Article
Biochemistry & Molecular Biology
Shaowei Kang, Bin Wang, Yanan Xie, Xu Cao, Mei Wang
Summary: M1 and M2 macrophages are crucial for cardiac healing post-MI, with M1 macrophages playing a critical role in promoting remodeling through activation of the EMT pathway.
Article
Oncology
Haoran Kong, Wenhui Yu, Zhuning Chen, Haonan Li, Guiwen Ye, Jiacong Hong, Zhongyu Xie, Keng Chen, Yanfeng Wu, Huiyong Shen
Summary: The study demonstrates that CCR9 promotes osteosarcoma lung metastasis by activating the Wnt/beta-catenin signaling pathway, suggesting that CCR9 may be a promising therapeutic target to inhibit lung metastasis and serve as a novel prognostic marker for osteosarcoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Manxiu Huai, Junxiang Zeng, Wensong Ge
Summary: The study found that artemisinin can ameliorate intestinal inflammation by promoting macrophage polarization to M2 phenotype and inhibiting the process of EMT. This suggests that artemisinin may be applied to the rehabilitation of IBD in the future.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naiade Calanca, Sara Martoreli Silveira Binato, Sabrina Daniela da Silva, Helena Paula Brentani, Luiz Ubirajara Sennes, Clovis Antonio Lopes Pinto, Maria Aparecida Custodio Domingues, Carlos Eduardo Fonseca-Alves, Claudia Aparecida Rainho, Silvia Regina Rogatto
Summary: Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor affecting male adolescents, and this study investigated the role of epithelial-mesenchymal transition (EMT) and WNT signaling pathways in JNA. The findings suggest the involvement of these pathways in JNA, providing promising druggable targets for treatment.
Article
Biotechnology & Applied Microbiology
Wen Bi, Mengyue Yang, Pengfei Xing, Tao Huang
Summary: This study investigated the association between miR-331-3p and OS development and identified MGAT1 as a target of miR-331-3p in OS. The results demonstrated that miR-331-3p acts as a tumor suppressor by inhibiting MGAT1 and related signaling pathways, leading to decreased proliferation and increased apoptosis in OS cells, as well as inhibited migration and invasion abilities.
Correction
Oncology
Xingrong Zheng, Jiaxin Lin, Hewei Wu, Zhishuo Mo, Yunwen Lian, Peipei Wang, Zhaoxia Hu, Zhiliang Gao, Liang Peng, Chan Xie
Summary: The paper has been amended and the revised version can be accessed through the original article.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell & Tissue Engineering
Le Phuong Hoang Anh, Ken Nishimura, Akihiro Kuno, Nguyen Thuy Linh, Tetsuo Kato, Manami Ohtaka, Mahito Nakanishi, Eiji Sugihara, Taka-Aki Sato, Yohei Hayashi, Aya Fukuda, Koji Hisatake
Summary: Somatic cell reprogramming proceeds through a series of events to generate induced pluripotent stem cells (iPSCs). In this study, the researchers found that the downregulation of Osr2 is crucial for efficient reprogramming by using a cell-based model. Osr2 acts as a novel EMT regulator and its downregulation diminishes TGF-beta signaling and activates Wnt signaling, promoting MET and acquiring pluripotency.
Article
Cell Biology
Xi Chen, Hong Yan, Ying Chen, Guo Li, Yue Bin, Xiyuan Zhou
Summary: The study demonstrates that both TGF-beta/Smad and canonical Wnt/beta-catenin pathways play a significant role in regulating epithelial-mesenchymal transformation of lens epithelial cells but might be in a different stage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Developmental Biology
Sara E. Billings, Nina M. Myers, Lee Quiruz, Alan G. Cheng
Summary: During mammalian cochlear development, epithelial sensory precursors and periotic mesenchymal cells from distinct lineages coordinate through Wnt activation to promote proliferation and differentiation, driving the transition between epithelial and mesenchymal states in a cell type-dependent manner.
Review
Neurosciences
Ze-Yan Liang, Xiong-Jie Xu, Jian Rao, Zhe-Lun Yang, Chun-Hua Wang, Chun-Mei Chen
Summary: This review discusses the research progress of MSC-derived exosomal miRNAs in promoting M2 macrophage differentiation in SCI. Research has shown the potential therapeutic effects of exosomal miRNAs in promoting nerve function recovery in SCI patients.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Minghan Guan, Yifeng Huang, Xiaowen Lin
Summary: This study found that sufentanil can inhibit the proliferation, migration, invasion, and epithelial-mesenchymal transition of lung cancer cells by regulating the Wnt/beta-catenin signaling pathway.
Article
Plant Sciences
Wenhao Liao, Yueqiang Wen, Jing Wang, Maoyuan Zhao, Shangbin Lv, Nianzhi Chen, Yuchen Li, Lina Wan, Qiao Zheng, Yu Mou, Ziyi Zhao, Jianyuan Tang, Jinhao Zeng
Summary: This study aims to investigate the role and potential mechanism of GA on gastric precancerous lesions (GPL), the key turning point of gastritis to gastric cancer, with the aim of delaying, blocking or reversing the dynamic overall process of inflammation-cancer transformation and thus blocking GPL to prevent the development of gastric cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Christina Anna Stratopoulou, Sophie Cussac, Marie d'Argent, Jacques Donnez, Marie-Madeleine Dolmans
Summary: This study found that M2 macrophages play an important role in the invasiveness of adenomyosis. M2 macrophages accumulate more in patients with adenomyosis compared to healthy tissue. Co-culture with M2 macrophages significantly enhances the invasion capacity of endometrial cells. The study did not find any gene expression differences indicating epithelial-mesenchymal transition (EMT).
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Biochemistry & Molecular Biology
Hua Fu, Yong-Hong Gu, Juan Tan, Ye-Ning Yang, Guo-Hui Wang
Summary: The crosstalk between macrophages and tubular epithelial cells is important in the progression of renal fibrosis. In this study, the significance of circular RNA ACTR2 (circACTR2) in regulating macrophage inflammation, epithelial-mesenchymal transition (EMT) of tubular epithelial cells, and the development of renal fibrosis was revealed. circACTR2 promoted the activation of NLRP3 inflammasome, inflammation in macrophages, and stimulated EMT and fibrosis of tubular epithelial cells by sponging miR-561. Knocking down circACTR2 and overexpressing miR-561 may benefit the treatment of renal fibrosis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Dexin Shen, Hongwei Peng, Caixia Xia, Zhao Deng, Xi Tong, Gang Wang, Kaiyu Qian
Summary: This study summarizes the detailed mechanisms and modes of long non-coding RNAs (lncRNAs) participating in the epithelial-mesenchymal transition (EMT) process of prostate cancer (PCa) by regulating multiple signaling pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Guoying Yu, Argyris Tzouvelekis, Rong Wang, Jose D. Herazo-Maya, Gabriel H. Ibarra, Anup Srivastava, Joao Pedro Werneck de Castro, Giuseppe DeIuliis, Farida Ahangari, Tony Woolard, Nachelle Aurelien, Rafael Arrojo e Drigo, Ye Gan, Morven Graham, Xinran Liu, Robert J. Homer, Thomas S. Scanlan, Praveen Mannam, Patty J. Lee, Erica L. Herzog, Antonio C. Bianco, Naftali Kaminski
Editorial Material
Cardiac & Cardiovascular Systems
David J. Hur, Lindsey M. Prescher, Judith L. Meadows, Steven E. Pfau, Robert J. Homer, George Tellides, James J. Yun
ANNALS OF THORACIC SURGERY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Kelly Brown, Robert Homer, Marina Baine, Justin D. Blasberg
ANNALS OF THORACIC SURGERY
(2019)
Editorial Material
Medicine, Research & Experimental
Benjamin L. Mazer, Robert J. Homer, David L. Rimm
LABORATORY INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Eriko Kudo, Eric Song, Laura J. Yockey, Tasfia Rakib, Patrick W. Wong, Robert J. Homer, Akiko Iwasaki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Oncology
Deborah Ayeni, Braden Miller, Alexandra Kuhlmann, Ping-Chih Ho, Camila Robles-Oteiza, Mmaserame Gaefele, Stellar Levy, Fernando J. de Miguel, Curtis Perry, Tianxia Guan, Gerald Krystal, William Lockwood, Daniel Zelterman, Robert Homer, Zongzhi Liu, Susan Kaech, Katerina Politi
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Oncology
Jessie Torgersen, Tamar H. Taddei, Lesley S. Park, Dena M. Carbonari, Michael J. Kallan, Kisha Mitchell Richards, Xuchen Zhang, Darshana Jhala, Norbert Br Au, Robert Homer, Kathryn D'Addeo, Rajni Mehta, Melissa Skanderson, Farah Kidwai-Khan, Amy C. Justice, Vincent Lo Re
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Pathology
Marina K. Baine, John H. Sinard, Guoping Cai, Robert J. Homer
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2020)
Article
Immunology
Benjamin Israelow, Eric Song, Tianyang Mao, Peiwen Lu, Amit Meir, Feimei Liu, Mia Madel Alfajaro, Jin Wei, Huiping Dong, Robert J. Homer, Aaron Ring, Craig B. Wilen, Akiko Iwasaki
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Ruoyi Jiang, Kenneth B. Hoehn, Casey S. Lee, Minh C. Pham, Robert J. Homer, Frank C. Detterbeck, Inmaculada Aban, Leslie Jacobson, Angela Vincent, Richard J. Nowak, Henry J. Kaminski, Steven H. Kleinstein, Kevin C. O'Connor
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Tianyang Mao, Benjamin Israelow, Mario A. Pena-Hernandez, Alexandra Suberi, Liqun Zhou, Sophia Luyten, Melanie Reschke, Huiping Dong, Robert J. Homer, W. Mark Saltzman, Akiko Iwasaki
Summary: This study developed a vaccine strategy called prime and spike, which activates mucosal immune memory within the respiratory tract and induces strong immune responses. It enhances both systemic and local immunity against SARS-CoV-2, and provides full protection against lethal infection in partially immune mice.
Article
Multidisciplinary Sciences
Ilianna Barbayianni, Paraskevi Kanellopoulou, Dionysios Fanidis, Dimitris Nastos, Eleftheria-Dimitra Ntouskou, Apostolos Galaris, Vaggelis Harokopos, Pantelis Hatzis, Eliza Tsitoura, Robert Homer, Naftali Kaminski, Katerina M. Antoniou, Bruno Crestani, Argyrios Tzouvelekis, Vassilis Aidinis
Summary: This study found that the formation of podosomes in lung fibroblasts is closely associated with extracellular matrix invasion in patients with idiopathic pulmonary fibrosis and mouse models. Targeting podosome formation or organization may be a potential therapeutic option for pulmonary fibrosis.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
John E. McDonough, Farida Ahangari, Qin Li, Siddhartha Jain, Stijn E. Verleden, Jose Herazo-Maya, Milica Vukmirovic, Giuseppe DeIuliis, Argyrios Tzouvelekis, Naoya Tanabe, Fanny Chu, Xiting Yan, Johny Verschakelen, Robert J. Homer, Dimitris Manatakis, Junke Zhang, Jun Ding, Karen Maes, Laurens De Sadeleer, Robin Vos, Arne Neyrinck, Panayiotis Benos, Ziv Bar-Joseph, Dean Tantin, James C. Hogg, Bart M. Vanaudenaerde, Wim A. Wuyts, Naftali Kaminski
Meeting Abstract
Critical Care Medicine
M. Vukmirovic, A. Fabre, X. Yan, G. Deluliis, T. Woolard, B. Hu, A. Mihaljinec, R. Homer, J. H. Maya, F. Ahangari, D. Smart, F. Conforti, B. Marshall, A. Alzetani, D. E. Davies, L. Richeldi, N. Kaminski, M. Jones
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
Z. Chen, S. Oh, P. Fang, Q. Li, F. Zhang, H. Tang, R. Homer, X. Zhang, N. Kaminski, T. Zheng, Z. Zhu
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)