Angiogenesis Dysregulation in the Pathogenesis of Systemic Sclerosis

The impact of transcription factor Fli1 deficiency on the regulation of angiogenesis

(2017) Tetsuo Toyama et al.   EXPERIMENTAL DERMATOLOGY

Searching for a good model for systemic sclerosis: the molecular profile and vascular changes occurring in UCD-200 chickens strongly resemble the early phase of human systemic sclerosis

(2016) Paola Cipriani et al.   Archives of Medical Science

Low serum fibroblast growth factor 2 levels not accompanied by increased serum pentraxin 3 levels in patients with systemic sclerosis

(2016) Ufuk İlgen et al.   CLINICAL RHEUMATOLOGY

Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic Factors

(2016) Pei-Suen Tsou et al.   Arthritis & Rheumatology

Decreased expression of neuropilin-1 as a novel key factor contributing to peripheral microvasculopathy and defective angiogenesis in systemic sclerosis

(2015) Eloisa Romano et al.   ANNALS OF THE RHEUMATIC DISEASES

Autologous Fat Grafting in the Treatment of Fibrotic Perioral Changes in Patients with Systemic Sclerosis

(2015) Nicoletta Del Papa et al.   CELL TRANSPLANTATION

Epigenetic suppression of Fli1, a potential predisposing factor in the pathogenesis of systemic sclerosis

(2015) Yoshihide Asano   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-  and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist

(2015) P. Cipriani et al.   JOURNAL OF RHEUMATOLOGY

Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines

(2015) Pei-Suen Tsou et al.   RHEUMATOLOGY

Vasculopathy in scleroderma

(2015) Yoshihide Asano et al.   Seminars in Immunopathology

Plexin-D1/Semaphorin 3E pathway may contribute to dysregulation of vascular tone control and defective angiogenesis in systemic sclerosis

(2015) Celestina Mazzotta et al.   ARTHRITIS RESEARCH & THERAPY

Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts

(2015) Paola Cipriani et al.   ARTHRITIS RESEARCH & THERAPY

Inhibition of angiogenesis by platelets in systemic sclerosis patients

(2015) Daniela Hirigoyen et al.   ARTHRITIS RESEARCH & THERAPY

Pathogenesis of Systemic Sclerosis

(2015) Debendra Pattanaik et al.   Frontiers in Immunology

Impaired Endothelium-Mesenchymal Stem Cells Cross-talk in Systemic Sclerosis: a Link Between Vascular and Fibrotic Features

(2014) Paola Cipriani et al.   ARTHRITIS RESEARCH & THERAPY

Scleroderma Mesenchymal Stem Cells display a different phenotype from healthy controls; implications for regenerative medicine

(2013) Paola Cipriani et al.   ANGIOGENESIS

Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis

(2013) Britta Maurer et al.   ANNALS OF THE RHEUMATIC DISEASES

Review: Evidence That Systemic Sclerosis Is a Vascular Disease

(2013) Marco Matucci-Cerinic et al.   ARTHRITIS AND RHEUMATISM

Mesenchymal stem cells (MSCs) from scleroderma patients (SSc) preserve their immunomodulatory properties although senescent and normally induce T regulatory cells (Tregs) with a functional phenotype: implications for cellular-based therapy

(2013) P. Cipriani et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications

(2012) TacGhee Yi et al.   ARCHIVES OF PHARMACAL RESEARCH

Adipose Tissue

(2012) Masafumi Takahashi   CIRCULATION JOURNAL

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

(2012) Feng Fang et al.   ARTHRITIS RESEARCH & THERAPY

Peripheral blood mononuclear cells from patients with systemic sclerosis spontaneously secrete increased amounts of vascular endothelial growth factor (VEGF) already in the early stage of the disease

(2011) M Bielecki et al.   Advances in Medical Sciences

Angiogenic cytokines and growth factors in systemic sclerosis

(2011) Vasiliki Liakouli et al.   AUTOIMMUNITY REVIEWS

Cellular players in angiogenesis during the course of systemic sclerosis

(2011) Paola Cipriani et al.   AUTOIMMUNITY REVIEWS

Overexpression of VEGF 165 b, an Inhibitory Splice Variant of Vascular Endothelial Growth Factor, Leads to Insufficient Angiogenesis in Patients With Systemic Sclerosis

(2011) Mirko Manetti et al.   CIRCULATION RESEARCH

Dysregulated expression of MIG/CXCL9, IP-10/CXCL10 and CXCL16 and their receptors in systemic sclerosis

(2011) Bradley J Rabquer et al.   ARTHRITIS RESEARCH & THERAPY

Angiogenesis and Vasculopathy in Systemic Sclerosis: Evolving Concepts

(2011) Bradley J. Rabquer et al.   Current Rheumatology Reports

A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis

(2010) Mirko Manetti et al.   ARTHRITIS AND RHEUMATISM

Association of a Functional Polymorphism in the Matrix Metalloproteinase-12 Promoter Region with Systemic Sclerosis in an Italian Population

(2010) M. MANETTI et al.   JOURNAL OF RHEUMATOLOGY

Klotho is associated with VEGF receptor-2 and the transient receptor potential canonical-1 Ca2+ channel to maintain endothelial integrity

(2010) T. Kusaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietins-1 and -2 are differentially expressed in the sera of patients with systemic sclerosis: high angiopoietin-2 levels are associated with greater severity and higher activity of the disease

(2010) Małgorzata Michalska-Jakubus et al.   RHEUMATOLOGY

What are the new milestones in the pathogenesis of systemic sclerosis?

(2009) N Hunzelmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Junctional adhesion molecule-A is abnormally expressed in diffuse cutaneous systemic sclerosis skin and mediates myeloid cell adhesion

(2009) Y Hou et al.   ANNALS OF THE RHEUMATIC DISEASES

The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis

(2009) Nicole Reich et al.   ARTHRITIS AND RHEUMATISM

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cytokines and Inflammatory Mediators [9-19]

(2009)   RHEUMATOLOGY

Angiogenesis in systemic sclerosis: Impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions

(2008) J. Avouac et al.   ARTHRITIS AND RHEUMATISM

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx

(2008) R. A. Dean et al.   BLOOD

Vascular Disease in Scleroderma: Mechanisms of Vascular Injury

(2008) Bashar Kahaleh   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Clinical burden of digital vasculopathy in limited and diffuse cutaneous systemic sclerosis

(2007) S I Nihtyanova et al.   ANNALS OF THE RHEUMATIC DISEASES