RNA Editing, ADAR1, and the Innate Immune Response

ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis

(2016) Maria Anna Zipeto et al.   Cell Stem Cell

ADAR1-Mediated RNA Editing, A Novel Mechanism Controlling Phenotypic Modulation of Vascular Smooth Muscle CellsNovelty and Significance

(2016) Jia Fei et al.   CIRCULATION RESEARCH

Interferon Treatment for Hepatitis B

(2016) Monica A. Konerman et al.   Clinics in Liver Disease

Identification of the long, edited dsRNAome of LPS-stimulated immune cells

(2016) Matthew G. Blango et al.   GENOME RESEARCH

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

(2016) Konstantinos Stellos et al.   NATURE MEDICINE

RNA editing generates cellular subsets with diverse sequence within populations

(2016) Dewi Harjanto et al.   Nature Communications

ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury

(2016) Hui Wang et al.   Scientific Reports

ADAR1 Prevents Liver Injury from Inflammation and Suppresses Interferon Production in Hepatocytes

(2015) Guoliang Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

RNA editing of non-coding RNA and its role in gene regulation

(2015) Chammiran Daniel et al.   BIOCHIMIE

RNA editing by ADAR1 marks dsRNA as “self”

(2015) Zhou Yu et al.   CELL RESEARCH

Hepatitis B

(2015) Thinesh Lee Krishnamoorthy et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development

(2015) Kathleen Pestal et al.   IMMUNITY

Reduced adenosine-to-inosine miR-455-5p editing promotes melanoma growth and metastasis

(2015) Einav Shoshan et al.   NATURE CELL BIOLOGY

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

(2015) B. J. Liddicoat et al.   SCIENCE

Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity

(2015) Meghan M. Painter et al.   PLoS Pathogens

ADAR1, inosine and the immune sensing system: distinguishing self from non-self

(2015) Brian J. Liddicoat et al.   Wiley Interdisciplinary Reviews-RNA

Adenosine Deaminase Acting on RNA 1 Limits RIG-I RNA Detection and Suppresses IFN Production Responding to Viral and Endogenous RNAs

(2014) Shengyong Yang et al.   JOURNAL OF IMMUNOLOGY

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

(2014) Gillian I Rice et al.   NATURE GENETICS

A genome-wide map of hyper-edited RNA reveals numerous new sites

(2014) Hagit T. Porath et al.   Nature Communications

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

(2014) Niamh M. Mannion et al.   Cell Reports

A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

(2013) L. Bazak et al.   GENOME RESEARCH

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study

(2013) Gillian I Rice et al.   LANCET NEUROLOGY

ADAR1 regulates ARHGAP26 gene expression through RNA editing by disrupting miR-30b-3p and miR-573 binding

(2013) Q. Wang et al.   RNA

A-to-I editing of protein coding and noncoding RNAs

(2012) Arka Mallela et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

ADAR1 ablation decreases bone mass by impairing osteoblast function in mice

(2012) Shibing Yu et al.   GENE

Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice

(2012) Richard A. Steinman et al.   INTERNATIONAL JOURNAL OF CANCER

Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome

(2012) Zhiyu Peng et al.   NATURE BIOTECHNOLOGY

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

(2012) Gillian I Rice et al.   NATURE GENETICS

A-to-I RNA Editing: Effects on Proteins Key to Neural Excitability

(2012) Joshua J.C. Rosenthal et al.   NEURON

RNA editing catalyzed by ADAR1 and its function in mammalian cells

(2011) Qingde Wang   BIOCHEMISTRY-MOSCOW

Identification of Widespread Ultra-Edited Human RNAs

(2011) Shai Carmi et al.   PLoS Genetics

Alu elements: know the SINEs

(2011) Prescott Deininger   GENOME BIOLOGY

Functions and Regulation of RNA Editing by ADAR Deaminases

(2010) Kazuko Nishikura   Annual Review of Biochemistry

SnapShot: Pathways of Antiviral Innate Immunity

(2010) Lijun Sun et al.   CELL

Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome

(2010) Masayuki Sakurai et al.   Nature Chemical Biology

Double-stranded RNAs containing multiple IU pairs are sufficient to suppress interferon induction and apoptosis

(2010) Patrice Vitali et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis

(2010) S. V. Ward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ADAR editing in double-stranded UTRs and other noncoding RNA sequences

(2010) Heather A. Hundley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Editing independent effects of ADARs on the miRNA/siRNA pathways

(2009) Bret S E Heale et al.   EMBO JOURNAL

Genome-Wide Identification of Human RNA Editing Sites by Parallel DNA Capturing and Sequencing

(2009) J. B. Li et al.   SCIENCE

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

(2008) Karen A. Cavassani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

(2008) Jochen C Hartner et al.   NATURE IMMUNOLOGY

Frequency and fate of microRNA editing in human brain

(2008) Y. Kawahara et al.   NUCLEIC ACIDS RESEARCH

C. elegans and H. sapiens mRNAs with edited 3' UTRs are present on polysomes

(2008) H. A. Hundley et al.   RNA