CpG and Non-CpG Methylation in Epigenetic Gene Regulation and Brain Function

DNA Methylation Profiles of Selected Pro-Inflammatory Cytokines in Alzheimer Disease

(2017) Vincenzina Nicolia et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease

(2016) Marta Blanch et al.   AMERICAN JOURNAL OF PATHOLOGY

DNA methylation profiling in human Huntington's disease brain

(2016) Rebecca A.G. De Souza et al.   HUMAN MOLECULAR GENETICS

Methylation of C9orf72 expansion reduces RNA foci formation and dipeptide-repeat proteins expression in cells

(2016) Peter O. Bauer   NEUROSCIENCE LETTERS

Transcriptional Reactivation of the FMR1 Gene. A Possible Approach to the Treatment of the Fragile X Syndrome

(2016) Elisabetta Tabolacci et al.   Genes

Space/Population and Time/Age in DNA methylation variability in humans: a study on IGF2/H19 locus in different Italian populations and in mono- and di-zygotic twins of different age

(2016) Chiara Pirazzini et al.   Aging-US

CpG methylation patterns of human mitochondrial DNA

(2016) Baojing Liu et al.   Scientific Reports

The C9orf72 repeat expansion itself is methylated in ALS and FTLD patients

(2015) Zhengrui Xi et al.   ACTA NEUROPATHOLOGICA

Non-CG Methylation in the Human Genome

(2015) Yupeng He et al.   Annual Review of Genomics and Human Genetics

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Role of 5-hydroxymethylcytosine in neurodegeneration

(2015) Shariq I. Sherwani et al.   GENE

Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease

(2015) Mattia Volta et al.   LANCET NEUROLOGY

L-dopa increasesα-synuclein DNA methylation in Parkinson's disease patientsin vivoandin vitro

(2015) Ina Schmitt et al.   MOVEMENT DISORDERS

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

(2015) Harrison W. Gabel et al.   NATURE

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

(2015) Jing Liao et al.   NATURE GENETICS

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

DNA methylation slows effects of C9orf72 mutations: An epigenetic brake on genetic inheritance

(2015) J. J. Day et al.   NEUROLOGY

Substantial DNA methylation differences between two major neuronal subtypes in human brain

(2015) Alexey Kozlenkov et al.   NUCLEIC ACIDS RESEARCH

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

(2015) Lin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

(2014) Xiaojing Yang et al.   CANCER CELL

The evidence for functional non-CpG methylation in mammalian cells

(2014) Vibha Patil et al.   Epigenetics

Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains

(2014) Guang Bai et al.   HUMAN MOLECULAR GENETICS

Critical Role of Tet3 in Neural Progenitor Cell Maintenance and Terminal Differentiation

(2014) Ting Li et al.   MOLECULAR NEUROBIOLOGY

Parkinson's disease correlates with promoter methylation in the α-synuclein gene

(2014) Lasse Pihlstrøm et al.   MOVEMENT DISORDERS

Abnormalities in human pluripotent cells due to reprogramming mechanisms

(2014) Hong Ma et al.   NATURE

The DNA methylation landscape of human early embryos

(2014) Hongshan Guo et al.   NATURE

Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain

(2014) Daniel Condliffe et al.   NEUROBIOLOGY OF AGING

A Brief History of Epigenetics

(2014) G. Felsenfeld   Cold Spring Harbor Perspectives in Biology

Transient Accumulation of 5-Carboxylcytosine Indicates Involvement of Active Demethylation in Lineage Specification of Neural Stem Cells

(2014) Lee M. Wheldon et al.   Cell Reports

The nexus of vitamin homeostasis and DNA synthesis and modification in mammalian brain

(2014) Reynold Spector et al.   Molecular Brain

Whole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain

(2014) Lu Wen et al.   GENOME BIOLOGY

Decrease in cytosine methylation at CpG island shores and increase in DNA fragmentation during zebrafish aging

(2013) Nobuyoshi Shimoda et al.   AGE

Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion

(2013) Zhengrui Xi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A novel method for detecting 7-methyl guanine reveals aberrant methylation levels in Huntington disease

(2013) Beena Thomas et al.   ANALYTICAL BIOCHEMISTRY

Loss of function of C9orf72 causes motor deficits in a zebrafish model of Amyotrophic Lateral Sclerosis

(2013) Sorana Ciura et al.   ANNALS OF NEUROLOGY

DNA methylation map of mouse and human brain identifies target genes in Alzheimer’s disease

(2013) Jose V. Sanchez-Mut et al.   BRAIN

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells

(2013) Wei Xie et al.   CELL

Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition

(2013) Run-Rui Zhang et al.   Cell Stem Cell

Distinctive patterns of DNA methylation associated with Parkinson disease

(2013) Eliezer Masliah et al.   Epigenetics

Dynamic DNA methylation across diverse human cell lines and tissues

(2013) K. E. Varley et al.   GENOME RESEARCH

MeCP2: a novel Huntingtin interactor

(2013) K. N. McFarland et al.   HUMAN MOLECULAR GENETICS

Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease

(2013) Fengli Wang et al.   HUMAN MOLECULAR GENETICS

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic changes in the progression of Alzheimer's disease

(2013) M.A. Bradley-Whitman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

DNA methylation: roles in mammalian development

(2013) Zachary D. Smith et al.   NATURE REVIEWS GENETICS

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain

(2013) Natacha Coppieters et al.   NEUROBIOLOGY OF AGING

Increased 5-Methylcytosine and Decreased 5-Hydroxymethylcytosine Levels are Associated with Reduced Striatal A2AR Levels in Huntington’s Disease

(2013) Izaskun Villar-Menéndez et al.   NEUROMOLECULAR MEDICINE

Aberrant Regulation of DNA Methylation in Amyotrophic Lateral Sclerosis: A New Target of Disease Mechanisms

(2013) Lee J. Martin et al.   Neurotherapeutics

Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites

(2013) Alexey Kozlenkov et al.   NUCLEIC ACIDS RESEARCH

Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method

(2013) Li Tan et al.   NUCLEIC ACIDS RESEARCH

Alteration of genic 5-hydroxymethylcytosine patterning in olfactory neurons correlates with changes in gene expression and cell identity

(2013) Bradley M. Colquitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis

(2013) Haiyun Gan et al.   Nature Communications

Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation

(2013) Romain Barres et al.   Cell Reports

Dynamics of 5-Hydroxymethylcytosine and Chromatin Marks in Mammalian Neurogenesis

(2013) Maria A. Hahn et al.   Cell Reports

Base-Resolution Analyses of Sequence and Parent-of-Origin Dependent DNA Methylation in the Mouse Genome

(2012) Wei Xie et al.   CELL

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System

(2012) Marian Mellén et al.   CELL

Age-associated DNA methylation in pediatric populations

(2012) R. S. Alisch et al.   GENOME RESEARCH

The incidence and prevalence of Huntington's disease: A systematic review and meta-analysis

(2012) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development

(2012) Tomoko Ichiyanagi et al.   NUCLEIC ACIDS RESEARCH

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

(2012) Claudia Figueroa-Romero et al.   PLoS One

Distinct DNA methylomes of newborns and centenarians

(2012) H. Heyn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases

(2012) Julia Arand et al.   PLoS Genetics

The Role of MeCP2 in the Brain

(2011) Jacky Guy et al.   Annual Review of Cell and Developmental Biology

DNA methylation in repetitive elements and Alzheimer disease

(2011) V. Bollati et al.   BRAIN BEHAVIOR AND IMMUNITY

Lineage-specific distribution of high levels of genomic

(2011) Alexey Ruzov et al.   CELL RESEARCH

Tet1 Is Dispensable for Maintaining Pluripotency and Its Loss Is Compatible with Embryonic and Postnatal Development

(2011) Meelad M. Dawlaty et al.   Cell Stem Cell

Amyotrophic lateral sclerosis

(2011) Mamede de Carvalho et al.   CURRENT OPINION IN NEUROLOGY

Dynamic stage-specific changes in imprinted differentially methylated regions during early mammalian development and prevalence of non-CpG methylation in oocytes

(2011) S.-i. Tomizawa et al.   DEVELOPMENT

α-Synuclein Sequesters Dnmt1 from the Nucleus

(2011) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

(2011) B. A. Chestnut et al.   JOURNAL OF NEUROSCIENCE

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

(2011) Ryan Lister et al.   NATURE

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

(2011) Christopher J Klein et al.   NATURE GENETICS

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

Genomic Distribution and Inter-Sample Variation of Non-CpG Methylation across Human Cell Types

(2011) Michael J. Ziller et al.   PLoS Genetics

Integrating 5-Hydroxymethylcytosine into the Epigenomic Landscape of Human Embryonic Stem Cells

(2011) Keith E. Szulwach et al.   PLoS Genetics

Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

(2010) Martin Münzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure and Function of Mammalian DNA Methyltransferases

(2010) Renata Zofia Jurkowska et al.   CHEMBIOCHEM

Dynamic changes in the human methylome during differentiation

(2010) L. Laurent et al.   GENOME RESEARCH

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

(2010) Peter J. Skene et al.   MOLECULAR CELL

Relationship between nucleosome positioning and DNA methylation

(2010) Ramakrishna K. Chodavarapu et al.   NATURE

Epigenetic modifications and human disease

(2010) Anna Portela et al.   NATURE BIOTECHNOLOGY

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

(2010) Julie A. Law et al.   NATURE REVIEWS GENETICS

Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA

(2010) Aleksandra Szwagierczak et al.   NUCLEIC ACIDS RESEARCH

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density

(2009) Romain Barrès et al.   Cell Metabolism

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Evolving role of MeCP2 in Rett syndrome and autism

(2009) Janine M LaSalle et al.   Epigenomics

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability

(2008) Heike C. Pieper et al.   NEUROBIOLOGY OF DISEASE

Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease

(2008) Jan Gründemann et al.   NUCLEIC ACIDS RESEARCH

A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci

(2008) Robert Illingworth et al.   PLOS BIOLOGY