An Evolutionary History of Defensins: A Role for Copy Number Variation in Maximizing Host Innate and Adaptive Immune Responses

Evidence of Convergent Evolution in Humans and Macaques Supports an Adaptive Role for Copy Number Variation of the β-Defensin-2 Gene

(2014) Barbara Ottolini et al.   Genome Biology and Evolution

Human gene copy number variation and infectious disease

(2014) Edward J. Hollox et al.   HUMAN GENETICS

Importance of  -defensins in sperm function

(2014) J. R. Dorin et al.   MOLECULAR HUMAN REPRODUCTION

Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma

(2014) Louise V. Wain et al.   PLoS One

Copy Number Variation of the Beta Defensin Gene Cluster on Chromosome 8p Influences the Bacterial Microbiota within the Nasopharynx of Otitis-Prone Children

(2014) Eric A. Jones et al.   PLoS One

Antifungal defensins and their role in plant defense

(2014) Ariane F. Lacerda et al.   Frontiers in Microbiology

Accurate measurement of gene copy number for human alpha-defensin DEFA1A3

(2013) Fayeza F Khan et al.   BMC GENOMICS

CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans

(2013) Eleni Aklillu et al.   BMC INFECTIOUS DISEASES

Estrogenic action on innate defense mechanisms in the urinary tract

(2013) Petra Lüthje et al.   MATURITAS

Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice

(2013) Yu S. Zhou et al.   PLoS Genetics

Beta-defensins activate macrophages and synergize in pro-inflammatory cytokine expression induced by TLR ligands

(2012) Nicola Barabas et al.   IMMUNOBIOLOGY

Variation in human β-defensin genes: new insights from a multi-population study

(2012) R. K. Mehlotra et al.   International Journal of Immunogenetics

 -defensin Genomic Copy Number Is Associated With HIV Load and Immune Reconstitution in Sub-Saharan Africans

(2012) R. J. Hardwick et al.   JOURNAL OF INFECTIOUS DISEASES

ß-Defensins: Multifunctional Modulators of Infection, Inflammation and More?

(2012) Fiona Semple et al.   Journal of Innate Immunity

Association of β-Defensin Copy Number and Psoriasis in Three Cohorts of European Origin

(2012) Philip E. Stuart et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Defining MC1R Regulation in Human Melanocytes by Its Agonist α-Melanocortin and Antagonists Agouti Signaling Protein and β-Defensin 3

(2012) Viki B. Swope et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Whole Cigarette Smoke Increased the Expression of TLRs, HBDs, and Proinflammory Cytokines by Human Gingival Epithelial Cells through Different Signaling Pathways

(2012) Abdelhabib Semlali et al.   PLoS One

Higher DEFB4 genomic copy number in SLE and ANCA-associated small vasculitis

(2012) Xu-Jie Zhou et al.   RHEUMATOLOGY

Alpha-Defensin DEFA1A3 Gene Copy Number Elevation in Danish Crohn’s Disease Patients

(2011) Cathrine Jespersgaard et al.   DIGESTIVE DISEASES AND SCIENCES

A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia

(2011) Robert J. Hardwick et al.   HUMAN MUTATION

The Toll-like receptor 1/2 agonists Pam3CSK4 and human β-defensin-3 differentially induce interleukin-10 and nuclear factor-κB signalling patterns in human monocytes

(2011) Nicholas T. Funderburg et al.   IMMUNOLOGY

A Common Mutation in the Defensin DEFB126 Causes Impaired Sperm Function and Subfertility

(2011) T. L. Tollner et al.   Science Translational Medicine

Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease

(2010) Marian C. Aldhous et al.   HUMAN MOLECULAR GENETICS

Human  -Defensin 2 and 3 and Their Mouse Orthologs Induce Chemotaxis through Interaction with CCR2

(2010) J. Rohrl et al.   JOURNAL OF IMMUNOLOGY

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

(2010) L. Peyrin-Biroulet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of Higher DEFB4 Genomic Copy Number With Crohn's Disease

(2009) Robert W Bentley et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Copy Number Variation of Defensin Genes and HIV Infection in Brazilian Children

(2009) Michele Milanese et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Human defensins and LL-37 in mucosal immunity

(2009) Mona Doss et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Reply to: “CCL3L1 and HIV/AIDS susceptibility” and “Experimental aspects of copy number variant assays at CCL3L1”

(2009) Weijing He et al.   NATURE MEDICINE

Experimental aspects of copy number variant assays at CCL3L1

(2009) Sarah F Field et al.   NATURE MEDICINE

β-Defensin-2 Protein Is a Serum Biomarker for Disease Activity in Psoriasis and Reaches Biologically Relevant Concentrations in Lesional Skin

(2009) Patrick A. M. Jansen et al.   PLoS One

Allelic recombination between distinct genomic locations generates copy number diversity in human β-defensins

(2009) Suhaili Abu Bakar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defensins and the dynamic genome: What we can learn from structural variation at human chromosome band 8p23.1

(2008) E. J. Hollox et al.   GENOME RESEARCH

High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes

(2008) Marco Groth et al.   HUMAN MUTATION

Macaque sperm coating protein DEFB126 facilitates sperm penetration of cervical mucus

(2008) T. L. Tollner et al.   HUMAN REPRODUCTION

Production of bioactive human beta-defensin 5 and 6 in Escherichia coli by soluble fusion expression

(2008) Lei Huang et al.   PROTEIN EXPRESSION AND PURIFICATION