Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

Hypoxia controls Flvcr1 gene expression in Caco2 cells through HIF2α and ETS1

(2014) Veronica Fiorito et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Heme Exporter FLVCR1a Regulates Heme Synthesis and Degradation and Controls Activity of Cytochromes P450

(2014) Francesca Vinchi et al.   GASTROENTEROLOGY

Lack of Plasma Protein Hemopexin Dampens Mercury-Induced Autoimmune Response in Mice

(2014) S. Fagoonee et al.   JOURNAL OF IMMUNOLOGY

Coupling Heme and Iron Metabolism via Ferritin H Chain

(2013) Raffaella Gozzelino et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage

(2013) C A Schaer et al.   CELL DEATH AND DIFFERENTIATION

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

(2013) Carine White et al.   Cell Metabolism

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

ATP-Binding Cassette B10 Regulates Early Steps of Heme Synthesis

(2013) Marina Bayeva et al.   CIRCULATION RESEARCH

Heme Oxygenase-1 and Breast Cancer Resistance Protein Protect Against Hemeinduced Toxicity

(2013) Frank A.D.T.G. Wagener et al.   CURRENT PHARMACEUTICAL DESIGN

A novel deletion mutation in the proton-coupled folate transporter (PCFT; SLC46A1) in a Nicaraguan child with hereditary folate malabsorption

(2013) N. Diop-Bove et al.   GENE

Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia

(2013) K. Kaneko et al.   HAEMATOLOGICA

Acute-Phase Protein Hemopexin Is a Negative Regulator of Th17 Response and Experimental Autoimmune Encephalomyelitis Development

(2013) S. Rolla et al.   JOURNAL OF IMMUNOLOGY

Heme and FLVCR-related transporter families SLC48 and SLC49

(2013) Anwar A. Khan et al.   MOLECULAR ASPECTS OF MEDICINE

Therapeutic Approaches to Limit Hemolysis-Driven Endothelial Dysfunction: Scavenging Free Heme to Preserve Vasculature Homeostasis

(2013) Francesca Vinchi et al.   Oxidative Medicine and Cellular Longevity

Lack of Plasma Protein Hemopexin Results in Increased Duodenal Iron Uptake

(2013) Veronica Fiorito et al.   PLoS One

Cell-Free Hemoglobin and Its Scavenger Proteins: New Disease Models Leading the Way to Targeted Therapies

(2013) D. J. Schaer et al.   Cold Spring Harbor Perspectives in Medicine

ABCB6 Mutations Cause Ocular Coloboma

(2012) Lejing Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The porphyrias: advances in diagnosis and treatment

(2012) M. Balwani et al.   BLOOD

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

ATP-dependent Mitochondrial Porphyrin Importer ABCB6 Protects against Phenylhydrazine Toxicity

(2012) Dagny L. Ulrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

(2012) Deborah Chiabrando et al.   JOURNAL OF CLINICAL INVESTIGATION

Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice

(2012) Yu Zeng et al.   JOURNAL OF NEUROCHEMISTRY

ABCB6 is dispensable for erythropoiesis and specifies the new blood group system Langereis

(2012) Virginie Helias et al.   NATURE GENETICS

Shifting the Paradigm: The Putative Mitochondrial Protein ABCB6 Resides in the Lysosomes of Cells and in the Plasma Membrane of Erythrocytes

(2012) Katalin Kiss et al.   PLoS One

Heme Cytotoxicity and the Pathogenesis of Immune-Mediated Inflammatory Diseases

(2012) Rasmus Larsen et al.   Frontiers in Pharmacology

Porphyria cutanea tarda – When skin meets liver

(2011) Jorge Frank et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency

(2011) K. V. Salojin et al.   BLOOD

Sickle Hemoglobin Confers Tolerance to Plasmodium Infection

(2011) Ana Ferreira et al.   CELL

ABCG transporters and disease

(2011) Owen M. Woodward et al.   FEBS Journal

Sideroblastic anemia: molecular analysis of the ALAS2 gene in a series of 29 probands and functional studies of 10 missense mutations

(2011) Sarah Ducamp et al.   HUMAN MUTATION

Topologically Conserved Residues Direct Heme Transport in HRG-1-related Proteins

(2011) Xiaojing Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of novel mutations in the proton-coupled folate transporter (PCFT-SLC46A1) associated with hereditary folate malabsorption

(2011) Daniel Sanghoon Shin et al.   MOLECULAR GENETICS AND METABOLISM

Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1

(2011) Hiroyuki Ishiura et al.   NEUROGENETICS

Transfusion Thresholds in FOCUS

(2011) Paul J. Barr et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Role for Hemopexin in Oligodendrocyte Differentiation and Myelin Formation

