Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

Genetic causes of amyotrophic lateral sclerosis: New genetic analysis methodologies entailing new opportunities and challenges

(2015) Giuseppe Marangi et al.   BRAIN RESEARCH

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

(2014) Yong-Jie Zhang et al.   ACTA NEUROPATHOLOGICA

C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD

(2014) Elaine Y. Liu et al.   ACTA NEUROPATHOLOGICA

Quantifying disease progression in amyotrophic lateral sclerosis

(2014) Neil G. Simon et al.   ANNALS OF NEUROLOGY

C9orf72andUNC13Aare shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: A genome-wide meta-analysis

(2014) Frank P. Diekstra et al.   ANNALS OF NEUROLOGY

Aggregation of ALS-linked FUS mutant sequesters RNA binding proteins and impairs RNA granules formation

(2014) Keisuke Takanashi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reply: Mutations in the CHCHD10 gene are a common cause of familial amyotrophic lateral sclerosis

(2014) Sylvie Bannwarth et al.   BRAIN

Two novel mutations in conserved codons indicate that CHCHD10 is a gene associated with motor neuron disease

(2014) Kathrin Müller et al.   BRAIN

Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients

(2014) Veronique V. Belzil et al.   BRAIN RESEARCH

Glial epigenetics in neuroinflammation and neurodegeneration

(2014) Ori Staszewski et al.   CELL AND TISSUE RESEARCH

Common Ground: Stem Cell Approaches Find Shared Pathways Underlying ALS

(2014) Soledad Matus et al.   Cell Stem Cell

Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1

(2014) Michael Tibshirani et al.   HUMAN MOLECULAR GENETICS

Hypermethylation of the CpG-island near the C9orf72 G4C2-repeat expansion in FTLD patients

(2014) Zhengrui Xi et al.   HUMAN MOLECULAR GENETICS

The RNA-binding Protein TDP-43 Selectively Disrupts MicroRNA-1/206 Incorporation into the RNA-induced Silencing Complex

(2014) Isabelle N. King et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Emerging Roles of MicroRNAs in the Pathogenesis of Frontotemporal Dementia–Amyotrophic Lateral Sclerosis (FTD-ALS) Spectrum Disorders

(2014) Eduardo Gascon et al.   JOURNAL OF NEUROGENETICS

A Meta-Analysis of Observational Studies of the Association Between Chronic Occupational Exposure to Lead and Amyotrophic Lateral Sclerosis

(2014) Ming-Dong Wang et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study

(2014) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Genetic heterogeneity of amyotrophic lateral sclerosis: Implications for clinical practice and research

(2014) Xiaowei W. Su et al.   MUSCLE & NERVE

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

(2014) Janel O Johnson et al.   NATURE NEUROSCIENCE

miR-338-3p is over-expressed in blood, CFS, serum and spinal cord from sporadic amyotrophic lateral sclerosis patients

(2014) Bruna De Felice et al.   NEUROGENETICS

Analysis of Novel NEFL mRNA Targeting microRNAs in Amyotrophic Lateral Sclerosis

(2014) Muhammad Ishtiaq et al.   PLoS One

MicroRNA-206: A Potential Circulating Biomarker Candidate for Amyotrophic Lateral Sclerosis

(2014) Janne M. Toivonen et al.   PLoS One

Environmental Risk Factors and Amyotrophic Lateral Sclerosis (ALS): A Case-Control Study of ALS in Michigan

(2014) Yu Yu et al.   PLoS One

SUMO3 Modification Accelerates the Aggregation of ALS-Linked SOD1 Mutants

(2014) Takako Niikura et al.   PLoS One

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

(2014) I. Kwon et al.   SCIENCE

Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways

(2014) C Valle et al.   Cell Death & Disease

An ALS-associated mutation in the FUS 3′-UTR disrupts a microRNA–FUS regulatory circuitry

(2014) Stefano Dini Modigliani et al.   Nature Communications

RNA metabolism in ALS: When normal processes become pathological

(2014) Cristian A. Droppelmann et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

(2014) Elizabeth B. Moloney et al.   Frontiers in Neuroscience

Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion

(2013) Zhengrui Xi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Muscle histone deacetylase 4 upregulation in amyotrophic lateral sclerosis: potential role in reinnervation ability and disease progression

(2013) Gaëlle Bruneteau et al.   BRAIN

The molecular link between inefficient GluA2 Q/R site-RNA editing and TDP-43 pathology in motor neurons of sporadic amyotrophic lateral sclerosis patients

(2013) Takenari Yamashita et al.   BRAIN RESEARCH

Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2delivery to motor neurons

(2013) Takenari Yamashita et al.   EMBO Molecular Medicine

ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN

(2013) Ewout J.N. Groen et al.   HUMAN MOLECULAR GENETICS

Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice

(2013) Erica D. Koval et al.   HUMAN MOLECULAR GENETICS

TARDBPandFUSMutations Associated with Amyotrophic Lateral Sclerosis: Summary and Update

(2013) Serena Lattante et al.   HUMAN MUTATION

Sodium Phenylbutyrate Enhances Astrocytic Neurotrophin Synthesis via Protein Kinase C (PKC)-mediated Activation of cAMP-response Element-binding Protein (CREB)

(2013) Grant T. Corbett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

(2013) Lydie Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

The epidemiology of ALS: a conspiracy of genes, environment and time

(2013) Ammar Al-Chalabi et al.   Nature Reviews Neurology

The changing scene of amyotrophic lateral sclerosis

(2013) Wim Robberecht et al.   NATURE REVIEWS NEUROSCIENCE

Genetic analysis of SS18L1 in French amyotrophic lateral sclerosis

(2013) Elisa Teyssou et al.   NEUROBIOLOGY OF AGING

Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

(2013) Peter E.A. Ash et al.   NEURON

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis

(2013) Shuo-Chien Ling et al.   NEURON

Active DNA demethylation in post-mitotic neurons: A reason for optimism

(2013) David P. Gavin et al.   NEUROPHARMACOLOGY

Epigenetics of Alzheimer’s Disease and Frontotemporal Dementia

(2013) Chendhore S. Veerappan et al.   Neurotherapeutics

Improvement of Neuromuscular Synaptic Phenotypes without Enhanced Survival and Motor Function in Severe Spinal Muscular Atrophy Mice Selectively Rescued in Motor Neurons

(2013) Ximena Paez-Colasante et al.   PLoS One

Downregulation of MicroRNA-9 in iPSC-Derived Neurons of FTD/ALS Patients with TDP-43 Mutations

(2013) Zhijun Zhang et al.   PLoS One

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

(2013) C. Lagier-Tourenne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

(2013) D. Sareen et al.   Science Translational Medicine

Neuronal dark matter: the emerging role of microRNAs in neurodegeneration

(2013) Emily F. Goodall et al.   Frontiers in Cellular Neuroscience

Histone deacetylases and their role in motor neuron degeneration

(2013) Rafael Lazo-Gómez et al.   Frontiers in Cellular Neuroscience

miR-9: a versatile regulator of neurogenesis

(2013) Marion Coolen et al.   Frontiers in Cellular Neuroscience

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation

(2013) C Parisi et al.   Cell Death & Disease

Altered microRNA expression profile in amyotrophic lateral sclerosis: a role in the regulation of NFL mRNA levels

(2013) Danae Campos-Melo et al.   Molecular Brain

Genetic and epigenetic studies of amyotrophic lateral sclerosis

(2013) Ammar Al-Chalabi et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Whole-blood global DNA methylation is increased in amyotrophic lateral sclerosis independently of age of onset

(2013) Lucio Tremolizzo et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Characterization of early pathogenesis in the SOD1G93Amouse model of ALS: part I, background and methods

(2013) Sharon Vinsant et al.   Brain and Behavior

The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons

(2013) Daiyu Honda et al.   FEBS Open Bio

Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis

(2013) Axel Freischmidt et al.   Acta Neuropathologica Communications

Smoking, Alcohol Consumption, and the Risk of Amyotrophic Lateral Sclerosis: A Population-based Study

(2012) S. W. de Jong et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

SOD1, ANG, TARDBP and FUS mutations in amyotrophic lateral sclerosis: A United States clinical testing lab experience

(2012) Jeffrey A. Brown et al.   Amyotrophic Lateral Sclerosis

Recent Advances in the Genetics of the ALS-FTLD Complex

(2012) Huw R. Morris et al.   Current Neurology and Neuroscience Reports

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Prion-like spread of protein aggregates in neurodegeneration: Figure 1.

(2012) Magdalini Polymenidou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic mechanisms governing the process of neurodegeneration

(2012) Irfan A. Qureshi et al.   MOLECULAR ASPECTS OF MEDICINE

Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease

(2012) Paula Desplats et al.   Molecular Neurodegeneration

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis

(2012) Aaron P. Russell et al.   NEUROBIOLOGY OF DISEASE

5′-Aza-dC sensitizes paraquat toxic effects on PC12 cell

(2012) Min Kong et al.   NEUROSCIENCE LETTERS

Identification of Epigenetically Altered Genes in Sporadic Amyotrophic Lateral Sclerosis

(2012) Claudia Figueroa-Romero et al.   PLoS One

TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

(2012) Y. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA turnover: when, how, and why

(2012) Stefan Rüegger et al.   TRENDS IN BIOCHEMICAL SCIENCES

FUS-SMN Protein Interactions Link the Motor Neuron Diseases ALS and SMA

(2012) Tomohiro Yamazaki et al.   Cell Reports

Identification of RNA bound to the TDP-43 ribonucleoprotein complex in the adult mouse brain

(2012) Ramesh K. Narayanan et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Smoking and Risk of Amyotrophic Lateral Sclerosis

(2011) Hao Wang et al.   ARCHIVES OF NEUROLOGY

A novel nuclear miRNA mediated modulation of a non-coding antisense RNA and its cognate sense coding mRNA

(2011) John J Rossi   EMBO JOURNAL

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

Phenotypic heterogeneity of amyotrophic lateral sclerosis: a population based study

(2011) A. Chio et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3 

(2011) F. H. Bardai et al.   JOURNAL OF NEUROSCIENCE

Epigenetic Regulation of Motor Neuron Cell Death through DNA Methylation

(2011) B. A. Chestnut et al.   JOURNAL OF NEUROSCIENCE

Misfolded SOD1 forms high-density molecular complexes with synaptic molecules in mutant SOD1-linked familial amyotrophic lateral sclerosis cases

(2011) Toshiyuki Araki et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress

(2011) Jodi Meyerowitz et al.   Molecular Neurodegeneration

Amyotrophic lateral sclerosis and palliative care: Where we are, and the road ahead

(2011) Leslie J. Blackhall   MUSCLE & NERVE

Clinical diagnosis and management of amyotrophic lateral sclerosis

(2011) Orla Hardiman et al.   Nature Reviews Neurology

Profound downregulation of the RNA editing enzyme ADAR2 in ALS spinal motor neurons

(2011) Takuto Hideyama et al.   NEUROBIOLOGY OF DISEASE

Amyotrophic Lateral Sclerosis: What Role Does Environment Play?

(2011) Aiesha Ahmed et al.   NEUROLOGIC CLINICS

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

FUS and TARDBP but Not SOD1 Interact in Genetic Models of Amyotrophic Lateral Sclerosis

(2011) Edor Kabashi et al.   PLoS Genetics

A comparative analysis of DNA methylation across human embryonic stem cell lines

(2011) Pao-Yang Chen et al.   GENOME BIOLOGY

Association Between Blood Lead and the Risk of Amyotrophic Lateral Sclerosis

(2010) F. Fang et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Senataxin mutations and amyotrophic lateral sclerosis

(2010) Michio Hirano et al.   Amyotrophic Lateral Sclerosis

Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated

(2010) Mun-Kit Choy et al.   BMC GENOMICS

Association of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective study

(2010) Alvaro Alonso et al.   BMC Neurology

The Promise of MicroRNA Replacement Therapy

(2010) A. G. Bader et al.   CANCER RESEARCH

Nuclear factor TDP-43 can affect selected microRNA levels

(2010) Emanuele Buratti et al.   FEBS Journal

Dynamic changes in the human methylome during differentiation

(2010) L. Laurent et al.   GENOME RESEARCH

Amyotrophic Lateral Sclerosis-associated Proteins TDP-43 and FUS/TLS Function in a Common Biochemical Complex to Co-regulate HDAC6 mRNA

(2010) Sang Hwa Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An estimate of amyotrophic lateral sclerosis heritability using twin data

(2010) A. Al-Chalabi et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2010) A. Alonso et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Differential Histone Deacetylase mRNA Expression Patterns in Amyotrophic Lateral Sclerosis

(2010) Claas Janssen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

(2010) A. Jowaed et al.   JOURNAL OF NEUROSCIENCE

DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models☆☆☆

(2010) Andrea Fuso et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor

(2010) C. M. Dewey et al.   MOLECULAR AND CELLULAR BIOLOGY

Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production

(2010) Keita Miyoshi et al.   MOLECULAR GENETICS AND GENOMICS

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

The Association of Exposure to Lead, Mercury, and Selenium and the Development of Amyotrophic Lateral Sclerosis and the Epigenetic Implications

(2010) Brian Callaghan et al.   Neurodegenerative Diseases

Dementia and cognitive impairment in amyotrophic lateral sclerosis: a review

(2010) Maria Teresa Giordana et al.   NEUROLOGICAL SCIENCES

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

AMPA receptor-mediated neuronal death in sporadic ALS

(2010) Shin Kwak et al.   NEUROPATHOLOGY

MicroRNA-29b Regulates the Expression Level of Human Progranulin, a Secreted Glycoprotein Implicated in Frontotemporal Dementia

(2010) Jian Jiao et al.   PLoS One

TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity

(2010) Aaron Voigt et al.   PLoS One

Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue

(2010) Liqun Liu-Yesucevitz et al.   PLoS One

miRNA malfunction causes spinal motor neuron disease

(2010) S. Haramati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulated microRNAs in neurodegenerative disorders

(2010) Pierre Lau et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis

(2009) Julia M. Morahan et al.   Amyotrophic Lateral Sclerosis

Tar DNA binding protein of 43 kDa (TDP-43), 14-3-3 proteins and copper/zinc superoxide dismutase (SOD1) interact to modulate NFL mRNA stability. Implications for altered RNA processing in amyotrophic lateral sclerosis (ALS)

(2009) Kathryn Volkening et al.   BRAIN RESEARCH

An operational definition of epigenetics

(2009) S. L. Berger et al.   GENES & DEVELOPMENT

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

(2009) B. J. Turner et al.   HUMAN MOLECULAR GENETICS

Mutation withinTARDBPleads to Frontotemporal Dementia without motor neuron disease

(2009) B. Borroni et al.   HUMAN MUTATION

TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

(2009) Brian S. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOD1 and cognitive dysfunction in familial amyotrophic lateral sclerosis

(2009) P. Wicks et al.   JOURNAL OF NEUROLOGY

Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery

(2009) Brian D. Freibaum et al.   JOURNAL OF PROTEOME RESEARCH

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

(2009) Rocio G Urdinguio et al.   LANCET NEUROLOGY

ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis

(2009) Kohsuke Kanekura et al.   MOLECULAR NEUROBIOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Genetics of motor neuron disorders: new insights into pathogenic mechanisms

(2009) Patrick A. Dion et al.   NATURE REVIEWS GENETICS

Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo

(2009) A. D'Ambrogio et al.   NUCLEIC ACIDS RESEARCH

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice

(2009) C. S. Lobsiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

(2009) A. H. Williams et al.   SCIENCE

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Phase 2 study of sodium phenylbutyrate in ALS

(2008) Merit E. Cudkowicz et al.   Amyotrophic Lateral Sclerosis

Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice

(2008) Steven J. Del Signore et al.   Amyotrophic Lateral Sclerosis

Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline

(2008) Vincent Dion et al.   HUMAN MOLECULAR GENETICS

Variants of the elongator protein 3 ( ELP3 ) gene are associated with motor neuron degeneration

(2008) Claire L. Simpson et al.   HUMAN MOLECULAR GENETICS

Cause of death and clinical grading criteria in a cohort of amyotrophic lateral sclerosis cases undergoing autopsy from the Scottish Motor Neurone Disease Register

(2008) K M Kurian et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE