标题
Heme as a Target for Therapeutic Interventions
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 8, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2017-04-04
DOI
10.3389/fphar.2017.00146
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung Injury
- (2016) Saurabh Aggarwal et al. ANTIOXIDANTS & REDOX SIGNALING
- Heme Oxygenase-1 in Kidney Health and Disease
- (2016) Jeremie M. Lever et al. ANTIOXIDANTS & REDOX SIGNALING
- Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red CellsClinical Perspective
- (2016) Jan A. Graw et al. CIRCULATION
- Red alert: labile heme is an alarmin
- (2016) Miguel P Soares et al. CURRENT OPINION IN IMMUNOLOGY
- Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation
- (2016) Johann Greil et al. HAEMATOLOGICA
- Alterations in Systemic Extracellular Heme and Hemopexin Are Associated With Adverse Clinical Outcomes in Ugandan Children With Severe Malaria
- (2016) Robyn E. Elphinstone et al. JOURNAL OF INFECTIOUS DISEASES
- Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage
- (2016) Bo Ma et al. Journal of Neuroinflammation
- Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis
- (2016) Tian Lin et al. MOLECULAR MEDICINE
- Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease
- (2016) Gregory M Vercellotti et al. MOLECULAR MEDICINE
- Regulation of intracellular heme trafficking revealed by subcellular reporters
- (2016) Xiaojing Yuan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hemin Preconditioning Upregulates Heme Oxygenase-1 in Deceased Donor Renal Transplant Recipients
- (2016) Rachel A. B. Thomas et al. TRANSPLANTATION
- Heme: Modulator of Plasma Systems in Hemolytic Diseases
- (2016) Lubka T. Roumenina et al. TRENDS IN MOLECULAR MEDICINE
- Sepsis: pathophysiology and clinical management
- (2016) Jeffrey E Gotts et al. BMJ-British Medical Journal
- Sepsis: pathophysiology and clinical management
- (2016) Jeffrey E Gotts et al. BMJ-British Medical Journal
- Mutating heme oxygenase-1 into a peroxidase causes a defect in bilirubin synthesis associated with microcytic anemia and severe hyperinflammation
- (2016) Johann Greil et al. HAEMATOLOGICA
- Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease
- (2015) S. M. Camus et al. BLOOD
- Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease
- (2015) F. Vinchi et al. BLOOD
- Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via Bach1 in primary human mononuclear cells
- (2015) Mirrin J. Dorresteijn et al. FREE RADICAL BIOLOGY AND MEDICINE
- Heme-induced contractile dysfunction in Human cardiomyocytes caused by oxidant damage to thick filament proteins
- (2015) Gerardo Alvarado et al. FREE RADICAL BIOLOGY AND MEDICINE
- Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma–hemorrhage
- (2015) Ryan Stapley et al. FREE RADICAL BIOLOGY AND MEDICINE
- Different target specificities of haptoglobin and hemopexin define a sequential protection system against vascular hemoglobin toxicity
- (2015) Jeremy W. Deuel et al. FREE RADICAL BIOLOGY AND MEDICINE
- Macrophage and epithelial cell H-ferritin expression regulates renal inflammation
- (2015) Subhashini Bolisetty et al. KIDNEY INTERNATIONAL
- Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation
- (2015) Nadine Keleku-Lukwete et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased Heme Levels in the Heart Lead to Exacerbated Ischemic Injury
- (2015) Konrad Teodor Sawicki et al. Journal of the American Heart Association
- Hemopexin and haptoglobin: allies against heme toxicity from hemoglobin not contenders
- (2015) Ann Smith et al. Frontiers in Physiology
- Hemopexin-dependent heme uptake via endocytosis regulates the Bach1 transcription repressor and heme oxygenase gene activation
- (2014) Hiroshi Hada et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease
- (2014) G. Chen et al. BLOOD
- Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages
- (2014) Malay Haldar et al. CELL
- Hemin Controls T Cell Polarization in Sickle Cell Alloimmunization
- (2014) H. Zhong et al. JOURNAL OF IMMUNOLOGY
- Extracellular hemoglobin - mediator of inflammation and cell death in the choroid plexus following preterm intraventricular hemorrhage
- (2014) Magnus Gram et al. Journal of Neuroinflammation
- Hemolysis-induced lethality involves inflammasome activation by heme
- (2014) Fabianno F. Dutra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mice are not men
- (2014) H. Shaw Warren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PECAM-1-dependent heme oxygenase-1 regulation via an Nrf2-mediated pathway in endothelial cells
- (2014) Yarúa Jaimes et al. THROMBOSIS AND HAEMOSTASIS
- Transfusion of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia
- (2014) Dong Wang et al. TRANSFUSION
- Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes
- (2014) Deborah Chiabrando et al. Frontiers in Pharmacology
- Heme on innate immunity and inflammation
- (2014) Fabianno F. Dutra et al. Frontiers in Pharmacology
- Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development
- (2014) Dominik J. Schaer et al. Frontiers in Physiology
- Red blood cell, hemoglobin and heme in the progression of atherosclerosis
- (2014) Viktória Jeney et al. Frontiers in Physiology
- Heme Oxygenase-1 As a Target for Drug Discovery
- (2013) Roberto Motterlini et al. ANTIOXIDANTS & REDOX SIGNALING
- The Multifunctional Role and Therapeutic Potential of HO-1 in the Vascular Endothelium
- (2013) Damien Calay et al. ANTIOXIDANTS & REDOX SIGNALING
- Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome
- (2013) M. Frimat et al. BLOOD
- Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
- (2013) J. D. Belcher et al. BLOOD
- Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases
- (2013) Francesca Vinchi et al. CIRCULATION
- Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: A critical role for heme oxygenase-1
- (2013) Yu Shen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Heme Sensor Proteins
- (2013) Hazel M. Girvan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Extracellular hemin crisis triggers acute chest syndrome in sickle mice
- (2013) Samit Ghosh et al. JOURNAL OF CLINICAL INVESTIGATION
- Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury
- (2013) Abolfazl Zarjou et al. JOURNAL OF CLINICAL INVESTIGATION
- Heme Levels Are Increased in Human Failing Hearts
- (2013) Arineh Khechaduri et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Severe Sepsis and Septic Shock
- (2013) Derek C. Angus et al. NEW ENGLAND JOURNAL OF MEDICINE
- Therapeutic Roles of Heme Oxygenase-1 in Metabolic Diseases: Curcumin and Resveratrol Analogues as Possible Inducers of Heme Oxygenase-1
- (2013) Yong Son et al. Oxidative Medicine and Cellular Longevity
- Genomic responses in mouse models poorly mimic human inflammatory diseases
- (2013) Junhee Seok et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hemoglobin Redox Reactions and Red Blood Cell Aging
- (2012) Joseph M. Rifkind et al. ANTIOXIDANTS & REDOX SIGNALING
- Heme binding to human alpha-1 proteinase inhibitor
- (2012) Elena Karnaukhova et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- One ring to rule them all: Trafficking of heme and heme synthesis intermediates in the metazoans
- (2012) Iqbal Hamza et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease
- (2012) C. J. Bean et al. BLOOD
- Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
- (2012) D. J. Schaer et al. BLOOD
- Heme Oxygenase Gene Targeting to Adipocytes Attenuates Adiposity and Vascular Dysfunction in Mice Fed a High-Fat Diet
- (2012) Jian Cao et al. HYPERTENSION
- Association between the Haptoglobin and Heme Oxygenase 1 Genetic Profiles and Soluble CD163 in Susceptibility to and Severity of Human Malaria
- (2012) Vitor R. R. Mendonça et al. INFECTION AND IMMUNITY
- Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy
- (2012) Jin Hyen Baek et al. JOURNAL OF CLINICAL INVESTIGATION
- Vasculature and Kidney Complications in Sickle Cell Disease
- (2012) K. A. Nath et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases
- (2012) Rasmus Larsen et al. Frontiers in Pharmacology
- Heme Oxygenase, Inflammation, and Fibrosis: The Good, the Bad, and the Ugly?
