Retinoic acid as a therapeutic option in Alzheimer’s disease: a focus on cholinergic restoration

The Pathology of “Vascular Dementia”: A Critical Update

(2017) Kurt A. Jellinger   JOURNAL OF ALZHEIMERS DISEASE

No evidence for role of extracellular choline-acetyltransferase in generation of gamma oscillations in rat hippocampal slices in vitro

(2015) J.O. Hollnagel et al.   NEUROSCIENCE

Intracellular redistribution of acetyl-CoA, the pivotal point in differential susceptibility of cholinergic neurons and glial cells to neurodegenerative signals

(2014) Andrzej Szutowicz et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Choline kinase alpha expression during RA-induced neuronal differentiation: Role of C/EBPβ

(2014) Pablo Domizi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

MicroRNA-432 contributes to dopamine cocktail and retinoic acid induced differentiation of human neuroblastoma cells by targeting NESTIN and RCOR1 genes

(2014) Eashita Das et al.   FEBS LETTERS

Original article Neuroprotective properties of ciliary neurotrophic factor on retinoic acid (RA)-predifferentiated SH-SY5Y neuroblastoma cells

(2014) Ke Wang et al.   FOLIA NEUROPATHOLOGICA

Retinoic Acid Isomers Facilitate Apolipoprotein E Production and Lipidation in Astrocytes through the Retinoid X Receptor/Retinoic Acid Receptor Pathway

(2014) Jing Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

(2014) Leon M Tai et al.   Molecular Neurodegeneration

Early detection of Alzheimer's disease using PiB and FDG PET

(2014) Ann D. Cohen et al.   NEUROBIOLOGY OF DISEASE

Retinoids as potential targets for Alzheimer's disease

(2014) Rupinder K. Sodhi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Nerve growth factor metabolic dysfunction in Alzheimer's disease and Down syndrome

(2014) M. Florencia Iulita et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Retinoic Acid-Elicited RARα/RXRα Signaling Attenuates Aβ Production by Directly Inhibiting γ-Secretase-Mediated Cleavage of Amyloid Precursor Protein

(2013) Arun Kapoor et al.   ACS Chemical Neuroscience

Plasma nutrient status of patients with Alzheimer's disease: Systematic review and meta-analysis

(2013) Sofia Lopes da Silva et al.   Alzheimers & Dementia

Morphological and functional differentiation in BE(2)-M17 human neuroblastoma cells by treatment with Trans-retinoic acid

(2013) Devon Andres et al.   BMC NEUROSCIENCE

p75 neurotrophin receptor and fenretinide-induced signaling in neuroblastoma

(2013) Veena R. Ganeshan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Amyloid β inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor α agonist

(2013) Maria B. Goncalves et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia

(2013) Guilherme Augusto dos Santos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The rhythm of retinoids in the brain

(2013) Jemma Ransom et al.   JOURNAL OF NEUROCHEMISTRY

Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective

(2013) Eleni Oberbauer et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Acetyl-CoA the Key Factor for Survival or Death of Cholinergic Neurons in Course of Neurodegenerative Diseases

(2013) Andrzej Szutowicz et al.   NEUROCHEMICAL RESEARCH

Magnetic Resonance Spectroscopy in Common Dementias

(2013) Kejal Kantarci   NEUROIMAGING CLINICS OF NORTH AMERICA

Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells

(2013) Naruyoshi Fujiwara et al.   NEUROSCIENCE LETTERS

The Extent of Neurodegeneration and Neuroprotection in Two Chemical In Vitro Models Related to Parkinson’s Disease is Critically Dependent on Cell Culture Conditions

(2013) D. Jantas et al.   NEUROTOXICITY RESEARCH

Phenotypic Characterization of Retinoic Acid Differentiated SH-SY5Y Cells by Transcriptional Profiling

(2013) Joanna A. Korecka et al.   PLoS One

Regulated Extracellular Choline Acetyltransferase Activity— The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway

(2013) Swetha Vijayaraghavan et al.   PLoS One

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Tamibarotene: A Candidate Retinoid Drug for Alzheimer’s Disease

(2012) Hiroshi Fukasawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Early post-treatment with 9-cis retinoic acid reduces neurodegeneration of dopaminergic neurons in a rat model of Parkinson’s disease

(2012) Lian-Hu Yin et al.   BMC NEUROSCIENCE

Serial CSF sampling over a period of 30 h via an indwelling spinal catheter in healthy volunteers: headache, back pain, tolerability and measured acetylcholine profile

(2012) Izaak den Daas et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Relation between Pro-inflammatory Cytokines and Acetylcholine Levels in Relapsing-Remitting Multiple Sclerosis Patients

(2012) Marcella Reale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function

(2012) Koichiro Kawashima et al.   LIFE SCIENCES

Acitretin, an Enhancer of Alpha-Secretase Expression, Crosses the Blood-Brain Barrier and Is Not Eliminated by P-Glycoprotein

(2012) David Holthoewer et al.   Neurodegenerative Diseases

Combination of Aβ clearance and neurotrophic factors as a potential treatment for Alzheimer’s disease

(2012) Lian-Feng Lin et al.   Neuroscience Bulletin

Vitamin A and Alzheimer's disease

(2011) Kenjiro Ono et al.   Geriatrics & Gerontology International

Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity

(2011) Fuxiang Bao et al.   NEUROBIOLOGY OF AGING

Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42IP4 (centaurin α1; ADAP1) in neuroblastoma cells

(2011) Claudia Borrmann et al.   NEUROCHEMISTRY INTERNATIONAL

Carotenoids and Alzheimer’s Disease: An insight into therapeutic role of retinoids in animal models

(2011) M. Obulesu et al.   NEUROCHEMISTRY INTERNATIONAL

Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease

(2011) M. D. Ikonomovic et al.   NEUROLOGY

BMP9 Protects Septal Neurons from Axotomy-Evoked Loss of Cholinergic Phenotype

(2011) Ignacio Lopez-Coviella et al.   PLoS One

The Controlled Generation of Functional Basal Forebrain Cholinergic Neurons from Human Embryonic Stem Cells

(2011) Christopher J. Bissonnette et al.   STEM CELLS

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

The cholinergic system in aging and neuronal degeneration

(2010) Reinhard Schliebs et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of Cholinesterase Inhibitors on the Activities and Protein Levels of Cholinesterases in the Cerebrospinal Fluid of Patients with Alzheimers Disease: A Review of Recent Clinical Studies

(2010) T. Darreh-Shori et al.   Current Alzheimer Research

Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β

(2010) C. I. Jarvis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Retinoids as a Perspective in Treatment of Alzheimer’s Disease

(2010) Falk Fahrenholz et al.   Neurodegenerative Diseases

Nitric Oxide Signaling in Brain Function, Dysfunction, and Dementia

(2010) Joern R. Steinert et al.   NEUROSCIENTIST

Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses

(2010) Richard J Wurtman et al.   NUTRITION REVIEWS

Towards Retinoid Therapy for Alzheimers Disease

(2009) K. Shudo et al.   Current Alzheimer Research

Differentiation of mouse Neuro 2A cells into dopamine neurons

(2009) Roger G. Tremblay et al.   JOURNAL OF NEUROSCIENCE METHODS

Long-term dietary administration of valproic acid does not affect, while retinoic acid decreases, the lifespan of G93A mice, a model for amyotrophic lateral sclerosis

(2009) Cristophe Crochemore et al.   MUSCLE & NERVE

Short-term effects of zinc on acetylcholine metabolism and viability of SN56 cholinergic neuroblastoma cells

(2009) Anna Ronowska et al.   NEUROCHEMISTRY INTERNATIONAL

Alzheimer's disease, metal ions and metal homeostatic therapy

(2009) Paolo Zatta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

(2008) Elliott J Mufson et al.   Expert Review of Neurotherapeutics

Thiamine deficiency-related brain dysfunction in chronic liver failure

(2008) Roger F. Butterworth   METABOLIC BRAIN DISEASE