Article
Nanoscience & Nanotechnology
Jing Zhao, Qing Zhao, Jing-Ze Lu, Dan Ye, Sheng Mu, Xiao-Di Yang, Wei-Dong Zhang, Bing-Liang Ma
Summary: Proteinaceous nanoparticles isolated from Coptidis Rhizoma extract can form a natural nano-drug delivery system with BBR, thus significantly improving the pharmacokinetics of oral BBR.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Plant Sciences
Ziwei Huang, Minhua Li, Zehui Qin, Xingdong Ma, Ronglei Huang, Yuhong Liu, Jianhui Xie, Huifang Zeng, Ruoting Zhan, Ziren Su
Summary: This study reveals the hypolipidemic mechanism of Berberine (BBR) from Rhizoma Coptidis (RC) through its unique intestines-erythrocytes-mediated biotransformation and disposition pathways. BBR undergoes biotransformation in both intestines and erythrocytes to the major metabolite oxyberberine (OBB). BBR and OBB are mainly presented and transported in the protein-bound form within circulating erythrocytes, potentially resulting in hepatocyte targeting accompanied by enterohepatic circulation. The unique extrahepatic metabolism and disposition of BBR via intestines and erythrocytes contribute significantly to its hypolipidemic effect. OBB is the important material basis for the hypolipidemic effect of BBR and RC.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jing Zhao, Ting Zhou, Jing-Ze Lu, Dan Ye, Sheng Mu, Xin-Hui Tian, Wei-Dong Zhang, Bing-Liang Ma
Summary: Primary plant metabolites can be used to prepare natural deep eutectic solvents (NADESs), which were found in Coptidis Rhizoma extract and shown to improve the pharmacokinetics of oral berberine hydrochloride (BBR) when diluted. The dilutions of NADES significantly enhanced the water solubility of BBR, reduced its efflux, and improved its metabolic stability.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Shengnan Wang, Rensong Yue, Xiaoying Huang, Linzhi Li, Chenyi Xu, Longyan Liu
Summary: Type 2 diabetes mellitus is a global epidemic with serious impact on individuals and society. This study aims to evaluate the effectiveness and safety of ginseng and coptis intervention in the treatment of T2DM, providing valuable evidence for future research.
Review
Biochemistry & Molecular Biology
Abdur Rauf, Tareq Abu-Izneid, Anees Ahmed Khalil, Muhammad Imran, Zafar Ali Shah, Talha Bin Emran, Saikat Mitra, Zidan Khan, Fahad A. Alhumaydhi, Abdullah S. M. Aljohani, Ishaq Khan, Md Mominur Rahman, Philippe Jeandet, Tanweer Aslam Gondal
Summary: Berberine, a potential bioactive agent, shows remarkable health benefits and promising anticancer activity. It inhibits cancer cell proliferation, invasion, and metastasis through various mechanisms, and also plays a role in the early stages of cancer development. Despite its potential, pure berberine preparations for specific ailments are currently not approved, but research on its sources, extraction methods, pharmacokinetics, and proposed mechanisms of action related to its anticancer potential continues.
Article
Pharmacology & Pharmacy
Yueh-Hsiang Huang, Geng-Hao Liu, Tzu-Yang Hsu, Lan-Yan Yang, Ming-Chung Lee, Chun-Teng Huang, Yi-Hong Wu
Summary: This study found a significant relationship between Rhizoma Coptidis extract granules (RCEG) dose and reduction in HbA1c levels when the dose reached 0.08 g/kg/day or higher. A dose exceeding 0.08 g/kg/day was defined as the minimum effective dose, separating patients into high-dose and low-dose RCEG groups. High-dose RCEG group showed significant decrease in total cholesterol and a trend toward triglyceride reduction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Mohamed S. Othman, Sofian T. Obeidat, Amal H. Al-Bagawi, Mohamed A. Fareid, Alaa Fehaid, Ahmed E. Abdel Moneim
Summary: This study evaluated the potential of green-synthesized selenium nanoparticles (SeNPs) containing berberine (SeNPs-Ber) as an anticancer agent. The results showed that SeNPs-Ber significantly improved survival rate, reduced tumor size, and activated apoptotic cascade in tumor cells. Moreover, SeNPs-Ber reduced oxidative stress and improved histopathological alterations in tumor tissue. These findings suggest that green-synthesized SeNPs-Ber has promising anticancer properties and can be used as supplementary medication during chemotherapy.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Plant Sciences
Pei Liu, Xing Yan, Jiaying Pu, Qi Liao, Kang Wang, Jiping Lan, Rui Wang, Zhengtao Wang, Lili Ding, Li Yang
Summary: The study explored the mechanisms of Plantaginis Semen-Coptidis Rhizoma Compound (CQC) on type 2 diabetes mellitus (T2DM) through network pharmacology and experimental research. The results showed that CQC improved hyperglycemia and liver injury in T2DM mice, and the potential mechanism may involve the regulation of the AGEs/RAGE signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Integrative & Complementary Medicine
Anchal Trivedi, Adria Hasan, Rumana Ahmad, Sahabjada Siddiqui, Aditi Srivastava, Aparna Misra, Snober S. Mir
Summary: Good nutrition is essential for a balanced lifestyle. Nutraceuticals, especially flavonoids found in fruits, vegetables, tea, cocoa, and wine, have been proven to have various health benefits, including anti-inflammatory, anti-allergic, anti-microbial, antioxidant, and anticancer properties. Myricetin, a flavonol present in fruits and vegetables, has shown potential as a nutraceutical that can protect against cancer. This review focuses on discussing recent studies on the anticancer potential of myricetin and the molecular mechanisms involved, aiming to contribute to the development of a novel anticancer nutraceutical with minimal side effects.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Chemistry, Inorganic & Nuclear
Johannes Karges, Kai Xiong, Olivier Blacque, Hui Chao, Gilles Gasser
Summary: The study found that copper (II) polypyridine complexes have significant cytotoxic effects on human adenocarcinomic alveolar basal epithelial cells, and are equally effective against cisplatin-resistant cells, potentially serving as a treatment option for drug-resistant tumors.
INORGANICA CHIMICA ACTA
(2021)
Article
Integrative & Complementary Medicine
Richard Y. Cao, Yuntao Zheng, Ying Zhang, Lingling Jiang, Qing Li, Wanqun Sun, Wenqin Gu, Weifeng Cao, Linyan Zhou, Hongchao Zheng, Jian Yang
Summary: Berberine has shown pleiotropic therapeutic effects against cardiometabolic diseases, involving mechanisms such as combating inflammation and oxidative stress, regulating electrical signals, promoting energy metabolism, modifying gut microbiota, and interacting with non-coding RNAs targeting multiple signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Nalini Devarajan, Jhansi Nathan, Ramalingam Mathangi, Jaideep Mahendra, Senthil Kumar Ganesan
Summary: Berberine (BBR), a traditional Chinese phytomedicine, has been used for centuries to treat diabetes, hypercholesterolemia, hypertension, and now it has gained attention as a potential treatment for cancer due to its pro-apoptotic, antiproliferative, and anti-inflammatory properties. BBR induces tumor apoptosis, inhibits cell proliferation and metastasis, and reverses drug resistance, making it a promising candidate for cancer therapy. This review comprehensively analyzes the pharmacological effects of BBR in different types of cancer and discusses the limitations and future research directions for developing BBR into pharmaceuticals for cancer treatment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mikhail V. Khvostov, Elizaveta D. Gladkova, Sergey A. Borisov, Nataliya A. Zhukova, Mariya K. Marenina, Yuliya V. Meshkova, Olga A. Luzina, Tatijana G. Tolstikova, Nariman F. Salakhutdinov
Summary: The new berberine derivative SHE-196 showed significant hypoglycemic activity by increasing insulin sensitivity and improving glucose tolerance, reducing obesity and fat mass, and increasing brown fat activity in obese T2DM mice. These effects were confirmed histologically, indicating potential as a therapeutic agent for diabetes mellitus treatment.
Review
Pharmacology & Pharmacy
Jordan Guggisberg, Megan Schumacher, Grace Gilmore, Dylan M. Zylla
Summary: This review examined the literature on the anticancer potential of cannabinoids, finding that most peer-reviewed case reports lack sufficient evidence to support cannabis as an anticancer agent. Strong clinical trial data are needed to confirm pre-clinical studies suggesting anticancer benefits of cannabinoids.
CANNABIS AND CANNABINOID RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Zhi-Hua Yang, Bin Wang, Qian Ma, Lin Wang, Ya-Xin Lin, Hai-Feng Yan, Zi-Xuan Fan, Hao-Jia Chen, Zhao Ge, Feng Zhu, Hui-Jie Wang, Bao-Nan Zhang, Hai-Dong Sun, Li-Min Feng
Summary: COVID-19 is an emergent infectious pneumonia caused by SARS-CoV-2, and Chinese patent medicines have played an important role in prevention and treatment with significant therapeutic efficacy. This study focuses on analyzing the potential targets, drug composition, and mechanisms of Chinese patent medicines to provide valuable information for their clinical application in COVID-19 treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Yuanjun Lu, Yau-Tuen Chan, Hor-Yue Tan, Cheng Zhang, Wei Guo, Yu Xu, Rakesh Sharma, Zhe-Sheng Chen, Yi-Chao Zheng, Ning Wang, Yibin Feng
Summary: Our study reveals that the ETS1/miR-23a-3p/ACSL4 axis contributes to sorafenib resistance in HCC by regulating ferroptosis. This suggests that miR-23a-3p could be a potential target for improving sorafenib responsiveness in HCC patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Review
Chemistry, Medicinal
Zhangfeng Zhong, Chi Teng Vong, Feiyu Chen, Horyue Tan, Cheng Zhang, Ning Wang, Liao Cui, Yitao Wang, Yibin Feng
Summary: Immunotherapy has great potential in cancer treatment, but there are challenges such as immunotoxicity, single-source antibodies, and single-targeting strategies. Natural compounds from herbal medicines have shown promise as lead compounds for cancer treatment. This study summarizes current medication for cancer immunotherapy and discusses the potential of herbal medicines as immune checkpoint inhibitors with broad immunomodulatory effects.
MEDICINAL RESEARCH REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Dandan Shen, Bo Wang, Ya Gao, Lijuan Zhao, Yaping Bi, Jinge Zhang, Ning Wang, Huiqin Kang, Jingru Pang, Ying Liu, Luping Pang, Zhe-Sheng Chen, Yi-Chao Zheng, Hong-Min Liu
Summary: This review focuses on the studies of structure, inhibitors development, and biological function of FTO and ALKBH5.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Integrative & Complementary Medicine
Cheng Zhang, Chi Wing Tam, Guoyi Tang, Yuanyuan Chen, Ning Wang, Yibin Feng
Summary: This study aimed to clarify the molecular features of Yang and Yin deficiency by reanalyzing transcriptomic data, using R-based machine learning analyses. The results provide a foundation for medical diagnosis, prevention, and treatment of unbalanced Yang or Yin.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dan-Dan Shen, Jing-Ru Pang, Ya-Ping Bi, Long-Fei Zhao, Yin-Rui Li, Li-Juan Zhao, Ya Gao, Bo Wang, Ning Wang, Liuya Wei, Huiqin Guo, Hong-Min Liu, Yi-Chao Zheng
Summary: The expression of LSD1 is significantly elevated in gastric cancer patients and is associated with PD-L1 expression. LSD1 inhibits the response of T cells in the gastric cancer microenvironment by inducing the accumulation of PD-L1 in exosomes. Exosomes can also serve as vehicles for LSD1 to regulate T cell immunity in other cancer cells.
Article
Immunology
Guoming Chen, Dongqiang Luo, Nan Zhong, Danyun Li, Jiyuan Zheng, Hui Liao, Zhuoyao Li, Xiaoxiao Lin, Qiqi Chen, Cheng Zhang, Yuanjun Lu, Yau-Tuen Chan, Qing Ren, Ning Wang, Yibin Feng
Summary: GPC2 shows high expression in most cancers, providing early diagnostic value and correlation with prognosis. It is also significantly associated with immune cell infiltration and DNA methylation, indicating its potential role in tumorigenesis and tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dan-Dan Shen, Ya-Ping Bi, Jing-Ru Pang, Li-Juan Zhao, Long-Fei Zhao, Ya Gao, Bo Wang, Hui-Min Liu, Ying Liu, Ning Wang, Yi-Chao Zheng, Hong-Min Liu
Summary: Cancer immunotherapy is a rapidly developing and effective treatment for various malignancies. PD-L1 and PD-1, as significant immune checkpoints, play crucial roles in cancer immune escape and immunotherapy. Combination therapy has become the main direction in the development of PD-L1 antibodies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Editorial Material
Pharmacology & Pharmacy
Zhi Shi, Ning Wang, Ying-Jie Zhang, Yi-Chao Zheng
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Xiang Chen, Menghan Liu, Jun Tang, Ning Wang, Yibin Feng, Haotian Ma
Summary: NAFLD is the most common chronic liver disease affecting global public health at present, and there is a lack of research on its mechanism and therapeutic strategy. The gut-liver axis theory has gradually disclosed the association between polysaccharides and the protective role in NAFLD by affecting multiple interrelated levels such as gut microbiota, metabolites regulation, and intestinal barrier function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Feiyu Chen, Zhangfeng Zhong, Cheng Zhang, Yuanjun Lu, Yau-Tuen Chan, Ning Wang, Di Zhao, Yibin Feng
Summary: Focal adhesion kinase (FAK) is a crucial protein involved in tumor development, with perturbations in its signaling pathways influencing tumor cell behaviors such as proliferation, migration, and adhesion. Understanding the complex biology of FAK family members and their activities in different types of cancer is important for screening natural compounds to combat tumor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yuanjun Lu, Yazhou Liu, Junjie Lan, Yau-Tuen Chan, Zixin Feng, Lan Huang, Ning Wang, Weidong Pan, Yibin Feng
Summary: This study identified HL23 as a novel HDAC inhibitor that enhances acetylation at the TXNIP promoter to trigger TXNIP-dependent potassium deprivation and enhance the efficacy of sorafenib in HCC treatment.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Chemistry, Medicinal
Junyu Wu, Yau-Tuen Chan, Yuanjun Lu, Ning Wang, Yibin Feng
Summary: Surgery is the main treatment for hepatocellular carcinoma (HCC), but postoperative recurrence, caused by intrahepatic metastasis or de novo tumorigenesis, significantly impairs its efficacy. Recent research shows that the postoperative tumor microenvironment (TME) plays a crucial role in tumor recurrence. This review discusses the impact of surgical stress and perturbation on the TME and highlights the potential of targeting the postoperative TME for adjuvant therapeutics.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Integrative & Complementary Medicine
Yuanyuan Chen, Cheng Zhang, Ning Wang, Yibin Feng
Summary: The COVID-19 pandemic has led to excessive deaths globally. Conventional antiviral drugs have limited effectiveness in relieving symptoms, but Lianhua Qingwen Capsule has shown remarkable anti-COVID-19 effects. This review aims to uncover the pharmacological actions of Lianhua Qingwen Capsule, verify its bioactive ingredients, investigate the compatibility of botanical drug pairs, and clarify the clinical evidence and safety of combined therapy with conventional drugs. Several bioactive ingredients in Lianhua Qingwen Capsule were found to target host cytokines and regulate immune defense against COVID-19. Genes such as androgen receptor, myeloperoxidase, epidermal growth factor receptor, insulin, and aryl hydrocarbon receptor were significantly involved in its pharmacological actions. Four botanical drug pairs in Lianhua Qingwen Capsule exhibited a synergistic effect in treating COVID-19. Clinical studies demonstrated the medicinal effect of combining Lianhua Qingwen Capsule with conventional drugs against COVID-19. In conclusion, the main pharmacological mechanisms of Lianhua Qingwen Capsule for managing COVID-19 have been revealed, showing therapeutic effects against the disease.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Review
Biochemistry & Molecular Biology
Zixin Feng, Junyu Wu, Yuanjun Lu, Yau-Tuen Chan, Cheng Zhang, Di Wang, Dan Luo, Yuan Huang, Yibin Feng, Ning Wang
Summary: Cancer is a severe disease with high morbidity and mortality globally. Early detection is crucial for successful treatment, but remains challenging. Various screening methods are widely used, but each has limitations and potential harms. Liquid biopsy is a convenient and non-invasive approach for early tumor screening and diagnosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Medicine, Research & Experimental
Yau-Tuen Chan, Yuanjun Lu, Junyu Wu, Cheng Zhang, Hor-Yue Tan, Zhao-xiang Bian, Ning Wang, Yibin Feng
Summary: CRISPR-Cas9 is a powerful gene editing tool that allows high-precision genetic engineering of the genomes of all organisms. The latest advancements include genome library screening, which can detect survival-essential and drug resistance genes. This technology has various applications in anti-cancer drug discovery.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)