New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis

Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats

(2018) Yoo-Cheol Hwang et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Effects of ginsenoside Rg1 on glucose metabolism and liver injury in streptozotocin-induced type 2 diabetic rats

(2017) W. Tian et al.   GENETICS AND MOLECULAR RESEARCH

Astragaloside IV from Astragalus membranaceus ameliorates renal interstitial fibrosis by inhibiting inflammation via TLR4/NF-кB in vivo and in vitro

(2017) Xiangjun Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Momordica charantia polysaccharides ameliorate oxidative stress, hyperlipidemia, inflammation, and apoptosis during myocardial infarction by inhibiting the NF-κB signaling pathway

(2017) Mohammad Raish   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ginsenoside Re Ameliorates Brain Insulin Resistance and Cognitive Dysfunction in High Fat Diet-Induced C57BL/6 Mice

(2017) Jong Min Kim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Islet inflammation in type 2 diabetes and physiology

(2017) Kosei Eguchi et al.   JOURNAL OF CLINICAL INVESTIGATION

Quercetin inhibited epithelial mesenchymal transition in diabetic rats, high-glucose-cultured lens, and SRA01/04 cells through transforming growth factor-β2/phosphoinositide 3-kinase/Akt pathway

(2017) Lei Du et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels

(2017) Jian Hui Xu et al.   Molecular Medicine Reports

Studies on the antidiabetic activities of Momordica charantia fruit juice in streptozotocin-induced diabetic rats

(2017) Mona F. Mahmoud et al.   PHARMACEUTICAL BIOLOGY

Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the Diabetes Autoimmunity Study in the Young (DAISY)

(2017) Kathleen Waugh et al.   PLoS One

Resveratrol ameliorates diabetic nephropathy in rats through negative regulation of the p38 MAPK/TGF-β1 pathway

(2017) Yuan Qiao et al.   Experimental and Therapeutic Medicine

Microbial transformation of ginsenoside Rb1, Re and Rg1 and its contribution to the improved anti-inflammatory activity of ginseng

(2017) Shanshan Yu et al.   Scientific Reports

Anti-adipogenic Effects and Mechanisms of Ginsenoside Rg3 in Pre-adipocytes and Obese Mice

(2017) Longyun Zhang et al.   Frontiers in Pharmacology

Berberine Attenuates Intestinal Mucosal Barrier Dysfunction in Type 2 Diabetic Rats

(2017) Jing Gong et al.   Frontiers in Pharmacology

The effect of quercetin on genetic expression of the commensal gut microbes Bifidobacterium catenulatum, Enterococcus caccae and Ruminococcus gauvreauii

(2016) Jenni Firrman et al.   ANAEROBE

Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes

(2016) Amit S. Pithadia et al.   CHEMICAL COMMUNICATIONS

Improved Glucose Homeostasis in Obese Mice Treated With Resveratrol Is Associated With Alterations in the Gut Microbiome

(2016) Miranda M. Sung et al.   DIABETES

Suppression of MAPKs/NF-κB Activation Induces Intestinal Anti-Inflammatory Action of Ginsenoside Rf in HT-29 and RAW264.7 Cells

(2016) Sungeun Ahn et al.   IMMUNOLOGICAL INVESTIGATIONS

Effects of bitter melon (Momordica charantiaL.) on the gut microbiota in high fat diet and low dose streptozocin-induced rats

(2016) Ying Zhu et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Astragaloside IV facilitates glucose transport in C2C12 myotubes through the IRS1/AKT pathway and suppresses the palmitate-induced activation of the IKK/IκBα pathway

(2016) RONGFENG ZHU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Response of gut microbiota and inflammatory status to bitter melon (Momordica charantia L.) in high fat diet induced obese rats

(2016) Juan Bai et al.   JOURNAL OF ETHNOPHARMACOLOGY

Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

(2016) Frederico R.C. Costa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of M1 macrophage activation in adipose tissue by berberine improves insulin resistance

(2016) Lifang Ye et al.   LIFE SCIENCES

Ginsenoside Rg1 ameliorates hippocampal long-term potentiation and memory in an Alzheimer's disease model

(2016) FENGLING LI et al.   Molecular Medicine Reports

Kuwanon G Preserves LPS-Induced Disruption of Gut Epithelial Barrier In Vitro

(2016) Hengli Guo et al.   MOLECULES

1-Deoxynojirimycin Alleviates Liver Injury and Improves Hepatic Glucose Metabolism in db/db Mice

(2016) Qingpu Liu et al.   MOLECULES

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

Modulation of Microbiota-Gut-Brain Axis by Berberine Resulting in Improved Metabolic Status in High-Fat Diet-Fed Rats

(2016) Honglin Sun et al.   Obesity Facts

Gegen Qinlian decoction alleviates experimental colitis via suppressing TLR4/NF-κB signaling and enhancing antioxidant effect

(2016) Ruiyan Li et al.   PHYTOMEDICINE

Effect of exercise on the quality of life in type 2 diabetes mellitus: a systematic review

(2016) Hong Cai et al.   QUALITY OF LIFE RESEARCH

Astragaloside IV ameliorates necrotizing enterocolitis by attenuating oxidative stress and suppressing inflammation via the vitamin D3-upregulated protein 1/NF-κB signaling pathway

(2016) Zhiyong Cai et al.   Experimental and Therapeutic Medicine

Lycium barbarumPolysaccharide Mediated the Antidiabetic and Antinephritic Effects in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats via Regulation of NF-κB

(2016) Mingzhao Du et al.   Biomed Research International

Anti-Inflammatory Effects of Ginsenoside Rg3 via NF-κB Pathway in A549 Cells and Human Asthmatic Lung Tissue

(2016) In-Seung Lee et al.   Journal of Immunology Research

Prevention Effects and Possible Molecular Mechanism of Mulberry Leaf Extract and its Formulation on Rats with Insulin-Insensitivity

(2016) Yan Liu et al.   PLoS One

Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes

(2015) Qianqian Mu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

(2015) Lucile Garidou et al.   Cell Metabolism

Ginsenoside Rg1 improves lipopolysaccharide-induced acute lung injury by inhibiting inflammatory responses and modulating infiltration of M2 macrophages

(2015) Suhong Bao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Disposition of Astragaloside IV via Enterohepatic Circulation Is Affected by the Activity of the Intestinal Microbiome

(2015) Yi Jin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Acacia ferrugineainhibits inflammation by regulating inflammatory iNOS and COX-2

(2015) Kunnathur Murugesan Sakthivel et al.   Journal of Immunotoxicology

1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice

(2015) Qingpu Liu et al.   MOLECULES

Interaction of dendritic cells and T lymphocytes for the therapeutic effect of Dangguiliuhuang decoction to autoimmune diabetes

(2015) Tingting Liu et al.   Scientific Reports

A review on the effects of Allium sativum (Garlic) in metabolic syndrome

(2015) A. Hosseini et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Curcumin, a component of golden spice: From bedside to bench and back

(2014) Sahdeo Prasad et al.   BIOTECHNOLOGY ADVANCES

Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer

(2014) Parham Jabbarzadeh Kaboli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula

(2014) Jia Xu et al.   ISME Journal

The in vivo and in vitro study of polysaccharides from a two-herb formula on ulcerative colitis and potential mechanism of action

(2014) Linjing Zhao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Reduction of adenovirus 36-induced obesity and inflammation by mulberry extract

(2014) Ha-Na Na et al.   MICROBIOLOGY AND IMMUNOLOGY

Berberine, an Epiphany Against Cancer

(2014) Luis Guamán Ortiz et al.   MOLECULES

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

(2014) Xiaoting Wang et al.   NATURE

Central Inflammation and Leptin Resistance Are Attenuated by Ginsenoside Rb1 Treatment in Obese Mice Fed a High-Fat Diet

(2014) Yizhen Wu et al.   PLoS One

Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells

(2014) Ming Ming et al.   PLoS One

Ginsenoside Rg3 Enhances Islet Cell Function and Attenuates Apoptosis in Mouse Islets

(2014) S.S. Kim et al.   TRANSPLANTATION PROCEEDINGS

Are new models needed to optimize the utilization of new medicines to sustain healthcare systems?

(2014) Brian Godman et al.   Expert Review of Clinical Pharmacology

TNF-α Modulation of Intestinal Epithelial Tight Junction Barrier Is Regulated by ERK1/2 Activation of Elk-1

(2013) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PATHOLOGY

The Crosstalk Between Nrf2 and AMPK Signal Pathways Is Important for the Anti-Inflammatory Effect of Berberine in LPS-Stimulated Macrophages and Endotoxin-Shocked Mice

(2013) Chunfen Mo et al.   ANTIOXIDANTS & REDOX SIGNALING

Nutritional strategies to modulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2

(2013) Ludmila F.M.F. Cardozo et al.   BIOCHIMIE

Astragaloside IV ameliorates renal injury in streptozotocin-induced diabetic rats through inhibiting NF-κB-mediated inflammatory genes expression

(2013) Dingkun Gui et al.   CYTOKINE

Enhanced NF- B Activity Impairs Vascular Function Through PARP-1-, SP-1-, and COX-2-Dependent Mechanisms in Type 2 Diabetes

(2013) M. Kassan et al.   DIABETES

Anti-inflammatory and antiobesity effects of mulberry leaf and fruit extract on high fat diet-induced obesity

(2013) Hyun Hwa Lim et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The Ginsenoside Rg1 Prevents Transverse Aortic Constriction–Induced Left Ventricular Hypertrophy and Cardiac Dysfunction by Inhibiting Fibrosis and Enhancing Angiogenesis

(2013) Yao-Jun Zhang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Ginsenoside Re reduces insulin resistance through activation of PPAR-γ pathway and inhibition of TNF-α production

(2013) Yang Gao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Reduction of atherogenic risk in patients with type 2 diabetes by curcuminoid extract: a randomized controlled trial

(2013) Somlak Chuengsamarn et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Attenuation of berberine on lipopolysaccharide-induced inflammatory and apoptosis responses in β-cells via TLR4-independent JNK/NF-κB pathway

(2013) Ying Wang   PHARMACEUTICAL BIOLOGY

Efficacy and Safety of Traditional Chinese Medicine for Diabetes: A Double-Blind, Randomised, Controlled Trial

(2013) Linong Ji et al.   PLoS One

Momordica charantia (Bitter Melon) Reduces Obesity-Associated Macrophage and Mast Cell Infiltration as well as Inflammatory Cytokine Expression in Adipose Tissues

(2013) Bin Bao et al.   PLoS One

Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats

(2012) Yong Pan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-inflammatory effects of Danggui Liuhuang Decoction (当归六黄汤) in RAW 264.7 cells

(2012) Sung-Bae Kim et al.   Chinese Journal of Integrative Medicine

Curcumin Extract for Prevention of Type 2 Diabetes

(2012) S. Chuengsamarn et al.   DIABETES CARE

The safety and effectiveness of TM81, a Chinese herbal medicine, in the treatment of type 2 diabetes: a randomized double-blind placebo-controlled trial

(2012) X. L. Tong et al.   DIABETES OBESITY & METABOLISM

Protective effects of Ligustrazine, Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis

(2012) Xi-Ping Zhang et al.   Hepatobiliary & Pancreatic Diseases International

Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells

(2012) You-Chang Oh et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Insulin receptor and IRS-1 co-immunoprecipitation with SOCS-3, and IKKα/β phosphorylation are increased in obese Zucker rat skeletal muscle

(2012) Ilya A. Zolotnik et al.   LIFE SCIENCES

Anti-diabetic Effect of Ginsenoside Rb3 in Alloxan-induced Diabetic Mice

(2012) Qi Tao Bu et al.   Medicinal Chemistry

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

Anti-diabetic activities of Gegen Qinlian Decoction in high-fat diet combined with streptozotocin-induced diabetic rats and in 3T3-L1 adipocytes

(2012) Chang-Hua Zhang et al.   PHYTOMEDICINE

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Protective effect of isoquinoline alkaloid berberine on spontaneous inflammation in the spleen, liver and kidney of non-obese diabetic mice through downregulating gene expression ratios of pro-/anti-inflammatory and Th1/Th2 cytokines

(2011) Wei-Han Chueh et al.   FOOD CHEMISTRY

Hypoglycemic effect of bitter melon compared with metformin in newly diagnosed type 2 diabetes patients

(2011) Anjana Fuangchan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Antidiabetic Potentials of Momordica charantia: Multiple Mechanisms Behind the Effects

(2011) Padmaja Chaturvedi   JOURNAL OF MEDICINAL FOOD

Bifidobacteria can protect from enteropathogenic infection through production of acetate

(2011) Shinji Fukuda et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs

(2009) Yiyi Sun et al.   ANTI-CANCER DRUGS

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Curcumin induces the tolerogenic dendritic cell that promotes differentiation of intestine-protective regulatory T cells

(2009) Yingzi Cong et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice

(2009) Guoliang Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations

(2009) Jun Tang et al.   JOURNAL OF ETHNOPHARMACOLOGY

The study of ginsenoside on PPARγ expression of mononuclear macrophage in type 2 diabetes

(2009) Hai-xiang Ni et al.   MOLECULAR BIOLOGY REPORTS

Hypoglycemic herbs and their action mechanisms

(2009) Hongxiang Hui et al.   Chinese Medicine

Effect and mechanism of ginsenoside Rg3 on postoperative life span of patients with non-small cell lung cancer

(2008) Ping Lu et al.   Chinese Journal of Integrative Medicine

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine

(2008) Yifei Zhang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ginsenoside Rb1 stimulates glucose uptake through insulin-like signaling pathway in 3T3-L1 adipocytes

(2008) Wenbin Shang et al.   JOURNAL OF ENDOCRINOLOGY

Traditional Chinese Medicine in Treatment of Metabolic Syndrome

(2008) Jun Yin et al.   Endocrine Metabolic & Immune Disorders-Drug Targets