Review
Biochemistry & Molecular Biology
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jerome Estaquier, Germain Gillet, Isabelle Guenal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stephen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernar Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Lu Poyet, Muriel Priault, Jean-Ehrlan Ricci, Franck B. Riquet, Santos A. Susin, Magal Suzanne, Pierre Vacher, Ludivine Walter, Bertran Mollereau
Summary: Since the Nobel Prize was awarded more than twenty years ago for discovering the core apoptotic pathway in C. elegans, researchers around the world have conducted extensive research on apoptosis and various other forms of regulated cell death. Although there are still many aspects of regulated cell death that need to be clarified in specific cell subtypes and disease conditions, the last decade has seen the description of multiple cell death modalities, some of which have been successfully used in clinical therapy. To keep research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN), which is at the forefront of emerging topics in cell death research. These research efforts will enhance our mechanistic knowledge of regulated cell death and its therapeutic applications in the coming years.
Article
Cell Biology
Vanessa F. Langness, Rik van der Kant, Utpal Das, Louie Wang, Rodrigo dos Santos Chaves, Lawrence S. B. Goldstein
Summary: This study demonstrates that statins can reduce the production of Aβ in human neurons by altering cholesterol metabolism, indicating a potential therapeutic approach for Alzheimer's disease.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Review
Cell Biology
Elizabeth G. Ames, Jess G. Thoene
Summary: Cystinosis is a lethal genetic disease with specific treatments. The cellular mechanisms are still unknown, but programmed cell death and apoptosis may be involved. Studies have shown that apoptosis rate is increased in cystinosis, but can be partially reversed with cysteamine.
Article
Cell Biology
Siyu Yuan, Can Wei, Guofang Liu, Lijun Zhang, Jiahao Li, Lingling Li, Shiyi Cai, Ling Fang
Summary: Sorafenib alleviates liver injury and fibrosis by inducing HSC ferroptosis through the HIF-1 alpha/SLC7A11 signaling pathway. Ferroptotic events triggered by sorafenib in HSC-T6 cells were not observed in hepatocytes or macrophages, highlighting the specificity of this process in liver fibrosis attenuation.
CELL PROLIFERATION
(2022)
Article
Multidisciplinary Sciences
Avishai Gavish, Benny Chain, Tomer M. Salame, Yaron E. Antebi, Shir Nevo, Shlomit Reich-Zeliger, Nir Friedman
Summary: Numerous methods have emerged for ordering single cells along developmental trajectories, but accurate depiction of developmental dynamics requires rescaling the trajectory based on the relative time spent at each developmental point. We propose a model that estimates local cell densities and fluxes, and incorporates cell division and apoptosis rates to infer the real-time dimension of the developmental trajectory. We validate the model using mathematical simulations and apply it to experimental high dimensional cytometry data from the mouse thymus to construct the true time profile of the thymocyte developmental process. Our method can be easily implemented in existing trajectory inference tools.
Article
Biochemistry & Molecular Biology
Pritam Bhagwan Bhosale, Hun Hwan Kim, Abuyaseer Abusaliya, Se Hyo Jeong, Min Yeong Park, Hyun-Wook Kim, Je Kyung Seong, Meejung Ahn, Kwang Il Park, Jeong Doo Heo, Young Sil Kim, Gon Sup Kim
Summary: Epidemiologic research suggests that flavonoids in the diet are beneficial for overall health. Apigetrin, a phytonutrient found in fruits and vegetables, has antioxidant and anti-inflammatory properties. This study investigated the effects of apigetrin on HepG2 cells and found that it reduced cell proliferation and induced cell death through the extrinsic apoptotic pathway.
Review
Cell Biology
Zhi Lin, Fei Long, Rui Kang, Daniel J. Klionsky, Minghua Yang, Daolin Tang
Summary: This article provides a comprehensive summary of the latest research on the role and potential mechanisms of different lipids in regulating regulated cell death processes, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy.
Review
Biochemistry & Molecular Biology
Gabriella Horvath, Dora Reglodi, Eszter Fabian, Balazs Opper
Summary: PACAP exerts protective effects against cell death in both neural and non-neural cells through its anti-apoptotic, anti-inflammatory, and antioxidant functions. It shows significant effects on cell death in different in vitro models, suggesting its potential therapeutic usage in various pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yetong Qi, Zhu Yang, Xinyuan Sun, Huan He, Lei Guo, Jing Zhou, Meng Xu, Ming Luo, Huilan Chen, Zhendong Tian
Summary: The potato transcription factor StERF3 promotes colonization of Phytophthora infestans in Nicotiana benthamiana and induces cell death. Its cell death-inducing ability is affected by two key amino acids in the ERF domain, and deletion or mutation of the EAR motif diminishes this ability. StERF3 interacts with co-repressors via the EAR motif and facilitates cell death, which is compromised by silencing of related genes in Nicotiana benthamiana. Moreover, StERF3-induced cell death is associated with ROS bursts and upregulation of cell death regulator genes.
Review
Cell Biology
Annamaria Paolini, Rebecca Borella, Sara De Biasi, Anita Neroni, Marco Mattioli, Domenico Lo Tartaro, Cecilia Simonini, Laura Franceschini, Gerolamo Cicco, Anna Maria Piparo, Andrea Cossarizza, Lara Gibellini
Summary: Cell death mechanisms play a crucial role in maintaining a healthy cellular environment, but dysregulation of these processes during viral infections can contribute to disease pathology. In COVID-19 patients, lymphopenia and monocytopenia are important factors in immunopathogenesis, and the underlying mechanisms are still not fully understood. Further research is needed to develop new therapeutic strategies for COVID-19.
Review
Pharmacology & Pharmacy
Sweata Hanson, Aiswarya Dharan, P. V. Jinsha, Sanjay Pal, Bipin G. Nair, Rekha Kar, Nandita Mishra
Summary: Programmed cell death (PCD) is a universal process that regulates cellular homeostasis and plays a crucial role in disease conditions, including cancer. Apoptosis is a major PCD, but cancer cells develop resistance to it, necessitating the search for alternative forms of programmed cell death such as paraptosis. Paraptosis is characterized by vacuolation and damage to cellular structures and has potential therapeutic implications in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Luke Loftus, Sarah R. Amend, Kenneth J. Pienta
Summary: Cell division and cell death are essential processes in growth and development. Cancer is caused by abnormal regulation of these processes, and traditional anti-cancer treatments trigger apoptosis, to which cancer cells are resistant. Understanding how drugs kill cancer cells is crucial for developing more effective treatments. Cell cycle-independent forms of cell death, such as necroptosis or ferroptosis, have potential immunogenic effects, providing alternative strategies against tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Natalia Ketelut-Carneiro, Katherine A. Fitzgerald
Summary: This review discusses the three main types of programmed cell death, apoptosis, pyroptosis, and necroptosis, highlighting their characteristics and commonalities. Understanding the similarities and differences of these cell death processes is crucial for the development of targeted therapeutic strategies.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Christa Caggiano, Barbara Celona, Fleur Garton, Joel Mefford, Brian L. Black, Robert Henderson, Catherine Lomen-Hoerth, Andrew Dahl, Noah Zaitlen
Summary: The study introduces an algorithm, CelFiE, for accurately estimating the relative abundances of cell types and tissues contributing to cell-free DNA in the bloodstream. The algorithm is versatile and can be applied in various contexts, such as pregnant women and ALS patients.
NATURE COMMUNICATIONS
(2021)
Review
Food Science & Technology
Chunhui Liu, Xiangzhao Mao, Lingyun Meng, Jiao Li
Summary: In recent years, programmed cell death (PCD) has attracted the attention of many scholars as an active death process. This phenomenon has not only been observed in multicellular organisms but also in microbes. Different stressors during modern food processing have been found to induce various forms of programmed death in microbes. Microbial PCD can be classified into apoptosis-like death, autolytic death, and toxin-antitoxin systems based on their intrinsic mechanisms. Potential applications of these PCD mechanisms include searching for new antimicrobial targets, developing new types of preservatives, engineering design in synthetic biology, and modifying fermentation strains.
FOOD RESEARCH INTERNATIONAL
(2022)