Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset

Thinking bedside at the bench: the NOD mouse model of T1DM

(2015) James C. Reed et al.   Nature Reviews Endocrinology

Peritoneal Cavity is a Route for Gut-Derived Microbial Signals to Promote Autoimmunity in Non-Obese Diabetic Mice

(2015) R. Emani et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation

(2015) Zachary M. Earley et al.   PLoS One

Immunoglobulin A Coating Identifies Colitogenic Bacteria in Inflammatory Bowel Disease

(2014) Noah W. Palm et al.   CELL

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

(2014) Lars Krogvold et al.   DIABETES

Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain

(2014) Rhiannon Parkhouse et al.   FEBS LETTERS

Detection of bacterial DNA in lymph nodes of Crohn's disease patients using high throughput sequencing

(2014) Claire L O'Brien et al.   GUT

A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increasedAkkermansiaspp. population in the gut microbiota of mice

(2014) Fernando F Anhê et al.   GUT

Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection

(2014) Duy M. Dinh et al.   JOURNAL OF INFECTIOUS DISEASES

Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study

(2013) Mora Murri et al.   BMC Medicine

Intestinal Epithelial Autophagy Is Essential for Host Defense against Invasive Bacteria

(2013) Jamaal L. Benjamin et al.   Cell Host & Microbe

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

Apoptosis-Associated Speck-like Protein Containing a Caspase Recruitment Domain Inflammasomes Mediate IL-1  Response and Host Resistance to Trypanosoma cruzi Infection

(2013) G. K. Silva et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

Nod2 deficiency is associated with an increased mucosal immunoregulatory response to commensal microorganisms

(2013) A Amendola et al.   Mucosal Immunology

Low Incidence of Spontaneous Type 1 Diabetes in Non-Obese Diabetic Mice Raised on Gluten-Free Diets Is Associated with Changes in the Intestinal Microbiome

(2013) Eric V. Marietta et al.   PLoS One

Virus Infections in Type 1 Diabetes

(2013) K. T. Coppieters et al.   Cold Spring Harbor Perspectives in Medicine

Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial

(2013) Stephen E Gitelman et al.   Lancet Diabetes & Endocrinology

 1-Acid Glycoprotein Decreases Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice

(2012) F. Spiller et al.   DIABETES

Fecal Microbiota Composition Differs Between Children With  -Cell Autoimmunity and Those Without

(2012) M. C. de Goffau et al.   DIABETES

Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction

(2012) P. Ylipaasto et al.   DIABETOLOGIA

Sensing of Commensal Organisms by the Intracellular Sensor NOD1 Mediates Experimental Pancreatitis

(2012) Yoshihisa Tsuji et al.   IMMUNITY

Dynamic changes of the Th17/Tc17 and regulatory T cell populations interfere in the experimental autoimmune diabetes pathogenesis

(2012) Juliana Navarro Ueda Yaochite et al.   IMMUNOBIOLOGY

Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice

(2012) Yan Y. Lam et al.   PLoS One

Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells

(2012) M. A. Kriegel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy

(2011) Sridevi Devaraj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Corrigendum to “Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes” [Cytokine 55 (2011) 441–445]

(2011) Sridevi Devaraj et al.   CYTOKINE

Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated  -Cell Death

(2011) S. Arif et al.   DIABETES

Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii

(2011) Braulia C. Caetano et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Detection bias and the association between inflammatory bowel disease andSalmonellaandCampylobacterinfection

(2011) Mark S Riddle et al.   GUT

IL-17 Silencing Does Not Protect Nonobese Diabetic Mice from Autoimmune Diabetes

(2011) J. Joseph et al.   JOURNAL OF IMMUNOLOGY

Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies

(2011) Tom L. Van Belle et al.   PHYSIOLOGICAL REVIEWS

Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes

(2011) Christopher T. Brown et al.   PLoS One

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes

(2010) M. Tiittanen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

(2009) J. A. Emamaullee et al.   DIABETES

Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice

(2009) A. S. Lee et al.   DIABETOLOGIA

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

The Toll-Like Receptor Signaling Molecule Myd88 Contributes to Pancreatic Beta-Cell Homeostasis in Response to Injury

(2009) Paul L. Bollyky et al.   PLoS One

The "Perfect Storm" for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

(2008) O. Vaarala et al.   DIABETES

Phlebotomine salivas inhibit immune inflammation-induced neutrophil migration via an autocrine DC-derived PGE2 /IL-10 sequential pathway

(2008) Vanessa Carregaro et al.   JOURNAL OF LEUKOCYTE BIOLOGY