GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

(2013) Jeffrey Burgdorf et al.   NEUROPSYCHOPHARMACOLOGY

A Randomized Trial of a Low-Trapping Nonselective N-Methyl-D-Aspartate Channel Blocker in Major Depression

(2012) Carlos A. Zarate et al.   BIOLOGICAL PSYCHIATRY

A randomized add-on trial of high-dose d-cycloserine for treatment-resistant depression

(2012) Uriel Heresco-Levy et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

A Randomized, Placebo-Controlled, Crossover Pilot Trial of the Oral Selective NR2B Antagonist MK-0657 in Patients With Treatment-Resistant Major Depressive Disorder

(2012) Lobna Ibrahim et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

The BCM theory of synapse modification at 30: interaction of theory with experiment

(2012) Leon N Cooper et al.   NATURE REVIEWS NEUROSCIENCE

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

(2012) Ronald S. Duman et al.   TRENDS IN NEUROSCIENCES

Brief environmental enrichment elicits metaplasticity of hippocampal synaptic potentiation in vivo

(2012) Arne Buschler et al.   Frontiers in Behavioral Neuroscience

A pivotal role of GSK-3 in synaptic plasticity

(2012) Clarrisa A. Bradley et al.   Frontiers in Molecular Neuroscience

The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults

(2011) Kelly Posner et al.   AMERICAN JOURNAL OF PSYCHIATRY

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

(2011) Anita E. Autry et al.   NATURE

Calmodulin as a direct detector of Ca2+ signals

(2011) Guido C Faas et al.   NATURE NEUROSCIENCE

Compartmentalized versus Global Synaptic Plasticity on Dendrites Controlled by Experience

(2011) Hiroshi Makino et al.   NEURON

Signaling pathways underlying the rapid antidepressant actions of ketamine

(2011) Ronald S. Duman et al.   NEUROPHARMACOLOGY

Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors

(2011) J. Burgdorf et al.   NEUROSCIENCE

Structural Determinants of D-Cycloserine Efficacy at the NR1/NR2C NMDA Receptors

(2010) S. M. Dravid et al.   JOURNAL OF NEUROSCIENCE

Making memories last: the synaptic tagging and capture hypothesis

(2010) Roger L. Redondo et al.   NATURE REVIEWS NEUROSCIENCE

Frequency-modulated 50kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect

(2010) Jeffrey Burgdorf et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists

(2010) N. Li et al.   SCIENCE

Safety and Efficacy of Repeated-Dose Intravenous Ketamine for Treatment-Resistant Depression

(2009) Marije aan het Rot et al.   BIOLOGICAL PSYCHIATRY

RESEARCH: Validation of the Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ)

(2009) Gregory M. Chandler et al.   CNS Neuroscience & Therapeutics

The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation

(2009) B S McEwen et al.   MOLECULAR PSYCHIATRY

The N-methyl-d-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats

(2009) Jeffrey Burgdorf et al.   NEUROBIOLOGY OF AGING

The discriminative stimulus effects of N-methyl-d-aspartate glycine-site ligands in NMDA antagonist-trained rats

(2009) Katherine L. Nicholson et al.   PSYCHOPHARMACOLOGY

A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

(2009) Stéphane Peineau et al.   Molecular Brain

Cannabinoid CB1 receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats

(2008) Fangqiong Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An Innovative Design to Establish Proof of Concept of the Antidepressant Effects of the NR2B Subunit Selective N-Methyl-D-Aspartate Antagonist, CP-101,606, in Patients With Treatment-Refractory Major Depressive Disorder

(2008) Sheldon H. Preskorn et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Metaplasticity: tuning synapses and networks for plasticity

(2008) Wickliffe C. Abraham   NATURE REVIEWS NEUROSCIENCE

A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral–CA1 synapses in hippocampus

(2008) Xiao-lei Zhang et al.   NEUROPHARMACOLOGY

Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation

(2008) Hongshi Qi et al.   NEUROPHARMACOLOGY

Differential effects of chronic antidepressant treatment on shuttle box escape deficits induced by uncontrollable stress

(2008) Gerald Valentine et al.   PSYCHOPHARMACOLOGY