The extended human PTPome: a growing tyrosine phosphatase family

The structure of phosphoinositide phosphatases: Insights into substrate specificity and catalysis

(2015) FoSheng Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML

(2015) Sewa Rijal et al.   BLOOD

INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia

(2015) I Dzneladze et al.   LEUKEMIA

PTEN: A yin-yang master regulator protein in health and disease

(2015) Rafael Pulido   METHODS

Mining the function of protein tyrosine phosphatases in health and disease

(2015) Hojin Lee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Phosphoinositide signaling in cancer: INPP4B Akt(s) out

(2015) John F. Woolley et al.   TRENDS IN MOLECULAR MEDICINE

INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor

(2015) S. Kofuji et al.   Cancer Discovery

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes

(2015) C. Li Chew et al.   Cancer Discovery

Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

(2015) Laura R. H. Ip et al.   Oncotarget

Dual-specificity phosphatases: critical regulators with diverse cellular targets

(2015) Kate I. Patterson et al.   BIOCHEMICAL JOURNAL

INPP4B: the New Kid on the PI3K Block

(2015) Irina U. Agoulnik et al.   Oncotarget

Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo

(2015)   Oncotarget

INPP4B suppresses prostate cancer cell invasion

(2014) Myles C Hodgson et al.   Cell Communication and Signaling

Allosteric Inhibitors of the Eya2 Phosphatase Are Selective and Inhibit Eya2-mediated Cell Migration

(2014) Aaron B. Krueger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer

(2014) Jessica A. Gasser et al.   MOLECULAR CELL

The human DEPhOsphorylation database DEPOD: a 2015 update

(2014) Guangyou Duan et al.   NUCLEIC ACIDS RESEARCH

The Pseudophosphatase MK-STYX Physically and Genetically Interacts with the Mitochondrial Phosphatase PTPMT1

(2014) Natalie M. Niemi et al.   PLoS One

Epigenetic Inactivation of Inositol polyphosphate 4-phosphatase B (INPP4B), a Regulator of PI3K/AKT Signaling Pathway in EBV-Associated Nasopharyngeal Carcinoma

(2014) Jessie Wai-Fong Yuen et al.   PLoS One

Structural Basis for Phosphoinositide Substrate Recognition, Catalysis, and Membrane Interactions in Human Inositol Polyphosphate 5-Phosphatases

(2014) Lionel Trésaugues et al.   STRUCTURE

INPP4B overexpression enhances the antitumor efficacy of PARP inhibitor AG014699 in MDA-MB-231 triple-negative breast cancer cells

(2014) Ying Sun et al.   TUMOR BIOLOGY

Effects of INPP4B gene transfection combined with PARP inhibitor on castration therapy—Resistant prostate cancer cell line, PC3

(2014) Huan Ding et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung

(2014) Annika Stjernström et al.   Cancer Medicine

Cytosolic Low Molecular Weight Protein-Tyrosine Phosphatase Activity and Clinical Manifestations of Diabetes

(2013) Fulvia Gloria-Bottini et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Bi-Domain Protein Tyrosine Phosphatases Reveal an Evolutionary Adaptation to Optimize Signal Transduction

(2013) Lalima Gagan Ahuja et al.   ANTIOXIDANTS & REDOX SIGNALING

Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities

(2013) Sandra M. Lopez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants

(2013) Boris S. Luis et al.   FEBS Journal

PTPs emerge as PIPs: protein tyrosine phosphatases with lipid-phosphatase activities in human disease

(2013) R. Pulido et al.   HUMAN MOLECULAR GENETICS

Identification and Structural Characterization of aLegionellaPhosphoinositide Phosphatase

(2013) Leila Toulabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Tumor Suppressor Function for the Lipid Phosphatase INPP4B in Melanocytic Neoplasms

(2013) Rolando Perez-Lorenzo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pseudophosphatases: Methods of analysis and physiological functions

(2013) Dmitri Kharitidi et al.   METHODS

PTP-central: A comprehensive resource of protein tyrosine phosphatases in eukaryotic genomes

(2013) Teri Hatzihristidis et al.   METHODS

C1-Ten Is a Protein Tyrosine Phosphatase of Insulin Receptor Substrate 1 (IRS-1), Regulating IRS-1 Stability and Muscle Atrophy

(2013) A. Koh et al.   MOLECULAR AND CELLULAR BIOLOGY

Transmembrane Prostatic Acid Phosphatase (TMPAP) Interacts with Snapin and Deficient Mice Develop Prostate Adenocarcinoma

(2013) Ileana B. Quintero et al.   PLoS One

Structure-Activity Relationships of Benzbromarone Metabolites and Derivatives as EYA Inhibitory Anti-Angiogenic Agents

(2013) Ram Naresh Pandey et al.   PLoS One

Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2

(2013) V. Reiterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis

(2013) S. T. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating Human Phosphatase-Substrate Networks

(2013) X. Li et al.   Science Signaling

The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis

(2013) Irina Alho et al.   TUMOR BIOLOGY

Functional interplay between Aurora B kinase and Ssu72 phosphatase regulates sister chromatid cohesion

(2013) Hyun-Soo Kim et al.   Nature Communications

Dual-Specificity MAP Kinase Phosphatases as Targets of Cancer Treatment

(2012) Caroline Nunes-Xavier et al.   Anti-Cancer Agents in Medicinal Chemistry

Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells

(2012) Jae-Sung Kim et al.   CANCER BIOLOGY & THERAPY

TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function

(2012) Steven H. Back et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Eyes Absent proteins in development and disease

(2012) Emmanuel Tadjuidje et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Purple acid phosphatase: A journey into the function and mechanism of a colorful enzyme

(2012) Gerhard Schenk et al.   COORDINATION CHEMISTRY REVIEWS

Paladin is an antiphosphatase that regulates neural crest cell formation and migration

(2012) Julaine Roffers-Agarwal et al.   DEVELOPMENTAL BIOLOGY

Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development

(2012) Elisabet Wallgard et al.   DEVELOPMENTAL DYNAMICS

Protein tyrosine phosphatase inhibitors: a patent review (2002 – 2011)

(2012) Masilamani Elizabeth Sobhia et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Protein tyrosine phosphatases in health and disease

(2012) Wiljan J. A. J. Hendriks et al.   FEBS Journal

Small molecule tools for functional interrogation of protein tyrosine phosphatases

(2012) Rongjun He et al.   FEBS Journal

Dual-specificity MAP kinase phosphatases (MKPs)

(2012) Christopher J. Caunt et al.   FEBS Journal

Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis

(2012) Frank Böhmer et al.   FEBS Journal

Protein tyrosine phosphatases - from housekeeping enzymes to master regulators of signal transduction

(2012) Nicholas K. Tonks   FEBS Journal

An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72

(2012) K. Xiang et al.   GENES & DEVELOPMENT

The RNA polymerase II CTD coordinates transcription and RNA processing

(2012) J.-P. Hsin et al.   GENES & DEVELOPMENT

Resveratrol attenuates experimental allergic asthma in mice by restoring inositol polyphosphate 4 phosphatase (INPP4A)

(2012) Jyotirmoi Aich et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Once Phosphorylated, Tyrosines in Carboxyl Terminus of Protein-tyrosine Kinase Syk Interact with Signaling Proteins, Including TULA-2, a Negative Regulator of Mast Cell Degranulation

(2012) Rodrigo Orlandini de Castro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ssu72 Phosphatase-dependent Erasure of Phospho-Ser7 Marks on the RNA Polymerase II C-terminal Domain Is Essential for Viability and Transcription Termination

(2012) David W. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TULA-family proteins: A new class of cellular regulators

(2012) Alexander Y. Tsygankov   JOURNAL OF CELLULAR PHYSIOLOGY

Prostatic Acid Phosphatase Is Required for the Antinociceptive Effects of Thiamine and Benfotiamine

(2012) Julie K. Hurt et al.   PLoS One

Myotubularin phosphoinositide phosphatases: cellular functions and disease pathophysiology

(2012) Karim Hnia et al.   TRENDS IN MOLECULAR MEDICINE

Loss-of-function of inositol polyphosphate-4-phosphatase reversibly increases the severity of allergic airway inflammation

(2012) Jyotirmoi Aich et al.   Nature Communications

DUSPs, to MAP kinases and beyond

(2012) Ching-Yu Huang et al.   Cell and Bioscience

Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue

(2011) Yong Zhang et al.   BIOCHEMICAL JOURNAL

Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

(2011) Kenneth L. Scott et al.   CANCER CELL

Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer

(2011) Myles C. Hodgson et al.   CANCER RESEARCH

Inositol Polyphosphate 4-Phosphatase B as a Regulator of Bone Mass in Mice and Humans

(2011) Mathieu Ferron et al.   Cell Metabolism

Characterization of the threonine-phosphatase of mouse eyes absent 3

(2011) Teruyuki Sano et al.   FEBS LETTERS

Regulation of protein tyrosine phosphatases by reversible oxidation

(2011) Arne Östman et al.   JOURNAL OF BIOCHEMISTRY

Congenital CNS Hypomyelination in the Fig4 Null Mouse Is Rescued by Neuronal Expression of the PI(3,5)P2 Phosphatase Fig4

(2011) J. J. Winters et al.   JOURNAL OF NEUROSCIENCE

Mannose 6 Dephosphorylation of Lysosomal Proteins Mediated by Acid Phosphatases Acp2 and Acp5

(2011) G. Makrypidi et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity

(2011) Ekkehart Lausch et al.   NATURE GENETICS

A Mutation in Synaptojanin 2 Causes Progressive Hearing Loss in the ENU-Mutagenised Mouse Strain Mozart

(2011) Shehnaaz S. M. Manji et al.   PLoS One

Redox Regulation of Protein Tyrosine Phosphatases: Structural and Chemical Aspects

(2010) John J. Tanner et al.   ANTIOXIDANTS & REDOX SIGNALING

The pseudophosphatase MK-STYX interacts with G3BP and decreases stress granule formation

(2010) Shantá D. Hinton et al.   BIOCHEMICAL JOURNAL

A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets

(2010) D. H. Thomas et al.   BLOOD

Bioinformatic identification and characterization of human endothelial cell-restricted genes

(2010) Manoj Bhasin et al.   BMC GENOMICS

Tartrate-resistant acid phosphatase isoform 5b (TRACP 5b) as a serum maker for cancer with bone metastasis

(2010) Tsu-Yi Chao et al.   CLINICA CHIMICA ACTA

The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion

(2010) Hyun-Soo Kim et al.   EMBO JOURNAL

Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function

(2010) Andrew Manford et al.   EMBO JOURNAL

Diversity, abundance and characterization of ruminal cysteine phytases suggest their important role in phytate degradation

(2010) Huoqing Huang et al.   ENVIRONMENTAL MICROBIOLOGY

Structural and functional analysis of human prostatic acid phosphatase

(2010) Md Imtaiyaz Hassan et al.   Expert Review of Anticancer Therapy

Human Prostatic Acid Phosphatase, an Authentic Tyrosine Phosphatase, Dephosphorylates ErbB-2 and Regulates Prostate Cancer Cell Growth

(2010) Tsai-Der Chuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cis-Proline-mediated Ser(P)5Dephosphorylation by the RNA Polymerase II C-terminal Domain Phosphatase Ssu72

(2010) Jon W. Werner-Allen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of the human symplekin–Ssu72–CTD phosphopeptide complex

(2010) Kehui Xiang et al.   NATURE

The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death

(2010) Junko Sasaki et al.   NATURE

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

(2010) C. G. Fedele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the PTEN-like Region of Auxilin, a Detector of Clathrin-Coated Vesicle Budding

(2010) Rong Guan et al.   STRUCTURE

Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

(2009) Clement Y. Chow et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structural and Functional Characterization of the 2H-Phosphatase Domain of Sts-2 Reveals an Acid-Dependent Phosphatase Activity†

(2009) Yunting Chen et al.   BIOCHEMISTRY

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling

(2009) Christina Gewinner et al.   CANCER CELL

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

(2009) Alastair J. Barr et al.   CELL

Combination of Reverse and Chemical Genetic Screens Reveals Angiogenesis Inhibitors and Targets

(2009) Mattias Kalén et al.   CHEMISTRY & BIOLOGY

Inpp5f Is a Polyphosphoinositide Phosphatase That Regulates Cardiac Hypertrophic Responsiveness

(2009) Wenting Zhu et al.   CIRCULATION RESEARCH

Use of Protein Tyrosine Phosphatase Inhibitors as Promising Targeted Therapeutic Drugs

(2009) P. Heneberg   CURRENT MEDICINAL CHEMISTRY

Synthetic lethal targeting ofPTENmutant cells with PARP inhibitors

(2009) Ana M. Mendes-Pereira et al.   EMBO Molecular Medicine

Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase

(2009) Barbro Ek-Rylander et al.   EXPERIMENTAL CELL RESEARCH

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

(2009) Suk-Kyeong Jung et al.   FASEB JOURNAL

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2

(2009) Cole J. Ferguson et al.   HUMAN MOLECULAR GENETICS

Dephosphorylation of the C-terminal Tyrosyl Residue of the DNA Damage-related Histone H2A.X Is Mediated by the Protein Phosphatase Eyes Absent

(2009) Navasona Krishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sac3 Is an Insulin-regulated Phosphatidylinositol 3,5-Bisphosphate Phosphatase

(2009) Ognian C. Ikonomov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Essential N Terminus of the Pta1 Scaffold Protein Is Required for snoRNA Transcription Termination and Ssu72 Function but Is Dispensable for Pre-mRNA 3'-End Processing

(2009) M. A. Ghazy et al.   MOLECULAR AND CELLULAR BIOLOGY

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

(2009) Peter J. Cook et al.   NATURE

Negative Regulators of Insulin Signaling Revealed in a Genome-Wide Functional Screen

(2009) Shih-Min A. Huang et al.   PLoS One

Mammalian phosphoinositide kinases and phosphatases

(2009) Takehiko Sasaki et al.   PROGRESS IN LIPID RESEARCH

Revisiting histidine-dependent acid phosphatases: a distinct group of tyrosine phosphatases

(2009) Suresh Veeramani et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Genetic Variation in Inositol Polyphosphate 4 Phosphatase A Enhances Susceptibility to Asthma

(2008) Mamta Sharma et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Identification of a Core Set of 58 Gene Transcripts With Broad and Specific Expression in the Microvasculature

(2008) Elisabet Wallgard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy

(2008) Alison R. Hayman   AUTOIMMUNITY

The histidine phosphatase superfamily: structure and function

(2008) Daniel J. Rigden   BIOCHEMICAL JOURNAL

Evolution of protein phosphatases in plants and animals

(2008) Greg B. G. Moorhead et al.   BIOCHEMICAL JOURNAL

Structural and Functional Characterization of the C-Terminal Domain of the Ecdysteroid Phosphate Phosphatase fromBombyx moriReveals a New Enzymatic Activity†

(2008) Yunting Chen et al.   BIOCHEMISTRY

From immune response to cancer: a spot on the low molecular weight protein tyrosine phosphatase

(2008) A. C. S. Souza et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Discovery of transcription factors and other candidate regulators of neural crest development

(2008) Meghan S. Adams et al.   DEVELOPMENTAL DYNAMICS

Protein tyrosine phosphatases: functional inferences from mouse models and human diseases

(2008) Wiljan J. A. J. Hendriks et al.   FEBS Journal

Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease

(2008) Rafael Pulido et al.   FEBS Journal

TULA proteins regulate activity of the protein tyrosine kinase Syk

(2008) Rachana Agrawal et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Catalytic Acid in the Dephosphorylation of the Cdk2-pTpY/CycA Protein Complex by Cdc25B Phosphatase

(2008) Guilherme Menegon Arantes   JOURNAL OF PHYSICAL CHEMISTRY B

The Sac1 Phosphoinositide Phosphatase Regulates Golgi Membrane Morphology and Mitotic Spindle Organization in Mammals

(2008) Yang Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Prostatic Acid Phosphatase Is an Ectonucleotidase and Suppresses Pain by Generating Adenosine

(2008) Mark J. Zylka et al.   NEURON

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

(2008) S. V. Voronov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins

(2008) P. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA