Editorial Material
Microbiology
James M. Fleckenstein, Jacob P. Bitoun
Summary: The study shows how bats have evolutionarily maintained fluid homeostasis signaling while avoiding the pathogenic effects of ST.
CELL HOST & MICROBE
(2021)
Review
Endocrinology & Metabolism
Hari Prasad, John Kandam Kulathu Mathew, Sandhya S. Visweswariah
Summary: This review highlights the importance of Receptor Guanylyl Cyclase C (GC-C) in regulating intestinal fluid and ion homeostasis, and its causal link to intestinal inflammation, dysbiosis, and tumorigenesis. The GC-C signaling pathway plays a role in extra gastrointestinal functions such as appetite control, energy expenditure, visceral nociception, and behavioral processes. Recent research has also uncovered the involvement of GC-C in the ion-microbiome-immune axis in inflammatory bowel disease and suggests potential therapeutic strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Moein Piroozkhah, Ali Aghajani, Pooya Jalali, Arvin Shahmoradi, Mobin Piroozkhah, Younes Tadlili, Zahra Salehi
Summary: This systematic review focuses on the latest research on the guanylate cyclase-C (GC-C) signaling axis in colorectal cancer (CRC). The findings reveal that alterations in GC-C signaling compartments in CRC tissue have potential as diagnostic, prognostic, and therapeutic markers. Moreover, the GC-C signaling axis may be a promising target for treating CRC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Rodger A. Liddle
Summary: Visceral pain associated with irritable bowel syndrome affects 15% of the US population. Recent studies have discovered a new pathway for gut signal communication to the nervous system through synaptic connections between guanylyl cyclase C (GUCY2C)-promoting neurons and submucosal neurons. Selective deletion of GUCY2C in mouse models indicates that defective GUCY2C neuropod-cell signaling is responsible for visceral pain. Unveiling the role of neuropod cells is a significant step in understanding and potentially treating visceral pain.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Joseph M. Holden, Sara Al Hussein Al Awamlh, Louis-Philippe Croteau, Andrew M. Boal, Tonia S. Rex, Michael L. Risner, David J. Calkins, Lauren K. Wareham
Summary: The nitric oxide-guanylyl cyclase-1-cyclic guanylate monophosphate (NO-GC-1-cGMP) pathway plays an important role in controlling vascular tone and morphology. In mice lacking the alpha catalytic domain of guanylate cyclase, retinal ganglion cell degeneration occurs with age, independent of fluctuation in intraocular pressure. Dysfunctional cGMP signaling leads to changes in the neurovascular unit, affecting retinal vessel morphology and contributing to retinal neurodegeneration and loss of visual acuity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Hari Prasad, Sandhya S. Visweswariah
Summary: This review discusses the importance of impaired sodium transport in the pathogenesis of inflammatory bowel disease (IBD) and the underlying genetic mutations. It proposes that impaired sodium transport may be an upstream pathogenic factor in the development of IBD, and explores how sodium malabsorption affects downstream pathophysiology. Further research into salt and water transport mechanisms in the intestine may provide new insights into the interaction between ions, the microbiome, and the immune system in driving IBD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ellis Nelissen, Melissa Schepers, Laura Ponsaerts, Sebastien Foulquier, Annelies Bronckaers, Tim Vanmierlo, Peter Sandner, Jos Prickaerts
Summary: Vascular cognitive impairment (VCI) is a neurodegenerative disorder characterized by a vascular component, involving decreased cerebral blood flow, white matter lesions, endothelial dysfunction, and blood-brain barrier impairments. Oxidative stress and inflammation are major underlying mechanisms. Modulation of soluble guanylate cyclase (sGC) activity can improve vascular and neural function, and has shown efficacy in cardiovascular diseases.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Wen Lu, Xiaoxiao Yang, Binghe Wang
Summary: The endogenous signaling roles of carbon monoxide (CO) have been established, but the molecular mechanism of how CO activates soluble guanylyl cyclase (sGC) is not clear. This review examines the discrepancies between the low affinity of sGC for CO and the reported activation, and suggests further studies to improve understanding of the CO-sGC axis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chien-Wei Chen, Luen-Kui Chen, Tai-Ying Huang, De-Ming Yang, Shui-Yu Liu, Pei-Jiun Tsai, Tien-Hua Chen, Heng-Fu Lin, Chi-Chang Juan
Summary: Plasma and tissue zinc ion levels are associated with obesity development. NO treatment stimulates intracellular Zn2+ mobilization through the GC/cGMP/PKG pathway, subsequently stimulating adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Chengfeng Xing, Tao Zhang, Xiaolin Liu, Canmei Li, Gang Yang, Hairong Zhang, Rui Wang, Kunhua Wang, Yinglei Miao, Danfeng Lan
Summary: Dysfunction of the intestinal immune barrier is closely associated with inflammatory bowel disease (IBD). This study finds that the guanylate cyclase-C (GC-C) signaling pathway, activated by the guanylin (Gn) ligand, can protect the intestinal immune barrier, providing important insights for the development of new IBD treatments.
Article
Pharmacology & Pharmacy
Kanglu Wu, Xudong Zhao, Xian Xiao, Miao Chen, Liang Wu, Chao Jiang, Jing Jin, Lei Li, Qinli Ruan, Jun Guo
Summary: This study demonstrated that BuShen HuoXue (BSHX) decoction can potentially improve fertility by increasing intestinal barrier function via the hsp-16.2-mediated heat-shock signaling pathway in Caenorhabditis elegans. BSHX decoction improved resistance to heat stress and reversed the adverse effects induced by Bisphenol A, significantly improving brood size and oocyte quality at different developmental stages. These findings contribute to a better understanding of the underlying regulatory mechanisms of heat resistance against fertility defects mediated by hsp-16.2.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Supachoke Mangmool, Ratchanee Duangrat, Warisara Parichatikanond, Hitoshi Kurose
Summary: Currently approved drugs for treating heart failure (HF) mainly target specific molecules involved in the regulation of the cardiac circulatory system. However, new drug classes with novel mechanisms have been introduced for HF intervention. SGLT2 inhibitors, in particular, have shown effectiveness in both reduced and preserved ejection fraction HF. Molecular pathways and clinical trials of emerging drug classes targeting cGMP signaling in HF treatment are summarized in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yali Hou, Alexis Wren, Namratha Mylarapu, Kaylin Browning, Bianca N. Islam, Rui Wang, Kenneth J. Vega, Darren D. Browning
Summary: The use of phosphodiesterase (PDE) inhibitors for colorectal cancer (CRC) prevention and treatment has been of interest. This study finds that PDE inhibitors do not inhibit growth and viability of CRC cell lines by increasing cGMP and activating PKG as previously thought. The lack of endogenous guanylyl cyclase activity in colon cancer cells prevents PDE inhibitors from activating cGMP signaling. The inhibitory effect of PDE inhibitors on CRC growth is due to toxic effects at clinically unobtainable drug concentrations.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2022)
Article
Oncology
David S. Weinberg, Nathan R. Foster, Gary Della'Zanna, Ryan P. McMurray, Walter K. Kraft, Angela Pallotto, David M. Kastenberg, Leo C. Katz, Christopher H. Henry, Stephanie M. Moleski, Paul J. Limburg, Scott A. Waldman
Summary: Studies suggest that oral GUCY2C agonist could be an effective chemoprevention agent for colorectal cancer, but the investigational oral uroguanylin analog dolcanatide did not activate GUCY2C in epithelial cells of the distal rectum in healthy volunteers, indicating its enhanced stability and extended persistence may not be sufficient to regulate GUCY2C across the colorectum for tumor prevention.
CANCER BIOLOGY & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Hairui Han, Nana He, Enzhuang Pan, Xuelian Tan, Zuwang Yang, Xueqing Li, Dahua Shi, Jingquan Dong
Summary: In this study, a 96-hour acute toxicity model was established to investigate the effects of Avermectin (AVM) on the intestinal tract of carp. The results showed that AVM exposure caused intestinal damage, decreased the expression of tight junction protein gene, activated oxidative stress, induced apoptosis, and induced intestinal inflammation in carp. Therefore, it was demonstrated that AVM has complex toxic effects on the fish intestinal tract, providing a new perspective for studying the toxicology of AVM on the fish intestinal tract.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Sean (Shuxin) Han, Rongli Zhang, Rajan Jain, Hong Shi, Lilei Zhang, Guangjin Zhou, Panjamaporn Sangwung, Derin Tugal, G. Brandon Atkins, Domenick A. Prosdocimo, Yuan Lu, Xiaonan Han, Patrick Tso, Xudong Liao, Jonathan A. Epstein, Mukesh K. Jain
NATURE COMMUNICATIONS
(2015)
Article
Immunology
Wilbur H. Chen, Mitchell B. Cohen, Beth D. Kirkpatrick, Rebecca C. Brady, David Galloway, Marc Gurwith, Robert H. Hall, Robert A. Kessler, Michael Lock, Douglas Haney, Caroline E. Lyon, Marcela F. Pasetti, Jakub K. Simon, Flora Szabo, Sharon Tennant, Myron M. Levine
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Gastroenterology & Hepatology
Andrea Lo Vecchio, Jorge Amil Dias, James A. Berkley, Chris Boey, Mitchell B. Cohen, Sylvia Cruchet, Ilaria Liguoro, Eduardo Salazar Lindo, Bhupinder Sandhu, Philip Sherman, Toshiaki Shimizu, Alfredo Guarino
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2016)
Article
Pediatrics
Nicholas J. CaJacob, Mitchell B. Cohen
PEDIATRICS IN REVIEW
(2016)
Article
Oncology
Harini Nivarthi, Claire Gordziel, Madeleine Themanns, Nina Kramer, Markus Eberl, Bjoern Rabe, Michaela Schlederer, Stefan Rose-John, Thomas Knoesel, Lukas Kenner, Patricia Freund, Fritz Aberger, Xiaonan Han, Robert Kralovics, Helmut Dolznig, Susanne Jennek, Karlheinz Friedrich, Richard Moriggl
Article
Gastroenterology & Hepatology
Natoshia R. Cunningham, Anjana Jagpal, James Peugh, Michael K. Farrell, Mitchell B. Cohen, Adam G. Mezoff, Anne Lynch-Jordan, Susmita Kashikar-Zuck
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2017)
Article
Oncology
P. Freund, M. A. Kerenyi, M. Hager, T. Wagner, B. Wingelhofer, H. T. T. Pham, M. Elabd, X. Han, P. Valent, F. Gouilleux, V. Sexl, O. H. Kraemer, B. Groner, R. Moriggl
Article
Biochemistry & Molecular Biology
N. Kramer, J. Schmoellerl, C. Unger, H. Nivarthi, A. Rudisch, D. Unterleuthner, M. Scherzer, A. Riedl, M. Artaker, I. Crncec, D. Lenhardt, T. Schwarz, B. Prieler, X. Han, M. Hengstschaelger, J. Schueler, R. Eferl, R. Moriggl, W. Sommergruber, H. Dolznig
Review
Biology
Karlheinz Friedrich, Helmut Dolznig, Xiaonan Han, Richard Moriggl
Article
Multidisciplinary Sciences
Madeleine Themanns, Kristina M. Mueller, Sonja M. Kessler, Nicole Golob-Schwarzl, Thomas Mohr, Doris Kaltenecker, Jerome Bourgeais, Jamile Paier-Pourani, Katrin Friedbichler, Doris Schneller, Michaela Schlederer, Eva Zebedin-Brandl, Luigi M. Terracciano, Xiaonan Han, Lukas Kenner, Kay-Uwe Wagner, Wolfgang Mikulits, Andrey V. Kozlov, Markus H. Heim, Fabrice Gouilleux, Johannes Haybaeck, Richard Moriggl
SCIENTIFIC REPORTS
(2016)
Article
Biochemistry & Molecular Biology
Doris Kaltenecker, Madeleine Themanns, Kristina M. Mueller, Katrin Spirk, Tobias Suske, Olaf Merkel, Lukas Kenner, Andreia Luis, Andrey Kozlov, Johannes Haybaeck, Mathias Mueller, Xiaonan Han, Richard Moriggl
Review
Biochemistry & Molecular Biology
Manuel Rauth, Patricia Freund, Anna Orlova, Stefan Gruenert, Nikola Tasic, Xiaonan Han, Hai-Bin Ruan, Heidi A. Neubauer, Richard Moriggl
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Cell Biology
Ming Zhao, Kaiqun Ren, Xiwen Xiong, Meng Cheng, Zengdi Zhang, Zan Huang, Xiaonan Han, Xiaoyong Yang, Emilyn U. Alejandro, Hai-Bin Ruan
Review
Biochemistry & Molecular Biology
Marta Surbek, William Tse, Richard Moriggl, Xiaonan Han
Summary: Cytokines, growth factors or hormones act through the JAK/STAT5 signaling pathway to regulate the intestinal response to infection and inflammation. However, the regulation of intestinal epithelial compartment by STAT5 is often ignored due to lack of genetic tools. This review article discusses the advances in growth factor/cytokine-JAK/STAT5 research in intestinal mucosal inflammation and immunity, highlighting the importance of studying intestinal STAT5 signaling.
Article
Biochemistry & Molecular Biology
Ruixue Liu, Haifeng Li, Juan Cai, Qiang Wei, Xiaonan Han
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2019)