Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate
出版年份 2016 全文链接
标题
Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate
作者
关键词
Regulatory T cells, T cells, Cell staining, Mouse models, Flow cytometry, Cytokines, Cell differentiation, DNA methylation
出版物
PLoS One
Volume 11, Issue 2, Pages e0148474
出版商
Public Library of Science (PLoS)
发表日期
2016-02-18
DOI
10.1371/journal.pone.0148474
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis
- (2014) Nagendra Singh et al. IMMUNITY
- tTregs, pTregs, and iTregs: similarities and differences
- (2014) Ethan M. Shevach et al. IMMUNOLOGICAL REVIEWS
- In Vivo Suppression of Naive CD4 T Cell Responses by IL-2- and Antigen-Stimulated T Lymphocytes in the Absence of APC Competition
- (2014) H. Inaba et al. JOURNAL OF IMMUNOLOGY
- Acquisition of Suppressive Function by Activated Human CD4+CD25- T Cells Is Associated with the Expression of CTLA-4 Not FoxP3
- (2014) Y. Zheng et al. JOURNAL OF IMMUNOLOGY
- TGF-β–Induced CD4+Foxp3+T Cells Attenuate Acute Graft-versus-Host Disease by Suppressing Expansion and Killing of Effector CD8+Cells
- (2014) Jian Gu et al. JOURNAL OF IMMUNOLOGY
- Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation
- (2014) H. Morikawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Insights into the pathogenesis of GvHD: what mice can teach us about man
- (2014) J. Hülsdünker et al. TISSUE ANTIGENS
- Induced and thymus-derived Foxp3+regulatory T cells share a common niche
- (2013) Yi-Ju Huang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos
- (2013) Madhav D. Sharma et al. IMMUNITY
- Th17 cell development: from the cradle to the grave
- (2013) Luis A. Zúñiga et al. IMMUNOLOGICAL REVIEWS
- Induced Regulatory T Cells Promote Tolerance When Stabilized by Rapamycin and IL-2 In Vivo
- (2013) P. Zhang et al. JOURNAL OF IMMUNOLOGY
- Active Demethylation of the Foxp3 Locus Leads to the Generation of Stable Regulatory T Cells within the Thymus
- (2013) A. Toker et al. JOURNAL OF IMMUNOLOGY
- All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities
- (2013) Siddharth Jhunjhunwala et al. JOURNAL OF LEUKOCYTE BIOLOGY
- STAT5 polarization promotes iTregs and suppresses human T-cell alloresponses while preserving CTL capacity
- (2013) Brian C. Betts et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
- (2013) Yukihiro Furusawa et al. NATURE
- Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
- (2013) Nicholas Arpaia et al. NATURE
- Regulatory T cells: recommendations to simplify the nomenclature
- (2013) Abul K Abbas et al. NATURE IMMUNOLOGY
- Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis
- (2013) Noriko Komatsu et al. NATURE MEDICINE
- Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
- (2013) Tomoyuki Yamaguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis
- (2013) P. M. Smith et al. SCIENCE
- Ex Vivo Expanded Human Regulatory T Cells Can Prolong Survival of a Human Islet Allograft in a Humanized Mouse Model
- (2013) Douglas C. Wu et al. TRANSPLANTATION
- Peripheral and Thymic Foxp3+ Regulatory T Cells in Search of Origin, Distinction, and Function
- (2013) Chetan Dhamne et al. Frontiers in Immunology
- Peripherally Induced Tregs – Role in Immune Homeostasis and Autoimmunity
- (2013) Mahesh Yadav et al. Frontiers in Immunology
- Generation and Function of Induced Regulatory T Cells
- (2013) Erica G. Schmitt et al. Frontiers in Immunology
- Molecular Determinants of Regulatory T Cell Development: The Essential Roles of Epigenetic Changes
- (2013) Yohko Kitagawa et al. Frontiers in Immunology
- Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance
- (2012) Angelina M. Bilate et al. Annual Review of Immunology
- Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict
- (2012) Robert M. Samstein et al. CELL
- Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability
- (2012) Jee H. Lee et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations
- (2012) C. Scotta et al. HAEMATOLOGICA
- Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells
- (2012) Takahisa Miyao et al. IMMUNITY
- T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development
- (2012) Naganari Ohkura et al. IMMUNITY
- Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+T reg cells
- (2012) Jonathan M. Weiss et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
- (2012) Mahesh Yadav et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-10 Produced by Induced Regulatory T Cells (iTregs) Controls Colitis and Pathogenic Ex-iTregs during Immunotherapy
- (2012) E. G. Schmitt et al. JOURNAL OF IMMUNOLOGY
- Extrathymically generated regulatory T cells control mucosal TH2 inflammation
- (2012) Steven Z. Josefowicz et al. NATURE
- Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells
- (2012) Michael G Strainic et al. NATURE IMMUNOLOGY
- A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
- (2012) Wenxian Fu et al. NATURE IMMUNOLOGY
- Foxp3+ Regulatory T-cells and IL-2: The Moirai of T-cell Fates?
- (2012) Georg Gasteiger et al. Frontiers in Immunology
- Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer
- (2012) Helene Pere et al. OncoImmunology
- Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease
- (2011) K. L. Hippen et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling
- (2011) K. Semple et al. BLOOD
- Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
- (2011) M. Di Ianni et al. BLOOD
- Regulatory T cells in stem cell transplantation: strategies and first clinical experiences
- (2011) Matthias Edinger et al. CURRENT OPINION IN IMMUNOLOGY
- Mouse models of graft-versus-host disease: advances and limitations
- (2011) M. A. Schroeder et al. Disease Models & Mechanisms
- Sub-optimal CD4+ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3+ regulatory T cells
- (2011) Vanessa G. Oliveira et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Nature and nurture in Foxp3+ regulatory T cell development, stability, and function
- (2011) Terrence L. Geiger et al. HUMAN IMMUNOLOGY
- A Requisite Role for Induced Regulatory T Cells in Tolerance Based on Expanding Antigen Receptor Diversity
- (2011) Dipica Haribhai et al. IMMUNITY
- Dendritic cells induce antigen-specific regulatory T cells that prevent graft versus host disease and persist in mice
- (2011) Uri Sela et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-2 Controls the Stability of Foxp3 Expression in TGF- -Induced Foxp3+ T Cells In Vivo
- (2011) Q. Chen et al. JOURNAL OF IMMUNOLOGY
- Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation
- (2011) Marc Beyer et al. NATURE IMMUNOLOGY
- Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease
- (2011) John Koreth et al. NEW ENGLAND JOURNAL OF MEDICINE
- Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells
- (2011) Tatiana N. Golovina et al. PLoS One
- All-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus
- (2011) Ling Lu et al. PLoS One
- Human Regulatory T Cells Rapidly Suppress T Cell Receptor-Induced Ca2+, NF- B, and NFAT Signaling in Conventional T Cells
- (2011) A. Schmidt et al. Science Signaling
- Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity
- (2011) K. L. Hippen et al. Science Translational Medicine
- Induced Foxp3+ regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?
- (2011) Q. Lan et al. Journal of Molecular Cell Biology
- Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
- (2010) C. G. Brunstein et al. BLOOD
- Frequency of Circulating Tregs with Demethylated FOXP3 Intron 1 in Melanoma Patients Receiving Tumor Vaccines and Potentially Treg-Depleting Agents
- (2010) I. J. M. de Vries et al. CLINICAL CANCER RESEARCH
- Generation of human regulatory T cells de novo with suppressive function prevent xenogeneic graft versus host disease
- (2010) Xiaofeng Qian et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
- (2010) Rachel A. Gottschalk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors: Figure 1.
- (2010) Matthias Merkenschlager et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
- (2010) Ye Zheng et al. NATURE
- Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid
- (2010) Ling Lu et al. PLoS One
- Ex Vivo–Expanded Human Regulatory T Cells Prevent the Rejection of Skin Allografts in a Humanized Mouse Model
- (2010) Fadi Issa et al. TRANSPLANTATION
- First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells
- (2009) Piotr Trzonkowski et al. CLINICAL IMMUNOLOGY
- Alloantigen-specificde novo-induced Foxp3+Treg revertin vivoand do not protect from experimental GVHD
- (2009) Christian Koenecke et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Control of Regulatory T Cell Lineage Commitment and Maintenance
- (2009) Steven Z. Josefowicz et al. IMMUNITY
- A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis
- (2009) D. Haribhai et al. JOURNAL OF IMMUNOLOGY
- De Novo Generation and Enhanced Suppression of Human CD4+CD25+ Regulatory T Cells by Retinoic Acid
- (2009) J. Wang et al. JOURNAL OF IMMUNOLOGY
- Eos Mediates Foxp3-Dependent Gene Silencing in CD4+ Regulatory T Cells
- (2009) F. Pan et al. SCIENCE
- Highly Sensitive Model for Xenogenic GVHD Using Severe Immunodeficient NOG Mice
- (2009) Ryoji Ito et al. TRANSPLANTATION
- Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3
- (2008) Sarah E. Allan et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- TGF‐β‐induced Foxp3+regulatory T cells rescue scurfy mice
- (2008) Eva N. Huter et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- DNA methylation controls Foxp3 gene expression
- (2008) Julia K. Polansky et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+cells
- (2008) Sokol Haxhinasto et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Induction and effector functions of TH17 cells
- (2008) Estelle Bettelli et al. NATURE
- TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
- (2008) Liang Zhou et al. NATURE
- The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt
- (2008) Nicolas Manel et al. NATURE IMMUNOLOGY
- T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
- (2008) S. Sauer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now