B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment

IgG4 Characteristics and Functions in Cancer Immunity

(2016) Silvia Crescioli et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Survival of patients with advanced metastatic melanoma: The impact of novel therapies

(2016) Selma Ugurel et al.   EUROPEAN JOURNAL OF CANCER

Tumor-associated B cells in cutaneous primary melanoma and improved clinical outcome

(2016) Kanika Garg et al.   HUMAN PATHOLOGY

Coinhibitory Pathways in the B7-CD28 Ligand-Receptor Family

(2016) Frank A. Schildberg et al.   IMMUNITY

Targeting Tumor-Infiltrating B Cells in Cutaneous T-Cell Lymphoma

(2016) Sebastian Theurich et al.   JOURNAL OF CLINICAL ONCOLOGY

A systematic review of serum autoantibodies as biomarkers for pancreatic cancer detection

(2016) Karin Dumstrei et al.   Oncotarget

CD40-activated B cells induce anti-tumor immunity in vivo

(2016) Kerstin Wennhold et al.   Oncotarget

IL-2 augments the therapeutic efficacy of adoptively transferred B cells which directly kill tumor cells via the CXCR4/CXCL12 and perforin pathways

(2016) Yang Xia et al.   Oncotarget

Prospective evaluation of 64 serum autoantibodies as biomarkers for early detection of colorectal cancer in a true screening setting

(2016) Hongda Chen et al.   Oncotarget

IgG subclass switching and clonal expansion in cutaneous melanoma and normal skin

(2016) Louise Saul et al.   Scientific Reports

Exposure to Melan-A/MART-126-35 tumor epitope specific CD8+T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS)

(2016) Frédéric Ebstein et al.   Scientific Reports

Pembrolizumab for the treatment of advanced melanoma

(2016) Michael C. Burns et al.   Expert Opinion on Orphan Drugs

Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together

(2016) Gareth W. Jones et al.   Frontiers in Immunology

Cancer stage at diagnosis in patients infected with the human immunodeficiency virus and transplant recipients

(2015) Meredith S. Shiels et al.   CANCER

An Autoimmune Response Signature Associated with the Development of Triple-Negative Breast Cancer Reflects Disease Pathogenesis

(2015) H. Katayama et al.   CANCER RESEARCH

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

B cells responses and cytokine production are regulated by their immune microenvironment

(2015) Monica I. Vazquez et al.   CYTOKINE

Processing and MHC class II presentation of exogenous soluble antigen involving a proteasome-dependent cytosolic pathway in CD40-activated B cells

(2015) Hans Jiro Becker et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL-10

(2015) Huimin Tao et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The era of the immunoglobulin A Fc receptor FcαRI; its function and potential as target in disease

(2015) Esil Aleyd et al.   IMMUNOLOGICAL REVIEWS

Regulatory B cells in anti-tumor immunity

(2015) Yu Zhang et al.   INTERNATIONAL IMMUNOLOGY

Melanoma Risk and Survival among Organ Transplant Recipients

(2015) Hilary A. Robbins et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

(2015) Shabnam Shalapour et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Revisiting the role of B cells in skin immune surveillance

(2015) Isioma U. Egbuniwe et al.   TRENDS IN IMMUNOLOGY

PD-L1hi B cells are critical regulators of humoral immunity

(2015) Adnan R. Khan et al.   Nature Communications

Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth

(2015) Sheila N. Ganti et al.   Scientific Reports

BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma

(2015) S. D. Bradley et al.   Cancer Immunology Research

Tertiary Lymphoid Structure-Associated B Cells are Key Players in Anti-Tumor Immunity

(2015) Claire Germain et al.   Frontiers in Immunology

Elevated IgG4 in patient circulation is associated with the risk of disease progression in melanoma

(2015) Panagiotis Karagiannis et al.   OncoImmunology

B Lymphocytes Promote Lymphogenous Metastasis of Lymphoma and Melanoma

(2015) Alanna Ruddell et al.   NEOPLASIA

B Cells Promote Tumor Immunity against B16F10 Melanoma

(2014) Tadahiro Kobayashi et al.   AMERICAN JOURNAL OF PATHOLOGY

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Tumor-Infiltrating Lymphocyte Therapy for Melanoma: Rationale and Issues for Further Clinical Development

(2014) Geok Choo Sim et al.   BIODRUGS

B Cells Regulate Macrophage Phenotype and Response to Chemotherapy in Squamous Carcinomas

(2014) Nesrine I. Affara et al.   CANCER CELL

Manipulation of tumour-infiltrating B cells and tertiary lymphoid structures: a novel anti-cancer treatment avenue?

(2014) Karīna Siliņa et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A significant percentage of CD20-positive TILs correlates with poor prognosis in patients with primary cutaneous malignant melanoma

(2014) Miguel Martinez-Rodriguez et al.   HISTOPATHOLOGY

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

(2014) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

Tumor infiltrating B-cells are increased in prostate cancer tissue

(2014) Jason R Woo et al.   Journal of Translational Medicine

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Melanoma—the run of success continues

(2014) Dirk Schadendorf et al.   Nature Reviews Clinical Oncology

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

IgG4 subclass antibodies impair antitumor immunity in melanoma

(2013) Panagiotis Karagiannis et al.   JOURNAL OF CLINICAL INVESTIGATION

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural Determinants of Unique Properties of Human IgG4-Fc

(2013) Anna M. Davies et al.   JOURNAL OF MOLECULAR BIOLOGY

Cutaneous melanoma

(2013) Alexander MM Eggermont et al.   LANCET

IgE immunotherapy

(2013) Debra H Josephs et al.   mAbs

B Cells Promote Tumor Progression via STAT3 Regulated-Angiogenesis

(2013) Chunmei Yang et al.   PLoS One

Natural Killer Cell Mediated Antibody-Dependent Cellular Cytotoxicity in Tumor Immunotherapy with Therapeutic Antibodies

(2013) Ursula J. E. Seidel et al.   Frontiers in Immunology

Autoantibodies targeting tumor-associated antigens in metastatic cancer

(2013) Martin Oaks et al.   OncoImmunology

IgG4 antibodies and cancer-associated inflammation

(2013) Panagiotis Karagiannis et al.   OncoImmunology

Cytokine-producing B cells as regulators of pathogenic and protective immune responses

(2012) Simon Fillatreau   ANNALS OF THE RHEUMATIC DISEASES

B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion

(2012) Yu Zhang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases

(2012) Arcadi Cipponi et al.   CANCER RESEARCH

Immunotype and Immunohistologic Characteristics of Tumor-Infiltrating Immune Cells Are Associated with Clinical Outcome in Metastatic Melanoma

(2012) G. Erdag et al.   CANCER RESEARCH

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

CTLA-4 Blockade with Ipilimumab: Long-term Follow-up of 177 Patients with Metastatic Melanoma

(2012) P. A. Prieto et al.   CLINICAL CANCER RESEARCH

CD20+ Tumor-Infiltrating Lymphocytes Have an Atypical CD27- Memory Phenotype and Together with CD8+ T Cells Promote Favorable Prognosis in Ovarian Cancer

(2012) J. S. Nielsen et al.   CLINICAL CANCER RESEARCH

Tumor-infiltrating lymphocytes are important pathologic predictors for neoadjuvant chemotherapy in patients with breast cancer

(2012) Rin Yamaguchi et al.   HUMAN PATHOLOGY

Different Adaptations of IgG Effector Function in Human and Nonhuman Primates and Implications for Therapeutic Antibody Treatment

(2012) M. Warncke et al.   JOURNAL OF IMMUNOLOGY

Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma

(2012) G. Forte et al.   JOURNAL OF IMMUNOLOGY

Crystal structure of the human IgG4 CH3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange

(2012) Anna M. Davies et al.   MOLECULAR IMMUNOLOGY

Targeting CD20 in Melanoma Patients at High Risk of Disease Recurrence

(2012) Alice Pinc et al.   MOLECULAR THERAPY

Involvement of activation of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors in enhanced IgG4 responses in autoimmune pancreatitis

(2011) Tomohiro Watanabe et al.   ARTHRITIS AND RHEUMATISM

The prognostic significance of B lymphocytes in invasive carcinoma of the breast

(2011) S. M. A. Mahmoud et al.   BREAST CANCER RESEARCH AND TREATMENT

The absence of B lymphocytes reduces the number and function of T-regulatory cells and enhances the anti-tumor response in a murine tumor model

(2011) Tamar Tadmor et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Prognostic impact of B-cell density in cutaneous melanoma

(2011) Andrea Ladányi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

(2011) P. B. Olkhanud et al.   CANCER RESEARCH

Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer

(2011) L. Martinet et al.   CANCER RESEARCH

Adoptive Transfer of Tumor Reactive B Cells Confers Host T-Cell Immunity and Tumor Regression

(2011) Q. Li et al.   CLINICAL CANCER RESEARCH

Systematic Review of Medical Treatment in Melanoma: Current Status and Future Prospects

(2011) C. Garbe et al.   ONCOLOGIST

Monitoring the Systemic Human Memory B Cell Compartment of Melanoma Patients for Anti-Tumor IgG Antibodies

(2011) Amy E. Gilbert et al.   PLoS One

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

(2010) Pauline Andreu et al.   CANCER CELL

Naive tumor-specific CD4+T cells differentiated in vivo eradicate established melanoma

(2010) Ying Xie et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B Cells Are Required for Optimal CD4+ and CD8+ T Cell Tumor Immunity: Therapeutic B Cell Depletion Enhances B16 Melanoma Growth in Mice

(2010) D. J. DiLillo et al.   JOURNAL OF IMMUNOLOGY

Mature B Cells Are Critical to T-cell-mediated Tumor Immunity Induced by an Agonist Anti-GITR Monoclonal Antibody

(2010) Pengfei Zhou et al.   JOURNAL OF IMMUNOTHERAPY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Collapse of the CD27+ B-Cell Compartment Associated with Systemic Plasmacytosis in Patients with Advanced Melanoma and Other Cancers

(2009) E. L. Carpenter et al.   CLINICAL CANCER RESEARCH

PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+CD25Hi regulatory T cells

(2009) Wenshi Wang et al.   INTERNATIONAL IMMUNOLOGY

The Microenvironment of Germ Cell Tumors Harbors a Prominent Antigen-Driven Humoral Response

(2009) S. N. Willis et al.   JOURNAL OF IMMUNOLOGY

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY

B lymphocytes: how they develop and function

(2008) T. W. LeBien et al.   BLOOD

CD40-activated B cells can be generated in high number and purity in cancer patients: analysis of immunogenicity and homing potential

(2008) E. Kondo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Characterization of intra-graft B cells during renal allograft rejection

(2008) Valeriya Zarkhin et al.   KIDNEY INTERNATIONAL

Optimization of antibody binding to Fc RIIa enhances macrophage phagocytosis of tumor cells

(2008) J. O. Richards et al.   MOLECULAR CANCER THERAPEUTICS