Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders

Inflammation in Atherosclerosis

(2012) Peter Libby   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation in Myocardial Diseases

(2012) David J. Marchant et al.   CIRCULATION RESEARCH

Noncanonical Notch Signaling Modulates Cytokine Responses of Dendritic Cells to Inflammatory Stimuli

(2012) M. E. Gentle et al.   JOURNAL OF IMMUNOLOGY

Notch–RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

(2012) Haixia Xu et al.   NATURE IMMUNOLOGY

Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders

(2012) D. Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch1 in Bone Marrow–Derived Cells Mediates Cardiac Repair After Myocardial Infarction

(2011) Yuxin Li et al.   CIRCULATION

Blocking the NOTCH Pathway Inhibits Vascular Inflammation in Large-Vessel Vasculitis

(2011) Kisha Piggott et al.   CIRCULATION

Notch and NF-κB Signaling Pathways in the Biology of Classical Hodgkin Lymphoma

(2011) R. Schwarzer et al.   CURRENT MOLECULAR MEDICINE

Proteolytic Cleavage of Notch: “HIT and RUN”

(2011) G. van Tetering et al.   CURRENT MOLECULAR MEDICINE

Notch Initiates the Endothelial-to-Mesenchymal Transition in the Atrioventricular Canal through Autocrine Activation of Soluble Guanylyl Cyclase

(2011) Alex C.Y. Chang et al.   DEVELOPMENTAL CELL

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Notch Signal Suppresses Toll-like Receptor-triggered Inflammatory Responses in Macrophages by Inhibiting Extracellular Signal-regulated Kinase 1/2-mediated Nuclear Factor κB Activation

(2011) Qinghua Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JAG2 Induction in Hypoxic Tumor Cells Alters Notch Signaling and Enhances Endothelial Cell Tube Formation

(2011) A. Pietras et al.   MOLECULAR CANCER RESEARCH

Toll-Like Receptor 9 Signaling Is Critical for Early Experimental Deep Vein Thrombosis Resolution

(2010) Peter K. Henke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation dysregulates Notch signaling in endothelial cells: Implication of Notch2 and Notch4 to endothelial dysfunction

(2010) Thibaut Quillard et al.   BIOCHEMICAL PHARMACOLOGY

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

Inhibition of Delta-Like-4–Mediated Signaling Impairs Reparative Angiogenesis After Ischemia

(2010) Ayman Al Haj Zen et al.   CIRCULATION RESEARCH

Potential Therapeutic Targets for Cardiac Fibrosis

(2010) Andrew Leask   CIRCULATION RESEARCH

A Dynamic Notch Injury Response Activates Epicardium and Contributes to Fibrosis Repair

(2010) Jamie L. Russell et al.   CIRCULATION RESEARCH

Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition

(2010) Michael Cohen et al.   DEVELOPMENTAL CELL

Notch and Transforming Growth Factor-β (TGFβ) Signaling Pathways Cooperatively Regulate Vascular Smooth Muscle Cell Differentiation

(2010) Yuefeng Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch1 Deficiency Results in Decreased Inflammation during Wound Healing and Regulates Vascular Endothelial Growth Factor Receptor-1 and Inflammatory Cytokine Expression in Macrophages

(2010) H. Hamilton Outtz et al.   JOURNAL OF IMMUNOLOGY

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

(2010) David Sprinzak et al.   NATURE

Monocytes in atherosclerosis: subsets and functions

(2010) Kevin J. Woollard et al.   Nature Reviews Cardiology

Nitric oxide and oxidative stress in vascular disease

(2010) Ulrich Förstermann   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

Vascular Responses to Hypoxia and Ischemia

(2009) Gregg L. Semenza   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch signaling regulates the differentiation of bone marrow-derived cells into smooth muscle-like cells during arterial lesion formation

(2009) Hiroshi Doi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

γ-Secretase inhibitor reduces diet-induced atherosclerosis in apolipoprotein E-deficient mice

(2009) Toru Aoyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes, blood "resident" monocytes, and embryonic macrophages suggests common functions and developmental relationships

(2009) F. Pucci et al.   BLOOD

Smooth Muscle Notch1 Mediates Neointimal Formation After Vascular Injury

(2009) Yuxin Li et al.   CIRCULATION

Distinct Roles for Cell-Autonomous Notch Signaling in Cardiomyocytes of the Embryonic and Adult Heart

(2009) Paschalis Kratsios et al.   CIRCULATION RESEARCH

The role of hypoxia in atherosclerosis

(2009) Lillemor Mattsson Hultén et al.   CURRENT OPINION IN LIPIDOLOGY

Signalling Cross Talk of the HIF System: Involvement of the FIH Protein

(2009) M. Coleman et al.   CURRENT PHARMACEUTICAL DESIGN

Notch1 upregulates LPS-induced macrophage activation by increasing NF-κB activity

(2009) Eva Monsalve et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TNF induction of jagged-1 in endothelial cells is NFκB-dependent

(2009) Douglas A. Johnston et al.   GENE

Jagged1 regulates the activation of astrocytes via modulation of NFκB and JAK/STAT/SOCS pathways

(2009) Eleonora Morga et al.   GLIA

Factor VIII and von Willebrand factor interaction: biological, clinical and therapeutic importance

(2009) V. TERRAUBE et al.   HAEMOPHILIA

Differential Regulation of Transforming Growth Factor β Signaling Pathways by Notch in Human Endothelial Cells

(2009) YangXin Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: Plasmacytoid Dendritic Cells Induce IL-10 Production in T Cells via the Delta-Like-4/Notch Axis

(2009) N. Kassner et al.   JOURNAL OF IMMUNOLOGY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

Notch2 Signaling Sensitizes Endothelial Cells to Apoptosis by Negatively Regulating the Key Protective Molecule Survivin

(2009) Thibaut Quillard et al.   PLoS One

The Role of Notch Signaling in Endothelial Progenitor Cell Biology

(2009) Sang-Mo Kwon et al.   TRENDS IN CARDIOVASCULAR MEDICINE

KSHV Manipulates Notch Signaling by DLL4 and JAG1 to Alter Cell Cycle Genes in Lymphatic Endothelia

(2009) Victoria Emuss et al.   PLoS Pathogens

Impaired Notch4 Activity Elicits Endothelial Cell Activation and Apoptosis

(2008) T. Quillard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli

(2008) Rui Benedito et al.   BMC DEVELOPMENTAL BIOLOGY

Cardiac Allograft Vasculopathy

(2008) Daniel Schmauss et al.   CIRCULATION

Hairy-Related Transcription Factors Inhibit Notch-Induced Smooth Muscle α-Actin Expression by Interfering With Notch Intracellular Domain/CBF-1 Complex Interaction With the CBF-1–Binding Site

(2008) Yuefeng Tang et al.   CIRCULATION RESEARCH

Notch and Vascular Smooth Muscle Cell Phenotype

(2008) David Morrow et al.   CIRCULATION RESEARCH

Tumor necrosis factor-α and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation

(2008) Luis Fernandez et al.   EXPERIMENTAL HEMATOLOGY

Downregulation by lipopolysaccharide of Notch signaling, via nitric oxide

(2008) M.-Y. Kim et al.   JOURNAL OF CELL SCIENCE

Control of the adaptive response of the heart to stress via the Notch1 receptor pathway

(2008) Adrien Croquelois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL

(2008) N. Peters et al.   JOURNAL OF NEUROLOGY

The immune system and cardiac repair

(2008) N FRANGOGIANNIS   PHARMACOLOGICAL RESEARCH

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

(2008) X. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling is activated by TLR stimulation and regulates macrophage functions

(2007) Tanapat Palaga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY