The era of the immunoglobulin A Fc receptor FcαRI; its function and potential as target in disease

Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice

(2015) C. Liu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Secretory IgA as a vaccine carrier for delivery of HIV antigen to M cells

(2015) Nicolas Rochereau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IgM and IgA Rheumatoid Factors Purified from Rheumatoid Arthritis Sera Boost the Fc Receptor– and Complement-Dependent Effector Functions of the Disease-Specific Anti–Citrullinated Protein Autoantibodies

(2015) Florence Anquetil et al.   JOURNAL OF IMMUNOLOGY

Antibody-Opsonized Bacteria Evoke an Inflammatory Dendritic Cell Phenotype and Polyfunctional Th Cells by Cross-Talk between TLRs and FcRs

(2015) Jantine E. Bakema et al.   JOURNAL OF IMMUNOLOGY

Gluten exacerbates IgA nephropathy in humanized mice through gliadin–CD89 interaction

(2015) Christina Papista et al.   KIDNEY INTERNATIONAL

Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding

(2015) M Jack Borrok et al.   mAbs

Immunoglobulin A nephropathy: current progress and future directions

(2015) Chunlei Zhang et al.   Translational Research

Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI

(2015) Masato Kiyoshi et al.   Nature Communications

Reversal of Arthritis by Human Monomeric IgA Through the Receptor-Mediated SH2 Domain-Containing Phosphatase 1 Inhibitory Pathway

(2015) Elisabetta Rossato et al.   Arthritis & Rheumatology

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

IgGA: A “Cross-Isotype” Engineered Human Fc Antibody Domain that Displays Both IgG-like and IgA-like Effector Functions

(2014) William Kelton et al.   CHEMISTRY & BIOLOGY

IgA rheumatoid factor as a serological predictor of poor response to tumour necrosis factor α inhibitors in rheumatoid arthritis

(2014) Rajalingham Sakthiswary et al.   International Journal of Rheumatic Diseases

Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis

(2014) Sanae Ben Mkaddem et al.   JOURNAL OF CLINICAL INVESTIGATION

Inside-Out Regulation of Fc RI (CD89) Depends on PP2A

(2014) J. E. Bakema et al.   JOURNAL OF IMMUNOLOGY

Human IgA Fc Receptor FcαRI (CD89) Triggers Different Forms of Neutrophil Death Depending on the Inflammatory Microenvironment

(2014) Marc Wehrli et al.   JOURNAL OF IMMUNOLOGY

IgA Enhances NETosis and Release of Neutrophil Extracellular Traps by Polymorphonuclear Cells via Fc  Receptor I

(2014) E. Aleyd et al.   JOURNAL OF IMMUNOLOGY

HIV-1 Specific IgA Detected in Vaginal Secretions of HIV Uninfected Women Participating in a Microbicide Trial in Southern Africa Are Primarily Directed Toward gp120 and gp140 Specificities

(2014) Kelly E. Seaton et al.   PLoS One

Pentraxins and IgA share a binding hot-spot on FcαRI

(2014) Jinghua Lu et al.   PROTEIN SCIENCE

Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility

(2014) Chanchal Sur Chowdhury et al.   ARTHRITIS RESEARCH & THERAPY

Rheumatoid factor and anti-citrullinated protein antibody positivity, but not level, are associated with increased mortality in patients with rheumatoid arthritis: results from two large independent cohorts

(2014) Jennifer H Humphreys et al.   ARTHRITIS RESEARCH & THERAPY

Celiac Disease

(2014) Stefano Guandalini et al.   JAMA Pediatrics

IgAEGFR antibodies mediate tumour killingin vivo

(2013) Peter Boross et al.   EMBO Molecular Medicine

Neutrophils as effector cells for antibody-based immunotherapy of cancer

(2013) Marjolein van Egmond et al.   SEMINARS IN CANCER BIOLOGY

Anti-inflammatory role of the IgA Fc receptor (CD89): From autoimmunity to therapeutic perspectives

(2012) Sanae Ben Mkaddem et al.   AUTOIMMUNITY REVIEWS

Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice

(2012) E. M. Hur et al.   BLOOD

Enhanced FcαRI-mediated neutrophil migration towards tumour colonies in the presence of endothelial cells

(2012) Marielle A. Otten et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Transglutaminase is essential for IgA nephropathy development acting through IgA receptors

(2012) Laureline Berthelot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blocking Fc  Receptor I on Granulocytes Prevents Tissue Damage Induced by IgA Autoantibodies

(2012) L. P. van der Steen et al.   JOURNAL OF IMMUNOLOGY

Pemphigoid diseases

(2012) Enno Schmidt et al.   LANCET

Homeland Security: IgA immunity at the frontiers of the body

(2012) Andrew J. Macpherson et al.   TRENDS IN IMMUNOLOGY

Targeting Fc RI on Polymorphonuclear Cells Induces Tumor Cell Killing through Autophagy

(2011) J. E. Bakema et al.   JOURNAL OF IMMUNOLOGY

Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

(2011) P. A. Ramsland et al.   JOURNAL OF IMMUNOLOGY

A Novel Human IgA Monoclonal Antibody Protects against Tuberculosis

(2011) S. Balu et al.   JOURNAL OF IMMUNOLOGY

Both IgA nephropathy and alcoholic cirrhosis feature abnormally glycosylated IgA1 and soluble CD89–IgA and IgG–IgA complexes: common mechanisms for distinct diseases

(2011) Emilie Tissandié et al.   KIDNEY INTERNATIONAL

Immunoglobulin A

(2011) Jantine E. Bakema et al.   mAbs

The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity

(2011) J E Bakema et al.   Mucosal Immunology

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Recognition and functional activation of the human IgA receptor (Fc RI) by C-reactive protein

(2011) J. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory ITAM Signaling Traps Activating Receptors with the Phosphatase SHP-1 to Form Polarized "Inhibisome" Clusters

(2011) S. Pfirsch-Maisonnas et al.   Science Signaling

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcαRI and FcRγ-chain

(2010) Jantine E. Bakema et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deglycosylation of FcαR at N58 increases its binding to IgA

(2010) Jing Xue et al.   GLYCOBIOLOGY

Selective IgA Deficiency

(2010) Leman Yel   JOURNAL OF CLINICAL IMMUNOLOGY

Premature replacement of   with   immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation

(2010) S. Duchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoglobulin A: FcαRI Interactions Induce Neutrophil Migration Through Release of Leukotriene B4

(2009) Lydia van der Steen et al.   GASTROENTEROLOGY

Inhibitory ITAMs as novel regulators of immunity

(2009) Ulrich Blank et al.   IMMUNOLOGICAL REVIEWS

Serum-free production and purification of chimeric IgA antibodies

(2009) T. Beyer et al.   JOURNAL OF IMMUNOLOGICAL METHODS

CXCR2‐specific chemokines mediate leukotriene B4–dependent recruitment of neutrophils to inflamed joints in mice with antigen‐induced arthritis

(2008) Renata Grespan et al.   ARTHRITIS AND RHEUMATISM

Functional expression of IgA receptor FcαRI on human platelets

(2008) Kun Qian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Excretion of Human Immunodeficiency Virus Type 1 through Polarized Epithelium by Immunoglobulin A

(2008) A. Wright et al.   JOURNAL OF VIROLOGY