Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions

Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells

(2018) Ubaid Ullah et al.   Cell Reports

Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses

(2017) Joanne E. Konkel et al.   IMMUNITY

The transcriptional repressor HIC1 regulates intestinal immune homeostasis

(2017) K Burrows et al.   Mucosal Immunology

Stability and function of regulatory T cells expressing the transcription factor T-bet

(2017) Andrew G. Levine et al.   NATURE

Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation

(2017) Avery J. Lam et al.   TRANSPLANTATION

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

(2017) Leena Halim et al.   Cell Reports

Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells

(2017) Enzo Candia et al.   PLoS One

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes

(2016) Anne M. Pesenacker et al.   DIABETES

Imprinting of Skin/Inflammation Homing in CD4+T Cells Is Controlled by DNA Methylation within theFucosyltransferase 7Gene

(2016) Matthias Pink et al.   JOURNAL OF IMMUNOLOGY

T-bet Regulates Natural Regulatory T Cell Afferent Lymphatic Migration and Suppressive Function

(2016) Yanbao Xiong et al.   JOURNAL OF IMMUNOLOGY

A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells

(2016) Leo C. Chen et al.   JOURNAL OF IMMUNOLOGY

T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN

(2016) Anna Nosko et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Peripheral tolerance can be modified by altering KLF2-regulated Treg migration

(2016) Sudheer K. Pabbisetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate

(2016) Angelika Schmidt et al.   PLoS One

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells

(2015) I. E. Dijke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Developing in vitro expanded CD45RA+regulatory T cells as an adoptive cell therapy for Crohn's disease

(2015) James B Canavan et al.   GUT

Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

(2015) Anika Fischer et al.   GUT

Control of Regulatory T Cell Migration, Function, and Homeostasis

(2015) Daniel J. Campbell   JOURNAL OF IMMUNOLOGY

Cytokines in Graft-versus-Host Disease

(2015) Andrea S. Henden et al.   JOURNAL OF IMMUNOLOGY

CXCR3+ Regulatory T Cells Control TH1 Responses in Crescentic GN

(2015) H.-J. Paust et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Environment of Regulatory T Cell Biology: Cytokines, Metabolites, and the Microbiome

(2015) Romy E. Hoeppli et al.   Frontiers in Immunology

Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy

(2014) David M. Barrett et al.   CYTOTHERAPY

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells

(2014) G Bakdash et al.   Mucosal Immunology

Fluorescently Activated Cell Sorting Followed by Microarray Profiling of Helper T Cell Subtypes from Human Peripheral Blood

(2014) Chiaki Ono et al.   PLoS One

Critical role of all-trans retinoic acid in stabilizing human natural regulatory T cells under inflammatory conditions

(2014) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines

(2013) A. M. Pesenacker et al.   BLOOD

Beta2-adrenergic receptor signaling in CD4+Foxp3+regulatory T cells enhances their suppressive function in a PKA-dependent manner

(2013) Marcia G. Guereschi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD4+T-cell subsets in transplantation

(2013) Zhongmin Liu et al.   IMMUNOLOGICAL REVIEWS

Dhrs3 Protein Attenuates Retinoic Acid Signaling and Is Required for Early Embryonic Patterning

(2013) Richard Kin Ting Kam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helios+ and Helios- Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans

(2013) M. E. Himmel et al.   JOURNAL OF IMMUNOLOGY

Homing of Regulatory T Cells to Human Skin Is Important for the Prevention of Alloimmune-Mediated Pathology in an In Vivo Cellular Therapy Model

(2013) Fadi Issa et al.   PLoS One

IL-4 Attenuates Th1-Associated Chemokine Expression and Th1 Trafficking to Inflamed Tissues and Limits Pathogen Clearance

(2013) Christopher A. Lazarski et al.   PLoS One

Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells

(2012) T. Duhen et al.   BLOOD

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations

(2012) C. Scotta et al.   HAEMATOLOGICA

The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology

(2012) Aisling O’Hara Hall et al.   IMMUNITY

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2

(2012) Meghan A. Koch et al.   IMMUNITY

CXCR3 ligands: redundant, collaborative and antagonistic functions

(2011) Joanna R Groom et al.   IMMUNOLOGY AND CELL BIOLOGY

Plasticity of Human Regulatory T Cells in Healthy Subjects and Patients with Type 1 Diabetes

(2011) Stephanie A. McClymont et al.   JOURNAL OF IMMUNOLOGY

Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule

(2011) Yujun Huang et al.   NATURE IMMUNOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells

(2011) Tatiana N. Golovina et al.   PLoS One

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Regulatory T cell expression of CLA or α4β7 and skin or gut acute GVHD outcomes

(2010) B G Engelhardt et al.   BONE MARROW TRANSPLANTATION

Epigenetic regulation of beta2-adrenergic receptor expression in TH1 and TH2 cells

(2010) Jaclyn W. McAlees et al.   BRAIN BEHAVIOR AND IMMUNITY

Retinoic acid-induced gut tropism improves the protective capacity of Treg in acute but not in chronic gut inflammation

(2010) Astrid Menning et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammatory Effects of Ex Vivo Human Th17 Cells Are Suppressed by Regulatory T Cells

(2010) S. Q. Crome et al.   JOURNAL OF IMMUNOLOGY

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

De Novo Generation and Enhanced Suppression of Human CD4+CD25+ Regulatory T Cells by Retinoic Acid

(2009) J. Wang et al.   JOURNAL OF IMMUNOLOGY

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

(2009) Ye Zheng et al.   NATURE

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

(2009) Meghan A Koch et al.   NATURE IMMUNOLOGY

CD4+ Regulatory T Cells Control TH17 Responses in a Stat3-Dependent Manner

(2009) A. Chaudhry et al.   SCIENCE

IL-23 and Th17 cytokines in intestinal homeostasis

(2008) K J Maloy et al.   Mucosal Immunology

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE