期刊
IMMUNE NETWORK
卷 16, 期 5, 页码 261-270出版社
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2016.16.5.261
关键词
Dengue; Influenza; Original antigenic sin; Vaccine
类别
资金
- TEPIK (Transgovernmental Enterprise for Pandemic Influenza in Korea)
- Ministry of Health & Welfare, Republic of Korea [A103001]
The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body's defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed 'original antigenic sin'. This adverse immunological effect can alter vaccine effectiveness and sometimes cause enhanced pathogenicity or additional inflammatory responses, according to the type of pathogen and the circumstances of infection. Here we aim to give a simplified conceptual understanding of virus infection and original antigenic sin by comparing and contrasting the two examples of recurring infections such as influenza and dengue viruses in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据