Article
Cell Biology
Xin Zhou, Allyson Beilter, Zhaohui Xu, Ruli Gao, Shunbin Xiong, Adriana Paulucci-Holthauzen, Guillermina Lozano, Benoit de Crombrugghe, Richard Gorlick
Summary: This study identified chondrocytes as an additional source for mesenchymal progenitor cells (MPCs) and showed that Wnt/ss-catenin pathway discretely regulates the development from chondrocytes to C-MPC and subsequently from C-MPC to osteoblasts. Furthermore, the study unveiled a previously unrecognized functional link between ss-catenin and p53, with p53 playing a negative role in MPC osteogenic differentiation induced by Wnt/ss-catenin signaling.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Meiyu Piao, Sung Ho Lee, Myeong Ji Kim, Hyung Sik Kim, Kwang Youl Lee
Summary: YY2, a paralog of YY1, regulates osteoblast differentiation by upregulating the promoter activity of the osteogenic transcription factor Osx.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Myeong Ji Kim, Meiyu Piao, Yuankuan Li, Sung Ho Lee, Kwang Youl Lee
Summary: USP17 plays a critical role in regulating osteoblast differentiation by participating in the deubiquitination of Osx.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jialiang S. Wang, Tushar Kamath, Courtney M. Mazur, Fatemeh Mirzamohammadi, Daniel Rotter, Hironori Hojo, Christian D. Castro, Nicha Tokavanich, Rushi Patel, Nicolas Govea, Tetsuya Enishi, Yunshu Wu, Janaina da Silva Martins, Michael Bruce, Daniel J. Brooks, Mary L. Bouxsein, Danielle Tokarz, Charles P. Lin, Abdul Abdul, Evan Z. Macosko, Melissa Fiscaletti, Craig F. Munns, Pearl Ryder, Maria Kost-Alimova, Patrick Byrne, Beth Cimini, Makoto Fujiwara, Henry M. Kronenberg, Marc N. Wein
Summary: The study reveals that deletion of the Sp7 gene causes defects in osteocyte dendrites, with Sp7 and its target gene Osteocrin playing crucial roles in osteocytogenesis. Single-cell RNA-sequencing shows that Sp7 deficiency affects osteocyte maturation. Additionally, Sp7-dependent gene networks are associated with human skeletal diseases.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Wei Peng, Wenjuan Zhang, Qici Wu, Shunyou Cai, Tingting Jia, Jiarui Sun, Zhichao Lin, Gulimiran Alitongbieke, Yixuan Chen, Yi Su, Jinmei Lin, Lisheng Cai, Yuqin Sun, Yutian Pan, Yu Xue
Summary: The study reveals that Glucosamine hydrochloride extracted from the cell wall of Agaricus bisporus plays a dose-dependent role in promoting cartilage and bone development, as well as caudal fin regeneration in adult fish, by regulating the expression of bone-related genes. Furthermore, GAH improves osteoporosis defects induced by high iron and promotes skeletal development and injury repair through bone morphogenetic protein signaling at the downstream of the receptor level.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Endocrinology & Metabolism
Vappu Nieminen-Pihala, Kati Tarkkonen, Julius Laine, Petri Rummukainen, Lauri Saastamoinen, Kenichi Nagano, Roland Baron, Riku Kiviranta
Summary: Ebf1 plays a role in promoting early osteoblast differentiation by regulating Osterix expression, but inhibits bone accrual in vivo in Osterix-expressing osteoblasts and is redundant in the maintenance of mature osteoblast function.
Article
Multidisciplinary Sciences
Su-Hyeon Cho, Seongsin Lee, Jae-Il Park, Yoon La Yang, Song-Rae Kim, Juhee Ahn, Hoibin Jeong, Hye-Yeon Jung, Nayoung Gwak, Kil-Nam Kim, Yumi Kim
Summary: This study explores aging traits in turquoise killifish spines and finds that aged fish exhibit body shape deformations and increased vertebral collapse, similar to age-related spinal stenosis in humans. The study also identifies gene expression changes related to age and reproduction.
Article
Cell Biology
Jianmei Chen, Di Liu, Bo Chen, Yang Yang, Hongying Zhu, Danyang Li, Kun Liu, Lina Zhu, Hongrui Liu, Minqi Li, Xu Zhang, Xiangzhi Li
Summary: Mof plays a role in promoting osteoblast differentiation by increasing the expression of Runx2 and Osterix through histone H4K16 acetylation. Mof also directly interacts with Runx2 and Osterix to further enhance osteoblast differentiation.
CELL AND TISSUE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hermizi Hapidin, Nor Munira Hashim, Mohamad Zahid Kasiram, Hasmah Abdullah
Summary: This study investigates the effect of combining tannic acid with pamidronate on human osteoblast cells. The combination treatment showed synergistic effects, promoting osteoblast proliferation and mineralization, as well as increasing the expression of bone-specific proteins and genes.
Article
Multidisciplinary Sciences
Kulisara Marupanthorn, Chairat Tantrawatpan, Pakpoom Kheolamai, Duangrat Tantikanlayaporn, Sirikul Manochantr
Summary: This study investigates the effect of BMP-2 on osteogenic differentiation of chorion- and placenta-derived MSCs, showing that BMP-2 enhances osteogenic differentiation of MSCs and miRNAs play a regulatory role in this process.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yoshiki Omatsu, Shota Aiba, Tomonori Maeta, Kei Higaki, Kazunari Aoki, Hitomi Watanabe, Gen Kondoh, Riko Nishimura, Shu Takeda, Ung-il Chung, Takashi Nagasawa
Summary: The transcription factors Runx1 and Runx2 play critical roles in the cellular niches of hematopoietic stem cells (HSCs). Lack of these transcription factors in CAR cells is associated with increased fibrosis and reduced HSCs in bone marrow. Runx1 is predominantly expressed in CAR cells and is induced by the transcription factor Foxc1, which decreases fibrotic gene expression in CAR cells.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jun Sun, Lingling Hu, Seoyeon Bok, Alisha R. Yallowitz, Michelle Cung, Jason McCormick, Ling J. Zheng, Shawon Debnath, Yuzhe Niu, Adrian Y. Tan, Sarfaraz Lalani, Kyle W. Morse, Daniel Shinn, Anthony Pajak, Mohammed Hammad, Vincentius Jeremy Suhardi, Zan Li, Na Li, Lijun Wang, Weiguo Zou, Vivek Mittal, Mathias P. G. Bostrom, Ren Xu, Sravisht Iyer, Matthew B. Greenblatt
Summary: A study has identified a distinct type of spinal skeletal stem cells that play a crucial role in vertebral bone formation and contribute to the high rate of metastasis observed in breast cancer and other solid tumors.
Article
Engineering, Chemical
Chul Joong Kim, Bimal Kumar Ghimire, Seon Kang Choi, Chang Yeon Yu, Jae Geun Lee
Summary: This study aimed to explore and compare the coumarin-based compounds, antioxidant activities, and anti-osteoporotic properties of different G. littoralis extracts on bone metabolism. The results showed that stem extracts had the highest amount of scopoletin and umbelliferone, while fruit and whole plant extracts had the highest amounts of imperatorin and phellopterin, respectively. The extracts also affected the activity of MC3T3-E1 osteoblasts and the expression of osteocalcin, osterix, and RUNX2 genes.
Article
Multidisciplinary Sciences
Lin Jin, Mahendra P. Kashyap, Yunjia Chen, Jasim Khan, Yuanyuan Guo, Jari Q. Chen, Madison B. Lee, Zhiping Weng, Allen Oak, Prasanth Patcha, Tiffany Mayo, Rajesh Sinha, Venkatram Atigadda, Shahid M. Mukhtar, Jessy S. Deshane, Chander Raman, Carly Elston, Boni E. Elewski, Craig A. Elmets, Mohammad Athar
Summary: Our research has identified that the eIF4F protein complex plays a crucial role in the development of HS and the regulation of follicular hyperproliferation. Specifically, Cyclin D1 and c-MYC, which are translational targets of eIF4F, contribute to the development of HS-associated KA. The unique spatial localization and functions of Cyclin D1 and c-MYC provide insights into the oncogenic transformation and differentiation of epithelial cells in HS lesions.
Article
Biology
Leyao Shen, Yilin Yu, Yunji Zhou, Shondra M. Pruett-Miller, Guo-Fang Zhang, Courtney M. Karner
Summary: Cellular differentiation is associated with unique biosynthetic demands. Osteoblast differentiation requires increased proline demand, provided by SLC38A2, for efficient synthesis of osteoblast proteins.
Meeting Abstract
Endocrinology & Metabolism
Rohit B. Sharma, Xiaoying Zheng, Brian Gablaski, Jason K. Kim, Amy S. Lee, Laura C. Alonso
Meeting Abstract
Endocrinology & Metabolism
Ping Lu, Rohit B. Sharma, Laura C. Alonso, Ronghua Zhuge, Ann R. Rittenhouse, Agata Jurczyk
Article
Endocrinology & Metabolism
Rohit B. Sharma, Christine Darko, Xiaoying Zheng, Brian Gablaski, Laura C. Alonso
Article
Medicine, Research & Experimental
Changli Wei, Jing Li, Brian D. Adair, Ke Zhu, Jian Cai, Michael Merchant, Beata Samelko, Zhongji Liao, Kwi Hye Koh, Nicholas J. Tardi, Ranadheer R. Dande, Shuangxin Liu, Jianchao Ma, Salvatore Dibartolo, Stefan Hagele, Vasil Peev, Salim S. Hayek, David J. Cimbaluk, Melissa Tracy, Jon Klein, Sanja Sever, Sanford J. Shattil, M. Amin Arnaout, Jochen Reiser
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Meeting Abstract
Endocrinology & Metabolism
Rohit B. Sharma, Christine O. Darko, Brian Gablaski, Laura C. Alonso
Article
Rheumatology
Sudesh Pawaria, Kerstin Nundel, Kevin M. Gao, Stephanie Moses, Patricia Busto, Kevin Holt, Rohit B. Sharma, Michael A. Brehm, Ellen M. Gravallese, Merav Socolovsky, Anette Christ, Ann Marshak-Rothstein
ARTHRITIS & RHEUMATOLOGY
(2020)
Review
Endocrinology & Metabolism
Rohit B. Sharma, Jarin T. Snyder, Laura C. Alonso
MOLECULAR METABOLISM
(2019)
Article
Multidisciplinary Sciences
Ke Zhu, Yumei Lai, Huiling Cao, Xiaochun Bai, Chuanju Liu, Qinnan Yan, Liting Ma, Di Chen, Giedrius Kanaporis, Junqi Wang, Luyuan Li, Tao Cheng, Yong Wang, Chuanyue Wu, Guozhi Xiao
NATURE COMMUNICATIONS
(2020)
Meeting Abstract
Endocrinology & Metabolism
Rachel E. Stamateris, Rohit B. Sharma, Brian Gablaski, Sushil G. Rane, Laura C. Alonso
Meeting Abstract
Endocrinology & Metabolism
Rohit B. Sharma, Christine O. Darko, Brian Gablaski, Amy S. Lee, Laura C. Alonso
Article
Biochemistry & Molecular Biology
Rohit B. Sharma, Christine Darko, Laura C. Alonso
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Urology & Nephrology
Onur K. Polat, Elena Isaeva, Yashwanth R. Sudhini, Brenna Knott, Ke Zhu, Manuel Noben, Varsha Suresh Kumar, Nicole Endlich, Steve Mangos, Tejasree Vallapu Reddy, Beata Samelko, Changli Wei, Mehmet M. Altintas, Stuart E. Dryer, Sanja Sever, Alexander Staruschenko, Jochen Reiser
Summary: Transient receptor potential canonical channels (TRPCs), including TRPC5, have been implicated in signal transduction. However, the role of TRPC5 in kidney physiology and pathophysiology remains controversial. This study suggests that TRPC5 does not play a significant role in podocyte injury and proteinuria, and is unlikely to be a therapeutic target for podocytopathies.
KIDNEY INTERNATIONAL
(2023)
Editorial Material
Endocrinology & Metabolism
Ke Zhu, Jochen Reiser
Summary: Diabetic kidney disease is affected by both genetic and environmental factors. A recent study has identified risk variants in the XOR promoter that increase its own activity in response to high blood sugar levels, which play a causative role in the development and progression of diabetic kidney disease.
Article
Cell Biology
Ke Zhu, Kamalika Mukherjee, Changli Wei, Salim S. Hayek, Agnieszka Collins, Changkyu Gu, Kristin Corapi, Mehmet M. Altintas, Yong Wang, Sushrut S. Waikar, Antonio C. Bianco, Alexander Koch, Frank Tacke, Jochen Reiser, Sanja Sever
Summary: D2D3 protein is associated with kidney diseases and insulin-dependent diabetes mellitus. It impairs the function of pancreatic beta cells and the kidneys, and targeting this protein could potentially provide a therapy.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Hongli Jiao, Brian E. Walczak, Ming-Song Lee, Madeleine E. Lemieux, Wan-Ju Li
Summary: Cellular reprogramming can reverse aging of cells by altering the activities of regulatory networks associated with inflammation and proliferation. The expression of GATA6 in reprogrammed cells is attenuated, leading to an increase in sonic hedgehog signaling and FOXP1 expression, which ameliorates cellular hallmarks of aging. GATA6 is identified as a critical regulator of aging-related activities in MSCs, controlling the downstream pathways to modulate cellular senescence.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.