Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis

Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ

(2012) R. Godfrey et al.   BLOOD

Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase

(2012) K. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isothiazolidinone (IZD) as a phosphoryl mimetic in inhibitors of theYersinia pestisprotein tyrosine phosphatase YopH

(2011) Sung-Eun Kim et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Do reactive oxygen species play a role in myeloid leukemias?

(2011) P. S. Hole et al.   BLOOD

Conformation-Sensing Antibodies Stabilize the Oxidized Form of PTP1B and Inhibit Its Phosphatase Activity

(2011) Aftabul Haque et al.   CELL

Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome”

(2011) Robert Karisch et al.   CELL

Regulation of protein tyrosine phosphatases by reversible oxidation

(2011) Arne Östman et al.   JOURNAL OF BIOCHEMISTRY

Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling

(2011) Deepika Arora et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule Receptor Protein Tyrosine Phosphatase γ (RPTPγ) Ligands That Inhibit Phosphatase Activity via Perturbation of the Tryptophan–Proline–Aspartate (WPD) Loop

(2011) Steven Sheriff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Utilization of Nitrophenylphosphates and Oxime-Based Ligation for the Development of Nanomolar Affinity Inhibitors of theYersinia pestisOuter Protein H (YopH) Phosphatase‡

(2011) Medhanit Bahta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and Substrate Recognition of the Staphylococcus aureus Protein Tyrosine Phosphatase PtpA

(2011) Carolina Vega et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structures of YwqE from Bacillus subtilis and CpsB from Streptococcus pneumoniae, unique metal-dependent tyrosine phosphatases

(2011) Hyoun Sook Kim et al.   JOURNAL OF STRUCTURAL BIOLOGY

Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148

(2011) James R. Whiteford et al.   MOLECULAR BIOLOGY OF THE CELL

Proteoglycan-Specific Molecular Switch for RPTP  Clustering and Neuronal Extension

(2011) C. H. Coles et al.   SCIENCE

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

Non-genomic loss of PTEN function in cancer: not in my genes

(2011) Nick R. Leslie et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of Mycobacterium tuberculosis tyrosine phosphatase PtpA by synthetic chalcones: Kinetics, molecular modeling, toxicity and effect on growth

(2010) Alessandra Mascarello et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A rapid oxime linker-based library approach to identification of bivalent inhibitors of the Yersinia pestis protein-tyrosine phosphatase, YopH

(2010) Fa Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis

(2010) Nicola J Beresford et al.   BMC GENOMICS

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Inactivation of Peroxiredoxin I by Phosphorylation Allows Localized H2O2 Accumulation for Cell Signaling

(2010) Hyun Ae Woo et al.   CELL

Targeting Protein Tyrosine Phosphatases for Anticancer Drug Discovery

(2010) Latanya M. Scott et al.   CURRENT PHARMACEUTICAL DESIGN

Reactive oxygen species in cancer

(2010) Geou-Yarh Liou et al.   FREE RADICAL RESEARCH

New strategies in fighting TB: targeting Mycobacterium tuberculosis-secreted phosphatases MptpA & MptpB

(2010) Ana PG Silva et al.   Future Medicinal Chemistry

A novel phosphatase cascade regulates differentiation in Trypanosoma brucei via a glycosomal signaling pathway

(2010) B. Szoor et al.   GENES & DEVELOPMENT

TheTrypanosoma bruceiLife Cycle SwitchTbPTP1 Is Structurally Conserved and Dephosphorylates the Nucleolar Protein NOPP44/46

(2010) Seemay Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases

(2010) M M Reddy et al.   LEUKEMIA

Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice

(2010) Kristen A. Lantz et al.   Obesity

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases

(2010) M. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nonphagocytic NADPH Oxidase Duox1 Mediates a Positive Feedback Loop During T Cell Receptor Signaling

(2010) J. Kwon et al.   Science Signaling

Mycobacterium tuberculosisPtkA is a novel protein tyrosine kinase whose substrate is PtpA

(2009) Horacio Bach et al.   BIOCHEMICAL JOURNAL

Redox Regulation of SH2-Domain-Containing Protein Tyrosine Phosphatases by Two Backdoor Cysteines

(2009) Cheng-Yu Chen et al.   BIOCHEMISTRY

Modulation of SHP-1 phosphatase activity by monovalent and bivalent SH2 phosphopeptide ligands

(2009) Kathleen Teichmann et al.   BIOPOLYMERS

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

(2009) Alastair J. Barr et al.   CELL

Blocking Receptor Protein Tyrosine Phosphatase β /ζ: A Potential Therapeutic Strategy for Parkinsons Disease

(2009) Gonzalo Herradon et al.   CURRENT MEDICINAL CHEMISTRY

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

(2009) Juxiang Cao et al.   EMBO JOURNAL

Dimeric Quaternary Structure of the Prototypical Dual Specificity Phosphatase VH1

(2009) Adem C. Koksal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Analysis of a Multifunctional, Tandemly Repeated Inositol Polyphosphatase

(2009) Robert J. Gruninger et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, Representatives of Two Families of Tyrosine Phosphatases that Regulate Capsule Assembly

(2009) Gregor Hagelueken et al.   JOURNAL OF MOLECULAR BIOLOGY

Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC

(2009) Amy E. Hower et al.   JOURNAL OF NEUROCHEMISTRY

Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway

(2009) R Naughton et al.   LEUKEMIA

Pathogen trafficking pathways and host phosphoinositide metabolism

(2009) Stefan S. Weber et al.   MOLECULAR MICROBIOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Interaction and conformational dynamics of membrane-spanning protein helices

(2009) Dieter Langosch et al.   PROTEIN SCIENCE

Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML

(2008) A. Sallmyr et al.   BLOOD

The protein-phosphatome of the human malaria parasite Plasmodium falciparum

(2008) Jonathan M Wilkes et al.   BMC GENOMICS

Mycobacterium tuberculosis Virulence Is Mediated by PtpA Dephosphorylation of Human Vacuolar Protein Sorting 33B

(2008) Horacio Bach et al.   Cell Host & Microbe

From immune response to cancer: a spot on the low molecular weight protein tyrosine phosphatase

(2008) A. C. S. Souza et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Plasmodium falciparum Serine/Threonine Phoshoprotein Phosphatases (PPP): From Housekeeper to the ‘Holy Grail’

(2008) Joanna Bajsa et al.   CURRENT DRUG TARGETS

Effect of ionic strength and oxidation on the P-loop conformation of the protein tyrosine phosphatase-like phytase, PhyAsr

(2008) Robert J. Gruninger et al.   FEBS Journal

Redox regulation of dimerization of the receptor protein-tyrosine phosphatases RPTPα, LAR, RPTPμ and CD45

(2008) Arnoud Groen et al.   FEBS Journal

Protein tyrosine phosphatases: structure-function relationships

(2008) Lydia Tabernero et al.   FEBS Journal

Protein tyrosine phosphatases: regulatory mechanisms

(2008) Jeroen den Hertog et al.   FEBS Journal

Thiol chemistry and specificity in redox signaling

(2008) Christine C. Winterbourn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protozoan protein tyrosine phosphatases

(2008) A ANDREEVA et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

p66Shc-generated Oxidative Signal Promotes Fat Accumulation

(2008) Ina Berniakovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of ROS signal transduction by NADPH oxidase 4 localization

(2008) Kai Chen et al.   JOURNAL OF CELL BIOLOGY

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Characterization of the As/Sb Reductase LmACR2 from Leishmania major

(2008) Rita Mukhopadhyay et al.   JOURNAL OF MOLECULAR BIOLOGY

Aryl Vinyl Sulfonates and Sulfones as Active Site-Directed and Mechanism-Based Probes for Protein Tyrosine Phosphatases

(2008) Sijiu Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Impaired Acid Catalysis by Mutation of a Protein Loop Hinge Residue in a YopH Mutant Revealed by Crystal Structures

(2008) Tiago A. S. Brandão et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Ser/Thr phosphatases of parasitic protozoa

(2008) Mikhail A. Kutuzov et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Reconciling the chemistry and biology of reactive oxygen species

(2008) Christine C Winterbourn   Nature Chemical Biology

Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking

(2008) K. Hellmuth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multimerisation of receptor-type protein tyrosine phosphatases PTPBR7 and PTP-SL attenuates enzymatic activity

(2007) Yvet E. Noordman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mycobacterial Ser/Thr protein kinases and phosphatases: Physiological roles and therapeutic potential

(2007) Annemarie Wehenkel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS