Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development

Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress

(2014) F Vallelian et al.   CELL DEATH AND DIFFERENTIATION

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin

(2014) Todd L. Mollan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Extracellular Hb Enhances Cardiac Toxicity in Endotoxemic Guinea Pigs: Protective Role of Haptoglobin

(2014) Jin Baek et al.   Toxins

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

Modeling hemoglobin and hemoglobin:haptoglobin complex clearance in a non-rodent species–pharmacokinetic and therapeutic implications

(2014) Felicitas S. Boretti et al.   Frontiers in Physiology

Human Hp1-1 and Hp2-2 Phenotype-Specific Haptoglobin Therapeutics Are Both Effective In Vitro and in Guinea Pigs to Attenuate Hemoglobin Toxicity

(2013) Miriam Lipiski et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

Mechanisms of haptoglobin protection against hemoglobin peroxidation triggered endothelial damage

(2013) C A Schaer et al.   CELL DEATH AND DIFFERENTIATION

Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases

(2013) Francesca Vinchi et al.   CIRCULATION

Extracellular hemin crisis triggers acute chest syndrome in sickle mice

(2013) Samit Ghosh et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute-Phase Protein Hemopexin Is a Negative Regulator of Th17 Response and Experimental Autoimmune Encephalomyelitis Development

(2013) S. Rolla et al.   JOURNAL OF IMMUNOLOGY

CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms

(2013) K. Subramanian et al.   JOURNAL OF IMMUNOLOGY

Haptoglobin Genotype Is a Consistent Marker of Coronary Heart Disease Risk Among Individuals With Elevated Glycosylated Hemoglobin

(2013) Leah E. Cahill et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chloroquine Interference with Hemoglobin Endocytic Trafficking Suppresses Adaptive Heme and Iron Homeostasis in Macrophages: The Paradox of an Antimalarial Agent

(2013) Christian A. Schaer et al.   Oxidative Medicine and Cellular Longevity

Haptoglobin Binding Stabilizes Hemoglobin Ferryl Iron and the Globin Radical on Tyrosine β145

(2012) Chris E. Cooper et al.   ANTIOXIDANTS & REDOX SIGNALING

Plasma Clearance of Hemoglobin and Haptoglobin in Mice and Effect of CD163 Gene Targeting Disruption

(2012) Anders Etzerodt et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production

(2012) G. B. Fortes et al.   BLOOD

Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins

(2012) D. J. Schaer et al.   BLOOD

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

(2012) Jin Hyen Baek et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemolysis and cell-free hemoglobin drive an intrinsic mechanism for human disease

(2012) Mark T. Gladwin et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Hemopexin as an Anti-Inflammatory Factor That Inhibits Synergy of Hemoglobin with HMGB1 in Sterile and Infectious Inflammation

(2012) T. Lin et al.   JOURNAL OF IMMUNOLOGY

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

(2012) Sen Lin et al.   Journal of Neuroinflammation

Increased Expression of Oxidation-Specific Epitopes and Apoptosis Are Associated With Haptoglobin Genotype

(2012) K-Raman Purushothaman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Structure of the haptoglobin–haemoglobin complex

(2012) Christian Brix Folsted Andersen et al.   NATURE

Activating Transcription Factor 1 Directs Mhem Atheroprotective Macrophages Through Coordinated Iron Handling and Foam Cell Protection

(2011) Joseph J. Boyle et al.   CIRCULATION RESEARCH

Postoperative acute kidney injury is associated with hemoglobinemia and an enhanced oxidative stress response

(2011) Frederic T. Billings et al.   FREE RADICAL BIOLOGY AND MEDICINE

Haptoglobin activates innate immunity to enhance acute transplant rejection in mice

(2011) Hua Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular Hemoglobin Polarizes the Macrophage Proteome toward Hb-Clearance, Enhanced Antioxidant Capacity and Suppressed HLA Class 2 Expression

(2011) Theresa Kaempfer et al.   JOURNAL OF PROTEOME RESEARCH

Hemoglobin Directs Macrophage Differentiation and Prevents Foam Cell Formation in Human Atherosclerotic Plaques

(2011) Aloke V. Finn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Acute renal failure associated to paroxysmal nocturnal haemoglobinuria leads to intratubular haemosiderin accumulation and CD163 expression

(2011) J. Ballarin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Hemolysis and Acute Kidney Failure

(2010) Qi Qian et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Inhibition of Neutrophil Migration by Hemopexin Leads to Increased Mortality Due to Sepsis in Mice

(2010) Fernando Spiller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

Red Cells, Hemoglobin, Heme, Iron, and Atherogenesis

(2010) Emőke Nagy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity

(2010) F. Vallelian et al.   BLOOD

Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163

(2010) Anders Etzerodt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Quantitative Mass Spectrometry Defines an Oxidative Hotspot in Hemoglobin that is Specifically Protected by Haptoglobin

(2010) Tatiana Pimenova et al.   JOURNAL OF PROTEOME RESEARCH

Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure

(2010) O. Boutaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design

(2010) Paul W. Buehler et al.   TRENDS IN MOLECULAR MEDICINE

Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage Phenotype

(2009) Joseph J. Boyle et al.   AMERICAN JOURNAL OF PATHOLOGY

Hemoglobin-based Oxygen Carriers

(2009) Toby A. Silverman et al.   ANESTHESIOLOGY

Differential Induction of Renal Heme Oxygenase and Ferritin in Ascorbate and Nonascorbate Producing Species Transfused with Modified Cell-Free Hemoglobin

(2009) Omer I. Butt et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin: Basic and Clinical Aspects

(2009) Andrew P. Levy et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme Degradation and Vascular Injury

(2009) John D. Belcher et al.   ANTIOXIDANTS & REDOX SIGNALING

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification

(2009) P. W. Buehler et al.   BLOOD

Haptoglobin deficiency facilitates the development of autoimmune inflammation

(2009) Georgina Galicia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

(2009) Felicitas S. Boretti et al.   JOURNAL OF CLINICAL INVESTIGATION

Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages

(2009) Xueya Liang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Characterization of high molecular weight multimeric states of human haptoglobin and hemoglobin-based oxygen carriers by high-mass MALDI MS

(2009) Tatiana Pimenova et al.   JOURNAL OF SEPARATION SCIENCE

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

(2009) Philipp Niethammer et al.   NATURE

Hemoglobin-based oxygen carriers: current status and future directions

(2009) Toby A. Silverman et al.   TRANSFUSION

Hemopexin Prevents Endothelial Damage and Liver Congestion in a Mouse Model of Heme Overload

(2008) Francesca Vinchi et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural Stabilization in Tetrameric or Polymeric Hemoglobin Determines Its Interaction with Endogenous Antioxidant Scavenger Pathways

(2008) Paul W. Buehler et al.   ANTIOXIDANTS & REDOX SIGNALING

The reaction of hydrogen peroxide with hemoglobin induces extensive α-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways

(2008) Florence Vallelian et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cell-Free Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death

(2008) Charles Natanson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tyrosine Residues as Redox Cofactors in Human Hemoglobin

(2008) Brandon J. Reeder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haptoglobin Genotype Is a Major Determinant of the Amount of Iron in the Human Atherosclerotic Plaque

(2008) Pedro R. Moreno et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Rate of nitric oxide scavenging by hemoglobin bound to haptoglobin

(2008) Ivan Azarov et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY