Increased 5-Methylcytosine and Decreased 5-Hydroxymethylcytosine Levels are Associated with Reduced Striatal A2AR Levels in Huntington’s Disease

Methylation Status of CpG Islands Flanking a cAMP Response Element Motif on the Protein Phosphatase 2Ac  Promoter Determines CREB Binding and Activity

(2014) K. Sunahori et al.   JOURNAL OF IMMUNOLOGY

Role of CpG context and content in evolutionary signatures of brain DNA methylation

(2012) Yurong Xin et al.   Epigenetics

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary

(2012) Tarang Khare et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity

(2012) Mónica Bañez-Coronel et al.   PLoS Genetics

5-Hydroxymethylcytosine, the Sixth Base of the Genome

(2011) Martin Münzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Functional changes in postsynaptic adenosine A2A receptors during early stages of a rat model of Huntington disease

(2011) Marco Orrú et al.   EXPERIMENTAL NEUROLOGY

Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease

(2011) Albert Giralt et al.   HUMAN MOLECULAR GENETICS

Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death

(2011) Yong-Joon Choi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

Next-Generation Sequencing Reveals Regional Differences of the α-Synuclein Methylation State Independent of Lewy Body Disease

(2011) L. de Boni et al.   NEUROMOLECULAR MEDICINE

Genomic mapping of 5-hydroxymethylcytosine in the human brain

(2011) Seung-Gi Jin et al.   NUCLEIC ACIDS RESEARCH

Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients

(2011) Masahiro Mishina et al.   PLoS One

A New Drug Design Targeting the Adenosinergic System for Huntington's Disease

(2011) Nai-Kuei Huang et al.   PLoS One

Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease

(2011) Maciej Pietrzak et al.   PLoS One

Role of Adenosine A2AReceptors in Modulating Synaptic Functions and Brain Levels of BDNF: a Possible Key Mechanism in the Pathophysiology of Huntington's Disease

(2011) Maria Teresa Tebano et al.   TheScientificWorldJOURNAL

Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

(2010) Martin Münzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA methylation and Yin Yang-1 repress adenosine A2A receptor levels in human brain

(2010) Sandra P. Buira et al.   JOURNAL OF NEUROCHEMISTRY

A DNA Methylation Study of the Amyloid Precursor Protein Gene in Several Brain Regions from Patients with Familial Alzheimer Disease

(2010) Jesper Brohede et al.   JOURNAL OF NEUROGENETICS

Activation of Adenosine A2A Receptors Induces TrkB Translocation and Increases BDNF-Mediated Phospho-TrkB Localization in Lipid Rafts: Implications for Neuromodulation

(2010) N. Assaife-Lopes et al.   JOURNAL OF NEUROSCIENCE

Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

(2010) A. Jowaed et al.   JOURNAL OF NEUROSCIENCE

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Cortical DNA methylation maintains remote memory

(2010) Courtney A Miller et al.   NATURE NEUROSCIENCE

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

(2010) Jian Feng et al.   NATURE NEUROSCIENCE

A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease

(2010) Stéphane Mievis et al.   NEUROBIOLOGY OF DISEASE

Age at onset in Huntington’s disease: replication study on the associations of ADORA2A, HAP1 and OGG1

(2010) Elahe Taherzadeh-Fard et al.   NEUROGENETICS

Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine

(2010) Seung-Gi Jin et al.   NUCLEIC ACIDS RESEARCH

CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

(2010) Lumine Matsumoto et al.   PLoS One

Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates

(2010) Daniel Globisch et al.   PLoS One

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum

(2009) A Saavedra et al.   CELL DEATH AND DIFFERENTIATION

A2A adenosine receptor overexpression and functionality, as well as TNF-α levels, correlate with motor symptoms in Parkinson’s disease

(2009) Katia Varani et al.   FASEB JOURNAL

The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin–proteasome system

(2009) Ming-Chang Chiang et al.   HUMAN MOLECULAR GENETICS

DNA methylation regulates adenosine A2Areceptor cell surface expression levels

(2009) Sandra P. Buira et al.   JOURNAL OF NEUROCHEMISTRY

DNA Methylation of Alzheimer Disease and Tauopathy-Related Genes in Postmortem Brain

(2009) Marta Barrachina et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease

(2009) Claire-Marie Dhaenens et al.   NEUROBIOLOGY OF DISEASE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

Brain banks: benefits, limitations and cautions concerning the use of post-mortem brain tissue for molecular studies

(2008) Isidre Ferrer et al.   CELL AND TISSUE BANKING

A Critical Evaluation of Adenosine A2A Receptors as Potentially “Druggable” Targets in Huntingtons Disease

(2008) Patrizia Popoli et al.   CURRENT PHARMACEUTICAL DESIGN

Dynamic changes in DNA methylation during thermal control establishment affect CREB binding to the brain-derived neurotrophic factor promoter

(2008) Maya Yossifoff et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability

(2008) Heike C. Pieper et al.   NEUROBIOLOGY OF DISEASE