Article
Biochemical Research Methods
Daniel Almeida, Gustavo Turecki
Summary: The transcriptome of a cell plays a vital role in the complexity and heterogeneity of cell-types in the mammalian brain. However, using bulk-tissue homogenates makes it difficult to distinguish whether observed differences in gene expression are due to disease or cellular composition. Laser capture microdissection (LCM) is a strategy that allows for the capture of specific cell-types or regions of interest.
Article
Neurosciences
Yanaika S. Hok-A-Hin, Anke A. Dijkstra, Alberto Rabano, Jeroen J. Hoozemans, Lucia Castillo, Harro Seelaar, John C. van Swieten, Yolande A. L. Pijnenburg, Charlotte E. Teunissen, Marta Del Campo
Summary: This study found increased levels of APOL1 in FTLD post-mortem brain tissue, regardless of the pathological subtypes. APOL1 was mainly expressed in neuronal and glial cells, but did not co-localize with pTau or pTDP-43. However, the levels of APOL1 in CSF were comparable between FTD patients and controls, and between pathological subtypes.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Renzo J. M. Riemens, Gunter Kenis, Jennifer Nolz, Sonia C. Susano C. Chaves, Diane Duroux, Ehsan Pishva, Diego Mastroeni, Kristel Van Steen, Thomas Haaf, Daniel L. A. van den Hove
Summary: A novel approach combining LCM and LDBSP is developed to quantify and analyze the DNA methylation patterns of individual genes in neuronal cells. The method proves to be efficient and accurate, providing further validity to this approach in neuroepigenomic studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Melanie J. Grubisha, Robert A. Sweet, Matthew L. MacDonald
Summary: Although gene expression and translation have been extensively studied in psychiatric disease, post-translational modifications (PTMs), as well as the use of mass spectrometry methods, have received less attention despite their importance in regulating neuronal and circuit function. Researchers should focus more on studying PTMs and their potential implications in neurological disorders.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Raphael Severino Bonadio, Larissa Barbosa Nunes, Patricia Natalia S. Moretti, Juliana Forte Mazzeu, Stefano Cagnin, Aline Pic-Taylor, Silviene Fabiana de Oliveira
Summary: The study analyzed the transcriptome of mouse brains after death in different environments and how these environments influenced post-mortem RNA abundance and biological processes.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
E. E. Amelie Mock, Eveliina Honkonen, Laura Airas
Summary: Synaptic loss seems to be present throughout the central nervous system, but there are inconsistencies in the results, possibly due to variations in methodology. The dynamic nature of synaptic loss suggests that in vivo synaptic density measurements may provide a clearer understanding of this pathology.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Tyler Saunders, Ciaran Gunn, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg, Susan D. Shenkin, Simon R. Cox, Ian J. Deary, Colin Smith, Declan King, Tara Spires-Jones
Summary: Neurogranin (Ng), a post-synaptic protein, has been investigated as a biomarker for Alzheimer's disease (AD) and aging in cerebrospinal fluid (CSF). Our study examined Ng abundance in post-mortem human brain tissue in AD, healthy aging (HA), and mid-life (ML) cohorts. Ng levels were quantified using immunohistochemistry in brain regions associated with cognitive change. The results showed significantly reduced Ng levels in AD compared to HA and ML cases, indicating loss of neurogranin in the brain. Our findings support the use of CSF Ng as a biomarker for AD and cognitive decline in healthy aging.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Behavioral Sciences
Rana Fetit, Robert F. Hillary, David J. Price, Stephen M. Lawrie
Summary: Post-mortem studies of individuals with autism have revealed consistent abnormalities in brain tissue, such as reduced minicolumn numbers and aberrant myelination. Transcriptomics consistently implicate abnormalities in synaptic, metabolic, proliferation, apoptosis, and immune pathways in autism pathogenesis. Larger studies are needed to further investigate these findings and potential treatments.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Genetics & Heredity
Eva Lindholm Carlstrom, Adnan Niazi, Mitra Etemadikhah, Jonatan Halvardson, Stefan Enroth, Craig A. Stockmeier, Grazyna Rajkowska, Bo Nilsson, Lars Feuk
Summary: The study identified an up-regulation of multiple immune response genes, including genes from the complement system, in schizophrenia patients, indicating important differences in disease etiology within the patient group. Weighted gene co-expression network analysis highlighted networks associated with both synaptic transmission and immune response activation. These findings suggest the importance of immune-related pathways in schizophrenia pathology and provide evidence for elevated expression of the complement cascade in the disease.
Article
Biochemistry & Molecular Biology
Lucas Baena Carstens, Raissa Campos D'amico, Karen Fernandes de Moura, Eduardo Morais de Castro, Flavia Centenaro, Giovanna Silva Barbosa, Guilherme Vieira Cavalcante da Silva, Isadora Brenny, Julio Cesar Honorio D'Agostini, Elisa Carolina Hlatchuk, Sabrina Pissette de Lima, Ana Paula Camargo Martins, Marina De Castro Deus, Carolline Konzen Klein, Ana Paula Kubaski Benevides, Seigo Nagashima, Cleber Machado-Souza, Ricardo A. Pinho, Cristina Pellegrino Baena, Lucia de Noronha
Summary: The activation of the inflammasome complex is significantly increased in COVID-19 patients, indicating its involvement in the pathogenesis of the disease. Additionally, levels of cell pyroptosis and inflammasome-derived cytokines are greatly elevated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Martina Rosato, Sven Stringer, Titia Gebuis, Iryna Paliukhovich, Ka Wan Li, Danielle Posthuma, Patrick F. Sullivan, August B. Smit, Ronald E. van Kesteren
Summary: A combined cellomics and proteomics approach was used to disentangle polygenic risk in schizophrenia by searching for shared neuronal morphology and cellular pathway phenotypes of candidate schizophrenia risk genes. It was found that certain schizophrenia risk genes shared a neuronal phenotype marked by a reduction in synapse numbers and converged onto the syntaxin-mediated neurotransmitter release pathway. This study provides new biological functions for schizophrenia risk genes and supports the idea that polygenic risk results from multiple small impacts on common neuronal signaling pathways.
MOLECULAR PSYCHIATRY
(2021)
Article
Medicine, Legal
Isabel Arnold, Nicole Schwendener, Paolo Lombardo, Christian Jackowski, Wolf-Dieter Zech
Summary: The study evaluated the quantitative values of post-mortem brain structures for a 3 Tesla PMMR application with regard to various corpse temperatures, finding temperature dependence mainly on T1 values. ANOVA testing showed significant differences of quantitative values between different anatomical brain structures in both groups.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Morgan A. Brown, Kara M. Zappitelli, Loveprit Singh, Rachel C. Yuan, Melissa Bemrose, Valerie Brogden, David J. Miller, Matthew C. Smear, Stuart F. Cogan, Timothy J. Gardner
Summary: This report describes the integration of a 3D microelectrode array on a thin-film flexible cable for neural recording. The fabrication process combines traditional thin-film processing techniques and direct laser writing of 3D structures at micron resolution via two-photon lithography. The report provides a method for producing high-aspect-ratio structures.
NATURE COMMUNICATIONS
(2023)
Review
Neurosciences
Claire S. Leblond, Thuy-Linh Le, Simon Malesys, Freddy Cliquet, Anne-Claude Tabet, Richard Delorme, Thomas Rolland, Thomas Bourgeron
Summary: The genetics of neurodevelopmental disorders has identified over 1,500 genes associated with conditions such as intellectual disability and autism, with these genes being expressed in early fetal brain development and enriched in various biological pathways. A list of high confidence NDD genes has been compiled for interpretation of large scale omics datasets or for diagnostic purposes. Genes related to synapses are a significant proportion of this gene set and are expressed in the cerebellum and cortex of the human brain.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2021)
Article
Plant Sciences
Oliver Berkowitz, Yue Xu, Lim Chee Liew, Yan Wang, Yanqiao Zhu, Bhavna Hurgobin, Mathew G. Lewsey, James Whelan
Summary: The research investigated the transcriptomes of different leaf tissues in Arabidopsis under various stress pathways, revealing a decrease in the overall number of expressed genes in response to stress stimuli. While no common stress response was identified, there was overlap of differentially expressed genes between tissues for individual treatments. Specific analysis indicated an interaction between auxin and ethylene in mediating retrograde signaling during mitochondrial dysfunction in the epidermis.
Article
Psychology, Clinical
Zeynep Yilmaz, Katherine Schaumberg, Matthew Halvorsen, Erica L. Goodman, Leigh C. Brosof, James J. Crowley, Carol A. Mathews, Manuel Mattheisen, Gerome Breen, Cynthia M. Bulik, Nadia Micali, Stephanie C. Zerwas
Summary: This study found a genetic overlap between anorexia nervosa (AN), obsessive-compulsive disorder (OCD), and anxiety symptoms, with a potential sex-specific contribution of genetic risk. AN and AN/OCD polygenic scores (PGS) played a more prominent role in predicting eating disorder and anxiety symptoms, while OCD PGS had a smaller effect. The results also suggest that compulsive exercise may have a transdiagnostic genetic etiology.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Jessica S. Johnson, Alanna C. Cote, Amanda Dobbyn, Laura G. Sloofman, Jiayi Xu, Liam Cotter, Alexander W. Charney, Andreas Birgegard, Jennifer Jordan, Martin Kennedy, Mikael Landen, Sarah L. Maguire, Nicholas G. Martin, Preben Bo Mortensen, Laura M. Thornton, Cynthia M. Bulik, Laura M. Huckins
Summary: This study used transcriptomic imputation and phenome-wide association studies to explore the clinical consequences of genetically regulated gene expression in anorexia nervosa (AN). The results identified several genes associated with AN and revealed associations with autoimmune, metabolic, and gastrointestinal diagnoses, as well as other clinical measures. The analysis also showed that body mass index (BMI) and sex moderated some of the associations. These findings provide potential avenues for further investigation into the functional mechanisms of AN-associated genes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Neus Sole-Morata, Isabel Baenas, Mikel Etxandi, Roser Granero, Manel Gene, Carme Barrot, Monica Gomez-Pena, Laura Moragas, Nicolas Ramoz, Philip Gorwood, Fernando Fernandez-Aranda, Susana Jimenez-Murcia
Summary: Gambling Disorder (GD) is influenced by both genetic and environmental factors. This study investigated the underlying mechanisms of GD severity by examining the interactions between genetic, psychological, socio-demographic, and clinical factors. Pathway analysis revealed that specific genetic variants, in interaction with other biopsychological features, predicted greater severity of GD. These findings highlight the complex interplay between biopsychosocial variables in the development and severity of GD, and provide support for the involvement of genetic variants from the neurotrophic factor family.
Article
Psychiatry
Nathan A. Kimbrel, Allison E. Ashley-Koch, Xue J. Qin, Jennifer H. Lindquist, Melanie E. Garrett, Michelle F. Dennis, Lauren P. Hair, Jennifer E. Huffman, Daniel A. Jacobson, Ravi K. Madduri, Jodie A. Trafton, Hilary Coon, Anna R. Docherty, Niamh Mullins, Douglas M. Ruderfer, Philip D. Harvey, Benjamin H. McMahon, David W. Oslin, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser
Summary: This study aimed to identify the genetic basis of suicidal thoughts and behaviors. Through genome-wide association analysis, several risk loci for suicide were identified, and some of these loci were replicated in independent samples, providing evidence for their involvement in suicide.
Article
Biochemistry & Molecular Biology
Julia Mattioni, Clement Vansteene, Daphnee Poupon, Philip Gorwood, Nicolas Ramoz
Summary: In this study, a population-based case-control and genetic association research was conducted on a large sample of young adults to assess the role of dopamine receptor D2 (DRD2) and ankyrin repeat and kinase domain-containing protein 1 (ANKK1) genes in harmful alcohol use. The study found that a specific gene mutation in DRD2 was associated with harmful alcohol use, and early onset of alcohol consumption and depressive symptoms moderated the effect of this gene on harmful alcohol use.
Review
Clinical Neurology
Camille Verebi, Juliette Nectoux, Philip Gorwood, Yann Le Strat, Philibert Duriez, Nicolas Ramoz, Thierry Bienvenu
Summary: Recent research has found that circulating nucleic acids (CNAs) can be used as a new diagnostic and monitoring tool for mental disorders, particularly for diseases involving difficult-to-assess organs or structures. This review examines the application of plasma and serum cell-free DNA (cfDNA) as biomarkers for psychiatric disorders, including diagnosis, prognosis, treatment response, and disease progression. The overall effect size of plasma nuclear and mitochondrial cfDNA studies was generally moderate for psychiatric disorders. The future applications of CNAs, particularly cfDNA, as non-invasive biomarkers for these diseases are also discussed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Chloe Tezenas du Montcel, Jingxian Cao, Julia Mattioni, Heloise Hamelin, Nicolas Lebrun, Nicolas Ramoz, Philip Gorwood, Virginie Tolle, Odile Viltart
Summary: In eating disorders, particularly anorexia nervosa (AN), patients exhibit intense physical activity which is inappropriate regarding food restriction and chronic undernutrition, and exacerbates weight loss and energy deprivation. Rodent models of food restriction exhibit increased running wheel activity in the food anticipation period, also known as Food Anticipatory Activity (FAA). We hypothesize that the drive for physical activity in chronic food restriction is triggered by metabolic factors but also relies on motivational aspects that we aim to decipher in this study.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychiatry
Aurelie Lacroix, Nicolas Ramoz, Murielle Girard, Brigitte Plansont, Daphnee Poupon, Philip Gorwood, Philippe Nubukpo
Summary: This study aimed to identify factors that influence the changes in brain-derived neurotrophic factor (BDNF) levels during alcohol abstinence. The researchers examined the associations between the change in serum BDNF levels and length of abstinence, anxiety and depression scores, a functional BDNF genotype, and methylation levels of 12 CpG sites within the BDNF gene. The results showed that serum BDNF levels increased during abstinence and correlated with the variation in methylation levels of the BDNF gene, particularly exon I. There was no significant effect of abstinence length, genotype, depression, or anxiety on serum BDNF levels. Therefore, epigenetic regulation of the BDNF gene may play a role in the variations of BDNF levels during alcohol abstinence.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Florent Abry, Philip Gorwood, Mouna Hanachi, Laura Di Lodovico
Summary: This study explored the long-term outcomes, quality of life, and attitudes towards treatment in patients involuntarily treated for extremely severe anorexia nervosa (AN). The findings suggest that involuntary treatment does not hinder weight restoration and clinical improvement, nor does it affect long-term attitudes towards treatment.
EUROPEAN EATING DISORDERS REVIEW
(2023)
Article
Psychiatry
Julia Eder, Geert Dom, Philip Gorwood, Hikka Kaerkkaeinen, Andre Decraene, Ulrike Kumpf, Julian Beezhold, Jerzy Samochowiec, Tamas Kurimay, Wolfgang Gaebel, Livia De Picker, Peter Falkai
Summary: The European Psychiatric Association has proposed a policy paper addressing the unmet healthcare and research needs of patients with depressive disorders. They emphasize the importance of increased awareness, development of new biomarkers, implementation of machine learning technology, use of electronic devices and apps for treatment, development of new treatment options, and comprehensive recovery approach. They also propose priorities at a political level regarding open science, data protection laws, ethical electronic health records, and better healthcare research and resource-saving.
EUROPEAN PSYCHIATRY
(2023)
Review
Psychiatry
Blazej Misiak, Jerzy Samochowiec, Krzysztof Kowalski, Wolfgang Gaebel, Claudio L. A. Bassetti, Andrew Chan, Philip Gorwood, Sergi Papiol, Geert Dom, Umberto Volpe, Agata Szulc, Tamas Kurimay, Hilkka Karkkainen, Andre Decraene, Jan Wisse, Andrea Fiorillo, Peter Falkai
Summary: The ongoing developments in psychiatric classification systems have improved the reliability of diagnosis for schizophrenia to some extent, but due to unknown pathophysiology and lack of biomarkers, its validity still remains low, requiring further advancements. In contrast, multiple sclerosis, with its established pathophysiology and defined biomarkers, has good validity and improved treatment options. Recognizing the clinical heterogeneity of schizophrenia and considering the similarities it shares with multiple sclerosis, it is crucial to deconstruct the psychosis spectrum and adopt dimensional approaches to refine current diagnostic boundaries.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Judit Simon, Patrice Boyer, Jose M. Caldas-de-Almeida, Martin Knapp, Paul McCrone, Philip Gorwood, Wolfgang Oertel, Celso Arango, Janet Treasure, Allan H. Young, Frederic Destrebecq, Vinciane Quoidbach
Summary: One in eight individuals worldwide and one in four individuals in many European countries have mental health problems. Three-quarters of mental health disorders develop before age 25, with undiagnosed symptoms often presenting in the mid-teens and lasting into old age. Evidence suggests that people frequently have multiple mental health disorders.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Alessio Maria Monteleone, Eugenia Barone, Giammarco Cascino, Ulrike Schmidt, Philip Gorwood, Umberto Volpe, Giovanni Abbate-Daga, Giovanni Castellini, Marina Diaz Marsa, Angela Favaro, Akira Fukutomi, Sebastien Guillaume, Petr Minarik, Jose Antonio Soriano Pacheco, Matteo Panero, Hana Papezova, Valdo Ricca, Cristina Segura-Garcia, Elisabetta Scanferla, Marta Tyszkiewicz-Nwafor, Fernando Fernandez-Aranda, Ulrich Voderholzer, Janet Treasure, Palmiero Monteleone
Summary: This study aimed to assess barriers and facilitators in accessing specialist care for eating disorders (EDs). The study found that most patients did not directly access specialist care, but sought treatment through mental health professionals and general practitioners. The involvement of multiple health professionals in seeking help, seeking treatment for general psychiatric symptoms, and lack of family support were associated with delayed access to ED units.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Elisabetta Scanferla, Katherine de Bienassis, Bernard Pachoud, Philip Gorwood
Summary: This study examines the impact of using standardized patient-reported indicators in acute psychiatric care. The findings suggest that subjective well-being indicators are relevant for evaluating the quality of hospital care, distinct from measures of symptom improvement and patient-reported experience.
EUROPEAN PSYCHIATRY
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
