Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts

Effects of Macitentan and Its Active Metabolite on Cultured Human Systemic Sclerosis and Control Skin Fibroblasts

(2015) M. Cutolo et al.   JOURNAL OF RHEUMATOLOGY

Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension

(2014) Marc Iglarz et al.   LIFE SCIENCES

Impaired Endothelium-Mesenchymal Stem Cells Cross-talk in Systemic Sclerosis: a Link Between Vascular and Fibrotic Features

(2014) Paola Cipriani et al.   ARTHRITIS RESEARCH & THERAPY

Bosentan reverses the pro-fibrotic phenotype of systemic sclerosis dermal fibroblasts via increasing DNA binding ability of transcription factor Fli1

(2014) Kaname Akamata et al.   ARTHRITIS RESEARCH & THERAPY

Scleroderma Mesenchymal Stem Cells display a different phenotype from healthy controls; implications for regenerative medicine

(2013) Paola Cipriani et al.   ANGIOGENESIS

2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative

(2013) Frank van den Hoogen et al.   ANNALS OF THE RHEUMATIC DISEASES

2013 Classification Criteria for Systemic Sclerosis: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative

(2013) Frank van den Hoogen et al.   ARTHRITIS AND RHEUMATISM

BUILD-3: A Randomized, Controlled Trial of Bosentan in Idiopathic Pulmonary Fibrosis

(2011) Talmadge E. King et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

(2011) Swati Bhattacharyya et al.   Nature Reviews Rheumatology

The Paradigm of G Protein Receptor Transactivation: A Mechanistic Definition and Novel Example

(2011) Peter J. Little et al.   TheScientificWorldJOURNAL

Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis

(2010) David Lagares et al.   ARTHRITIS AND RHEUMATISM

REVIEW: Endothelin Receptor Antagonists for Pulmonary Arterial Hypertension: An Overview

(2010) Shahzad G. Raja   Cardiovascular Therapeutics

Thrombin Stimulation of Proteoglycan Synthesis in Vascular Smooth Muscle Is Mediated by Protease-activated Receptor-1 Transactivation of the Transforming Growth Factor β Type I Receptor

(2010) Micah L. Burch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelin receptors: what's new and what do we need to know?

(2009) Stephanie W. Watts   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis

(2009) Naozumi Hashimoto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endothelin: 20 years from discovery to therapyThis article is one of a selection of papers published in the special issue (part 2 of 2) on Forefronts in Endothelin.

(2008) Matthias Barton et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Targeting the TGFβ, endothelin-1 and CCN2 axis to combat fibrosis in scleroderma

(2008) Andrew Leask   CELLULAR SIGNALLING

Transforming Growth Factor  -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth

(2008) A. C. Daly et al.   MOLECULAR AND CELLULAR BIOLOGY

Endothelin and scleroderma lung disease

(2008) R. M. Silver   RHEUMATOLOGY

Pathogenesis and therapeutic approaches for improved topical treatment in localized scleroderma and systemic sclerosis

(2008) I. Badea et al.   RHEUMATOLOGY

BUILD-1: A Randomized Placebo-controlled Trial of Bosentan in Idiopathic Pulmonary Fibrosis

(2007) Talmadge E. King et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE