Efficacy, safety, and tolerability of plecanatide in patients with irritable bowel syndrome with constipation: results of two phase 3 randomized clinical trials

Plecanatide and Dolcanatide, Guanylate Cyclase-C Agonists, Attenuate Paracellular Permeability and Enhance Normal Localization of Tight Junctional Proteins to Maintain Intestinal Barrier Function

(2017) Anusha Thadi et al.   GASTROENTEROLOGY

Randomized clinical trial: efficacy and safety of plecanatide in the treatment of chronic idiopathic constipation

(2017) Michael DeMicco et al.   Therapeutic Advances in Gastroenterology

Bowel Disorders

(2016) Brian E. Lacy et al.   GASTROENTEROLOGY

Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation

(2016) L. Neri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Spectrum of Constipation-Predominant Irritable Bowel Syndrome and Chronic Idiopathic Constipation: US Survey Assessing Symptoms, Care Seeking and Disease Burden

(2015) Joel J Heidelbaugh et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Guanylate Cyclase C Agonists: Emerging Gastrointestinal Therapies and Actions

(2015) Michael Camilleri   GASTROENTEROLOGY

Emerging treatments in Neurogastroenterology: Perspectives of guanylyl cyclase C agonists use in functional gastrointestinal disorders and inflammatory bowel diseases

(2015) A. Jarmuż et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Tight junctions and IBS - the link between epithelial permeability, low-grade inflammation, and symptom generation?

(2014) T. Piche   NEUROGASTROENTEROLOGY AND MOTILITY

Reduced E-cadherin expression is associated with abdominal pain and symptom duration in a study of alternating and diarrhea predominant IBS

(2013) E. Wilcz-Villega et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Emerging receptor target in the pharmacotherapy of irritable bowel syndrome with constipation

(2013) L Ashley Blackshaw et al.   Expert Review of Gastroenterology & Hepatology

Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis

(2012) Rebecca M. Lovell et al.   Clinical Gastroenterology and Hepatology

Intestinal barrier function in health and gastrointestinal disease

(2012) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Expression and the Cellular Distribution of the Tight Junction Proteins Are Altered in Irritable Bowel Syndrome Patients With Differences According to the Disease Subtype

(2011) Nathalie Bertiaux-Vandaële et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Uroguanylin Regulates Net Fluid Secretion via the NHE2 Isoform of the Na+/H+ Exchanger in an Intestinal Cellular Model

(2011) Roxana Toriano et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Health-related quality of life, work productivity and health care resource use associated with constipation predominant irritable bowel syndrome

(2011) Marco DiBonaventura et al.   CURRENT MEDICAL RESEARCH AND OPINION

Loss of Guanylyl Cyclase C (GCC) Signaling Leads to Dysfunctional Intestinal Barrier

(2011) Xiaonan Han et al.   PLoS One

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

International Survey of Patients With IBS

(2009) Douglas A. Drossman et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY