Article
Biochemistry & Molecular Biology
Soichiro Sawamura, Katsunari Makino, Maho Ide, Shuichi Shimada, Ikko Kajihara, Takamitsu Makino, Masatoshi Jinnin, Satoshi Fukushima
Summary: In patients with systemic sclerosis (SSc), the levels of alpha 2(I) collagen are higher than alpha 1(I) collagen in fibroblasts. Further investigation of the overall regulatory mechanisms of type I collagen may help to understand the aberrant collagen metabolism in SSc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Long-Jie Yan, Le-Chang Sun, Kai-Yuan Cao, Yu-Lei Chen, Ling-Jing Zhang, Guang-Ming Liu, Tengchuan Jin, Min-Jie Cao
Summary: The study revealed that during autolysis, sea cucumber collagen fibers are disaggregated into fibrils, with MMP-2 playing a crucial role in this process. The pepsin-soluble collagen of sea cucumber has a native triple helix structure, and antibodies can be used to detect collagen degradation during autolysis.
Article
Dermatology
Hiroyasu Iwahashi, Yoshihito Kawashima, Hitoshi Masaki
Summary: Endo180 reduction leads to impaired collagen fiber formation and decreased collagen production, replicating structural changes seen in photoaged skin.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Review
Polymer Science
Ruth Naomi, Pauzi Muhd Ridzuan, Hasnah Bahari
Summary: The review discusses the unique high biocompatibility of Collagen type I (Col-I) in human tissue and its widespread applications in various fields. It covers the structure, sources, synthesis, extraction methods, characteristics, applications, and biomarkers of Col-I, providing specific information on its availability over the past five years for researchers interested in collagen-based products for therapeutic purposes.
Article
Biotechnology & Applied Microbiology
Meagan E. E. Ita, Sagar Singh, Harrison R. R. Troche, Rachel L. L. Welch, Beth A. A. Winkelstein
Summary: Chronic joint pain is a significant healthcare challenge with a large socioeconomic burden. This study investigates the role of MMP-1 in mediating pain in synovial joints and its effects on the collagen network, biomechanical response, and neuronal regulation of the capsular ligament. The findings suggest that MMP-1 may play a crucial role in neuronal signaling in joint pain and that MMP-1 presence in the joint space could lead to altered responses to loading. These findings have implications for the development of new treatments for degenerative joint pain.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yu-Lei Chen, Ming-Hui Zhang, Le-Le Su, Le-Chang Sun, Xu-Jian Qiu, Duanquan Lin, Ling-Jing Zhang, Tengchuan Jin, Min-Jie Cao
Summary: This study reveals that collagenases are involved in the postmortem tissue self-degradation of Haliotis discus hannai by degrading type I collagen. The study also highlights the crucial role of tissue inhibitors of metalloproteinases (TIMPs) in regulating the activity of collagenases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Liang Shan, Fengling Wang, Dandan Zhai, Xiangyun Meng, Jianjun Liu, Xiongwen Lv
Summary: Liver fibrosis is a consequence of chronic liver injuries, characterized by the imbalance of extracellular matrix production and degradation. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are crucial in collagen synthesis and lysis. This article reviews experimental studies on liver fibrosis based on MMPs/TIMPs and highlights the potential of targeting this interaction as a therapeutic strategy for hepatic fibrosis. The article also summarizes drugs, including natural products, that have been found to reduce liver fibrosis by altering the ratio of MMPs/TIMPs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Cell Biology
Xiao-Dan Xia, Adekunle Alabi, Maggie Wang, Hong-Mei Gu, Rui Zhe Yang, Gui-Qing Wang, Da-Wei Zhang
Summary: Lipids play essential roles in physiological functions, and dysregulation of lipid metabolism can lead to various human diseases. The regulation of lipid metabolism involves multiple mechanisms at different levels to maintain homeostasis.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Surgery
Jing Shen, Jian-bo Song, Jun Fan, Zhe Zhang, Zheng-jia Yi, Shuo Bai, Xiao-lin Mu, Yao-bo Yang, Liang Xiao
Summary: This study simulated the process of neointima generation and regression after stent implantation, demonstrating the spatial distribution and dynamic changes of MMP-2, MMP-9, and collagen in ISR. The expression of MMP-2 and MMP-9 decreased and collagen content reached its maximum when ISR occurred, suggesting their potential contribution to ISR.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Min-Seob Kim, Se-Eun Ha, Moxin Wu, Hannah Zogg, Charles F. Ronkon, Moon-Young Lee, Seungil Ro
Summary: The composition and changes of the cellular microenvironment play a crucial role in cancer development, with alterations in the ECM significantly impacting the tumor microenvironment. ECM components are important in colorectal cancer and have potential roles as biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Viviano Gomes de Oliveira Neves, Marcela M. Blascke de Mello, Daniel Rodrigues, Laena Pernomian, Isadora Sousa de Oliveira, Juliana M. Parente, Eliane Candiani Arantes, Rita C. Tostes, Michele M. Castro
Summary: During early hypertension, increased MMP-2 activity leads to the cleavage of various proteins in the extracellular matrix, promoting VSMC proliferation. Cleaved products of Type I collagen may activate focal adhesion kinases (FAK) and trigger migration and proliferation signals in VSMC.
VASCULAR PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiabo Shi, Ruizhen Zhang, Na Yang, Yi Zhang, Bradley W. Mansel, Sujay Prabakar, Jianzhong Ma
Summary: The surface functionalization of LAP NPs with THPS can enhance their incorporation with type I collagen matrix, resulting in improved thermal stability and mechanical properties of the collagen-based nanocomposites. The formation of covalent and hydrogen bonds between collagen and functionalized NPs stabilizes the triple-helical conformation of collagen, contributing to the design and fabrication of hierarchical collagen-based bionanocomposites with multifunctionality.
Article
Entomology
Yi Wei, Xiao-Lin Zhou, Peng Chen, Tai-Hang Liu, Cheng Lu, Min-Hui Pan
Summary: The study found that matrix metalloproteinase 2 (MMP2) is highly expressed in the ovarian capsules and ovarioles of B. mori, and knockout of MMP2 leads to abnormal ovarian development. The abnormal degradation of collagen I due to MMP2 deletion results in abnormal development of ovarioles and eggs. Furthermore, insulin-like peptide (ILP) expression also undergoes significant changes during ovarian development, and abnormal expression of ILP significantly affects ovarian development and MMP2 expression.
Article
Multidisciplinary Sciences
Xuezhi Cao, Yong Liang, Zhenxiang Hu, Huiyu Li, Jiaming Yang, Eric J. Hsu, Jiankun Zhu, Jin Zhou, Yang-Xin Fu
Summary: The study introduces a novel masked IFN-I prodrug activated by tumor-associated proteases, which enhances anti-tumor immune response with reduced toxicity and improved tumor targeting. This engineered prodrug shows prolonged serum half-life, improved tumor-targeting effect, enhanced DC cross-priming, increased CD8(+) infiltration and effector function in the tumor microenvironment, as well as improved checkpoint blockade and radiation efficacy for tumors. Overall, this effective tumor-activating IFN has promising long-term pharmacokinetics with minimal toxicity.
NATURE COMMUNICATIONS
(2021)
Article
Polymer Science
Igor da Silva Brum, Carlos Nelson Elias, Ana Lucia Rosa Nascimento, Cherley Borba Vieira de Andrade, Ronaldo Sergio de Biasi, Jorge Jose de Carvalho
Summary: In this study, in vitro testing was used to investigate the properties of non-crosslinked type 1 bovine derived collagen membranes for bone regeneration surgery. The membranes were found to be composed of type 1 collagen, have hydrophilic properties, good mechanical strength, and are suitable for tissue regeneration.