ON or OFF?: Modulating the N-Methyl-D-Aspartate Receptor in Major Depression

Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate

(2016) Darragh Downey et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

NMDAR inhibition-independent antidepressant actions of ketamine metabolites

(2016) Panos Zanos et al.   NATURE

Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition

(2016) Oliver H. Miller et al.   NEUROPHARMACOLOGY

Differential role of AMPA receptors in mouse tests of antidepressant and anxiolytic action

(2015) Jesper T Andreasen et al.   BRAIN RESEARCH

Recent insights into the mode of action of memantine and ketamine

(2015) Jon W Johnson et al.   CURRENT OPINION IN PHARMACOLOGY

How does ketamine elicit a rapid antidepressant response?

(2015) Ege T Kavalali et al.   CURRENT OPINION IN PHARMACOLOGY

NMDA receptor subunit mutations in neurodevelopmental disorders

(2015) Nail Burnashev et al.   CURRENT OPINION IN PHARMACOLOGY

Behavioral and cognitive effects of the N-methyl-d-aspartate receptor co-agonist d-serine in healthy humans: Initial findings

(2015) Raz Levin et al.   JOURNAL OF PSYCHIATRIC RESEARCH

AMPA Receptor–mTOR Activation is Required for the Antidepressant-Like Effects of Sarcosine during the Forced Swim Test in Rats: Insertion of AMPA Receptor may Play a Role

(2015) Kuang-Ti Chen et al.   Frontiers in Behavioral Neuroscience

Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy

(2015) Charles F. Zorumski et al.   Frontiers in Psychiatry

Glycine Induces Bidirectional Modifications inN-Methyl-d-aspartate Receptor-mediated Synaptic Responses in Hippocampal CA1 Neurons

(2014) Xiao-Yan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Organization, control and function of extrasynaptic NMDA receptors

(2014) T. Papouin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses

(2014) E. S. Gideons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine

(2014) Oliver H Miller et al.   eLife

mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats

(2013) Valentina Sabino et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibition of Glycine Transporter-I as a Novel Mechanism for the Treatment of Depression

(2013) Chih-Chia Huang et al.   BIOLOGICAL PSYCHIATRY

Glycine Transporter-I Inhibitors: A New Class of Antidepressant?

(2013) Sanjay J. Mathew   BIOLOGICAL PSYCHIATRY

GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

(2013) Joseph R Moskal et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Involvement of the GluN2A and GluN2B Subunits in Synaptic and Extrasynaptic N -methyl-d-aspartate Receptor Function and Neuronal Excitotoxicity

(2013) Xianju Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute Suppression of Spontaneous Neurotransmission Drives Synaptic Potentiation

(2013) E. Nosyreva et al.   JOURNAL OF NEUROSCIENCE

Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects

(2013) G Sanacora et al.   MOLECULAR PSYCHIATRY

BDNF-induced local protein synthesis and synaptic plasticity

(2013) Graciano Leal et al.   NEUROPHARMACOLOGY

GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

(2013) Jeffrey Burgdorf et al.   NEUROPSYCHOPHARMACOLOGY

Does increasing the ratio of AMPA-to-NMDA receptor mediated neurotransmission engender antidepressant action? Studies in the mouse forced swim and tail suspension tests

(2013) Jesper T. Andreasen et al.   NEUROSCIENCE LETTERS

Effects of Chronic D-Serine Elevation on Animal Models of Depression and Anxiety-Related Behavior

(2013) David-Marian Otte et al.   PLoS One

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Synaptic plasticity of NMDA receptors: mechanisms and functional implications

(2012) David L Hunt et al.   CURRENT OPINION IN NEUROBIOLOGY

A randomized add-on trial of high-dose d-cycloserine for treatment-resistant depression

(2012) Uriel Heresco-Levy et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Synaptic NMDA Receptors Mediate Hypoxic Excitotoxic Death

(2012) C. M. Wroge et al.   JOURNAL OF NEUROSCIENCE

Acute d-serine treatment produces antidepressant-like effects in rodents

(2011) Oz Malkesman et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Potentiation of μ-opioid receptor-mediated signaling by ketamine

(2011) Achla Gupta et al.   JOURNAL OF NEUROCHEMISTRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit

(2011) Chihiro Nozaki et al.   NATURE NEUROSCIENCE

GluN2B-containing NMDA receptors as possible targets for the neuroprotective and antidepressant effects of fluoxetine

(2011) Janos P. Kiss et al.   NEUROCHEMISTRY INTERNATIONAL

A Critical Role for GluN2B-Containing NMDA Receptors in Cortical Development and Function

(2011) Chih-Chieh Wang et al.   NEURON

Role of Glycine Receptors in Glycine-Induced LTD in Hippocampal CA1 Pyramidal Neurons

(2011) Rong-Qing Chen et al.   NEUROPSYCHOPHARMACOLOGY

Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm

(2010) Severine Farley et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term Potentiation

(2010) K. A. Foster et al.   JOURNAL OF NEUROSCIENCE

High dose D-serine in the treatment of schizophrenia

(2010) Joshua T. Kantrowitz et al.   SCHIZOPHRENIA RESEARCH

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine

(2009) Hai Xia Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

The glycine transport inhibitor sarcosine is an inhibitory glycine receptor agonist

(2009) Hai Xia Zhang et al.   NEUROPHARMACOLOGY