Review
Pharmacology & Pharmacy
Hang Wang, Xianghuan Dong, Maher Un Nisa Awan, Jie Bai
Summary: This review briefly summarizes the studies on epigenetics involved in METH addiction, elucidating the molecular mechanism of METH addiction and the effects of METH on neurotransmitter release and brain area activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Fan Luo, Zimo Zhu, Yang Du, Lei Chen, Yong Cheng
Summary: Postpartum depression is a serious mood disorder that occurs after childbirth and can have lifelong consequences for women and their families. It is influenced by various risk factors, including environmental and genetic factors. Gene-environment interactions play a role in postpartum depression, as evidenced by studies on genes related to neurotransmitters, the HPA axis, and the kynurenine pathway. However, the conclusions regarding these risk factors, especially genetic factors, are not consistent, and further research is needed to understand the heritability and susceptibility of postpartum depression.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pathology
Sarah Abdulmalek, Gary Hardiman
Summary: Opioid use disorder is a global problem with the challenge of relapse hindering long-term efficacy of treatments. Understanding the neurobiology of addiction and relapse can lead to more targeted and effective treatment, as well as diagnostic tools for identifying vulnerable individuals. The limitations of current screening tools for opioid use disorder are also discussed.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Cell Biology
Maryna Koskela, T. Petteri Piepponen, Maria Lindahl, Brandon K. Harvey, Jaan-Olle Andressoo, Vootele Voikar, Mikko Airavaara
Summary: The study explored the impact of GDNF and BDNF on alcohol-seeking behavior in group-housed female mice. While an increase in endogenous Gdnf mRNA level was found to affect behavioral responses to alcohol consumption, overexpression of AVV-GDNF in the nucleus accumbens suppressed alcohol-seeking behavior.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Yuliannis Lugones, Pia Loren, Luis A. Salazar
Summary: Cisplatin is a widely used anti-cancer drug, but tumor cells can develop resistance to its damaging effects through genetic and epigenetic changes, as well as other resistance mechanisms.
Review
Oncology
Teresa Gagliano, Claudio Brancolini
Summary: This review article delves into the communication between cancer cells and non-cancerous cells, focusing on the role of epigenetics in cell-cell interactions. Studies suggest that epigenetic regulations are closely linked to tumor-stroma interactions, which could be crucial for future cancer therapy design.
Review
Biochemistry & Molecular Biology
Lukasz Ustianowski, Jakub Udzik, Joanna Szostak, Anna Goracy, Klaudia Ustianowska, Andrzej Pawlik
Summary: This narrative review discusses the role of genetic and epigenetic factors in the pathogenesis of gestational diabetes mellitus (GDM) and explores the risk factors of GDM, including obesity, advanced maternal age, and polycystic ovary syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Alexandre A. Lussier, Tamara S. Bodnar, Joanne Weinberg
Summary: Prenatal alcohol exposure can have detrimental effects on immune function and epigenetic patterns, impacting immune system development and long-term health outcomes. Epigenetic mechanisms play a crucial role in reprogramming immune function and may offer new therapeutic strategies for individuals prenatally exposed to alcohol.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Chemistry, Medicinal
Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Yuan Zhou, Jun Ren
Summary: This article discusses the pathogenesis of alcohol-related liver disease (ARLD) and alcoholic liver disease (ALD), with a focus on the role of epigenetic factors in the development of liver disorders. Through cellular and animal model studies, the alcohol-induced epigenetic modifications (AIEM) and their relationship with liver diseases are explored, and epigenetics-based therapeutic options for managing ARLD and ALD are proposed.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Cell Biology
You-Wei Wang, Nan Hu, Xiao-Hong Li
Summary: Revealing the mechanisms of neural development and neural diseases is a challenging task in life science. Brain organoids derived from pluripotent stem cells can mimic the development, function, and signal generation of human brains, providing a unique advantage for studying neurology. Single-cell RNA sequencing and multielectrode array analysis have shown the similarity between brain organoids and the immature human brain at early developmental stages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Psychiatry
Livio Provenzi, Marco Villa, Fabiana Mambretti, Andrea Citterio, Serena Grumi, Emanuela Bertazzoli, Giacomo Biasucci, Lidia Decembrino, Barbara Gardella, Roberta Giacchero, Maria Luisa Magnani, Renata Nacinovich, Camilla Pisoni, Federico Prefumo, Simona Orcesi, Barbara Scelsa, Roberto Giorda, Renato Borgatti
Summary: This study suggests that pandemic-related stress may increase the risk of anxiety in mothers, and BDNF epigenetic regulation might play a significant role in this association.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Allergy
Bernard S. S. Stikker, Rudi W. W. Hendriks, Ralph Stadhouders
Summary: Asthma is a complex inflammatory disease influenced by both environmental and genetic factors. Genome-wide association studies (GWAS) have identified thousands of genetic variants associated with asthma, but most of these variants are located in non-coding regions, making it difficult to understand their functional impact and relevance to disease mechanisms. Advances in genomics technology and epigenetics have allowed for the identification of gene regulatory elements linked to genetic variants in non-coding regions, shedding light on the (epi)genetic mechanisms of asthma. This article provides an integrated overview of asthma-associated (epi)genetic variants and their connection to asthma pathophysiology using state-of-the-art genomics methodology. It also discusses the potential of decoding the genetic and epigenetic basis of asthma to transform clinical management and predict asthma risk.
Review
Biochemistry & Molecular Biology
Charalabos Antonatos, Katerina Grafanaki, Paschalia Asmenoudi, Panagiotis Xiropotamos, Paraskevi Nani, Georgios K. Georgakilas, Sophia Georgiou, Yiannis Vasilopoulos
Summary: This review provides an overview of the environmental factors, epigenetic modifications, and non-coding RNAs associated with the onset and progression of psoriasis. It also discusses therapeutic applications targeting the epigenome to suppress the inflammatory cutaneous cascade.
Review
Pharmacology & Pharmacy
Christopher A. Blackwood, Jean Lud Cadet
Summary: Opioid use disorder is on the rise in the United States, with racial disparities observed in opioid overdose deaths. The compulsive drug consumption, withdrawal, and relapse, along with epigenetic changes and genetic factors in some racial groups, may impact responses to pharmacological therapeutic approaches.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jian Zou, T. Jordan Walter, Alexandra Barnett, Aaron Rohlman, Fulton T. Crews, Leon G. Coleman
Summary: Adult hippocampal neurogenesis (AHN) is involved in learning and memory as well as regulation of mood. Binge ethanol reduces AHN, though the mechanism is unknown. Microglia promote neurogenesis through the secretion of pro-neurogenic extracellular vesicles (pn-EVs), but ethanol inhibits neurogenesis and causes secretion of proinflammatory EVs (EtOH-EVs), resulting in the loss of adult hippocampal neurogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychology, Clinical
Zeynep Yilmaz, Katherine Schaumberg, Matthew Halvorsen, Erica L. Goodman, Leigh C. Brosof, James J. Crowley, Carol A. Mathews, Manuel Mattheisen, Gerome Breen, Cynthia M. Bulik, Nadia Micali, Stephanie C. Zerwas
Summary: This study found a genetic overlap between anorexia nervosa (AN), obsessive-compulsive disorder (OCD), and anxiety symptoms, with a potential sex-specific contribution of genetic risk. AN and AN/OCD polygenic scores (PGS) played a more prominent role in predicting eating disorder and anxiety symptoms, while OCD PGS had a smaller effect. The results also suggest that compulsive exercise may have a transdiagnostic genetic etiology.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Jessica S. Johnson, Alanna C. Cote, Amanda Dobbyn, Laura G. Sloofman, Jiayi Xu, Liam Cotter, Alexander W. Charney, Andreas Birgegard, Jennifer Jordan, Martin Kennedy, Mikael Landen, Sarah L. Maguire, Nicholas G. Martin, Preben Bo Mortensen, Laura M. Thornton, Cynthia M. Bulik, Laura M. Huckins
Summary: This study used transcriptomic imputation and phenome-wide association studies to explore the clinical consequences of genetically regulated gene expression in anorexia nervosa (AN). The results identified several genes associated with AN and revealed associations with autoimmune, metabolic, and gastrointestinal diagnoses, as well as other clinical measures. The analysis also showed that body mass index (BMI) and sex moderated some of the associations. These findings provide potential avenues for further investigation into the functional mechanisms of AN-associated genes.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Neus Sole-Morata, Isabel Baenas, Mikel Etxandi, Roser Granero, Manel Gene, Carme Barrot, Monica Gomez-Pena, Laura Moragas, Nicolas Ramoz, Philip Gorwood, Fernando Fernandez-Aranda, Susana Jimenez-Murcia
Summary: Gambling Disorder (GD) is influenced by both genetic and environmental factors. This study investigated the underlying mechanisms of GD severity by examining the interactions between genetic, psychological, socio-demographic, and clinical factors. Pathway analysis revealed that specific genetic variants, in interaction with other biopsychological features, predicted greater severity of GD. These findings highlight the complex interplay between biopsychosocial variables in the development and severity of GD, and provide support for the involvement of genetic variants from the neurotrophic factor family.
Article
Psychiatry
Nathan A. Kimbrel, Allison E. Ashley-Koch, Xue J. Qin, Jennifer H. Lindquist, Melanie E. Garrett, Michelle F. Dennis, Lauren P. Hair, Jennifer E. Huffman, Daniel A. Jacobson, Ravi K. Madduri, Jodie A. Trafton, Hilary Coon, Anna R. Docherty, Niamh Mullins, Douglas M. Ruderfer, Philip D. Harvey, Benjamin H. McMahon, David W. Oslin, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser
Summary: This study aimed to identify the genetic basis of suicidal thoughts and behaviors. Through genome-wide association analysis, several risk loci for suicide were identified, and some of these loci were replicated in independent samples, providing evidence for their involvement in suicide.
Article
Biochemistry & Molecular Biology
Julia Mattioni, Clement Vansteene, Daphnee Poupon, Philip Gorwood, Nicolas Ramoz
Summary: In this study, a population-based case-control and genetic association research was conducted on a large sample of young adults to assess the role of dopamine receptor D2 (DRD2) and ankyrin repeat and kinase domain-containing protein 1 (ANKK1) genes in harmful alcohol use. The study found that a specific gene mutation in DRD2 was associated with harmful alcohol use, and early onset of alcohol consumption and depressive symptoms moderated the effect of this gene on harmful alcohol use.
Article
Health Care Sciences & Services
Theodore Vinais, Aurelie Lacroix, Thibaut Gelle, Philippe Nubukpo
Summary: This pilot study compares the effectiveness of the therapeutic community (TC) model with classic and socio-educational care in French prisons for addiction treatment. Results show that TC care is more effective in improving the primary addiction status, self-esteem, and social/familial status of male repeat offenders.
Review
Clinical Neurology
Camille Verebi, Juliette Nectoux, Philip Gorwood, Yann Le Strat, Philibert Duriez, Nicolas Ramoz, Thierry Bienvenu
Summary: Recent research has found that circulating nucleic acids (CNAs) can be used as a new diagnostic and monitoring tool for mental disorders, particularly for diseases involving difficult-to-assess organs or structures. This review examines the application of plasma and serum cell-free DNA (cfDNA) as biomarkers for psychiatric disorders, including diagnosis, prognosis, treatment response, and disease progression. The overall effect size of plasma nuclear and mitochondrial cfDNA studies was generally moderate for psychiatric disorders. The future applications of CNAs, particularly cfDNA, as non-invasive biomarkers for these diseases are also discussed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Florent Abry, Philip Gorwood, Mouna Hanachi, Laura Di Lodovico
Summary: This study explored the long-term outcomes, quality of life, and attitudes towards treatment in patients involuntarily treated for extremely severe anorexia nervosa (AN). The findings suggest that involuntary treatment does not hinder weight restoration and clinical improvement, nor does it affect long-term attitudes towards treatment.
EUROPEAN EATING DISORDERS REVIEW
(2023)
Article
Psychiatry
Judit Simon, Patrice Boyer, Jose M. Caldas-de-Almeida, Martin Knapp, Paul McCrone, Philip Gorwood, Wolfgang Oertel, Celso Arango, Janet Treasure, Allan H. Young, Frederic Destrebecq, Vinciane Quoidbach
Summary: One in eight individuals worldwide and one in four individuals in many European countries have mental health problems. Three-quarters of mental health disorders develop before age 25, with undiagnosed symptoms often presenting in the mid-teens and lasting into old age. Evidence suggests that people frequently have multiple mental health disorders.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Alessio Maria Monteleone, Eugenia Barone, Giammarco Cascino, Ulrike Schmidt, Philip Gorwood, Umberto Volpe, Giovanni Abbate-Daga, Giovanni Castellini, Marina Diaz Marsa, Angela Favaro, Akira Fukutomi, Sebastien Guillaume, Petr Minarik, Jose Antonio Soriano Pacheco, Matteo Panero, Hana Papezova, Valdo Ricca, Cristina Segura-Garcia, Elisabetta Scanferla, Marta Tyszkiewicz-Nwafor, Fernando Fernandez-Aranda, Ulrich Voderholzer, Janet Treasure, Palmiero Monteleone
Summary: This study aimed to assess barriers and facilitators in accessing specialist care for eating disorders (EDs). The study found that most patients did not directly access specialist care, but sought treatment through mental health professionals and general practitioners. The involvement of multiple health professionals in seeking help, seeking treatment for general psychiatric symptoms, and lack of family support were associated with delayed access to ED units.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Elisabetta Scanferla, Katherine de Bienassis, Bernard Pachoud, Philip Gorwood
Summary: This study examines the impact of using standardized patient-reported indicators in acute psychiatric care. The findings suggest that subjective well-being indicators are relevant for evaluating the quality of hospital care, distinct from measures of symptom improvement and patient-reported experience.
EUROPEAN PSYCHIATRY
(2023)
