Dihydroceramides: From Bit Players to Lead Actors

Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity

(2015) S. Rodriguez-Cuenca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

Increased Dihydroceramide/Ceramide Ratio Mediated by Defective Expression ofdegs1Impairs Adipocyte Differentiation and Function

(2014) Nuria Barbarroja et al.   DIABETES

Regulation of De Novo Ceramide Synthesis: The Role of Dihydroceramide Desaturase and Transcriptional Factors NFATC and Hand2 in the Hypoxic Mouse Heart

(2013) Raed Azzam et al.   DNA AND CELL BIOLOGY

Plasma ceramides are elevated in female children and adolescents with type 2 diabetes

(2013) Ximena Lopez et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Ablation of Dihydroceramide Desaturase 1, a Therapeutic Target for the Treatment of Metabolic Diseases, Simultaneously Stimulates Anabolic and Catabolic Signaling

(2013) M. M. Siddique et al.   MOLECULAR AND CELLULAR BIOLOGY

Plasma dihydroceramide species associate with waist circumference in Mexican American families

(2013) Manju Mamtani et al.   Obesity

Identification of Sphingolipid Metabolites That Induce Obesity via Misregulation of Appetite, Caloric Intake and Fat Storage in Drosophila

(2013) Stanley M. Walls et al.   PLoS Genetics

The end of autophagic cell death?

(2012) Shensi Shen et al.   Autophagy

Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death

(2012) Aintzane Apraiz et al.   Biochemistry and Cell Biology

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

(2012) Q.-J. Zhang et al.   DIABETES

Dihydroceramide delays cell cycle G1/S transition via activation of ER stress and induction of autophagy

(2012) Vincenzo Gagliostro et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet

(2012) J T Brozinick et al.   INTERNATIONAL JOURNAL OF OBESITY

Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis

(2012) Benjamin T. Bikman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

Ablation of Dihydroceramide Desaturase Confers Resistance to Etoposide-Induced Apoptosis In Vitro

(2012) Monowarul M. Siddique et al.   PLoS One

Autophagy: for better or for worse

(2011) Ellen Wirawan et al.   CELL RESEARCH

Resveratrol, a Phytochemical Inducer of Multiple Cell Death Pathways: Apoptosis, Autophagy and Mitotic Catastrophe

(2011) D. Delmas et al.   CURRENT MEDICINAL CHEMISTRY

Dihydroceramide-based Response to Hypoxia

(2011) Cecilia M. Devlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Dihydroceramide Desaturase as a Directin VitroTarget for Fenretinide

(2011) Mehrdad Rahmaniyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Regulation of Dihydroceramide Desaturase by PalmitateversusMonounsaturated Fatty Acids

(2011) Wei Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Ceramides as modulators of cellular and whole-body metabolism

(2011) Benjamin T. Bikman et al.   JOURNAL OF CLINICAL INVESTIGATION

Myristic Acid Increases Dihydroceramide Δ4-Desaturase 1 (DES1) Activity in Cultured Rat Hepatocytes

(2011) Hélène Ezanno et al.   LIPIDS

Phosphorylated Dihydroceramides from Common Human Bacteria Are Recovered in Human Tissues

(2011) Frank C. Nichols et al.   PLoS One

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

(2011) Hyunmi Lee et al.   PLoS One

Dihydroceramide desaturase and dihydrosphingolipids: Debutant players in the sphingolipid arena

(2011) Gemma Fabrias et al.   PROGRESS IN LIPID RESEARCH

Dihydroceramide desaturase activity is modulated by oxidative stress

(2010) Jolanta Idkowiak-Baldys et al.   BIOCHEMICAL JOURNAL

Ceramide channels and their role in mitochondria-mediated apoptosis

(2010) Marco Colombini   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Dihydrosphingomyelin Impairs HIV-1 Infection by Rigidifying Liquid-Ordered Membrane Domains

(2010) Catarina R. Vieira et al.   CHEMISTRY & BIOLOGY

Kdo2-Lipid A, a TLR4-specific Agonist, Inducesde NovoSphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy

(2010) Kacee Sims et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Lipids from a Common Human Bacterium Represent a New Class of Toll-Like Receptor 2 Ligands Capable of Enhancing Autoimmunity

(2009) Frank C. Nichols et al.   AMERICAN JOURNAL OF PATHOLOGY

Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis

(2009) Frederic Preitner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Dihydroceramide intracellular increase in response to resveratrol treatment mediates autophagy in gastric cancer cells

(2009) Paola Signorelli et al.   CANCER LETTERS

A strong correlation between fusogenicity and membrane insertion depth of the HIV fusion peptide

(2009) W. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of C. elegans from Anoxia by HYL-2 Ceramide Synthase

(2009) V. Menuz et al.   SCIENCE