1N1 Influenza A Viruses In Vitro and In Vivo

(2011) Emanuel Haasbach et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Modulation of human β-defensin-1 (hBD-1) in plasmacytoid dendritic cells (PDC), monocytes, and epithelial cells by influenza virus, Herpes simplex virus, and Sendai virus and its possible role in innate immunity

(2011) Lisa K. Ryan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interplay between Innate Immunity and Negative-Strand RNA Viruses: towards a Rational Model

(2011) D. Gerlier et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Activation of Toll-Like Receptor 3 Impairs the Dengue Virus Serotype 2 Replication through Induction of IFN-β in Cultured Hepatoma Cells

(2011) Zhaoduan Liang et al.   PLoS One

Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment

(2011) Aprille Rapista et al.   Retrovirology

Progress in understanding and controlling respiratory syncytial virus: Still crazy after all these years

(2011) Peter L. Collins et al.   VIRUS RESEARCH

Activation of the Innate Immune Response against DENV in Normal Non-Transformed Human Fibroblasts

(2011) José Bustos-Arriaga et al.   PLoS Neglected Tropical Diseases

A Dynamic Landscape for Antibody Binding Modulates Antibody-Mediated Neutralization of West Nile Virus

(2011) Kimberly A. Dowd et al.   PLoS Pathogens

Interaction of Human β-Defensin 2 (HBD2) with Glycosaminoglycans

(2010) Emily S. Seo et al.   BIOCHEMISTRY

Differential and coordinated expression of defensins and cytokines by gingival epithelial cells and dendritic cells in response to oral bacteria

(2010) Lei Yin et al.   BMC IMMUNOLOGY

A meta-analysis of the efficacy and tolerability of interferon-β in multiple sclerosis, overall and by drug and disease type

(2010) Shekoufeh Nikfar et al.   CLINICAL THERAPEUTICS

Specific Binding and Chemotactic Activity of mBD4 and Its Functional Orthologue hBD2 to CCR6-expressing Cells

(2010) Johann Röhrl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response

(2010) Cristina L. Swanson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human  -Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2

(2010) J. Rohrl et al.   JOURNAL OF IMMUNOLOGY

Direct Evidence from Single-Cell Analysis that Human  -Defensins Block Adenovirus Uncoating To Neutralize Infection

(2010) E. K. Nguyen et al.   JOURNAL OF VIROLOGY

Identification of Five Interferon-Induced Cellular Proteins That Inhibit West Nile Virus and Dengue Virus Infections

(2010) D. Jiang et al.   JOURNAL OF VIROLOGY

Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes

(2010) Santiago F Gonzalez et al.   NATURE IMMUNOLOGY

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

(2010) K. Edfeldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the Mechanisms of Adenovirus Capsid Disassembly from Studies of Defensin Neutralization

(2010) Jason G. Smith et al.   PLoS Pathogens

Artificial β-defensin based on a minimal defensin template

(2009) Nikolinka Antcheva et al.   BIOCHEMICAL JOURNAL

The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus

(2009) Abraham L. Brass et al.   CELL

Interactions of  -,  -, and  -Defensins with Influenza A Virus and Surfactant Protein D

(2009) M. Doss et al.   JOURNAL OF IMMUNOLOGY

Regulation of Inflammatory Monocyte/Macrophage Recruitment from the Bone Marrow during Murine Cytomegalovirus Infection: Role for Type I Interferons in Localized Induction of CCR2 Ligands

(2009) M. J. Crane et al.   JOURNAL OF IMMUNOLOGY

Multivalent Binding of Carbohydrates by the Human  -Defensin, HD5

(2009) R. I. Lehrer et al.   JOURNAL OF IMMUNOLOGY

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

(2009) C. L. Wohlford-Lenane et al.   JOURNAL OF VIROLOGY

Mechanism of Adenovirus Neutralization by Human α-Defensins

(2008) Jason G. Smith et al.   Cell Host & Microbe

Isolation, Synthesis, and Antimicrobial Activities of Naturally Occurring  -Defensin Isoforms from Baboon Leukocytes

(2008) A. E. Garcia et al.   INFECTION AND IMMUNITY

Human α-Defensins Inhibit BK Virus Infection by Aggregating Virions and Blocking Binding to Host Cells

(2008) Aisling S. Dugan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Human β-Defensin-2 during Tumor Necrosis Factor-α/NF-κB-mediated Innate Antiviral Response against Human Respiratory Syncytial Virus

(2008) Srikanth Kota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY