标题
Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target
作者
关键词
-
出版物
Frontiers in Physiology
Volume 8, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2017-06-30
DOI
10.3389/fphys.2017.00460
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Enhanced Expression of the Voltage-Dependent Anion Channel 1 (VDAC1) in Alzheimer's Disease Transgenic Mice: An Insight into the Pathogenic Effects of Amyloid-β
- (2018) Mar Cuadrado-Tejedor et al. JOURNAL OF ALZHEIMERS DISEASE
- Reduced VDAC1 Protects Against Alzheimer's Disease, Mitochondria, and Synaptic Deficiencies
- (2018) Maria Manczak et al. JOURNAL OF ALZHEIMERS DISEASE
- Update on the Neuroprotective Effect of Estrogen Receptor Alpha Against Alzheimer's Disease
- (2018) Yu-Long Lan et al. JOURNAL OF ALZHEIMERS DISEASE
- Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening
- (2017) Hao Zhou et al. Journal of the American Heart Association
- Recombinant Human Voltage Dependent Anion Selective Channel Isoform 3 (hVDAC3) Forms Pores with a Very Small Conductance
- (2017) Vanessa Checchetto et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins
- (2016) Mariusz Jaremko et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- VDAC electronics: 3. VDAC-Creatine kinase-dependent generation of the outer membrane potential in respiring mitochondria
- (2016) Victor V. Lemeshko BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Current state of theoretical and experimental studies of the voltage-dependent anion channel (VDAC)
- (2016) Sergei Yu. Noskov et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Mitochondria-Targeted Analogues of Metformin Exhibit Enhanced Antiproliferative and Radiosensitizing Effects in Pancreatic Cancer Cells
- (2016) Gang Cheng et al. CANCER RESEARCH
- MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression
- (2016) Amrita Datta Chaudhuri et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ROS homeostasis and metabolism: a dangerous liason in cancer cells
- (2016) E Panieri et al. Cell Death & Disease
- Mitochondria-Associated Membranes: Composition, Molecular Mechanisms, and Physiopathological Implications
- (2015) Carlotta Giorgi et al. ANTIOXIDANTS & REDOX SIGNALING
- VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore
- (2015) Masateru Okazaki et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- The mitochondrial voltage-dependent anion channel 1 in tumor cells
- (2015) Varda Shoshan-Barmatz et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Bim and VDAC1 are hierarchically essential for mitochondrial ATF2 mediated cell death
- (2015) Zhaoyun Liu et al. Cancer Cell International
- The SR/ER-mitochondria calcium crosstalk is regulated by GSK3β during reperfusion injury
- (2015) L Gomez et al. CELL DEATH AND DIFFERENTIATION
- Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells
- (2015) Ewa Kwiatkowska et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- The Voltage-dependent Anion Channel 1 Mediates Amyloid β Toxicity and Represents a Potential Target for Alzheimer Disease Therapy
- (2015) Angela Smilansky et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells
- (2015) Li Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology
- (2015) Paolo Bernardi et al. PHYSIOLOGICAL REVIEWS
- Plasmalemmal VDAC-1 corroborated as amyloid Aß-receptor
- (2015) Friedrich P. Thinnes Frontiers in Aging Neuroscience
- After all, plasmalemmal expression of type-1 VDAC can be understood. Phosphorylation, nitrosylation, and channel modulators work together in vertebrate cell volume regulation and either apoptotic pathway
- (2015) Friedrich P. Thinnes Frontiers in Physiology
- Dual Mechanism of Ion Permeation through VDAC Revealed with Inorganic Phosphate Ions and Phosphate Metabolites
- (2015) Eva-Maria Krammer et al. PLoS One
- Transient complex I inhibition at the onset of reperfusion by extracellular acidification decreases cardiac injury
- (2014) Aijun Xu et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- 3-Bromopyruvic Acid, A Hexokinase II Inhibitor, is an Effective Antitumor Agent on the Hepatoma Cells : in vitro and in vivo Findings
- (2014) Lei Gong et al. Anti-Cancer Agents in Medicinal Chemistry
- Mitochondrial import and degradation of amyloid-β peptide
- (2014) Catarina Moreira Pinho et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- VDAC electronics: 2. A new, anaerobic mechanism of generation of the membrane potentials in mitochondria
- (2014) Victor V. Lemeshko BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- VDAC electronics: 1. VDAC-hexo(gluco)kinase generator of the mitochondrial outer membrane potential
- (2014) Victor V. Lemeshko BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Acidification Asymmetrically Affects Voltage-dependent Anion Channel Implicating the Involvement of Salt Bridges
- (2014) Oscar Teijido et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Channel Formation by Yeast F-ATP Synthase and the Role of Dimerization in the Mitochondrial Permeability Transition
- (2014) Michela Carraro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genetic manipulation of the cardiac mitochondrial phosphate carrier does not affect permeability transition
- (2014) Manuel Gutiérrez-Aguilar et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- VDAC phosphorylation, a lipid sensor influencing the cell fate
- (2014) Cécile Martel et al. MITOCHONDRION
- Mitochondrial substrates in cancer: Drivers or passengers?
- (2014) Björn Kruspig et al. MITOCHONDRION
- ATP/ADP ratio, the missed connection between mitochondria and the Warburg effect
- (2014) Eduardo N. Maldonado et al. MITOCHONDRION
- Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1
- (2014) Om P Choudhary et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer’s disease
- (2014) C. Fernandez-Echevarria et al. NEUROSCIENCE
- Mitochondrial ion channels as oncological targets
- (2014) L Leanza et al. ONCOGENE
- Reversible Blockade of Complex I or Inhibition of PKCβ Reduces Activation and Mitochondria Translocation of p66Shc to Preserve Cardiac Function after Ischemia
- (2014) Meiying Yang et al. PLoS One
- An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore
- (2014) K. N. Alavian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Silencing VDAC1 Expression by siRNA Inhibits Cancer Cell Proliferation and Tumor Growth In Vivo
- (2014) Tasleem Arif et al. Molecular Therapy-Nucleic Acids
- ATP Transport through VDAC and the VDAC–Tubulin Complex Probed by Equilibrium and Nonequilibrium MD Simulations
- (2013) Sergei Yu. Noskov et al. BIOCHEMISTRY
- Molecular origin of VDAC selectivity towards inorganic ions: A combined molecular and Brownian dynamics study
- (2013) Eva-Maria Krammer et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- MAM (mitochondria-associated membranes) in mammalian cells: Lipids and beyond
- (2013) Jean E. Vance BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- RNA silencing of genes involved in Alzheimer's disease enhances mitochondrial function and synaptic activity
- (2013) Maria Manczak et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage
- (2013) P. Hemachandra Reddy BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Voltage-dependent anion channels (VDACs, porin) expressed in the plasma membrane regulate the differentiation and function of human osteoclasts
- (2013) Shigeru Kotake et al. CELL BIOLOGY INTERNATIONAL
- Role of the c subunit of the FOATP synthase in mitochondrial permeability transition
- (2013) Massimo Bonora et al. CELL CYCLE
- Hexokinase II and Reperfusion Injury
- (2013) Philippe Pasdois et al. CIRCULATION RESEARCH
- Targeting VDAC-bound hexokinase II: a promising approach for concomitant anti-cancer therapy
- (2013) George S Krasnov et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Akt Phosphorylates HK-II at Thr-473 and Increases Mitochondrial HK-II Association to Protect Cardiomyocytes
- (2013) David J. Roberts et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- An Interaction between Bcl-xLand the Voltage-dependent Anion Channel (VDAC) Promotes Mitochondrial Ca2+Uptake
- (2013) Huiya Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Voltage-dependent Anion Channels Modulate Mitochondrial Metabolism in Cancer Cells
- (2013) Eduardo N. Maldonado et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
- (2013) Edward T Chouchani et al. NATURE MEDICINE
- Differential S-nitrosylation of proteins in Alzheimer’s disease
- (2013) S. Zahid et al. NEUROSCIENCE
- Dimers of mitochondrial ATP synthase form the permeability transition pore
- (2013) V. Giorgio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial Permeability Transition and Cell Death: The Role of Cyclophilin D
- (2013) Sabzali Javadov et al. Frontiers in Physiology
- Structure-based analysis of VDAC1: N-terminus location, translocation, channel gating and association with anti-apoptotic proteins
- (2012) Shay Geula et al. BIOCHEMICAL JOURNAL
- Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging
- (2012) Meiying Yang et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome
- (2012) Rita Guzun et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Is the mitochondrial outermembrane protein VDAC1 therapeutic target for Alzheimer's disease?
- (2012) P. Hemachandra Reddy BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Disruption of the VDAC2–Bak interaction by Bcl-xS mediates efficient induction of apoptosis in melanoma cells
- (2012) M Plötz et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial VDAC1: Function in Cell Life and Death and a Target for Cancer Therapy
- (2012) V. Shoshan-Barmatz et al. CURRENT MEDICINAL CHEMISTRY
- Glycogen synthase kinase 3-mediated voltage-dependent anion channel phosphorylation controls outer mitochondrial membrane permeability during lipid accumulation
- (2012) Cecile Martel et al. HEPATOLOGY
- Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease
- (2012) M. Manczak et al. HUMAN MOLECULAR GENETICS
- Mediation of the Antiapoptotic Activity of Bcl-xL Protein upon Interaction with VDAC1 Protein
- (2012) Nir Arbel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clotrimazole Preferentially Inhibits Human Breast Cancer Cell Proliferation, Viability and Glycolysis
- (2012) Cristiane M. Furtado et al. PLoS One
- β-Barrel Mobility Underlies Closure of the Voltage-Dependent Anion Channel
- (2012) Ulrich Zachariae et al. STRUCTURE
- Damage to mitochondrial complex I during cardiac ischemia reperfusion injury is reduced indirectly by anti-anginal drug ranolazine
- (2011) Ashish K. Gadicherla et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- VDAC inhibition by tubulin and its physiological implications
- (2011) Tatiana K. Rostovtseva et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Calcium signaling around Mitochondria Associated Membranes (MAMs)
- (2011) Simone Patergnani et al. Cell Communication and Signaling
- VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria
- (2011) D De Stefani et al. CELL DEATH AND DIFFERENTIATION
- Targeting mitochondria as a therapeutic target in cancer
- (2011) Charles E. Wenner JOURNAL OF CELLULAR PHYSIOLOGY
- Identification of Bax-voltage-dependent anion channel 1 complexes in digitonin-solubilized cerebellar granule neurons
- (2011) Dennis B. Huckabee et al. JOURNAL OF NEUROCHEMISTRY
- The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore
- (2011) Pinadda Varanyuwatana et al. MITOCHONDRION
- Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts
- (2011) Mohammed Aldakkak et al. PHARMACOLOGICAL RESEARCH
- Mitochondrial Approaches to Protect Against Cardiac Ischemia and Reperfusion Injury
- (2011) Amadou K. S. Camara et al. Frontiers in Physiology
- The Native Conformation of the Human VDAC1 N Terminus
- (2010) Robert Schneider et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Closure of VDAC causes oxidative stress and accelerates the Ca2+-induced mitochondrial permeability transition in rat liver mitochondria
- (2010) Andrey Tikunov et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Isolating the segment of the mitochondrial electron transport chain responsible for mitochondrial damage during cardiac ischemia
- (2010) Qun Chen et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Peroxynitrite-Mediated Oxidative Modifications of Complex II: Relevance in Myocardial Infarction
- (2010) Liwen Zhang et al. BIOCHEMISTRY
- Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo
- (2010) Varda Shoshan-Barmatz et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Characterization of human VDAC isoforms: A peculiar function for VDAC3?
- (2010) Vito De Pinto et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- VDAC3 has differing mitochondrial functions in two types of striated muscles
- (2010) Keltoum Anflous-Pharayra et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Free Tubulin Modulates Mitochondrial Membrane Potential in Cancer Cells
- (2010) E. N. Maldonado et al. CANCER RESEARCH
- Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel
- (2010) Qunli Cheng et al. FEBS LETTERS
- Voltage-dependent anion-selective channel (VDAC) in the plasma membrane
- (2010) Vito De Pinto et al. FEBS LETTERS
- Regulation of the Inner Membrane Mitochondrial Permeability Transition by the Outer Membrane Translocator Protein (Peripheral Benzodiazepine Receptor)
- (2010) Justina Šileikytė et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of Bak Activation by VDAC2 Is Dependent on the Bak Transmembrane Anchor
- (2010) Michael Lazarou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oligomerization of the Mitochondrial Protein Voltage-Dependent Anion Channel Is Coupled to the Induction of Apoptosis
- (2010) N. Keinan et al. MOLECULAR AND CELLULAR BIOLOGY
- Functional dynamics in the voltage-dependent anion channel
- (2010) S. Villinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Potential Therapeutic Benefits of Strategies Directed to Mitochondria
- (2009) Amadou K.S. Camara et al. ANTIOXIDANTS & REDOX SIGNALING
- Cardioprotection and altered mitochondrial adenine nucleotide transport
- (2009) Charles Steenbergen et al. BASIC RESEARCH IN CARDIOLOGY
- The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins
- (2009) S. Abu-Hamad et al. JOURNAL OF CELL SCIENCE
- Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3β-dependent attenuation of mitochondrial dysfunction
- (2009) Sabzali Javadov et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Mitochondrial Permeability Transition Pore Opening as a Promising Therapeutic Target in Cardiac Diseases
- (2009) S. Javadov et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The published 3D structure of the VDAC channel: native or not?
- (2009) Marco Colombini TRENDS IN BIOCHEMICAL SCIENCES
- Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase
- (2008) Varda Shoshan-Barmatz et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Cardioprotection by N -Acetylglucosamine Linkage to Cellular Proteins
- (2008) Steven P. Jones et al. CIRCULATION
- Glycogen Synthase Kinase 3 Inhibition Slows Mitochondrial Adenine Nucleotide Transport and Regulates Voltage-Dependent Anion Channel Phosphorylation
- (2008) Samarjit Das et al. CIRCULATION RESEARCH
- Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis
- (2008) Shaopeng Yuan et al. FASEB JOURNAL
- Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding
- (2008) Annette H. Erbse et al. FEBS Journal
- Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents
- (2008) Eriko Simamura et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- The Mitochondrial Phosphate Carrier Interacts with Cyclophilin D and May Play a Key Role in the Permeability Transition
- (2008) Anna W. C. Leung et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hexokinase-I Protection against Apoptotic Cell Death Is Mediated via Interaction with the Voltage-dependent Anion Channel-1
- (2008) Salah Abu-Hamad et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enhanced Na+/H+ Exchange During Ischemia and Reperfusion Impairs Mitochondrial Bioenergetics and Myocardial Function
- (2008) Mohammed Aldakkak et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Disruption of the hexokinase–VDAC complex for tumor therapy
- (2008) L Galluzzi et al. ONCOGENE
- Hexokinase II Detachment from Mitochondria Triggers Apoptosis through the Permeability Transition Pore Independent of Voltage-Dependent Anion Channels
- (2008) Federica Chiara et al. PLoS One
- Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration
- (2008) T. K. Rostovtseva et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structure of the human voltage-dependent anion channel
- (2008) M. Bayrhuber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating
- (2008) R. Ujwal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The amyloid -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae
- (2008) C. A. Hansson Petersen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles
- (2008) S. Hiller et al. SCIENCE
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