The Extent of Neurodegeneration and Neuroprotection in Two Chemical In Vitro Models Related to Parkinson’s Disease is Critically Dependent on Cell Culture Conditions

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Parkin-mediated K63-linked polyubiquitination: A signal for targeting misfolded proteins to the aggresome-autophagy pathway

(2014) James A. Olzmann et al.   Autophagy

Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo

(2012) P. Rajendran et al.   Cancer Prevention Research

Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90

(2012) Wen-Bo Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells

(2012) Zhiyin Xun et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Evidence for Synergism Between Cell Death Mechanisms in a Cellular Model of Neurodegeneration in Parkinson’s Disease

(2012) C. J. Yong-Kee et al.   NEUROTOXICITY RESEARCH

Differential Effects of UCHL1 Modulation on Alpha-Synuclein in PD-Like Models of Alpha-Synucleinopathy

(2012) Anna E. Cartier et al.   PLoS One

Distinct Effects of Rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on Cellular Bioenergetics and Cell Death

(2012) Samantha Giordano et al.   PLoS One

Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways

(2011) Radhamani Kannaiyan et al.   APOPTOSIS

Isoflurane preconditioning involves upregulation of molecular chaperone genes

(2011) Chad A. McClintick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells

(2011) Guozhu Chen et al.   BMC CANCER

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Celastrol Inhibits Breast Cancer Cell Invasion via Suppression of NF-ĸB-mediated Matrix Metalloproteinase-9 Expression

(2011) Yoonseo Kim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress

(2011) Lonnie Schneider et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial Dysfunction Precedes Other Sub-Cellular Abnormalities in an In Vitro Model Linked with Cell Death in Parkinson’s Disease

(2011) C. J. Yong-Kee et al.   NEUROTOXICITY RESEARCH

Terpenoids from root bark of Celastrus orbiculatus

(2011) Jian Wu et al.   PHYTOCHEMISTRY

Celastrol: A New Therapeutic Potential of Traditional Chinese Medicine

(2010) T. Morita   AMERICAN JOURNAL OF HYPERTENSION

Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies

(2010) Fernanda Martins Lopes et al.   BRAIN RESEARCH

Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer

(2010) Radhamani Kannaiyan et al.   CANCER LETTERS

Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells

(2010) Shantel E. Walcott et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Development and Validation of a Screening Assay for the Evaluation of Putative Neuroprotective Agents in the Treatment of Parkinson’s Disease

(2010) C. J. Yong-Kee et al.   NEUROTOXICITY RESEARCH

Mechanisms of rotenone-induced proteasome inhibition

(2010) Arthur P. Chou et al.   NEUROTOXICOLOGY

Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs

(2010) Hakryul Jo et al.   PLoS One

Natural Proteasome Inhibitor Celastrol Suppresses Androgen-Independent Prostate Cancer Progression by Modulating Apoptotic Proteins and NF-kappaB

(2010) Yao Dai et al.   PLoS One

Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer

(2010) Vivek R. Yadav et al.   Toxins

Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

(2009) Oren A. Levy et al.   APOPTOSIS

Neuroprotective effects of compounds with antioxidant and anti-inflammatory properties in a Drosophila model of Parkinson's disease

(2009) Katharina Faust et al.   BMC NEUROSCIENCE

Lactacystin requires reactive oxygen species and Bax redistribution to induce mitochondria-mediated cell death

(2009) Sergio Perez-Alvarez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Celastrol Potentiates Radiotherapy by Impairment of DNA Damage Processing in Human Prostate Cancer

(2009) Yao Dai et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Brain mitochondrial dysfunction and oxidative damage in Parkinson’s disease

(2009) Ana Navarro et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The PINK1/Parkin pathway: a mitochondrial quality control system?

(2009) Alexander J. Whitworth et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity

(2009) Parvana Hajieva et al.   JOURNAL OF NEUROCHEMISTRY

Celastrol Synergistically Enhances Temozolomide Cytotoxicity in Melanoma Cells

(2009) M. Chen et al.   MOLECULAR CANCER RESEARCH

Reciprocal Effects of α-Synuclein Overexpression and Proteasome Inhibition in Neuronal Cells and Tissue

(2009) Melanie Dyllick-Brenzinger et al.   NEUROTOXICITY RESEARCH

Why SH-SY5Y cells should be differentiated

(2009) Dirk W. Luchtman et al.   NEUROTOXICOLOGY

New considerations in the medical management of early Parkinson's disease: Impact of recent clinical trials on treatment strategy

(2009) Robert A. Hauser   PARKINSONISM & RELATED DISORDERS

Nurr1 deficiency predisposes to lactacystin-induced dopaminergic neuron injury in vitro and in vivo

(2008) Tianhong Pan et al.   BRAIN RESEARCH

BV-2 stimulation by lactacystin results in a strong inflammatory reaction and apoptotic neuronal death in SH-SY5Y cells

(2008) Seon-Joo Kwon et al.   BRAIN RESEARCH

Natural Compounds with Proteasome Inhibitory Activity for Cancer Prevention and Treatment

(2008) H. Yang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Parkinson’s disease: genetic versus toxin-induced rodent models

(2008) Mügen Terzioglu et al.   FEBS Journal

Mitochondria and ubiquitin-proteasomal system interplay: Relevance to Parkinson's disease

(2008) Ana F. Domingues et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

(2008) Hwan-Ching Tai et al.   NATURE REVIEWS NEUROSCIENCE

Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

(2008) Tianhong Pan et al.   NEUROBIOLOGY OF DISEASE

Pramipexole has astrocyte-mediated neuroprotective effects against lactacystin toxicity

(2008) Keiko Imamura et al.   NEUROSCIENCE LETTERS

Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

(2008) Yuen-Ting Cheung et al.   NEUROTOXICOLOGY

Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat

(2008) W.-S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells

(2007) D. Jantas et al.   NEUROCHEMISTRY INTERNATIONAL