(2011) Noemi Morello et al.   PLoS One

Mutations in FLVCR1 Cause Posterior Column Ataxia and Retinitis Pigmentosa

(2010) Anjali M. Rajadhyaksha et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in FLVCR2 Are Associated with Proliferative Vasculopathy and Hydranencephaly-Hydrocephaly Syndrome (Fowler Syndrome)

(2010) Esther Meyer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inhibition of Neutrophil Migration by Hemopexin Leads to Increased Mortality Due to Sepsis in Mice

(2010) Fernando Spiller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Heme Oxygenase in the Regulation of Vascular Biology: From Molecular Mechanisms to Therapeutic Opportunities

(2010) Young-Myeong Kim et al.   ANTIOXIDANTS & REDOX SIGNALING

Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis

(2010) W. Chen et al.   BLOOD

Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution

(2010) G. Kovtunovych et al.   BLOOD

Ribosomopathies: human disorders of ribosome dysfunction

(2010) A. Narla et al.   BLOOD

Heme and non-heme iron transporters in non-polarized and polarized cells

(2010) Izumi Yanatori et al.   BMC CELL BIOLOGY

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Congenital Hydrocephalus-Hydrencephaly in Five Siblings, with Autopsy Studies: a New Disease

(2010) Malcolm Fowler et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal

(2010) Maria Almira Correia et al.   DRUG METABOLISM REVIEWS

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

(2010) S. Marro et al.   HAEMATOLOGICA

High-throughput sequencing of a 4.1 Mb linkage interval reveals FLVCR2 deletions and mutations in lethal cerebral vasculopathy

(2010) Sophie Thomas et al.   HUMAN MUTATION

ABCG2 Transports and Transfers Heme to Albumin through Its Large Extracellular Loop

(2010) Elodie Desuzinges-Mandon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics and Specificity of Feline Leukemia Virus Subgroup C Receptor (FLVCR) Export Function and Its Dependence on Hemopexin

(2010) Zhantao Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

(2010) Hong Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Heme Oxygenase-1 Deficiency Presenting With Hemolysis, Nephritis, and Asplenia

(2010) Nita Radhakrishnan et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

The Fowler Syndrome-Associated Protein FLVCR2 Is an Importer of Heme

(2010) S. P. Duffy et al.   MOLECULAR AND CELLULAR BIOLOGY

The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people

(2010) K. Yamagishi et al.   RHEUMATOLOGY

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Mitochondrial Iron Metabolism and Sideroblastic Anemia

(2009) Alex D. Sheftel et al.   ACTA HAEMATOLOGICA

Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease

(2009) Joan D. Beckman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Heme Scavenging and the Other Facets of Hemopexin

(2009) Emanuela Tolosano et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme Degradation and Vascular Injury

(2009) John D. Belcher et al.   ANTIOXIDANTS & REDOX SIGNALING

The putative heme transporter HCP1 is expressed in cultured astrocytes and contributes to the uptake of hemin

(2009) Theresa N. Dang et al.   GLIA

Heme–Hemopexin Complex Attenuates Neuronal Cell Death and Stroke Damage

(2009) Rung-chi Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identification of a Feline Leukemia Virus Variant That Can Use THTR1, FLVCR1, and FLVCR2 for Infection

(2009) Z. Shalev et al.   JOURNAL OF VIROLOGY

Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia

(2009) Duane L Guernsey et al.   NATURE GENETICS

Erythropoietic protoporphyria

(2009) Mario Lecha et al.   Orphanet Journal of Rare Diseases

Systematic molecular genetic analysis of congenital sideroblastic anemia: Evidence for genetic heterogeneity and identification of novel mutations

(2009) Anke K. Bergmann et al.   PEDIATRIC BLOOD & CANCER

Heme oxygenase-1 affords protection against noncerebral forms of severe malaria

(2009) E. Seixas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

(2009) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria

(2009) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C-Terminal Deletions in the ALAS2 Gene Lead to Gain of Function and Cause X-linked Dominant Protoporphyria without Anemia or Iron Overload

(2008) Sharon D. Whatley et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload

(2008) Francesca Vinchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Human ABC transporter isoform B6 (ABCB6) localizes primarily in the Golgi apparatus

(2008) Masashi Tsuchida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Erythropoietic Porphyrias: Animal Models and Update in Gene-Based Therapies

(2008) Emmanuel Richard et al.   CURRENT GENE THERAPY

Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis

(2008) M. A. Rey et al.   HAEMATOLOGICA

RPS19 mutations in patients with Diamond-Blackfan anemia

(2008) Maria Francesca Campagnoli et al.   HUMAN MUTATION

Haemopexin affects iron distribution and ferritin expression in mouse brain

(2008) Noemi Morello et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A central role for free heme in the pathogenesis of severe malaria: the missing link?

(2008) Ana Ferreira et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin

(2008) Jianyu Zheng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

(2008) S. B. Keel et al.   SCIENCE