- (2012) Ditte M. S. Lundvig et al. Frontiers in Pharmacology
- Transfusion of older stored blood and risk of death: a meta-analysis
- (2011) Dong Wang et al. TRANSFUSION
- Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys
- (2011) Björn Petersen et al. XENOTRANSPLANTATION
- Inhibition of Neutrophil Migration by Hemopexin Leads to Increased Mortality Due to Sepsis in Mice
- (2010) Fernando Spiller et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Mechanisms of Cell Protection by Heme Oxygenase-1
- (2010) Raffaella Gozzelino et al. Annual Review of Pharmacology and Toxicology
- The Redox Activity of Hemoglobins: From Physiologic Functions to Pathologic Mechanisms
- (2010) Brandon J. Reeder ANTIOXIDANTS & REDOX SIGNALING
- Red Cells, Hemoglobin, Heme, Iron, and Atherogenesis
- (2010) Emőke Nagy et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential
- (2010) Ananta Paine et al. BIOCHEMICAL PHARMACOLOGY
- Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution
- (2010) G. Kovtunovych et al. BLOOD
- Haem arginate infusion stimulates haem oxygenase-1 expression in healthy subjects
- (2010) D Doberer et al. BRITISH JOURNAL OF PHARMACOLOGY
- Expression of heme oxygenase-1 in human leukemic cells and its regulation by transcriptional repressor Bach1
- (2010) Takuya Miyazaki et al. CANCER SCIENCE
- Lentiviral-Human Heme Oxygenase Targeting Endothelium Improved Vascular Function in Angiotensin II Animal Model of Hypertension
- (2010) Jian Cao et al. HUMAN GENE THERAPY
- Heme Impairs Prostaglandin E2 and TGF- Production by Human Mononuclear Cells via Cu/Zn Superoxide Dismutase: Insight into the Pathogenesis of Severe Malaria
- (2010) B. B. Andrade et al. JOURNAL OF IMMUNOLOGY
- Synergistic Inflammation Is Induced by Blood Degradation Products with Microbial Toll‐Like Receptor Agonists and Is Blocked by Hemopexin
- (2010) Tian Lin et al. JOURNAL OF INFECTIOUS DISEASES
- Heme oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease
- (2010) John D. Belcher et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- GAPDH regulates cellular heme insertion into inducible nitric oxide synthase
- (2010) R. Chakravarti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Central Role for Free Heme in the Pathogenesis of Severe Sepsis
- (2010) R. Larsen et al. Science Translational Medicine
- Heme Scavenging and the Other Facets of Hemopexin
- (2009) Emanuela Tolosano et al. ANTIOXIDANTS & REDOX SIGNALING
- Myeloid heme oxygenase–1 regulates innate immunity and autoimmunity by modulating IFN-β production
- (2009) Sotiria Tzima et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The L-4F mimetic peptide prevents insulin resistance through increased levels of HO-1, pAMPK, and pAKT in obese mice,
- (2009) Stephen J. Peterson et al. JOURNAL OF LIPID RESEARCH
- Heme oxygenase-1 affords protection against noncerebral forms of severe malaria
- (2009) E. Seixas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality?
- (2009) Christophe Lelubre et al. TRANSFUSION
- Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload
- (2008) Francesca Vinchi et al. AMERICAN JOURNAL OF PATHOLOGY
- Mechanisms of Endothelial Dysfunction, Injury, and Death
- (2008) Jordan S. Pober et al. Annual Review of Pathology-Mechanisms of Disease
- The Heme Oxygenase System Abates Hyperglycemia in Zucker Diabetic Fatty Rats by Potentiating Insulin-Sensitizing Pathways
- (2008) Joseph Fomusi Ndisang et al. ENDOCRINOLOGY
- The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis
- (2008) Krisztina Horváth et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Nuclear Hormone Receptors for Heme: REV-ERBα and REV-ERBβ Are Ligand-Regulated Components of the Mammalian Clock
- (2008) Thomas P. Burris MOLECULAR ENDOCRINOLOGY
- Pharmacological and Clinical Aspects of Heme Oxygenase
- (2008) N. G. Abraham et al. PHARMACOLOGICAL REVIEWS
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