Review
Biochemistry & Molecular Biology
Justine Bonetti, Alessandro Corti, Lucie Lerouge, Alfonso Pompella, Caroline Gaucher
Summary: Monocytes/macrophages and vascular smooth muscle cells (vSMCs) play key roles in atherosclerosis development and exhibit plasticity in response to environmental changes; vSMCs can switch from a contractile to a secretory phenotype and display macrophage characteristics, contributing to foam cell formation in atherosclerotic plaques. Nitric oxide levels impact molecular pathways involved in these processes, suggesting potential therapeutic targets for further exploration.
Article
Hematology
Ran Ran, Dunpeng Cai, Skylar D. King, Xingyi Que, Jonathan M. Bath, Shi-You Chen
Summary: The study revealed that SPA plays a crucial role in SMC phenotype modulation and vascular remodeling, with SPA deficiency leading to increased expression of contractile proteins. Blocking the abnormal elevation of SPA could be a potential strategy to inhibit the development of proliferative vascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yulong Song, Xiuju He, Wenbing Yang, Yaoxing Wu, Jun Cui, Tian Tang, Rui Zhang
Summary: This study developed an editing identification pipeline specifically for RNA viruses and constructed an atlas of A-to-I RNA editing sites in SARS-CoV-2 from diverse samples. The findings showed that A-to-I editing was dynamically regulated, varied between tissue and cell types, and correlated with the intensity of innate immune response. Additionally, editing hotspots were observed, including recoding sites in the spike gene that affect viral infectivity and antigenicity. The study also provided evidence that RNA editing accelerated SARS-CoV-2 evolution in humans during the epidemic.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Tony Sun, Yingpu Yu, Xianfang Wu, Ashley Acevedo, Ji-Dung Luo, Jiayi Wang, William M. Schneider, Brian Hurwitz, Brad R. Rosenberg, Hachung Chung, Charles M. Rice
Summary: Defective ADAR1 editing can lead to disorders, with the two protein isoforms p150 and p110 showing different contributions to RNA editing. The challenges in expressing p150 without p110 may explain the differences in editing landscape between the two isoforms.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, Yuan Chen, Xusheng Yang, Xueyi Liao, Muhua He, Zihui Jia, Jun Fan, Jin-Song Bian, Xiaowei Nie
Summary: This study demonstrates that ADAR1 contributes to the development of PH through the m1A modification of circCDK17 and subsequent proliferation of PASMCs. The findings provide a novel therapeutic strategy for treating PH and identify circCDK17 as a potential new marker for the diagnosis of this disease.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zeyu Cai, Ze Gong, Zhiqing Li, Li Li, Wei Kong
Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Biochemistry & Molecular Biology
Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Karim J. Brandt, Kapka Miteva
Summary: The study demonstrated that oxLDL-activated monocytes can directly affect VSMCs in a co-culture system, leading to reduced expression of certain markers and upregulation of others, as well as activation of caspase 1, secretion of IL-1 beta, and pyroptosis in VSMCs. The activation of VSMC NLRP3 inflammasome by monocytes may play a detrimental role in atherosclerotic plaque stability in human atherosclerosis, as evidenced by findings in both mice and human atherosclerotic plaques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Slaven Crnkovic, Francesco Valzano, Elisabeth Fliesser, Juergen Gindlhuber, Helene Thekkekara Puthenparampil, Maria Basil, Mike P. Morley, Jeremy Katzen, Elisabeth Gschwandtner, Walter Klepetko, Edward Cantu, Heimo Wolinski, Horst Olschewski, Joerg Lindenmann, You-Yang Zhao, Edward E. Morrisey, Leigh M. Marsh, Grazyna Kwapiszewska
Summary: This study utilized single-cell RNA sequencing to reveal cellular composition changes in pulmonary arterial hypertension and donor lungs. The results showed that remodeling altered communication between immune and structural cells, especially smooth muscle cells. Different populations of smooth muscle cells were enriched in specific biological processes and associated with the development of vascular remodeling.
Article
Cardiac & Cardiovascular Systems
Shan-Hu Cao, Zhi-Huan Chen, Ru-Yuan Ma, Lin Yue, Han-Mei Jiang, Li-Hua Dong
Summary: In this study, modified omics and proteomic analysis were used to investigate the role of nonhistone protein crotonylation and ubiquitination in vascular smooth muscle cell (VSMC) phenotypic remodeling. The results revealed that crotonylation and ubiquitination play important roles in VSMC phenotypic transformation induced by PDGF-BB stimulation. The cross talk between crotonylation and ubiquitination in glycolysis may be a novel mechanism during VSMC phenotypic remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Jizhe Liu, Fei Wang, Yindan Zhang, Jingfeng Liu, Bixing Zhao
Summary: RNA stability, RNA-protein interaction, and correct protein translation are significant forces in driving the transition from normal cell to malignant tumor. ADAR1 is an RNA editing enzyme that modifies the transcriptome by catalyzing the deamination of adenosine to inosine. Dysregulation of ADAR1 can lead to aberrant editing and affect phenotypic changes in cancer. ADAR1's overediting phenomenon is observed in many cancers and promotes tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Tingyu Zong, Yanyan Yang, Xiaotong Lin, Shaoyan Jiang, Hui Zhao, Meixin Liu, Yuanyuan Meng, Yong Li, Liang Zhao, Guozhang Tang, Kun Gong, Zhibin Wang, Tao Yu
Summary: The study demonstrates that 5'-tiRNA-Cys-GCA is involved in the pathogenesis of aortic dissection, regulating the abnormal proliferation, migration, and phenotypic transition of VSMCs. Furthermore, 5'-tiRNA-Cys-GCA exerts its effects by inhibiting the STAT4 signaling pathway, reducing the incidence of aortic dissection and preventing its malignant progression.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Xiaowei Nie, Chenyou Shen, Jianxin Tan, Xusheng Yang, Wei Wang, Youai Dai, Haijian Sun, Zhiyuan Wu, Jingyu Chen
Summary: The study demonstrated that Andrographolide (ANDRO) may reverse pulmonary vascular remodeling through modulation of NOX/Nrf2-mediated oxidative stress and NF-kappa B-mediated inflammation, suggesting therapeutic potential in the treatment of pulmonary hypertension.
Review
Cell Biology
Jiali Yao, Linqian Cai, Yingrui Chen, Jie Zhang, Wenwen Zhuang, Jingyan Liang, Hongliang Li
Summary: This review discusses the impact of Exosomes on atherosclerosis (AS) from different perspectives, focusing on the phenotypic transition of vascular smooth muscle cells (VSMCs). It provides insights into the current status and potential future directions in this field, offering new ideas for clinical research and treatment of AS.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Karim J. Brandt, Fabienne Burger, Daniela Baptista, Aline Roth, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Kapka Miteva
Summary: The study revealed the crucial role of GDF10 in the phenotypic switch of VSMCs, which may have a detrimental impact on the stability of atherosclerotic plaques and increase the risk of carotid artery disease (CAD) events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Xia Guo, Ning Shi, Xiao-Bing Cui, Jia-Ning Wang, Yoshinori Fukui, Shi-You Chen
CIRCULATION RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Cheng Wang, Jianyan Wen, Yun Zhou, Li Li, Xiaobing Cui, Jinyu Wang, Lin Pan, Zhidong Ye, Peng Liu, Liling Wu
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Xiao-Bing Cui, Jun-Na Luan, Shi-You Chen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Hematology
Rui Tang, Xiao-Bing Cui, Jia-Ning Wang, Shi-You Chen
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Xiao-Bing Cui, Cheng Wang, Li Li, Dong Fan, Yun Zhou, Dan Wu, Qing-Hua Cui, Feng-Ying Fu, Li-Ling Wu
CARDIOVASCULAR RESEARCH
(2012)
Article
Cardiac & Cardiovascular Systems
Li Li, Dong Fan, Cheng Wang, Jin-Yu Wang, Xiao-Bing Cui, Dan Wu, Yun Zhou, Li-Ling Wu
CARDIOVASCULAR RESEARCH
(2011)
Article
Cardiac & Cardiovascular Systems
Xiao-Bing Cui, Xia Guo, Shi-You Chen
CARDIOVASCULAR RESEARCH
(2013)
Article
Cell Biology
Dong Fan, Li Li, Cheng Wang, Xiao-Bing Cui, Yun Zhou, Li-Ling Wu
JOURNAL OF CELLULAR PHYSIOLOGY
(2011)
Article
Endocrinology & Metabolism
Xiao-Bing Cui, Jun-Na Luan, Jianping Ye, Shi-You Chen
JOURNAL OF ENDOCRINOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Li Li, Yun Zhou, Cheng Wang, Ya-Li Zhao, Zhi-Guo Zhang, Dong Fan, Xiao-Bing Cui, Li-Ling Wu
Article
Pharmacology & Pharmacy
Jinfei Li, Wei Wang, Yuan Yuan, Xiaobing Cui, Huimin Bian, Hongmei Wen, Xingde Zhang, Hongli Yu, Hao Wu
Summary: Pinellia ternata, a traditional Chinese medicine, contains a strong mucosal irritant called Pinellia ternata lectin (PTL). This study found that PTL activates the PI3K/Akt/mTOR and NF-kappa B pathways, leading to inflammation by releasing proinflammatory cytokines. PTL was shown to bind Toll-like receptor 4 (TLR4) and mediate inflammation through the PI3K/Akt/mTOR pathway.
Article
Hematology
Yung-Chun Wang, Xiao-Bing Cui, Ya-Hui Chuang, Shi-You Chen
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2017)
Article
Hematology
Ning Shi, Chen-Xiao Li, Xiao-Bing Cui, Stanislav I. Tomarev, Shi-You Chen
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2017)