The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus

Sphingosine 1-phosphate receptor modulation suppresses pathogenic astrocyte activation and chronic progressive CNS inflammation

(2017) Veit Rothhammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction

(2016) Fuyang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of p38 mitogen-activated protein kinase signaling reduces multidrug transporter activity and anti-epileptic drug resistance in refractory epileptic rats

(2016) Yiye Shao et al.   JOURNAL OF NEUROCHEMISTRY

Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus

(2016) Nicholas H. Varvel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTRup-regulation and astrocyte-mediated inflammation

(2015) Andrés Miguez et al.   HUMAN MOLECULAR GENETICS

Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide

(2014) Emanuela Colombo et al.   ANNALS OF NEUROLOGY

FTY720 enhances chemosensitivity of colon cancer cells to doxorubicin and etoposide via the modulation of P-glycoprotein and multidrug resistance protein 1

(2014) Ying Xing et al.   Journal of Digestive Diseases

Prominence of Central Sphingosine-1-Phosphate Receptor-1 in Attenuating Aβ-Induced Injury by Fingolimod

(2014) Masoumeh Asle-Rousta et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation

(2014) Stine Mencl et al.   JOURNAL OF NEUROIMMUNOLOGY

Neurorestorative effect of FTY720 in a rat model of Alzheimer's disease: Comparison with Memantine

(2013) Fatemeh Hemmati et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of Brain IKKβ Gene Silencing by Small Interfering RNA on P-Glycoprotein Expression and Brain Damage in the Rat Kainic Acid-Induced Seizure Model

(2013) Nian Yu et al.   CNS & Neurological Disorders-Drug Targets

Adjunctive use of verapamil in patients with refractory temporal lobe epilepsy: A pilot study

(2013) Ali A. Asadi-Pooya et al.   EPILEPSY & BEHAVIOR

P-glycoprotein expression and function in patients with temporal lobe epilepsy: a case-control study

(2013) Maria Feldmann et al.   LANCET NEUROLOGY

FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection

(2013) Peter Kraft et al.   STROKE

Neuropathology of the blood–brain barrier and pharmaco-resistance in human epilepsy

(2012) Joan Y. W. Liu et al.   BRAIN

Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes

(2012) MYUNG-HEE MOON et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model

(2012) Fei Gao et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain

(2012) R. E. Cannon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis

(2011) Jeffrey A. Cohen et al.   ANNALS OF NEUROLOGY

A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood-Brain Barrier

(2011) J. P. Bankstahl et al.   JOURNAL OF NEUROSCIENCE

Nuclear Factor-Kappa B Activity Regulates Brain Expression of P-Glycoprotein in the Kainic Acid-Induced Seizure Rats

(2011) Nian Yu et al.   MEDIATORS OF INFLAMMATION

Drug-Resistant Epilepsy

(2011) Patrick Kwan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy

(2010) J Schlichtiger et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivo

(2010) Afraa Zrieki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of Multidrug Resistance Protein 1 by Tumor Necrosis Factor   in Cultured Glial Cells: Involvement of Nuclear Factor- B and c-Jun N-Terminal Kinase Signaling Pathways

(2010) P. T. Ronaldson et al.   MOLECULAR PHARMACOLOGY

Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier

(2009) Birk Poller et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeting Prostaglandin E2 EP1 Receptors Prevents Seizure-Associated P-glycoprotein Up-Regulation

(2009) A. Pekcec et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

(2009) Guido Zibell et al.   NEUROPHARMACOLOGY

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

(2009) Erwin A. van Vliet et al.   NEUROPHARMACOLOGY

Activation of Sphingosine 1-Phosphate Receptor-1 by FTY720 Is Neuroprotective After Ischemic Stroke in Rats

(2009) Yu Hasegawa et al.   STROKE

Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus

(2008) Jens P. Bankstahl et al.   EPILEPSY RESEARCH

Central nervous system-directed effects of FTY720 (fingolimod)

(2008) Veronique E. Miron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain

(2008) Jens P. Bankstahl et al.   NEUROPHARMACOLOGY

Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling

(2007) B. Bauer et al.   MOLECULAR PHARMACOLOGY

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE